442 research outputs found
The Effect of Post Type and Length on the Fracture Resistance of Endodontically Treated Teeth
Master of ScienceRestorative DentistryUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/90959/1/McLaren_John_Duncan-THESIS_FINAL.pd
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Prevalence of iron deficiency in 62,685 women of seven race/ethnicity groups: The HEIRS Study.
BackgroundFew cross-sectional studies report iron deficiency (ID) prevalence in women of different race/ethnicity and ages in US or Canada.Materials and methodsWe evaluated screening observations on women who participated between 2001-2003 in a cross-sectional, primary care-based sample of adults ages ≥25 y whose observations were complete: race/ethnicity; age; transferrin saturation; serum ferritin; and HFE p.C282Y and p.H63D alleles. We defined ID using a stringent criterion: combined transferrin saturation <10% and serum ferritin <33.7 pmol/L (<15 μg/L). We compared ID prevalence in women of different race/ethnicity subgrouped by age and determined associations of p.C282Y and p.H63D to ID overall, and to ID in women ages 25-44 y with or without self-reported pregnancy.ResultsThese 62,685 women included 27,079 whites, 17,272 blacks, 8,566 Hispanics, 7,615 Asians, 449 Pacific Islanders, 441 Native Americans, and 1,263 participants of other race/ethnicity. Proportions of women with ID were higher in Hispanics and blacks than whites and Asians. Prevalence of ID was significantly greater in women ages 25-54 y of all race/ethnicity groups than women ages ≥55 y of corresponding race/ethnicity. In women ages ≥55 y, ID prevalence did not differ significantly across race/ethnicity. p.C282Y and p.H63D prevalence did not differ significantly in women with or without ID, regardless of race/ethnicity, age subgroup, or pregnancy.ConclusionsID prevalence was greater in Hispanic and black than white and Asian women ages 25-54 y. p.C282Y and p.H63D prevalence did not differ significantly in women with or without ID, regardless of race/ethnicity, age subgroup, or pregnancy
Apparent synergism between amino donors for CTP synthesis in Chinese hamster fibroblasts
The synergistic effects of potential amino donors were studied in the assay of CTP synthetase in extracts of Chinese hamster fibroblasts. We found that L-glutamine was not effective as the sole amino donor, but combinations of L-glutamine with NH 4 HCO 3 , L-arginine or potassium phosphate did result in the conversion of UTP to CTP. L-arginine or potassium phosphate were also not effective when used alone, and NH 4 HCO 3 was only slightly effective. Our studies demonstrate that the individual synergistic combinations were not additive; multiple combinations of components decreased rather than increased the formation of CTP.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45347/1/11010_2004_Article_BF00223531.pd
Radon and King Solomons Miners: Faynan Orefeild, Jordanian desert
Concentrations of 222Rn were measured in ancient copper mines which exploited the Faynan Orefield in the South-Western Jordanian Desert. The concentrations of radon gas detected indicate that the ancient metal workers would have been exposed to a significant health risk and indicate that any future attempt to exploit the copper ores must deal with the hazard identified. Seasonal variations in radon concentrations are noted and these are linked to the ventilation of the mines. These modern data are used to explore the differential exposure to radon and the health of ancient mining communities
Should Burden of Disease Estimates Include Cannabis Use as a Risk Factor for Psychosis?
Louise Degenhardt and colleagues discuss the evidence and the debate about whether Global Burden of Disease estimates should include cannabis use as a risk factor for psychosis
Potassium-induced release of endogenous glutamate and two as yet unidentified substances from the lateral line of Xenopus laevis
The release of endogenous glutamate and other primary amines from the lateral line of Xenopus laevis was studied using an in vitro superfusion technique and high performance liquid chromatography. Potassium stimulation (50 mM KCl) applied to 60 or 120 lateral-line organs dissected from the skin and pooled in a perfusion chamber induced the release of glutamate and aspartate. The release of aspartate was smaller than that of glutamate and more variable. A variable release of two, as yet, unidentified substances was also detected. In low calcium (0.1 mM CaCl2), high magnesium (10 mM MgCl2) solution, 50 mM potassium failed to induce an increase in glutamate, aspartate and the two unknowns, suggesting they are released in a transmitter-like manner. The technique presents a new and simple method for studying transmitters in hair-cell systems. Although other interpretations are possible, the results are consistent with the hypothesis that glutamate is a hair-cell transmitter and suggest a potential role for other substances in the transduction process, perhaps as neuromodulators.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27844/1/0000254.pd
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