CATALYTIC AND ADSORPTION PROPERTIES OF Al- AND Ti-MCM-41 SYNTHESIZED AT ROOM TEMPERATURE

Aluminosilicate and titanosilicate MCM-41 were synthesized using a room temperature method. A preliminary catalytic evaluation was performed in the promotion of the 1-butene double bond isomerization, which was successful in probing differences in the acidity of the samples prepared

Relacionamentos Externos no âmbito da Inovação Empresarial: Modelo aplicado aos avanços inovadores

A inovação assume-se cada vez mais como um factor chave da competitividade empresarial. Várias abordagens teóricas, desenvolvidas nos últimos anos, sustentam que a inovação não é algo que resulta da acção isolada de um único actor, mas é vista como um processo não linear, complexo, evolucionário e interactivo entre a empresas e o seu meio envolvente. Esta investigação tem por finalidade analisar se a capacidade inovadora empresarial, ao nível dos avanços inovadores, é estimulada pelos relacionamentos estabelecidos com parceiros no âmbito da inovação. Para tal aplica-se um modelo de regressão logística aos dados do Segundo Inquérito Comunitário à Inovação – CIS II (Community Innovation Survey II).Relacionamentos externos, Inovação Empresarial, Avanços inovadores, Modelo de regressão linear generalizado, Função logit, CIS II.

Relacionamentos universidade – empresa: problemática e perspectivas

Nos últimos anos o conceito de inovação alterou-se consideravelmente. Várias abordagens teóricas sustentam que as empresas não inovam isoladas e que a inovação surge como um processo complexo evolucionário e interactivo de aprendizagem, realizado com a contribuição de variados agentes económicos e sociais que possuem acesso a diferentes tipos de informações e conhecimentos. Neste trabalho, evidenciam-se os relacionamentos dos relacionamentos externos no estímulo da inovação empresarial, destacando-se os relacionamentos estabelecidos entre a universidade e o tecido empresarial. Dado que este tipo de relacionamentos proporcionam às empresas vantagens indiscutíveis no âmbito da inovação. No obstante, existem problemas neste tipo de relacionamentos, que urge identificar e solucionar. Assim, esta investigação tem por finalidade apresentar os contributos e as vantagens associadas aos relacionamentos estabelecidos entre as universidades e as empresas, bem como, descrever os principais problemas resultantes desses relacionamentos. Por fim, apresentam-se as perspectivas futuras de desenvolvimento da investigação, com recurso a estudos de caso

A dinâmica da criação de empresas impulsionada por Instituições de Ensino Superior através de redes de inovação

El objetivo principal de esta investigación es identificar si las Instituciones de Enseñanza Superior (IES) estimulan la creación de empresas por medio de redes de innovación. El abordaje teórico, apoyado en la teoría de las redes y en la teoría del espíritu de empresa, sostiene la idea básica de la importancia de las redes de innovación en el proceso de creación de empresas, pues ellas permiten colmatar deficiencias y reforzar aspectos positivos para influenciar el proceso de creación de empresas. Para a colecta de datos fue elaborado un cuestionario, que posteriormente fue respondido por los nuevos emprendedores que pertenecen a instituciones de enseñanza superior, obteniéndose un total de 255 respuestas. Los resultados obtenidos muestran que la cooperación y el desarrollo de relaciones con otros agentes en la red de innovación surgen como las principales formas para que las IES incentiven la creación de empresas, y demuestran que la actitud de las IES para la creación de empresas influencia la decisión de los nuevos emprendedores en avanzar en ese proceso. Cuanto a la identificación de los factores que permiten la creación de empresas soportadas en redes de innovación, los principales son los actores de la red y los recursos organizacionales. Además de eso, en lo que se refiere a identificar y analizar los obstáculos a la creación de empresas soportada en redes de innovación, se constató que los principales factores son el conocimiento y la ubicación. Las principales conclusiones de esta investigación dejan evidente la importancia de las IES en el fenómeno de la creación de empresas por medio de redes de innovación.O objectivo principal desta investigação é identificar se as Instituições de Ensino Superior (IES) impulsionam a criação de empresas por meio de redes de inovação. A abordagem teórica, suportada na teoria das redes e na teoria do empreendedorismo, sustenta a ideia básica da importância das redes de inovação no processo de criação de empresas, pois elas permitem colmatar deficiências e reforçar aspectos positivos de forma a influenciar o processo de criação de empresas. Para a recolha de dados foi elaborado um questionário, que posteriormente foi respondido pelos empreendedores nascentes pertencentes a instituições de ensino superior, obtendo-se um total de 255 respostas. Os resultados alcançados mostram que a cooperação e o desenvolvimento de relações com outros agentes na rede de inovação surgem como as principais formas de as IES incentivarem a criação de empresas, e demonstram que a atitude das IES para a criação de empresas influencia a decisão dos empreendedores nascentes em avançar nesse processo. Quanto à identificação dos factores que facilitam a criação de empresas suportada em redes de inovação, os principais são os actores da rede e os recursos organizacionais. Além disso, no que concerne à identificação e à análise dos obstáculos à criação de empresas suportada em redes de inovação, constatou-se que os principais factores são o conhecimento e a localização. As principais conclusões desta investigação evidenciam a importância das IES no fenómeno da criação de empresas por meio de redes de inovação.The main purpose of this research is to identify whether the Higher Education Institutions (HEIs) stimulate the creation of business through innovation networks. The theoretical approach, based on network theory and entrepreneurship theory, supports the basic idea of the importance of innovation networks in the process of business creation, since they allow remedying shortcomings and reinforcing positive aspects in order to influence the process of business creation. A questionnaire was developed for data collection, which was subsequently answered by nascent entrepreneurs belonging to higher education institutions, with 255 answers. The results obtained show that cooperation and development of relations with other actors of the innovation network emerge as the main ways of how HEIs encourage business creation, and show that HEIs' attitude for the creation of companies influences the decision of nascent entrepreneurs to go ahead with this process. The main factors that facilitate the creation of companies present in innovation networks are the network actors and organizational resources. Furthermore, with regard to identifying and analyzing obstacles to business creation based on innovation networks, it was found that the main factors are knowledge and location. The main conclusions of this research show the importance of HEIs in the phenomenon of business creation through innovation networks

Managing the Technology for Selectively Collecting Solid Waste in the Western Amazon Sub Region

This study's main objective is to study the complexity of technological management of the collection of solid waste, through the prism of reverse logistics; and to propose certain specific objectives: (1) to describe the form of concentration of solid waste in the group studied; (2) to analyze the impact of the volume of solid waste; and (3) to propose intervention measures for solid waste management. It asks what technology management model should guide the selective collection of solid waste in the Amazon. Based on the theory of convergence, it studies the strategy of competitive advantage in understanding the organizational system in the environment in which it operates; on this theory, Nobre (2011) addresses knowledge as a source that transmits competitive edge in order to contribute to a company's organizational system. The research is qualitative and descriptive; it applies the Case Study method, and related procedures. As a study, it confirms that the investigated collector cooperatives are vulnerable, which influences the conclusions of this study. It finds that the collectors employed by these organizations are the significant environmental agents in the process of reusing and recycling materials and thus play a key role in reverse logistics because they can return the waste to the production chain adding value and promoting shared management,. The results also point to the absence of a system to promote environmental education, despite the potential viability of the materials and regardless of the possible economic and social improvements to the Amazonians and their families. The system proposed here involves the selective collection of solid waste by intelligent machines, applying reverse logistics. This study could benefit business people, the government and other stakeholders in public policy and sustainability in fragile environments such as the Brazilian Amazon.info:eu-repo/semantics/publishedVersio

Estudo português de miocardiopatias dilatadas familiares : estudo FATIMA

© Sociedade Portuguesa de CardiologiaDilated cardiomyopathy (DCM) is a myocardial disease, characterized by ventricular dilatation and impaired systolic function, that in more than 30% of cases has a familial or genetic origin. Given its age-dependent penetrance, DCM frequently manifests in adults by signs or symptoms of heart failure, arrhythmias or sudden death. The predominant mode of inheritance is autosomal dominant, and in these cases mutations are identified in genes coding for cytoskeletal, sarcomeric or nuclear envelope proteins. To date, most studies aimed at molecular diagnosis of DCM have been in selected families, or in larger groups of patients, but screening for mutations in a limited number of genes. Consequently, the epidemiology of mutations in familial DCM remains unknown. There is thus a need for multicenter studies, involving screening for a wide range of mutations in several families and in cases of idiopathic DCM. The present article describes the methodology of a multicenter study, aimed at clinical and molecular characterization of familial DCM patients in the Portuguese population.A miocardiopatia dilatada (MCD) é uma doença do músculo cardíaco caracterizada pela dilatação ventricular e compromisso da função sistólica, sendo possível identificar, numa percentagem superior a 30% dos casos, uma origem familiar ou genética. Dada a penetrância dependente da idade, manifesta-se muitas vezes em adultos por sinais ou sintomas de insuficiência cardíaca, arritmias ou morte súbita. O padrão autossómico dominante predomina, sendo possível identificar, nestes casos, mutações em genes de proteínas do citoesqueleto celular, sarcómero ou membrana nuclear. Até ao momento, a maioria dos trabalhos visando o diagnóstico molecular nos casos de MCD foi realizada em famílias seleccionadas, ou em grupos mais abrangentes de doentes, mas rastreando mutações num número restrito de genes. Consequentemente a epidemiologia das mutações nos casos familiares de MCD continua por esclarecer. É neste contexto que se coloca a necessidade de efectuar estudos multicêntricos, envolvendo uma pesquisa mutacional diversificada em várias familias e nos casos idiopáticos de MCD. O presente artigo descreve a metodologia de um estudo multicêntrico que tem como objectivo a caracterização clínica e molecular de casos familiares de MCD na população portuguesa.info:eu-repo/semantics/publishedVersio

Identification of yeast and non-pigmented cultivable endodontic bacteria in adult portuguese patients

Introduction This study has focused on the identification of the yeasts and non-pigmented bacteria present on adult patients with necrosis or apical periodontitis and the ones who resisted chemomechanical preparation and intracanal dressing with calcium hydroxide paste (Ca(OH)2) or 2% chlorohexidine digluconate gel (CHX). Methods 69 single-rooted teeth of adult patients with necrosis associated or not with apical periodontitis were selected (strict inclusion criteria); CHX group: 34 teeth; Ca(OH)2 group: 35 teeth. Bacteria samples were taken at baseline (S1), after chemo-mechanical preparation (S2) and after 14 days of intracanal dressing (S3). Bacteria and fungal presence was evaluate by means of culture in three atmospheres (aerobic, anaerobic, microaerofilic) in appropriate culture broads. Strict techniques were used for serial dilution, plating, incubation and identification. Results The most represented, abundant and prevalent strains of non-pigmented bacteria were Propionibacterium acnes (detected in S1, S2 and S3), Gemella morbillorum and Clostridium difficile. Candida albicans was found in 9 patients. The higher number of isolates proceeded from S1, being S2 the moment with lowest number of isolates. CHX had a worst performance in disinfection of the root canal system; consequently the number of isolates from S3 samples was bigger compared to Ca(OH)2. The number of identified bacterial species per canal/moment of sampling, varied from zero till 5, including yeasts (Candida albicans). Conclusions: Our findings confirm that the microbiota from primary endodontic infections is polymicrobial, and the anaerobes Gram-positive non-pigmented bacteria are well represented. CHX performed worse, consequently the number of isolates from S3 samples was bigger when compared to Ca(OH)2 as well as with diagnosis of necrosis.info:eu-repo/semantics/publishedVersio

Histological and ultrastructural analysis of cryopreserved sheep preantral follicles

The aim of this study was to verify the histological and ultrastructural characteristics of sheep preantral follicles after exposure of ovarian tissue to cryopreservation in glycerol (GLY), ethylene glycol (EG), propanediol (PROH) or dimethyl sulfoxide (DMSO) in order to determine the optimum method to store sheep ovarian tissue for later experimental or clinical use. Each ovarian pair from five mixed-breed ewes was divided into 17 fragments. One (control) fragment was immediately fixed for routine histological and ultrastructural studies and the remaining (test) fragments were randomly distributed in cryotubes, equilibrated at 20 °C/20 min in 1.8 mL of minimal essential medium (MEM) containing 1.5 or 3 M GLY, EG, PROH or DMSO and then either fixed for morphological studies to determine their possible toxic effect or frozen/thawed and then fixed to test the effect of cryopreservation on preantral follicles. Histological analysis showed that, compared to control fragments, all cryoprotectants at both concentrations significantly reduced the percentage of normal preantral follicles in ovarian fragments prior to or after cryopreservation. PROH 3.0 M appeared to exert a more toxic effect (P < 0.05) than the other cryoprotectants in noncryopreserved tissues. After freezing/thawing, the highest (P < 0.05) percentages of lightmicroscopical normal preantral follicles were observed in ovarian fragments cryopreserved in EG (1.5 and 3 M) or DMSO (1.5 M). However, transmission electronic microscopical (TEM) examination showed that only the DMSO-cryopreserved preantral follicles had normal ultrastructure. The data suggest that sheep preantral follicles should be cryopreserved with 1.5 M DMSO for later clinical or experimental application

Morphological and ultrastructural analysis of sheep primordial follicles preserved in 0.9% saline solution and TCM 199

The objective was to determine the morphological and ultrastructural features of sheep primordial follicles preserved in either 0.9% saline solution or TCM 199 at different temperatures. Soon after death, the ovarian pair of each ewe (n=5) was divided into 25 fragments. One fragment was immediately fixed for morphological evaluation (control). The other 24 fragments were randomly distributed in tubes containing 2 ml of 0.9% saline solution or TCM 199 and maintained at 4, 20 or 39 °C for 2, 4, 12, or 24 h. Based on histological assessment, storage of ovarian fragments in 0.9% saline solution at 20 °C for up to 24 h and in both solutions at 39 °C for 4, 12 or 24 h increased (P<0.01) the percentage of degenerate primordial follicles compared with controls. In contrast, preservation at 4 °C in both solutions, kept the percentage of morphologically normal primordial follicles similar to control values. Although histological integrity of primordial follicles was maintained in fragments stored at 20 °C for up to 24 h in TCM 199, these results were not confirmed by ultrastructural analysis. Based on transmission electron microscopy, only primordial follicles stored at 4 °C for up to 24 h, at 20 °C for up to 12 h and at 39 °C for up to 2 h in both solutions were ultrastructurally normal. In conclusion, sheep primordial follicles were successfully preserved at 4 °C for up to 24 h, at 20 °C for up to 12 h and at 39 °C for 2 h in 0.9% saline solution or TCM 199