Investigational Drugs for the Treatment of Postherpetic Neuralgia: Systematic Review of Randomized Controlled Trials

The pharmacological treatment of postherpetic neuralgia (PHN) is unsatisfactory, and there is a clinical need for new approaches. Several drugs under advanced clinical development are addressed in this review. A systematic literature search was conducted in three electronic databases (Medline, Web of Science, Scopus) and in the ClinicalTrials.gov register from 1 January 2016 to 1 June 2023 to identify Phase II, III and IV clinical trials evaluating drugs for the treatment of PHN. A total of 18 clinical trials were selected evaluating 15 molecules with pharmacological actions on nine different molecular targets: Angiotensin Type 2 Receptor (AT2R) antagonism (olodanrigan), Voltage-Gated Calcium Channel (VGCC) 2 subunit inhibition (crisugabalin, mirogabalin and pregabalin), Voltage-Gated Sodium Channel (VGSC) blockade (funapide and lidocaine), Cyclooxygenase-1 (COX-1) inhibition (TRK-700), Adaptor-Associated Kinase 1 (AAK1) inhibition (LX9211), Lanthionine Synthetase C-Like Protein (LANCL) activation (LAT8881), N-Methyl-D-Aspartate (NMDA) receptor antagonism (esketamine), mu opioid receptor agonism (tramadol, oxycodone and hydromorphone) and Nerve Growth Factor (NGF) inhibition (fulranumab). In brief, there are several drugs in advanced clinical development for treating PHN with some of them reporting promising results. AT2R antagonism, AAK1 inhibition, LANCL activation and NGF inhibition are considered first-in-class analgesics. Hopefully, these trials will result in a better clinical management of PHNTraining University Lecturers program (FPU21/02736) of the Spanish Ministry of Economy and Competitiveness (MINECO

Projective system approach to the martingale characterization of the absence of arbitrage

The equivalence between the absence of arbitrage and the existence of an equivalent martingale measure fails when an infinite number of trading dates is considered. By enlarging the set of states of nature and the probability measure through a projective system of topological spaces and Radon measures, we characterize the absence of arbitrage when the time set is countable

Optimal Fair Scheduling in S-TDMA Sensor Networks for Monitoring River Plumes

Underwater wireless sensor networks (UWSNs) are a promising technology to provide oceanographers with environmental data in real time. Suitable network topologies to monitor estuaries are formed by strings coming together to a sink node.This network may be understood as an oriented graph. A number of MAC techniques can be used in UWSNs, but Spatial-TDMA is preferred for fixed networks. In this paper, a scheduling procedure to obtain the optimal fair frame is presented, under ideal conditions of synchronization and transmission errors. The main objective is to find the theoretical maximum throughput by overlapping the transmissions of the nodes while keeping a balanced received data rate from each sensor, regardless of its location in the network. The procedure searches for all cliques of the compatibility matrix of the network graph and solves a Multiple-Vector Bin Packing (MVBP) problem. This work addresses the optimization problem and provides analytical and numerical results for both the minimum frame length and the maximum achievable throughput

Using Genetic Algorithms with Variable-length Individuals for Planning Two-Manipulators Motion

International Conference on Artificial Neural Networks and Genetic Algorithms. 01/01/1997. NorwichA method based on genetic algorithms for obtaining coordinated motion plans of manipulator robots is presented. A decoupled planning approach has been used; that is, the problem has been decomposed into two subproblems: path planning and trajectory planning. This paper focuses on the second problem. The generated plans minimize the total motion time of the robots along their paths. The optimization problem is solved by evolutionary algorithms using a variable-length individuals codification and specific genetic operators

Multi-Utilitarian Bargaining Solutions.

This paper introduces and analyzes the class of multi-utilitarian solutions for cooperative bargaining problems. We show that generalized Gini solutions and inequality averse Choquet bargaining solutions are particular cases of this new multi-valued solution concept and provide a complete characterization of inequality averse multi-utilitarian solutions in which an invariance property consisting of a weakening of both the linear invariance axiom in Blackorby et al. (1994) and the restricted invariance axiom in Ok and Zhou (2000). Moreover, by relaxing the assumptions involved in the characterization, the class is extended to include equality averse multi-utilitarian solutions which are also studied in the paper.Axiomatic bargaining theory, multi-valued bargaining solutions, generalized Gini solutions, inequality adverse Choquet solutions.

PROJECTIVE SYSTEM APPROACH TO THE MARTINGALE CHARACTERIZATION OF THE ABSENCE OF ARBITRAGE

The equivalence between the absence of arbitrage and the existence of an equivalent martingale measure fails when an infinite number of trading dates is considered. By enlarging the set of states of nature and the probability measure through a projective system of topological spaces and Radon measures, we characterize the absence of arbitrage when the time set is countable.

Snow avalanche susceptibility in the eastern hillside of the Aramo Range (Asturian Central Massif, Cantabrian Mountains, NW Spain)

A detailed snow avalanche susceptibility map of the eastern hillside in the Aramo Range (Cantabrian Mountains) is presented at a scale of 1:25,000. The Aramo Range is one of the major middle-altitude mountains of the Asturian Central Massif. Although it has of moderate height (maximum altitude of 1791 m a.s.l.), its eastern slope presents unusual snow avalanche activity. Specifically, a hundred of snow avalanche tracks have been mapped based on meticulous fieldwork and supported by interviews with local people, searches in newspaper archives, photointerpretation, and calculations based on the digital terrain model and geographic information system. As a result, a susceptibility map has been elaborated, which shows the suitability of combining fieldwork and geographic information technology. The composition consists of two maps that detail how the susceptibility mapping is obtained. The section analysed is limited to the eastern slope of the Aramo Range, whose total surface area is 1555.62 ha

Amber imitation? Two unusual cases of Pinus resin-coated beads in Iberian Late Prehistory (3rd and 2nd millennia BC)

A group of beads from the artificial cave of La Molina (Lora de Estepa, Sevilla) and Cova del Gegant (Sitges, Barcelona) were made from a biogenic raw material and intentionally covered by a layer of resin. This is the first time this type of treatment has been documented on elements of adornment in the Late Prehistory of the Iberian Peninsula. The composition and nature of the coatings are analysed and the symbolic role of such alterations and imitations of prehistoric adornments is discussed.Ministerio de Economía y Competitividad HAR2012- 34620, HAR2017-83474-