Development of new analytical tools for monitoring of cardiovascular disease markers – towards the detection of homocysteine-thiolactone

Poster presented at the 4th International Conference on Bio-Sensing Technology, 10-13 May 2015, Lisbon, Portuga

New PON1-based biosensor for the detection of homocysteine-thiolactone in human plasma

Poster presented at the XXIII International Symposium on Bioelectrochemistry and Bioenergetics, 14-18 June 2015, Malmo, Sweden

An intelligent home automation control system based on A novel heat pump and wireless sensor networks

One of technology's main goals is to providing comfort to humans. However, in order to be an aid, it has to be easy to install, use and maintain. The ever growing complexity of technological systems can only be achieved by converging different technologies. This is usually expressed as Cyber-Physical Systems (CPS), previews the symbiosis of several technologies in order to make them more accessible. This paper attempts to demonstrate the integration between two technologies such as: Heat-pump System and Wireless Sensor Network (WSN) to provide a new control mechanism for new building generations so-called smart houses. The proposed control architecture benefits from our developed WSN hardware platform. It enables the user to control and monitor the ventilation system using our developed mobile application and/or a personal computer. Also, the performance of the proposed hardware platform is measured in three different environments in order to observer the coverage area of the WSN.Tiago Gomes is supported by FCT, the Portuguese Foundation for Science and Technology (grant SFRH/BD/90162/2012). This work is supported by FEDER through COMPETE and national funds through FCT - Foundation for Science and Technology in the framework of the project FCOMP-OI-0124-FEDER-022674

Coastal halophilous Limonium communities from West Iberian Peninsula

In the present work, we studied seven communities occurring in salt marshes in the west of the Iberian Peninsula, mostly ascribable to Sarcocornietea fruticosae class. Three new syntaxa are described: Myriolimo diffusi-Limonietum algarvensis, Triglochino maritimae-Sarcocornietum alpini subass. puccinellietosum maritimae and Limonion lanceolati-algarvensis. The first one is a chamaephytic community existing on thermomediterranean dry salt marshes, only inundated during high tides; it occupies welldrained sands from the Algarve (Coastal Lusitanian- Andalusian Province, Mediterranean Region), which the director species are the Iberian endemisms Myriolimon diffusum and Limonium algarvense. The second one is a halophytic community formed by Sarcocornia perennis subsp. alpini, Triglochin maritima, Halimione portulacoides, Puccinellia maritima, and Plantago maritima on sites occasionally inundated by saltwater, rich in sand and silt, north of the Ria de Aveiro (Miniense District, Cantabrian- Atlantic Subprovince, Eurosiberian Region). The last one is the alliance Limonion lanceolati-algarviensis, formed by Limonium sp. pl. communities from the Coastal Lusitanian-Andalusian Province. We also extend the distribution area of Puccinellio tenuifoliae- Limonietum plurisquamati to the Tagus estuary We propose the segregation between Myriolimetum ferulacei, from the Algarve sea cliffs, and Inulo crithmoidis- Myriolimetum ferulacei, from salt marshe

About the hygrophilous woodlands and edges of Portuguese Divisory

Orlas e bosques higrofílicos do Divisório Português: Salici purpureae-Populetea nigrae e Rubus vigo

Diabetic and Elder Patients Experience Superior Cardiovascular Benefits After Gastric Bypass Induced Weight Loss

Background/Objetives: Obesity and obesity related co-morbidities are well-recognized risks for cardiovascular (CV) disease and mortality. Weight loss improves CV risk factors and the efficacy of bariatric surgery in decreasing CV mortality is now well-established. Our aim was to assess CV risk progression and occurrence of CV events in a cohort of patients that underwent Roux-en-Y gastric bypass (RYGB) for obesity treatment in a single academic public center.Subjects and Methods: Ten year CV risk was estimated using the Framingham Equation at baseline and 2 years after RYGB surgery in our patients cohort (n = 260). In the subgroup with a follow-up time longer than 4 years after surgery (n = 185; mean 5.4 ± 0.1 years), CV risk adjusted for the time length after RYGB was similarly estimated and the occurrence of CV events for outcome adjudication was monitored during the same time period by reviewing the hospital patients' record, the electronic national health system patient register and our center outpatient clinic records.Results: Ten year CV risk was significantly reduced 2 years after surgery when compared to baseline, with reductions of 1.65 ± 0.25% in the risk of CV disease. Patients with prior type 2 diabetes and aged 50 years or older experienced a significantly superior CV risk reduction, with diabetic patients experiencing a reduction of their 10–year CV disease risk of 3.58 ± 1.11% vs. a reduction of 1.31 ± 0.20% in non-diabetic patients and with the 10–year risk of CV disease dropping 3.41 ± 0.75% in patients older than 50 vs. a reduction of 0.99 ± 0.18 in patients up to 50 years. For the subgroup of patients with a longer follow-up time, baseline CV risk estimation predicted the occurrence of 6.08 ± 0.56 cardiovascular disease (CVD) events, 3.87 ± 0.39 coronary heart disease (CHD) events, 1.49 ± 0.22 myocardial infarctions (MI), 0.71 ± 0.09 strokes, 0. 28 ± 0.05 deaths from CHD and 0.35 ± 0.05 deaths from CVD. No CV events were adjudicated in this subgroup during follow-up.Conclusions: RYGB significantly improves CV risk and prevents the occurrence of CV events. For similar weight loss, diabetic and elder patients experience a superior CV risk improvement and may have additional CV benefits after bariatric surgery

Using a distance map and an active contour model to segment the carotid artery boundary from the lumen contour in proton density weighted magnetic resonance images

Segmentation methods have assumed an important role in image-based diagnosis of several cardiovascular diseases. Particularly, the segmentation of the boundary of the carotid artery is demanded in the detection and characterization of atherosclerosis and assessment of the disease progression. In this article, a fully automatic approach for the segmentation of the carotid artery boundary in Proton Density Weighted Magnetic Resonance Images is presented. The approach relies on the expansion of the lumen contour based on a distance map built using the gray-weighted distance relative to the center of the identified lumen region in the image under analysis. Then, a Snake model with a modified weighted external energy based on the combination of a balloon force along with a Gradient Vector Flow-based external energy is applied to the expanded contour towards the correct boundary of the carotid artery. The average values of the Dice coefficient, Polyline distance, mean contour distance and centroid distance found in the segmentation of 139 carotid arteries were 0.83 ± 0.11, 2.70 ± 1.69 pixels, 2.79 ± 1.89 pixels and 3.44 ± 2.82 pixels, respectively. The segmentation results of the proposed approach were also compared against the ones obtained by related approaches found in the literature, which confirmed the outstanding performance of the new approach. Additionally, the proposed weighted external energy for the Snake model was shown to be also robust to carotid arteries with large thickness and weak boundary image edges. (c) 202