Economic and Environmental Study of Wineries Powered by Grid-Connected Photovoltaic Systems in Spain

This research developed a system that can make factories more independent from the grid. The system enhances efficiency since factory operation is powered by the renewable energy generated during the production process. Winemaking is a key sector that can profit from such a system because wineries can recycle much of the waste from the raw materials employed in wine production. Moreover, the solar energy collected at winemaking facilities can also be used to reduce electricity consumption and thus increase energy efficiency. This study investigated the feasibility of using renewable energy sources, such as solar energy, in wineries in Spain, given the quantity of renewable energy produced in the country. For this purpose, cost-effectiveness, power generation, CO2 emissions and the renewable energy fraction were taken into account. The assumption was that the photovoltaic system was grid-connected. Research results showed a reduction in electrical power costs ranging from 4% to 36%. This reduction was accompanied by an increase in the use of renewable energy of up to 57%. The results obtained are based on self-consumption or net metering policy as well as the production capacity of the winery

Del contenido al argumento: una unidad didáctica para mejorar los niveles de argumentación a partir de la reacción química y sus múltiples representaciones

La presente investigación de enfoque cuantitativo, con alcance explicativo y de diseño cuasi -experimental se desarrolló desde la línea de investigación del Macroproyecto en Didácticas de las Ciencias Naturales adscrita a la Maestría en Educación de la Universidad Tecnológica de Pereira cohorte I del departamento de La Guajira, realizada con estudiantes de grado décimo de dos instituciones oficiales de Riohacha. La investigación identificó a partir de la práctica de aula..

Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic condition which includes ulcerative colitis (UC) and Crohn’s disease (CD), the origins of which are not yet fully understood. Both conditions involve an exacerbated immune response in the intestinal tract, leading to tissue inflammation. Dendritic cells (DCs) are antigen-presenting cells crucial for maintaining tolerance in the gastrointestinal mucosa. Previous research has indicated that DC recruitment to the intestinal mucosa is more pronounced in individuals with IBD, but the specific mechanisms governing this migration remain unclear. This study aimed to assess the expression of various homing markers and the migratory abilities of circulating DC subsets in response to intestinal chemotactic signals. Additionally, this study examined how golimumab and ustekinumab impact these characteristics in individuals with IBD compared to healthy controls. The findings revealed that a particular subset of DCs known as type 2 conventional DCs (cDC2) displayed a more pronounced migratory profile compared to other DC subsets. Furthermore, the study observed that golimumab and ustekinumab had varying effects on the migratory profile of cDC1 in individuals with CD and UC. While CCL2 did not exert a chemoattractant effect on DC subsets in this patient cohort, treatment with golimumab and ustekinumab enhanced their migratory capacity towards CCL2 and CCL25 while reducing their migration towards MadCam1. In conclusion, this study highlights that cDC2 exhibits a heightened migratory profile towards the gastrointestinal mucosa compared to other DC subsets. This finding could be explored further for the development of new diagnostic biomarkers or the identification of potential immunomodulatory targets in the context of IB

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus

[Aims/hypothesis]: A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, through the manipulation of molecular and cellular targets, would provide a means to counteract the deteriorating glycaemic control associated with diabetes mellitus. The aims of the current study were to investigate the therapeutic potential of such a target, the islet-enriched and diabetes-linked transcription factor paired box 4 (PAX4), to restrain experimental autoimmune diabetes (EAD) in the RIP-B7.1 mouse model background and to characterise putative cellular mechanisms associated with preserved BCM. [Methods]: Two groups of RIP-B7.1 mice were genetically engineered to: (1) conditionally express either PAX4 (BPTL) or its diabetes-linked mutant variant R129W (mutBPTL) using doxycycline (DOX); and (2) constitutively express luciferase in beta cells through the use of RIP. Mice were treated or not with DOX, and EAD was induced by immunisation with a murine preproinsulin II cDNA expression plasmid. The development of hyperglycaemia was monitored for up to 4 weeks following immunisation and alterations in the BCM were assessed weekly by non-invasive in vivo bioluminescence intensity (BLI). In parallel, BCM, islet cell proliferation and apoptosis were evaluated by immunocytochemistry. Alterations in PAX4- and PAX4R129W-mediated islet gene expression were investigated by microarray profiling. PAX4 preservation of endoplasmic reticulum (ER) homeostasis was assessed using thapsigargin, electron microscopy and intracellular calcium measurements. [Results]: PAX4 overexpression blunted EAD, whereas the diabetes-linked mutant variant PAX4R129W did not convey protection. PAX4-expressing islets exhibited reduced insulitis and decreased beta cell apoptosis, correlating with diminished DNA damage and increased islet cell proliferation. Microarray profiling revealed that PAX4 but not PAX4R129W targeted expression of genes implicated in cell cycle and ER homeostasis. Consistent with the latter, islets overexpressing PAX4 were protected against thapsigargin-mediated ER-stress-related apoptosis. Luminal swelling associated with ER stress induced by thapsigargin was rescued in PAX4-overexpressing beta cells, correlating with preserved cytosolic calcium oscillations in response to glucose. In contrast, RNA interference mediated repression of PAX4-sensitised MIN6 cells to thapsigargin cell death. [Conclusions/interpretation]: The coordinated regulation of distinct cellular pathways particularly related to ER homeostasis by PAX4 not achieved by the mutant variant PAX4R129W alleviates beta cell degeneration and protects against diabetes mellitus. The raw data for the RNA microarray described herein are accessible in the Gene Expression Omnibus database under accession number GSE62846

Characterization of the plankton community composition in Málaga Bay (NW Alboran Sea) by means of integrative taxonomy.

The Alboran Sea is highly dynamic from a hydrographical point of view. Depending on the strength of the currents and the direction of the wind the surface coastal water masses can be either of Atlantic or Mediterranean origin. This variability affects both the phytoplankton and zooplankton components of the community inhabiting the Bay of Málaga. In addition, fish larvae distribution varies with the diel cycle, affecting zooplankton distribution in shallow waters. In order to provide a first insight into the variability of the planktonic community composition in the area during a 24 hour cycle, we applied an integrative approach combining morphological and molecular tools

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Departamentos de Córdoba y Antioquia.

Las representaciones narrativas se ocupan de generar estrategias útiles en los procesos psicosociales, que determinan los relatos de violencias que Colombia ha sufrido años tras años, lo cual se ocupa de lograr espacios de reflexión con el fin de brindar apoyo y ayudas necesarias que le permitan mejorar la calidad de vida de las personas. Es evidente que estas víctimas han desarrollado escenarios de violencias y que estas situaciones en ellos han desencadenado tristeza, inestabilidad emocional, angustias, preocupaciones desarraigos emocionales y que todos estos factores asociados han generado traumas psicológicos que afectan el desarrollo emocional social y familiar de quienes han vivido este flagelo. Por lo que este ejercicio académico giro entorno al análisis de relatos de vida de esas personas víctimas del conflicto armado, permitiéndonos generar análisis y reflexiones reales directamente sobre la práctica de la intervención psicosocial, en base al desarrollo de preguntas de tipo estratégicas, circulares y reflexivas que dan paso a la comprensión de un caso como tal en este caso, el de Ana Ligia Higinio; de igual forma se trabajó en torno al desarrollo del caso de la comunidad de Peñas Coloradas, mediante la identificación de aspectos puntuales relevantes en el caso que dieran paso a la realización de estrategias y acciones que procuraran la superación de los hechos vivenciados, además de fortalecer sus recursos internos y externos como comunidad. Buscando lograr generar estrategias que mitiguen los factores de riesgo y cambios de conductas en toda estas victima donde su principal objetivo es brindad apoyo psicosocial y exonerar a estas víctimas que cambien los eventos negativos por sucesos positivos significativos que les incentive a mejorar su desenvolvimiento a lo largo de sus días. El psicólogo en formación estará en la capacidad competitiva de intervenir, analizar y diagnosticar en determinado contexto de violencia diseñando de forma profesional estrategias que contribuyan con la mitigación de eventos traumáticos, resiliencia y construcción de bienestar psicológico y físico, validando cada una de las manifestaciones de las víctimas del conflicto, historias reales que remembran las voces de esperanza transformadora que siguen latentes y que a pesar de las circunstancias apuestan por continuar.The narrative representations are concerned with generating useful strategies in the psychosocial processes, which determine the accounts of violence that Colombia has suffered years after years, which is responsible for achieving spaces for reflection in order to provide support and necessary help that allow it to improve the quality of life of the people. It is evident that these victims have developed scenarios of violence and that these situations in them have triggered sadness, emotional instability, anguish, worries, emotional uprooting and that all these associated factors have generated psychological traumas that affect the social and family emotional development of those who have lived this scourge. Therefore, this academic exercise revolves around the analysis of the life stories of those victims of the armed conflict, allowing us to generate real analysis and reflections directly on the practice of psychosocial intervention, based on the development of strategic, circular and reflective questions. that give way to the understanding of a case as such in this case, that of Ana Ligia Higinio; Similarly, work was carried out on the development of the case of the community of Peñas Coloradas, by identifying relevant specific aspects in the case that led to the implementation of strategies and actions that would seek to overcome the facts experienced, in addition to strengthening your internal and external resources as a community. seeking to generate strategies that mitigate risk factors and behavior changes in all these victims where their main objective is to provide psychosocial support and exonerate these victims who change negative events for significant positive events that encourage them to improve their development throughout of his days. The psychologist in training will be in the competitive capacity to intervene, analyze and diagnose in a certain context of violence, professionally designing strategies that contribute to the mitigation of traumatic events, resilience and construction of psychological and physical well-being, validating each of the manifestations of the victims of the conflict, real stories that recall the voices of transforming hope that are still latent and that despite the circumstances are committed to continuing

Role of small-sized phytoplankton in triggering an ecosystem disruptive algal bloom in a Mediterranean hypersaline coastal lagoon

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