133 research outputs found
Molecular Mechanism and Potential Targets for Blocking HPV-Induced Lesion Development
Persistent infection with high-risk HPV is the etiologic agent associated with the development of cervical cancer (CC) development. However, environmental, social, epidemiological, genetic, and host factors may have a joint influence on the risk of disease progression. Cervical lesions caused by HPV infection can be removed naturally by the host immune response and only a small percentage may progress to cancer; thus, the immune response is essential for the control of precursor lesions and CC. We present a review of recent research on the molecular mechanisms that allow HPV-infected cells to evade immune surveillance and potential targets of molecular therapy to inhibit tumor immune escape
Individualschutz durch Wirtschaftsgrundrechte im Gesellschaftsrecht
Los procesos de diseño, fabricación y explotación de la
maquinaria agrícola están estrechamente relacionados
con el aumento de los niveles de productividad, consumo
de combustible y mejoramiento de las cosechas
de caña. La presente investigación tiene como objetivo
realizar un análisis comparativo de los indicadores
técnicos explotativos en las cosechadoras de caña
KTP-2M y KTP-3000S. En el análisis se demostró
que el desempeño de la cosechadora KTP-3000S es superior
a la KTP-2M, alcanzando valores significativos
en cuanto a tiempo, eficiencia en el campo, coeficiente
de seguridad técnica, materias extrañas durante el
corte y valores de producción total, no teniendo este
mismo comportamiento con los indicadores de consumo
de combustible y valores de las pérdidas en
cosecha de todo el período.Por lo que se puede afirmar que la cosechadora cañera
KTP-3000S presentó un mejor desempeño durante el
cumplimiento de su destino de servicio. // The processes of design, manufacture and operation
of agricultural machinery are closely related to increased
levels of productivity, fuel consumption and
improving cane crops. This research aims to make
a comparative analysis of the exploitative technical
indicators cane harvesters KTP-2M and KTP-3000S.
In the analysis it was demonstrated that the performance
of the KTP-3000S harvester exceeds the KTP
2M, achieving significant values in terms of time, field
efficiency, coefficient of technical safety, foreign matter
field during cutting and values of total production
not having this same behavior with fuel consumption
indicators and values of crop losses throughout the
period.So we can say that the KTP-3000S sugar cane harvester,
presented a better performance during the
fulfillment of its service destiny
México y Jalisco en la coyuntura : segundo semestre de 1998
Análisis de coyuntura sobre los principales sucesos del segundo semestre de 1998 en Jalisco y México. El caso del FOBAPROA, la seguridad pública, los derechos humanos, las elecciones efectuadas en el período y las estrategias de los partidos políticos en Jalisco son analizados por autores diversos. Se estudia también el caso de la industria electrónica en Guadalajara y la relación de los grupos de la sociedad civil con el gobierno.ITESO, A.C
México y Jalisco en la coyuntura : primer semestre de 1998
Análisis de coyuntura sobre los principales sucesos del primer semestre de 1997 en Jalisco, a nivel político, económico y social: la situación en el estado de los tres principales partidos políticos (PAN, PRI y PRD), la cuestión laboral, los derechos humanos y el problema de abastecimiento de agua en la zona metropolitana de Guadalajara.ITESO, A.C
TESLA Technical Design Report Part III: Physics at an e+e- Linear Collider
The TESLA Technical Design Report Part III: Physics at an e+e- Linear
ColliderComment: 192 pages, 131 figures. Some figures have reduced quality. Full
quality figures can be obtained from http://tesla.desy.de/tdr. Editors -
R.-D. Heuer, D.J. Miller, F. Richard, P.M. Zerwa
Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver
<p>Abstract</p> <p>Background</p> <p>The NO - cGMP system plays a key role in the regulation of sinusoidal tonus and liver blood flow with phosphodiesterase-5 (PDE-5) terminating the dilatory action of cGMP. We, therefore, investigated the effects of PDE-5 inhibitors on hepatic and systemic hemodynamics in rats.</p> <p>Methods</p> <p>Hemodynamic parameters were monitored for 60 min. after intravenous injection of sildenafil and vardenafil [1, 10 and 100 μg/kg (sil1, sil10, sil100, var1, var10, var100)] in anesthetized rats.</p> <p>Results</p> <p>Cardiac output and heart rate remained constant. After a short dip, mean arterial blood pressure again increased. Systemic vascular resistance transiently decreased slightly. Changes in hepatic hemodynamic parameters started after few minutes and continued for at least 60 min. Portal (var10 -31%, sil10 -34%) and hepatic arterial resistance (var10 -30%, sil10 -32%) decreased significantly (p < 0.05). At the same time portal venous (var10 +29%, sil10 +24%), hepatic arterial (var10 +34%, sil10 +48%), and hepatic parenchymal blood flow (var10 +15%, sil10 +15%) increased significantly (p < 0.05). The fractional liver blood flow (total liver flow/cardiac output) increased significantly (var10 26%, sil10 23%). Portal pressure remained constant or tended to decrease. 10 μg/kg was the most effective dose for both PDE-5 inhibitors.</p> <p>Conclusion</p> <p>Low doses of phosphodiesterase-5 inhibitors have distinct effects on hepatic hemodynamic parameters. Their therapeutic use in portal hypertension should therefore be evaluated.</p
The generation challenge programme platform: semantic standards and workbench for crop science.
doi:10.1155/2008/369601
Dietary cadmium and risk of invasive postmenopausal breast cancer in the VITAL cohort.
This study does not support the hypothesis that dietary cadmium intake is a risk factor for breast cancer. However, non-differential measurement error in the estimate of cadmium intake is likely the most important factor that could have obscured an association
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