Beiträge zur deutschen Grammatik: Gesammelte Schriften von Tilman N. Höhle

A new edition of this book is available at  http://langsci-press.org/catalog/book/234. This volume contains the complete collection of published and unpublished work on German grammar by Tilman N. Höhle. It consists of two parts. The first part is Topologische Felder, a book-length manuscript that was written in 1983 but was never finished nor published. It is a careful examination of the topological properties of German sentences, including a discussion of typological assumptions. The second part assembles all other published and unpublished papers by Höhle on German grammar.All of these papers were highly influential in German linguistics, in theoretical linguistics in general, and in a specific variant of theoretical linguistics, Head-Driven Phrase Structure Grammar. Topics covered are clause structure, constituent order, coordination, (verum) focus, word structure, the relationship between relative pronouns and verbs in V2, extraction, and the foundations of a theory of phonology in constraint-based grammar.   As per legal requirement, we state that this book is available in Germany for 70 EUR

Beiträge zur deutschen Grammatik: Gesammelte Schriften von Tilman N. Höhle

A new edition of this book is available at  http://langsci-press.org/catalog/book/234. This volume contains the complete collection of published and unpublished work on German grammar by Tilman N. Höhle. It consists of two parts. The first part is Topologische Felder, a book-length manuscript that was written in 1983 but was never finished nor published. It is a careful examination of the topological properties of German sentences, including a discussion of typological assumptions. The second part assembles all other published and unpublished papers by Höhle on German grammar.All of these papers were highly influential in German linguistics, in theoretical linguistics in general, and in a specific variant of theoretical linguistics, Head-Driven Phrase Structure Grammar. Topics covered are clause structure, constituent order, coordination, (verum) focus, word structure, the relationship between relative pronouns and verbs in V2, extraction, and the foundations of a theory of phonology in constraint-based grammar.   As per legal requirement, we state that this book is available in Germany for 70 EUR

Subducted seafloor relief stops rupture in South American great earthquakes: Implications for rupture behaviour in the 2010 Maule, Chile earthquake

Great subduction earthquakes cause destructive surface deformation and ground shaking over hundreds of kilometres. Their rupture length is limited by the characteristic strength of the subduction plate interface, and by lateral variations in its mechanical properties. It has been proposed that subduction of topographic features such as ridges and seamounts can affect these properties and stop rupture propagation, but the required relief and physical mechanisms of topographic rupture limitation are not well understood. Here, we show that the rupture limits of thirteen historic great earthquakes along the South America-Nazca plate margin are strongly correlated with subducted topography with relief >1000m, including the Juan Fernandez Ridge. The northern limit of rupture in the Mw 8.8 Maule, Chile earthquake of 27 February 2010 is located where this ridge subducts. Analysis of intermediate-magnitude earthquakes shows that in most places, the subduction of high seafloor relief creates weak, aseismic zones at the plate interface, which prevent rupture propagation, but that the Juan Fernandez Ridge is associated with a locally strong plate interface. The maximum rupture length, and thus magnitude, of great subduction earthquakes is therefore determined by the size and lateral spacing of topographic features where they are present on the subducting plate. © 2010 Elsevier B.V

Design of PIAA coronagraphs over square apertures

The purpose of this paper is to present the results of a theoretical study pertaining to the feasibility of PIAA units using Deformable Mirrors. We begin by reviewing the general derivation of the design equations driving PIAA. We then show how to solve these equations for square apertures and show the performance of pure PIAA systems in the ray optics regime. We tie these design equations into the study of edge diffraction effects, and provide a general expression for the field after a full propagation through a PIAA coronagraph. Third, we illustrate how a combination of pre and post apodisers yields to a contrast of 10^10 even in the presence of diffractive effects, for configuration with neither wavefront errors or wavefront control. Finally we present novel PIAA configurations over square apertures which circumvent the constraints on the manufacturing of PIAA optics by inducing the apodisation with two square Deformable Mirrors (DM). Such solutions rely on pupil size smaller than currently envisioned static PIAA solutions and thus require aggressive pre and post-apodizing screens in order to mitigate for diffractive effect between the two mirrors. As a result they are associated to significant loss in performance, throughput in particular

Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression

The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental stages of chondrocytes, characterized by the expression of collagen types II and X, are arranged in arrays across the growth zone. Mutations in collagen II and X genes as well as the absence of their gene products lead to different, altered patterns of chondrocyte stages which remain aligned across the growth plate (GP). Here we analyze GP of rats bearing the mutation toothless (tl) which, apart from bone defects, develop a progressive, severe chondrodystrophy during postnatal weeks 3 to 6. Mutant GP exhibited disorganized, non-aligned chondrocytes and mineralized metaphyseal bone but without cartilage mineralization or cartilaginous extensions into the metaphysis. Expression of mRNA coding for collagen types II (Col II) and X (Col X) was examined in the tibial GP by in situ hybridization. Mutant rats at 2 weeks exhibited Col II RNA expression and some hypertrophied chondrocytes (HC) but no Col X RNA was detected. By 3rd week, HC had largely disappeared from the central part of the mutant GP and Col II RNA expression was present but weak and in 2 separate bands. Peripherally the GP contained HC but without Col X RNA expression. This abnormal pattern was exacerbated by the fourth week. Bone mineralized but cartilage in the GP did not. These data suggest that the tl mutation involves a regulatory function for chondrocyte maturation, including Col X RNA synthesis and mineralization, and that the GP abnormalities are related to the Col X deficiency. The differences in patterning in the tl rat GP compared to direct Col X mutations may be explained by compensatory effects

Superficial simplicity of the 2010 El Mayor–Cucapah earthquake of Baja California in Mexico

The geometry of faults is usually thought to be more complicated at the surface than at depth and to control the initiation, propagation and arrest of seismic ruptures. The fault system that runs from southern California into Mexico is a simple strike-slip boundary: the west side of California and Mexico moves northwards with respect to the east. However, the M_w 7.2 2010 El Mayor–Cucapah earthquake on this fault system produced a pattern of seismic waves that indicates a far more complex source than slip on a planar strike-slip fault. Here we use geodetic, remote-sensing and seismological data to reconstruct the fault geometry and history of slip during this earthquake. We find that the earthquake produced a straight 120-km-long fault trace that cut through the Cucapah mountain range and across the Colorado River delta. However, at depth, the fault is made up of two different segments connected by a small extensional fault. Both segments strike N130° E, but dip in opposite directions. The earthquake was initiated on the connecting extensional fault and 15 s later ruptured the two main segments with dominantly strike-slip motion. We show that complexities in the fault geometry at depth explain well the complex pattern of radiated seismic waves. We conclude that the location and detailed characteristics of the earthquake could not have been anticipated on the basis of observations of surface geology alone

EULAR recommendations for the management of familial Mediterranean fever

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, but many rheumatologists are not well acquainted with its management. The objective of this report is to produce evidence-based recommendations to guide rheumatologists and other health professionals in the treatment and follow-up of patients with FMF. A multidisciplinary panel, including rheumatologists, internists, paediatricians, a nurse, a methodologist and a patient representative, was assembled. Panellists came from the Eastern Mediterranean area, Europe and North America. A preliminary systematic literature search on the pharmacological treatment of FMF was performed following which the expert group convened to define aims, scope and users of the guidelines and established the need for additional reviews on controversial topics. In a second meeting, recommendations were discussed and refined in light of available evidence. Finally, agreement with the recommendations was obtained from a larger group of experts through a Delphi survey. The level of evidence (LoE) and grade of recommendation (GR) were then incorporated. The final document comprises 18 recommendations, each presented with its degree of agreement (0-10), LoE, GR and rationale. The degree of agreement was greater than 7/10 in all instances. The more controversial statements were those related to follow-up and dose change, for which supporting evidence is limited. A set of widely accepted recommendations for the treatment and monitoring of FMF is presented, supported by the best available evidence and expert opinion. It is believed that these recommendations will be useful in guiding physicians in the care of patients with FMF

BACE1 Processing of NRG1 Type III Produces a Myelin-Inducing Signal but Is Not Essential for the Stimulation of Myelination

Myelin sheath thickness is precisely adjusted to axon caliber, and in the peripheral nervous system, neuregulin 1 (NRG1) type III is a key regulator of this process. It has been proposed that the protease BACE1 activates NRG1 dependent myelination. Here, we characterize the predicted product of BACE1-mediated NRG1 type III processing in transgenic mice. Neuronal overexpression of a NRG1 type III-variant, designed to mimic prior cleavage in the juxtamembrane stalk region, induces hypermyelination in vivo and is sufficient to restore myelination of NRG1 type III-deficient neurons. This observation implies that the NRG1 cytoplasmic domain is dispensable and that processed NRG1 type III is sufficient for all steps of myelination. Surprisingly, transgenic neuronal overexpression of full-length NRG1 type III promotes hypermyelination also in BACE1 null mutant mice. Moreover, NRG1 processing is impaired but not abolished in BACE1 null mutants. Thus, BACE1 is not essential for the activation of NRG1 type III to promote myelination. Taken together, these findings suggest that multiple neuronal proteases collectively regulate NRG1 processing. © 2011 Wiley Periodicals, Inc

Boundary-Layer-Ingesting Inlet Flow Control

This paper gives an overview of a research study conducted in support of the small-scale demonstration of an active flow control system for a boundary-layer-ingesting (BLI) inlet. The effectiveness of active flow control in reducing engine inlet circumferential distortion was assessed using a 2.5% scale model of a 35% boundary-layer-ingesting flush-mounted, offset, diffusing inlet. This experiment was conducted in the NASA Langley 0.3-meter Transonic Cryogenic Tunnel at flight Mach numbers with a model inlet specifically designed for this type of testing. High mass flow actuators controlled the flow through distributed control jets providing the active flow control. A vortex generator point design configuration was also tested for comparison purposes and to provide a means to examine a hybrid vortex generator and control jets configuration. Measurements were made of the onset boundary layer, the duct surface static pressures, and the mass flow through the duct and the actuators. The distortion and pressure recovery were determined by 40 total pressure measurements on 8 rake arms each separated by 45 degrees and were located at the aerodynamic interface plane. The test matrix was limited to a maximum free-stream Mach number of 0.85 with scaled mass flows through the inlet for that condition. The data show that the flow control jets alone can reduce circumferential distortion (DPCPavg) from 0.055 to about 0.015 using about 2.5% of inlet mass flow. The vortex generators also reduced the circumferential distortion from 0.055 to 0.010 near the inlet mass flow design point. Lower inlet mass flow settings with the vortex generator configuration produced higher distortion levels that were reduced to acceptable levels using a hybrid vortex generator/control jets configuration that required less than 1% of the inlet mass flow