Detection of gamma-ray transients with wild binary segmentation

In the context of time domain astronomy, we present an offline detection search of gammaray transients using a wild binary segmentation analysis called F-WBSB targeting both short and long gamma-ray bursts (GRBs) and covering the soft and hard gamma-ray bands. We use NASA Fermi/GBM archival data as a training and testing data set. This paper describes the analysis applied to the 12 NaI detectors of the Fermi/GBM instrument. This includes background removal, change-point detection that brackets the peaks of gamma-ray flares, the evaluation of significance for each individual GBM detector, and the combination of the results among the detectors. We also explain the calibration of the ~10 parameters present in the method using one week of archival data. Finally, we present our detection performance result for 60 d of a blind search analysis with F-WBSB by comparing to both the onboard and offline GBM search as well as external events found by others surveys such as Swift-BAT. We detect 42/44 onboard GBM events but also other gamma-ray flares at a rate of 1 per hour in the 4-50 keV band. Our results show that F-WBSB is capable of recovering gamma-ray flares, including the detection of soft X-ray long transients. FWBSB offers an independent identification of GRBs in combination with methods for determining spectral and temporal properties of the transient as well as localization. This is particularly useful for increasing the GRB rate and that will help the joint detection with gravitational-wave events

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old

GRANDMA observations of advanced LIGO’s and advanced Virgo’s third observational campaign

International audienceGRANDMA (Global Rapid Advanced Network Devoted to the Multi-messenger Addicts) is a network of 25 telescopes of different sizes, including both photometric and spectroscopic facilities. The network aims to coordinate follow-up observations of gravitational-wave (GW) candidate alerts, especially those with large localization uncertainties, to reduce the delay between the initial detection and the optical confirmation. In this paper, we detail GRANDMA’s observational performance during Advanced LIGO/Advanced Virgo Observing Run 3 (O3), focusing on the second part of O3; this includes summary statistics pertaining to coverage and possible astrophysical origin of the candidates. To do so, we quantify our observation efficiency in terms of delay between GW candidate trigger time, observations, and the total coverage. Using an optimized and robust coordination system, GRANDMA followed-up about 90 per cent of the GW candidate alerts, that is 49 out of 56 candidates. This led to coverage of over 9000 deg^2 during O3. The delay between the GW candidate trigger and the first observation was below 1.5 h for 50 per cent of the alerts. We did not detect any electromagnetic counterparts to the GW candidates during O3, likely due to the very large localization areas (on average thousands of degrees squares) and relatively large distance of the candidates (above 200 Mpc for 60 per cent of binary neutron star, BNS candidates). We derive constraints on potential kilonova properties for two potential BNS coalescences (GW190425 and S200213t), assuming that the events’ locations were imaged

The first six months of the Advanced LIGO’s and Advanced Virgo’s third observing run with GRANDMA

International audienceWe present the Global Rapid Advanced Network Devoted to the Multi-messenger Addicts (GRANDMA). The network consists of 21 telescopes with both photometric and spectroscopic facilities. They are connected together thanks to a dedicated infrastructure. The network aims at coordinating the observations of large sky position estimates of transient events to enhance their follow-up and reduce the delay between the initial detection and optical confirmation. The GRANDMA programme mainly focuses on follow-up of gravitational-wave alerts to find and characterize the electromagnetic counterpart during the third observational campaign of the Advanced LIGO and Advanced Virgo detectors. But it allows for follow-up of any transient alerts involving neutrinos or gamma-ray bursts, even those with poor spatial localization. We present the different facilities, tools, and methods we developed for this network and show its efficiency using observations of LIGO/Virgo S190425z, a binary neutron star merger candidate. We furthermore report on all GRANDMA follow-up observations performed during the first six months of the LIGO–Virgo observational campaign, and we derive constraints on the kilonova properties assuming that the events’ locations were imaged by our telescopes

GRANDMA Observations of ZTF/Fink Transients during Summer 2021

We present our follow-up observations with GRANDMA of transient sources revealed by the Zwicky Transient Facility (ZTF). Over a period of six months, all ZTF triggers were examined in real time by a dedicated science module implemented in the Fink broker, which will be used for the data processing of the Vera C. Rubin Observatory. In this article, we present three selection methods to identify kilonova candidates. Out of more than 35 million candidates, a hundred sources have passed our selection criteria. Six were then followed-up by GRANDMA (by both professional and amateur astronomers). The majority were finally classified either as asteroids or as supernovae events. We mobilized 37 telescopes, bringing together a large sample of images, taken under various conditions and quality. To complement the orphan kilonova candidates (those without associated gamma-ray bursts, which were all), we included three additional supernovae alerts to conduct further observations of during summer 2021. We demonstrate the importance of the amateur astronomer community that contributed images for scientific analyzes of new sources discovered in a magnitude range r'=17-19 mag. We based our rapid kilonova classification on the decay rate of the optical source that should exceed 0.3 mag/day. GRANDMA's follow-up determined the fading rate within 1.5+/-1.2 days post-discovery, without waiting for further observations from ZTF. No confirmed kilonovae were discovered during our observing campaign. This work will be continued in the coming months in the view of preparing for kilonova searches in the next gravitational-wave observing run O4