Examination of the Role of Religious and Psychosocial Factors in HIV Medication Adherence Rates

Optimal adherence to antiretroviral therapy (ART) is associated with favorable HIV outcomes, including higher CD4 cell counts, HIV virus suppression and a lower risk of HIV transmission. However, only 25% of people living with HIV/AIDS (PLWH) in the USA are virally suppressed. Sub-optimal adherence (p\u3c 0.05). Social support satisfaction was also significantly associated with ART adherence (OR = 1.52, 95% CI [1.11–2.08], p \u3c 0.05) and energy/fatigue/vitality (OR = 1.03, 95% CI [1.00–1.05], p \u3c 0.05)

Feasibility testing a family level intervention to prevent risky sex behaviors among middle school age Latinas

Purpose: In this article, we report a pilot study that tested the feasibility and initial efficacy of a culturally, linguistically, and developmentally tailored risky sex prevention intervention for middle school–age Latinas and their mothers. Design: We used a one-group pre-test, post-test, and 3-month post-intervention follow-up design. Data were collected at three points on aspects of the girls’ communication, beliefs, and behaviors. Results: Promising results included improvements in girl’s self-efficacy regarding condom communication and condom consistent use, and in mother–teen sexual risk communication. There were also trends in demonstration of fewer risky sex behaviors. Discussion: These findings suggest that the “Latina–Girls Empowered through Mind and Mission” (L-GEMM) intervention for young Latinas and their mothers is feasible and warrants further testing. Implications: Nurses are uniquely positioned to deliver risky sex preventive interventions to young Latinas. Including mothers and tailoring interventions to build on cultural strengths are important for success

Inherited variation in immune genes and pathways and glioblastoma risk

To determine whether inherited variations in immune function single-nucleotide polymorphisms (SNPs), genes or pathways affect glioblastoma risk, we analyzed data from recent genome-wide association studies in conjunction with predefined immune function genes and pathways. Gene and pathway analyses were conducted on two independent data sets using 6629 SNPs in 911 genes on 17 immune pathways from 525 glioblastoma cases and 602 controls from the University of California, San Francisco (UCSF) and a subset of 6029 SNPs in 893 genes from 531 cases and 1782 controls from MD Anderson (MDA). To further assess consistency of SNP-level associations, we also compared data from the UK (266 cases and 2482 controls) and the Mayo Clinic (114 cases and 111 controls). Although three correlated epidermal growth factor receptor (EGFR) SNPs were consistently associated with glioblastoma in all four data sets (Mantel–Haenzel P values = 1 × 10−5 to 4 × 10−3), independent replication is required as genome-wide significance was not attained. In gene-level analyses, eight immune function genes were significantly (minP < 0.05) associated with glioblastoma; the IL-2RA (CD25) cytokine gene had the smallest minP values in both UCSF (minP = 0.01) and MDA (minP = 0.001) data sets. The IL-2RA receptor is found on the surface of regulatory T cells potentially contributing to immunosuppression characteristic of the glioblastoma microenvironment. In pathway correlation analyses, cytokine signaling and adhesion–extravasation–migration pathways showed similar associations with glioblastoma risk in both MDA and UCSF data sets. Our findings represent the first systematic description of immune genes and pathways that characterize glioblastoma risk

Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma

<p>Abstract</p> <p>Background</p> <p>Malignant glioma is a rare cancer with poor survival. The influence of diet and antioxidant intake on glioma survival is not well understood. The current study examines the association between antioxidant intake and survival after glioma diagnosis.</p> <p>Methods</p> <p>Adult patients diagnosed with malignant glioma during 1991-1994 and 1997-2001 were enrolled in a population-based study. Diagnosis was confirmed by review of pathology specimens. A modified food-frequency questionnaire interview was completed by each glioma patient or a designated proxy. Intake of each food item was converted to grams consumed/day. From this nutrient database, 16 antioxidants, calcium, a total antioxidant index and 3 macronutrients were available for survival analysis. Cox regression estimated mortality hazard ratios associated with each nutrient and the antioxidant index adjusting for potential confounders. Nutrient values were categorized into tertiles. Models were stratified by histology (Grades II, III, and IV) and conducted for all (including proxy) subjects and for a subset of self-reported subjects.</p> <p>Results</p> <p>Geometric mean values for 11 fat-soluble and 6 water-soluble individual antioxidants, antioxidant index and 3 macronutrients were virtually the same when comparing all cases (n = 748) to self-reported cases only (n = 450). For patients diagnosed with Grade II and Grade III histology, moderate (915.8-2118.3 mcg) intake of fat-soluble lycopene was associated with poorer survival when compared to low intake (0.0-914.8 mcg), for self-reported cases only. High intake of vitamin E and moderate/high intake of secoisolariciresinol among Grade III patients indicated greater survival for all cases. In Grade IV patients, moderate/high intake of cryptoxanthin and high intake of secoisolariciresinol were associated with poorer survival among all cases. Among Grade II patients, moderate intake of water-soluble folate was associated with greater survival for all cases; high intake of vitamin C and genistein and the highest level of the antioxidant index were associated with poorer survival for all cases.</p> <p>Conclusions</p> <p>The associations observed in our study suggest that the influence of some antioxidants on survival following a diagnosis of malignant glioma are inconsistent and vary by histology group. Further research in a large sample of glioma patients is needed to confirm/refute our results.</p

Plunge Show Card

Haggerty Gallery Inaugural Opening. Show Card for Plunge.https://digitalcommons.udallas.edu/plunge/1000/thumbnail.jp

Diet and Dietary Preference of the Juvenile Gopher Tortoise (\u3cem\u3eGopherus Polyphemus\u3c/em\u3e)

We documented both the diet and dietary preference of free-ranging juvenile gopher tortoises (Gopherus polyphemus) by direct observation. All observations were conducted on a 1-ha plot of sandhill habitat that has been maintained on a 1-yr fire periodicity by controlled burning for more than 25 yr. Seventeen foraging observations of juvenile gopher tortoises were included in our analyses. Juvenile gopher tortoises ate 26 plant genera. To determine if juvenile gopher tortoises were selecting particular genera, either positively or negatively, we used Resampling Stats. Plants of 16 genera were selected positively by at least one juvenile gopher tortoise. The most abundant plant genus along the foraging paths, Aristida, was selected negatively. Other grasses (Poaceae) were consumed mostly during the cool months when forbs, several of which were selected positively, were in decline. Grasses mostly were eaten in proportion to their availability. Juvenile gopher tortoises foraged only for brief time periods and traveled short distances during a foraging bout. Individuals may satiate quickly and/or may be predisposed to remain near their burrow because they are vulnerable to thermal stress and/or predation. Turtles residing in habitats with high quality and abundant forage grow rapidly to sexual maturity, which, in turn, can increase population growth rate. Understanding the biology of the juvenile gopher tortoise can help shape management practices that prevent declines of gopher tortoise populations

Economic Analysis of Future Offshore Oil & Gas Development: Beaufort Sea, Chukchi Sea, and North Aleutian Basin

This study describes and quantifies the potential economic benefits to the State of Alaska and local communities from developing oil and gas resources in Alaska’s Outer Continental Shelf (OCS) areas. The findings of this study are not predictions of the future for Alaska, but rather they describe a reasonable approach that one might expect for OCS development. The findings also provide a basis for thinking about potential actions that state and local governments, industry, and other stakeholders might undertake to deal most effectively with the effects that do occur. While there have been other studies in the past that looked at the potential effects of OCS development, this study is based on more recent information and represents the current state of knowledge in OCS resource estimates, exploration, development, and production activities; recent technology improvements; and state and local government fiscal systems. The economic benefits described here are based on assumptions about when and how OCS development, as well as other economic development in the state, might occur during the next 50 years. The magnitude of the economic effects of OCS development are contingent on assumptions about petroleum prices, volumes of OCS resources that might be economically recoverable, the levels of investment that the petroleum industry would be willing to spend to develop in the OCS areas, and the fiscal regime or tax structure that would be in effect as OCS oil and gas development occurs.Shell Exploration and Productio