The transdisciplinary team in Neurorehabilitation

El equipo de salud es definido por la OMS, en 1973, como una asociación no jerarquizada de personas, con diferentes disciplinas profesionales, pero con un objetivo común que es el de proveer en cualquier ámbito a los pacientes y familias la atención más integral de salud posible. En rehabilitación, al igual que en otras disciplinas, existen diferentes tipos de trabajo en equipo como son el multidisciplinar, el interdisciplinar y el transdisciplinar, este último con unas características que pueden resultar de gran interés a la hora de intervenir con un paciente que precisa de rehabilitación neurológica.The health team is defined by the WHO, in 1973, as a non-hierarchical association of people, with different professional disciplines, but with a common goal that is to provide in any field to patients and families the most comprehensive health care possible. In rehabilitation, as in other disciplines, there are different types of teamwork such as multidisciplinary, interdisciplinary and transdisciplinary, the latter with characteristics that may be of great interest when intervening with a patient who needs neurological rehabilitation. Key words: teamwork, health teams, neurorehabilitation, transdisciplinary team

"Influence of a psychomotricity program in aquatic environment on the balance of institutionalized elderly people with alterations thereof"

Se ha comprobado que el número de caídas aumenta con la edad y aún más en personas institucionalizadas. Las caídas pueden ser causadas por factores intrínsecos siendo las alteraciones de equilibrio una de las principales causas. El objetivo de este estudio fue determinar si un programa de psicomotricidad en medio acuático influye en el equilibrio de personas mayores institucionalizadas con alteraciones del mismo. Como conclusión, un programa de psicomotricidad en medio acuático influye en el equilibrio de personas mayores institucionalizadas con alteración del mismo.It has been proven that the number of falls increases with age and even more in institutionalized people. The falls can be caused by intrinsic factors, the balance alterations being one of the main causes. The objective of this study was to determine if a program of psychomotricity in aquatic environment influences the balance of institutionalized elderly people with alterations of it. In conclusion, a program of psychomotricity in aquatic environment influences the balance of institutionalized older people with alteration of it

Estudio de las vías de degradación enzimática de la melatonina en el tracto reproductor masculino de la especie ovina

La melatonina es una de las moléculas más antiguas y biológicamente activas. Se encuentra en una amplia variedad de organismos, siendo su principal función la defensa antioxidante. La melatonina es sintetizada en la glándula pineal durante la noche, y es degradada por diversos órganos como el hígado, cerebro o retina. Estudios previos han determinado la presencia de las enzimas de síntesis de melatonina en el testículo ovino (serotonin-N-acetiltransferasa (AANAT) y N-acetilserotonin-O-metiltransferasa (ASMT)) y altas concentraciones de melatonina en el plasma seminal ovino. Sin embargo, las posibles vías de degradación de esta hormona en el tracto reproductor del macho no han sido estudiadas previamente. Con el fin de determinar si la melatonina es degradada en el aparato reproductor del morueco, se realizaron diversos estudios de las principales vías de degradación enzimática de la hormona en los tejidos del tracto genital (testículo, epidídimo y glándulas accesorias) mediante RT-PCR, q-PCR y Western-Blot. Las enzimas que se estudiaron fueron: Mieloperoxidasa (MPO), Indoleamina-2,3-dioxigenasa 1 (IDO1) y 2 (IDO2). Se demostró la expresión génica mediante RT-PCR de las tres enzimas en todos los tejidos estudiados, mientras que la q-PCR permitió comprobar que la expresión génica de la enzima MPO es predominante sobre IDO1 e IDO2 en casi todos los tejidos, siendo el testículo y glándulas bulbouretrales los tejidos que presentan los mayores niveles de expresión. Mediante Western-Blot, se demostró la traducción de la proteína MPO en las glándulas bulbouretrales, aunque en el caso de IDO, los resultados obtenidos no fueron concluyentes. En conclusión, nuestros resultados indican la existencia de una ruta de degradación enzimática de la melatonina en el tracto genital. Dado que los metabolitos producidos en la degradación de esta hormona son compuestos antioxidantes, su producción en el aparato reproductor podría tener una implicación directa en la defensa de los espermatozoides ante las especies reactivas de oxígeno

The relation of the geriatric patient and the physical rehabilitation. Bibliographical review

El reconocimiento de los efectos beneficiosos del ejercicio, tanto desde un punto físico como psicológico está cada vez más introducida en nuestra población a través de diversas actividades de ocio, de entretenimiento y de la ocupación del tiempo libre. Muchas de las diferencias individuales que presentan los ancianos en cuanto a su capacidad funcional y su aptitud física guardan relación con su historia y su previo estilo de vida. Por eso, un estilo de vida activo en la vejez va a permitir disfrutar de los beneficios asociados a la actividad física generando bienestar y aumentando la calidad de vida.The recognition of the beneficial effects of the exercise, so much from a physical point since psychological it is introduced increasingly in our population across diverse activities of leisure, of entertainment and of the occupation of the free time. Many of the individual differences that the elders present as for his functional capacity and his physical aptitude guard relation with his history and his previous way of life. Because of it, an active way of life in the oldness is going to allow to enjoy the benefits associated with the physical activity generating well-being and increasing the quality of life

Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles

[EN] Mesoporous silica nanoparticles (MSNs) are amongst the most used nanoparticles in biomedicine. However, the potentially toxic effects of MSNs have not yet been fully evaluated, being a controversial matter in research. In this study, bare MSNs, PEGylated MSNs (MSNs-PEG), and galacto-oligosaccharide-functionalized MSNs (MSNs-GAL) are synthesized and characterized to assess their genotoxicity and transforming ability on human lung epithelial BEAS-2B cells in short- (48 h) and long-term (8 weeks) exposure scenarios. Initial short-term treatments show a dose-dependent increase in genotoxicity for MSNs-PEG-treated cells but not oxidative DNA damage for MSNs, MSNs-PEG, or for MSNs-GAL. In addition, after 8 weeks of continuous exposure, neither induced genotoxic nor oxidative DNA is observed. Nevertheless, long-term treatment with MSNsPEG and MSNs-GAL, but not bare MSNs, induces cell transformation features, as evidenced by the cell¿s enhanced ability to grow independently of anchorage, to migrate, and to invade. Further, the secretome from cells treated with MSNs and MSNs-GAL, but not MSNs-PEG, shows certain tumor-promoting abilities, increasing the number and size of HeLa cell colonies formed in the indirect soft-agar assay. These results show that MSNs, specifically the functionalized ones, provoke some measurable adverse effects linked to tumorigenesis. These effects are in the order of other nanomaterials, such as carbon nanotubes or cerium dioxide nanoparticles, but they are lower than those provoked by some approved drugs, such as doxorubicin or dexamethasone.This work was supported by PID2021-126304OB-C41, PID2021-128141OB-C22, and PID2020-116789RB-C43 funded by MCIN/AEI/10.13039/501100011033/, by the European Regional Development Fund `A way of doing Europe¿, by Generalitat Valenciana (CIPROM/2021/007), and by the Generalitat de Catalunya (2021-SGR-00731). The work was also supported by CIBER `Consorcio Centro de Investigación Biomédica en Red¿ (CB06/01/2012), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación. This study forms part of the Advanced Materials programme (MFA/2022/049) and was supported by MCIN with funding from European Union NextGenerationEU (PRTR-C17.I1) and from Generalitat Valenciana. This project has also received funding from the European Union¿s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 965196. Alba Hernández was granted an ICREA ACADEMIA award. Vicente Candela-Noguera thanks the Spanish Government for his fellowship (FPU15/02753). Paula Díez thanks the Generalitat Valenciana for her contract APOSTD/2020/153 and thanks the Instituto de Salud Carlos III and the European Social Fund for the financial support `Sara Borrell¿, CD20/00120. The authors thank the Electron Microscopy Service at UPV for support.Barguilla, I.; Candela-Noguera, V.; Oliver, P.; Annangi, B.; Diez-Sánchez, P.; Aznar, E.; Martínez-Máñez, R.... (2023). Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles. International Journal of Molecular Sciences. 24(22):1-14. https://doi.org/10.3390/ijms242216158114242

Are movement-based mindful exercises (QIGONG, TAI CHI, AND YOGA) beneficial for stroke and Parkinson's disease? A scoping review

Objective: To synthesize evidence from systematic reviews on the effects of qigong, tai chi, and yoga in people with neurological diseases. Methods: A systematic search was conducted in PubMed, PsycINFO, Embase, CINAHL and Cochrane Library until September 2022. Methodological quality was assessed using the AMSTAR 2 tool. A qualitative synthesis of included reviews and meta-analyses was performed. Citation matrices and the corrected covered area were used to explore the overlap of randomized controlled trials among reviews. Results: Nineteen systematic reviews (containing 74 trials and 80 meta-analyses) in people with Parkinson's disease (PD) or stroke were included. The critical domains of the AMSTAR 2 were not satisfied in more than half of the reviews, and only 4 evaluated the certainty of the evidence. The overlap was very high (21.7%) and high (11%) for tai chi studies in PD and stroke, respectively. In people with PD, qigong, yoga, and tai chi can improve balance, with tai chi being beneficial to increase functional mobility. For stroke patients, tai chi was better than controls to enhance motor function and independence, but not for health-related quality of life and quality of sleep. Findings on balance, walking ability and depression were inconclusive in stroke population. Conclusions: Qigong, tai chi, and yoga appear to be effective to improve balance performance in people with PD. Tai chi practice enhances motor function and independency in stroke patients.13 página

Towards automatic waste containers management in cities via computer vision: containers localization and geo-positioning in city maps

This paper describes the scientific achievements of a collaboration between a research group and the waste management division of a company. While these results might be the basis for several practical or commercial developments, we here focus on a novel scientific contribution: a methodology to automatically generate geo-located waste container maps. It is based on the use of Computer Vision algorithms to detect waste containers and identify their geographic location and dimensions. Algorithms analyze a video sequence and provide an automatic discrimination between images with and without containers. More precisely, two state-of-the-art object detectors based on deep learning techniques have been selected for testing, according to their performance and to their adaptability to an on-board real-time environment: EfficientDet and YOLOv5. Experimental results indicate that the proposed visual model for waste container detection is able to effectively operate with consistent performance disregarding the container type (organic waste, plastic, glass and paper recycling,…) and the city layout, which has been assessed by evaluating it on eleven different Spanish cities that vary in terms of size, climate, urban layout and containers’ appearanceThis work has been supported by URBASER S.A. and the Universidad Autonoma ´ de Madrid under project REVGA of the ”Segunda Edicion ´ del Programa de Fomento de la Transferencia del Conocimiento” cal

Plants Probiotics as a Tool to Produce Highly Functional Fruits: The Case of Phyllobacterium and Vitamin C in Strawberries

10 páginas, 1 tabla, 1 figuraThe increasing interest in the preservation of the environment and the health of consumers is changing production methods and food consumption habits. Functional foods are increasingly demanded by consumers because they contain bioactive compounds involved in health protection. In this sense biofertilization using plant probiotics is a reliable alternative to the use of chemical fertilizers, but there are few studies about the effects of plant probiotics on the yield of functional fruits and, especially, on the content of bioactive compounds. In the present work we reported that a strain of genus Phyllobacterium able to produce biofilms and to colonize strawberry roots is able to increase the yield and quality of strawberry plants. In addition, the fruits from plants inoculated with this strain have significantly higher content in vitamin C, one of the most interesting bioactive compounds in strawberries. Therefore the use of selected plant probiotics benefits the environment and human health without agronomical losses, allowing the production of highly functional foods.This work was granted by “Junta de Castilla y León” (Regional Government, Grant SA183A11-2) and MINECO (Central Government, Grant AGL2011-29227). Paula García-Fraile is recipient of a postdoctoral researcher contract from Academy of Sciences of the Czech Republic. José David Flores-Félix was supported by a fellowship of Salamanca University. Marta Marcos García was supported by a fellowship of Fundación Miguel Casado San José. Luís R. Silva is grateful to the financial support from the European Union (FEDER funds through COMPETE) and National Funds (FCT, Fundação para a Ciência e Tecnologia) through project Pest-C/EQB/LA0006/2013 and from the European Union (FEDER funds) under the framework of QREN through Project NORTE-07-0124-FEDER- 000069.Peer reviewe

Au-Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

[EN] We report a delivery system based on Au-mesoporous silica (MS) nanoparticles functionalized with acetylcholinesterase on the Au face as a control unit and with disulfide-containing oligo(ethylene glycol) chains on the MS face as caps. The control unit handles the chemical information in the environment (the presence of acetyl-thiocholine or enzyme inhibitors) that results in a tuned cargo delivery from the nanocarrier. The nanodevice displayed an enhanced cargo delivery in cancer cells (safranin O and doxorubicin) in the presence of acetylthiocholine.A. Llopis-Lorente thanks "La Caixa" Banking Foundation for his PhD fellowship. A. Garcia-Fernandez is grateful to the Spanish government for an FPU grant. The authors are grateful to the Spanish Government (MINECO Projects MAT2015-64139-C4-1, CTQ2014-58989-P and CTQ2015-71936-REDT) and the Generalitat Valencia (Project PROMETEOII/2014/047) for support. The Comunidad de Madrid (S2013/MIT-3029, Programme NANOAVANSENS) is also gratefully acknowledged.Llopis-Lorente, A.; De Luis-Fernández, B.; García-Fernández, A.; Diez, P.; Sánchez, A.; Marcos Martínez, MD.; Villalonga, R.... (2017). Au-Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit. Journal of Materials Chemistry B. 5(33):6734-6739. https://doi.org/10.1039/c7tb02045gS6734673953

Glucose-triggered release using enzyme-gated mesoporous silica nanoparticles

[EN] A new gated nanodevice design able to control cargo delivery using glucose as a trigger and cyclodextrin-modified glucose oxidase as a capping agent is reported.Financial support from the Spanish Government (projects MAT2012-38429-C04-01 and CTQ2011-24355), Generalitat Valenciana (project PROMETEO/2009/016), UPV (project SP20120795) and Ramon y Cajal Programme (to R. V.) is gratefully acknowledged.Aznar Gimeno, E.; Villalonga, R.; Giménez Morales, C.; Sancenón Galarza, F.; Marcos Martínez, MD.; Martínez Mañez, R.; Díez, P.... (2013). Glucose-triggered release using enzyme-gated mesoporous silica nanoparticles. Chemical Communications. 49(57):6391-6393. https://doi.org/10.1039/c3cc42210kS639163934957Coll, C., Bernardos, A., Martínez-Máñez, R., & Sancenón, F. (2012). Gated Silica Mesoporous Supports for Controlled Release and Signaling Applications. Accounts of Chemical Research, 46(2), 339-349. doi:10.1021/ar3001469Aznar, E., Martínez-Máñez, R., & Sancenón, F. (2009). 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