4-Cyclo­butyl­amino-3-nitro­benzoic acid

The asymmetric unit of the title compound, C11H12N2O4, contains two crystallographically independent mol­ecules with similar geometries. Both mol­ecules contain an intra­molecular N—H⋯O hydrogen bond. The dihedral angles between the benzene ring and the mean plane of the cyclo­butane ring are 38.29 (7) and 57.04 (8)° in the two mol­ecules, and the nitro group is twisted slightly away from the plane of the benzene ring [dihedral angles = 9.15 (12) and 9.55 (12)° in the two mol­ecules]. In the crystal, the independent mol­ecules are linked into dimers by O—H⋯O hydrogen bonds between their carboxyl groups, and C—H⋯O and C—H⋯π inter­actions are formed between dimers

SentiMLBench: Benchmark Evaluation of Machine Learning Algorithms for Sentiment Analysis

Sentiment Analysis has been a topic of interest for researchers due to its increasing usage by Industry. To measure end-user sentiment., there is no clear verdict on which algorithms are better in real-time scenarios. A rigorous benchmark evaluation of various algorithms running across multiple datasets and different hardware architectures is required that can guide future researchers on potential advantages and limitations. In this paper, proposed SentiMLBench is a critical evaluation of key ML algorithms as standalone classifiers, a novel cascade feature selection (CFS) based ensemble technique in multiple benchmark environments each using a different twitter dataset and processing hardware. The best trained ensemble model with CFS enhancement surpasses current state-of-the-art models, according to experimental results. In a study, though ensemble model provides good accuracy, it falls short of neural networks accuracy by 2%. ML algorithms accuracy is poor as standalone classifiers across all three studies. The supremacy of neural networks is further stamped in study three where it outperforms other algorithms in accuracy by over 10%. Graphical processing unit provide speed and higher computational power at a fraction of a cost compared to a normal processor thereby providing critical architectural insights into developing a robust expert system for sentiment analysis

Ethyl 4-(2-hydroxy­ethyl­amino)-3-nitro­benzoate

In the title compound, C11H14N2O5, the mol­ecular structure is stabilized by an intra­molecular N—H⋯O hydrogen bond, which generates an S(6) ring motif. The nitro group is twisted slightly from the attached benzene ring, forming a dihedral angle of 5.2 (2)°. In the crystal packing, inter­molecular O—H⋯O and C—H⋯O hydrogen bonds link the mol­ecules into a three-dimensional network. The crystal studied was a non-merohedral twin, the refined ratio of the twin components being 0.264 (2):0.736 (2)

Human Adipose Tissue Derived ECM Based Composites for Tissue Engineering Applications

The present study describes the preparation of extracellular matrix (ECM) based composite films, porous scaffolds, nanofibers and alginate beads for tissue engineering applications. The porous ECM-chitosan composite scaffolds were fabricated by freeze drying method for large soft tissue defects. The ECM composite injectable micro-beads were prepared by incorporating ECM within alginate by aid of centrifugal force for soft tissue engineering application. The ECM composite films were prepared by varying the ECM concentration in sodium alginate and chitosan for by solvent casting method for development of wound dressing materials. The ECMPVA, ECM-chitosan-PVA composite electrospun fibers were fabricated using free surface electrospinning technique for use in tissue engineering applications. The interactions amongst the composites were analyzed by FTIR and XRD studies. It was noticed that the porous scaffold were bio-compatible and with increase in chitosan content the pore size decreased as observed in electron microscope. The injectable microbeads can be fabricated using a 250 µm diameter needle at 1000 rpm in bucket centrifuge, with 3 % alginate and 100 mM of calcium chloride with 0.1 % tween 80 as surfactant to reduce the coalescence of the formed beads. The films were thoroughly characterized for surface hydrophilicity, moisture retention capability, water vapor permeability, mechanical and biocompatibility. The mechanical properties suggested that the composite films had sufficient properties to be used for wound dressing applications. The ECM composite based electrospun fibers were formed at a working distance of 16cm and a working voltage of greater than or equal to 55 kV. It was noticed that with 10% PVA, and ECM concentration of 100mg/mL, with 0.02% SDS it was electrospinnable and the average fiber thickness was found to be 198±28 nm. With incorporation of chitosan, the ECM-PVA-chitosan solution was electrospinnable in 0.5M acetic acid and the average fiber thickness was found to be 356 ± 65 nm. Thus the ECM was successfully electrospun with the incorporation of chitosan and PVA to enhance the electrospinnablity of the ECM for development of ECM composite electrospun fiber for tissue engineering application

Pemphigus vulgaris: a rare case report

Pemphigus Vulgaris (PV) is an organ-specific autoimmune disorder affecting skin and mucous membranes with a characteristic of intraepithelial blistering. The first common sign of this disease is involvement of oral mucosa followed by skin involvement. We here in report a rare case one such recently seen by us, where oral lesions and skin lesions in a 24 year old female patient presenting with a five months history of multiple fluid filled lesions all over the body, who is known case of psychosis finally diagnosed as having pemphigus vulgaris

Extended Models of Silicon On Sapphire transistors for Analog and Digital Design at elevated temperatures (200�C)

This work focuses on extending the vendor supplied SOS MOSFET models to suit high temperature (200�C) CMOS circuit design or more specifically accurate simulation. The SPICE parameters required have been extracted through measurement of High Vt and Low Vt NMOS and PMOS transistors on five spatially separated die (6 transistors of each type on each die) on a wafer with a wide range combinations of lengths and widths over the temperature range of interest (120�C to 200�C). Both analog and digital models were extracted and validated. Transistor mismatch (critical to analog design) was characterized as a function of device width and length for NMOS and PMOS. To support high voltage applications e.g. EEPROM read/write, a (Lightly Doped Drain) High voltage LDD SOS MOSFET was developed and its LDD length-specific model was extracted and verified. In section-II circuit techniques suitable for high temperature operation were developed and verified with a sense amplifier (25�C to 200�C) for an 8KX8 Magneto-resistive Random Access Memory.School of Electrical & Computer Engineerin

Mayer-Rokitansky-Kuster-Hauser syndrome with gonadohypoplasia:a rare case report

MRKH (Mayer Rokitansky Kuster Hauser) syndrome is a congenital abnormality seen in one out of 5,000 women characterized by the agenesis of the vagina, cervix, and uterus. It is also associated with kidney, bone and hearing difficulties. The ovaries are present with a normal function similar to that of a healthy reproductive woman’s by producing eggs and female hormones. Chromosomes are the normal 46xx female karyotype. We report this rare syndrome in a 26–year-old female where she had presented with complaints of absence of uterus with the absence of left kidney. She didn’t attain menarchy, secondary sexual characters are well developed. Small right ovarian follicular cyst with a rim of ovarian tissue was observed. She had undergone vaginoplasty

Implementation of High Security Cryptographic System with Improved Error Correction and Detection Rate using FPGA

In this article, an encryption algorithm with an error detection technique is presented for highly secured reliable data transmission over unreliable communication channels. In this algorithm, an input data is mapped into orthogonal code first. After that the code is encrypted with the help of Linear Feedback Shift Register (LFSR). The technique has been successfully verified and synthesized using Xilinx by Spartan-3E FPGA. The results show that the error detection rate has been increased to 100% by proposed encryption scheme is effective and improves bandwidth efficiency

Electric field tunable magnetic properties of lead-free Na0.5Bi0.5TiO3/CoFe2O4 multiferroic composites

Lead-free multiferroic particulate composites of Na0.5Bi0.5TiO3 (NBT) and CoFe2O4 (CFO) have been synthesized by solid-state sintering method. A systematic study of structural, magnetic and magnetoelectric (ME) properties is undertaken. Structural and morphology studies carried out by x-ray diffraction and field emission scanning electron microscopy indicate formation of single phase for parent phases and presence of both phases in the composites. Magnetic properties are investigated using vibrating sample magnetometer and ferromagnetic resonance (FMR) measurements at room temperature. Strong ME coupling is demonstrated in NBT-CFO 70-30 mol% composite by an electrostatically tunable FMR field shift up to 428 Oe (at E = 3.9 kV/cm), which increases to a large value of 640 Oe at E = 6.8 kV/cm. Furthermore, these lead-free multiferroic composites exhibiting electrostatically induced magnetic resonance field at microwave frequencies provide great opportunities for electric field tunable microwave devices

Comparative study of adverse drug reaction pattern of two anti-asthma groups of drugs in a tertiary care hospital

Background: Bronchial Asthma is one of the worldwide health problems associated with increased morbidity and also mortality. Bronchial Asthma is a disease of airways that is characterized by increased responsiveness of the trachea-bronchial tree. Anti asthmatic drugs are associated with adverse effects which can affect the compliance and course of treatment. Monitoring adverse drug reactions in asthma will play a vital role in alerting physicians about the possibility and circumstances of such events, thereby protecting the user population from avoidable harm.Methods: The study was conducted in 500 bronchial asthma patients (250 patients in Beta 2 agonist group (Salbutamol) and 250 patients in Methylxanthine group (Deriphyllin) who fulfilled the study criteria and were observed for three months at Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai. Their prescriptions were collected and analysed. Adverse drug reactions(ADRs) in each group were collected and evaluated. The causality assessment was done by WHO-UMC assessment scale and severity by using Modified Hartwig-Seigel severity assessment scale.Results: Total 38% of patients taking anti-asthma drugs were encountered adverse drug reactions and were more common in elderly females (61 to 70 years). Adverse Drug Reactions were more common in Methylxanthine group (48%) compared to Beta 2 agonist group (28%). Headache (38%) was the commonest ADR in Methylxanthine group and Tremors (31%) in Beta 2 agonist group. Most of ADRs were mild (95 %), manageable and comes under possible (60 %) category of WHO causality assessment scale.Conclusions: Treatment of Bronchial Asthma is mainly based on Beta 2 agonist and Methylxanthine group. So, occurrence of ADR is much common. Our study offers a representative idea of the ADR profile of anti asthmatic drugs. Constant vigil in detecting ADRs and subsequent dose adjustments can make therapy with anti asthmatic drugs safer and more effective. This, in turn, will improve compliance