Automedicación por venta indiscriminada de los antibioticos en usuarios de la farmacia de Los Ángeles Callao Lima febrero 2022

El objetivo del trabajo es comprobar de determinar la relación que existe entre la automedicación por venta indiscriminada de antibióticos en usuarios de la Farmacia de Los Ángeles Callao Lima febrero 2022, Metodología: Estudio de enfoque cuantitativo, básico, descriptivo de diseño no experimental, que contó con una muestra de 120 usuarios de la Farmacia de Los Ángeles Callao Lima febrero 2022, para la toma de los datos se empleó dos cuestionarios; uno de 20 ítems para medir el nivel de los automedicación por venta indiscriminada de los antibióticos en usuarios de la Farmacia de Los Ángeles Callao Lima febrero 2022, con resultados óptimos para nuestra investigación, nuestros Resultados en cuanto al 41.67% menciona son independiente de ocupación, 57.50% menciona ESSALUD está afiliado a un seguro de salud , 49.17% menciona a veces su demanda de antibióticos es semanal y 83.33% menciona si porque tiene conocimiento sobre los antibióticos para tratar su enfermedad y nuestras Conclusiones 82.50% menciona si automedicación con antibióticos puede causar alergias, 73.33% menciona si los antibióticos usados inadecuadamente causarán resistencia bacteriana, 70.00% menciona si del uso de antibióticos en inyectables puede producirle un shock (intoxicación) y 79.17% menciona para infecciones por bacterias de para qué se usan los antibióticoshttp://repositorio.unid.edu.pe/handle/unid/288?show=ful

Durabilidad de hormigones autocompactantes con prestaciones especiales expuestos en atmósferas marinas y urbanas.

El hormigón autocompactante es aún una tecnología relativamente nueva y se tiene un escaso conocimiento acerca del comportamiento frente a durabilidad de este material. Sin embargo, la creciente tendencia al desarrollo de códigos y normativas que contemplan tanto la durabilidad del hormigón desde la fase de diseño como el empleo de nuevos materiales, implica un mayor conocimiento de las propiedades durables de este tipo de hormigón. En el presente trabajo se presentan los resultados obtenidos a partir de un estudio de durabilidad con hormigón autocompactante convencional fabricado con filler calizo, así como hormigones autocompactantes, con la misma dosificación pero modificados bien con incorporación de fibras (metálicas y poliméricas) o bien con sustitución del filler calizo por residuos de lodos de naturaleza caliza. Se han llevado a cabo tanto ensayos en laboratorio para determinación de indicadores de durabilidad como ensayos de exposición durante un año a atmósferas naturales (marina y urbana con distinta humedad relativa). Los indicadores de durabilidad analizados arrojan una elevada calidad de los distintos hormigones autocompactantes, lo cual se confirma a partir de ensayos de exposición en atmósferas reales. Si bien no se ha visto que la incorporación de fibras influya en la interacción de este material con el cloruro ni con el CO2, la sustitución del filler calizo por residuo de lodo indica un ligero aumento en la carbonatación y el transporte de cloruros

The Influence of Infection and Colonization on Outcomes in Inpatients With COVID-19 : Are We Forgetting Something?

The COVID-19 epidemic has been a great challenge to health systems and especially hospitals. A prospective observational epidemiological study was planned as of February 26, 2020 in a tertiary hospital in the Valencia region. The total number of patients followed up with complete information during the first year was 2,448. Among other variables, the comorbidities of the patients were collected (and grouped in the Charson index), the stay in the intensive care unit (ICU), the co-infections, and the colonizations. Data on nosocomial infections due to said virus were also collected. The median days from the onset of symptoms to diagnosis were 4 + 4.6, while an additional 4.4 days had to pass for the patients to be admitted to the ICU. The factors associated with a higher risk of death were those with coinfection, especially with Candida auris [odds ratio (OR): 4.6], a situation that also occurred in the ICU (OR: 3.18). Charlson Index comorbidity and C. auris colonization were also very important both in general hospitalization and in the ICU

Smart Drug-Delivery Systems for Cancer Nanotherapy

Despite all the advances achieved in the field of tumor-biology research, in most cases conventional therapies including chemotherapy are still the leading choices. The main disadvantage of these treatments, in addition to the low solubility of many antitumor drugs, is their lack of specificity, which explains the frequent occurrence of serious side effects due to nonspecific drug uptake by healthy cells. Progress in nanotechnology and its application in medicine have provided new opportunities and different smart systems. Such systems can improve the intracellular delivery of the drugs due to their multifunctionality and targeting potential. The purpose of this manuscript is to review and analyze the recent progress made in nanotherapy applied to cancer treatment. First, we provide a global overview of cancer and different smart nanoparticles currently used in oncology. Then, we analyze in detail the development of drug-delivery strategies in cancer therapy, focusing mainly on the intravenously administered smart nanoparticles with protein corona to avoid immune-system clearance. Finally, we discuss the challenges, clinical trials, and future directions of the nanoparticle-based therapy in cancer.Comment: Preprint version, 25 pages, 7 figures, 3 tables. Authors thank to Bentham Science the posibility of deposit the ACCEPTED VERSION of the peer-reviewed article after 12 months of publication on journal web site on arXiv repository. The published manuscript is available at EurekaSelect via https://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/138945011766616052714254

Effects of dietary chromium-yeast level on growth performance, blood metabolites, meat traits and muscle fatty acids profile, and microminerals content in liver and bone of lambs

To assess the effect of dietary supplement levels of chromium-yeast (Cr-yeast) on growth performance, blood glucose and triglycerides, fatty acid (FA) profile in intramuscular fat, carcase and meat traits, iron, copper, chromium and zinc concentrations in liver and bone, 24 Rambouillet male lambs (29.2 ± 0.17 kg body weight) were randomly assigned to four diets with 0, 0.2, 0.4 and 0.6mg Cr/kg DM. The growth performance trial lasted 49 d. Supplemental Cryeast did not affect growth performance and carcase characteristics (p>.05), but reduced (p<.05) perirenal and intramuscular fat, as well as 3 h post-feeding blood glucose and triglycerides concentration. In liver, Fe and Cu concentration decreased (p<.05), while Cr concentrations in liver increased with increasing Cr-yeast dietary levels. In bone, Fe decreased (p<.05) as Cryeast dietary levels increasing, and Cr-yeast supplementation increased Cr concentrations (p<.05). As Cr-yeast dietary level increased, palmitic (C16:0) and stearic (C18:0) SFA decreased linearly (p<.05), while palmitoleic (C16:1n-7), vaccenic (C18:1n-7), linoleic (C18:2n-6) and arachidic (C20:4) unsaturated fatty acids (UFA) increased linearly (p<.01). In conclusion, Cr-yeast did not affect growth performance and carcase quality, but decreased the perirenal and intramuscular fat, blood glucose and triglyceride content, and Fe and Cu concentrations in liver as increased Cr-yeast levels in the diet. Because supplemental Cr-yeast improved index of atherogenicity and unsaturated to saturated FA ratio in muscle of lambs, it could be of human nutritional interest

A palaeoecological approach to understanding the past and present of Sierra Nevada, a Southwestern European biodiversity hotspot

Mediterranean mountainous environments are biodiversity hotspots and priority areas in conservation agendas. Although they are fragile and threatened by forecasted global change scenarios, their sensitivity to long-term environmental variability is still understudied. The Sierra Nevada range, located in southern Spain on the north-western European flanks of the Mediterranean basin, is a biodiversity hotspot. Consequently, Sierra Nevada provides an excellent model system to apply a palaeoecological approach to detect vegetation changes, explore the drivers triggering those changes, and how vegetation changes link to the present landscape in such a paradigmatic mountain system. A multi-proxy strategy (magnetic susceptibility, grain size, loss-on-ignition, macroremains, charcoal and palynological analyses) is applied to an 8400-year long lacustrine environmental archive from the Laguna de la Mosca (2889 masl). The long-term ecological data show how the Early Holocene pine forests transitioned towards mixed Pinus-Quercus submediterranean forests as a response to a decrease in seasonality at ~7.3 cal. kyr BP. The mixed Pinus-Quercus submediterranean forests collapsed drastically giving way to open evergreen Quercus formations at ~4.2 cal. kyr BP after a well-known aridity crisis. Under the forecasted northward expansion of the Mediterranean area due to global change-related aridity increase, mountain forests inhabiting territories adjacent to the Mediterranean Region could experience analogous responses to those detected in the Sierra Nevada forests to the Mid to Late Holocene aridification, moving from temperate to submediterranean and then Mediterranean formations

Versatile Graphene-Based Platform for Robust Nanobiohybrid Interfaces

Technologically useful and robust graphene-based interfaces for devices require the introduction of highly selective, stable, and covalently bonded functionalities on the graphene surface, whilst essentially retaining the electronic properties of the pristine layer. This work demonstrates that highly controlled, ultrahigh vacuum covalent chemical functionalization of graphene sheets with a thiol-terminated molecule provides a robust and tunable platform for the development of hybrid nanostructures in different environments. We employ this facile strategy to covalently couple two representative systems of broad interest: metal nanoparticles, via S-metal bonds, and thiol-modified DNA aptamers, via disulfide bridges. Both systems, which have been characterized by a multi-technique approach, remain firmly anchored to the graphene surface even after several washing cycles. Atomic force microscopy images demonstrate that the conjugated aptamer retains the functionality required to recognize a target protein. This methodology opens a new route to the integration of high-quality graphene layers into diverse technological platforms, including plasmonics, optoelectronics, or biosensing. With respect to the latter, the viability of a thiol-functionalized chemical vapor deposition graphene-based solution-gated field-effect transistor array was assessed