298 research outputs found
Indicadores y medidas de desempeño del transporte urbano de pasajeros empleando datos de GPS y validadores de los ómnibus
Fil: Schmadke Martin, Italo Federico. Universidad Católica de Córdoba; Argentina.Fil: Herz, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Maestría en Ciencias de la Ingeniería Mención Transporte; Argentina.La gestión, evaluación, monitoreo y planificación del transporte público se realiza a través de procesos que emplean medidas e indicadores de desempeño como instrumentos primarios. La dificultad se centra en la correcta selección y diseño de estos indicadores y medidas, y también en la recolección de los datos para su valoración.Este trabajo propone diseñar indicadores y medidas de performance a partir de la informaciónque almacenan GPS y máquinas de ticket de boleto electrónico de los ómnibus de la ciudad de Córdoba, Argentina.Se busca obtener información automática, más fiable, económica y extensiva que con las técnicas de medicióntradicional. Para validar estos resultados se realizaron diversos estudios de campo. La evaluación de desempeño se presenta junto con el valor de los indicadores y medidas propuestas, en un cuadro de mando que facilita la interpretación y toma de decisiones de las autoridades de transporte y de las empresas prestatarias.http://anpet.org.brFil: Schmadke Martin, Italo Federico. Universidad Católica de Córdoba; Argentina.Fil: Herz, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Maestría en Ciencias de la Ingeniería Mención Transporte; Argentina.Ingeniería del Transport
LUCHA MARAJOARA: DIÁLOGOS CON EL DEPORTE, LA SALUD Y LA EDUCACIÓN
A produção do conhecimento no âmbito das lutas ganha espaço acadêmico nos últimos anos, principalmente quando atrelado a saúde e ao setor educacional. Frente a tal configuração o presente ensaio tem como objetivo abordar a Luta Marajoara (LM) a partir de uma perspectiva interdisciplinar, considerando aspectos esportivos, educacionais e sua interlocução com a dimensão da saúde. Os pressupostos metodológicos configuram o ensaio como um estudo descritivo baseado em uma revisão bibliográfica nas ferramentas de buscas, Periódicos Capes, Google Acadêmico e obras clássicas anteriores a este período. Evidencia-se que paralelo a um crescente processo de expansão enquanto esporte de combate, a LM experimenta no campo educacional um maior reconhecimento enquanto elemento integrante do componente curricular da educação física. O debate passa a ser controverso quando a ênfase em questões técnicas predomina no trabalho pedagógico. O trato interdisciplinar da LM com a dimensão da saúde é um dos cenários possíveis quando se considera a escola como contexto de prática. Tal concepção deve pautar-se em atitudes pedagógicas que visem a incorporação de hábitos de vida saudáveis e a reflexão crítica sobre a prática esportiva. Assim articulada, a LM na escola seria associada a prevenção da saúde, através de práticas supervisionadas de lutas visando antes de tudo a formação integral do aluno. A abordagem levaria em consideração o processo de desenvolvimento de hábitos motores, mediando o processo de iniciação a luta não somente pelo viés técnico-esportivo, mas com base no desenvolvimento integral da criança, viabilizando assim, o trato interdisciplinar da LM com outras áreas do conhecimento.The production of knowledge in the context of struggles has gained academic space in recent years, especially when linked to health and the educational sector. Faced with this configuration, the present essay aims to approach the Marajoara Wrestling (MW) from an interdisciplinary perspective, considering sports and educational aspects and their interlocution with the health dimension. The methodological assumptions configure the essay as a descriptive study based on a literature review in search tools, Capes Periodicals, Academic Google and classic works prior to this period. It is evident that in parallel with a growing expansion process as a combat sport, MW experiences greater recognition in the educational field as an integral element of the curriculum component of physical education. The debate becomes controversial when the emphasis on technical issues predominates in pedagogical work. The interdisciplinary approach of the MW with the health dimension is one of the possible scenarios when considering the school as a context of practice. Such conception must be guided by pedagogical attitudes that aim at incorporating healthy lifestyle habits and critical reflection on sports practice. Thus articulated, the MW in the school would be associated with health prevention, through supervised practices of struggles aiming first of all at the integral education of the student. The approach would take into account the process of developing motor habits, mediating the initiation process to fight not only for the technical-sporting bias, but based on the integral development of the child, thus enabling the interdisciplinary treatment of MW with other areas of knowledge.La producción de conocimiento en el contexto de las luchas ha ganado espacio académico en los últimos años, especialmente cuando se vincula con la salud y el sector educativo. Frente a esta configuración, el presente ensayo pretende abordar la Lucha Marajoara (LM) desde una perspectiva interdisciplinar, considerando los aspectos deportivos y educativos y su interlocución con la dimensión de la salud. Los supuestos metodológicos configuran el ensayo como un estudio descriptivo basado en una revisión de la literatura. Es evidente que, en paralelo a un creciente proceso de expansión como deporte de combate, LM está experimentando un mayor reconocimiento en el campo educativo como un elemento integral del componente curricular de la educación física. El debate se vuelve controvertido cuando el énfasis en los aspectos técnicos predomina en el trabajo pedagógico. El abordaje interdisciplinario de la LM con la dimensión salud es uno de los escenarios posibles al considerar la escuela como contexto de práctica. Tal concepción debe estar guiada por actitudes pedagógicas que tengan como objetivo la incorporación de hábitos de vida saludables y la reflexión crítica sobre la práctica deportiva. Así articulado, la LM en la escuela estaría asociada a la prevención de la salud, a través de prácticas supervisadas de luchas dirigidas, sobre todo, a la formación integral del alumno. El abordaje tomaría en cuenta el proceso de desarrollo de hábitos motores, mediando el proceso de iniciación para luchar no solo por el sesgo técnico-deportivo, sino basado en el desarrollo integral del niño, posibilitando así el tratamiento interdisciplinario de la LM con otras áreas del conocimiento
Parâmetros De Avaliação Do Equilíbrio Sagital Cervical Na Escoliose Idiopática
There are no values defined as standard in the literature for the parameters of assessment of cervical sagittal balance in patients with idiopathic scoliosis. This study describes the sagittal cervical parameters in patients with idiopathic scoliosis. Methods: Study carried out in a tertiary public hospital in patients with adolescent idiopathic scoliosis, through the evaluation of panoramic radiographs in lateral view. The Cobb method was used to evaluate cervical lordosis from C2 to C7, distance from the center of gravity (COG) of the skull to C7, measurement of T1 slope, thoracic inlet angle (TIA), neck tilt, and plumb line from C7 to S1 (SVA C7-S1). A statistical analysis was performed, to demonstrate the relationship between the alignment of the thoracic spine in the sagittal plane and the cervical sagittal balance of patients with scoliosis. Results: Thirty-four patients were female (69.4%) and 15 male (30.6%). The mean values for COG-C7 were 0.71 mm (median 0.8 mm/standard deviation [SD]= 0.51 mm). For Cobb C2-C7, the mean was -11.7° (median -10°/SD= 20.4°). The mean slope of T1 was 23.5° (median 25°/SD= 9.5°). The mean cervical version was 58.8° (median 60°/DP= 15.4°). The mean TIA was 81.8° (median 85°/SD= 16.7°). The mean plumb line C7-S1 was -0.28 (-0.3/SD= 1.0). Conclusion: The analysis of the results showed that the mean values for the cervical lordosis are lower than the values described as normal in the literature, suggesting a loss of sagittal cervical balance in these patients.161384
Computational simulation of a double-deck bus dynamics in a bend turning coupled with crosswind effects
Stability of high-sided road vehicles (trucks, vans, double-deck buses, etc) is highly influenced by crosswinds. Double-deck buses have an increased demand in some countries of Latin America due to their large passenger transportation capability. The variable conditions of the roads and mass distribution of the bus, i.e. vehicle with all passengers in the lower/upper level, empty or full, coupled with the wind action acting on it may lead to dangerous situations. To further understand this subject, a computational fluid dynamics (CFD) simulation of a double-deck bus taking a bend road coupled with crosswind is performed in this work. Some comments about the open source CFD toolbox OpenFOAM implementation to reproduce some dynamics characteristics of the rollover instability are made.Fil: Castro, Hugo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Modelado e Innovación Tecnológica. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Modelado e Innovación Tecnológica; ArgentinaFil: Adotti, Marcelo Italo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Modelado e Innovación Tecnológica. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Modelado e Innovación Tecnológica; ArgentinaFil: Medina, Julian. Universidad Nacional del Nordeste. Facultad de Ingeniería. Departamento de Estabilidad; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaFil: Paz, Rodrigo Rafael. Livermore Software Technology Corporation.; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: del Pin, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; ArgentinaFil: Caldichouri, Iñaki. Livermore Software Technology Corporation.; Estados UnidosXII Congreso Argentino de Mecánica ComputacionalSan Miguel de TucumánArgentinaAsociación Argentina de Mecánica Computaciona
Relação Entre Qualidade De Vida E Osteólise Em Torno De Parafusos Pediculares Lombares
To evaluate whether the presence of osteolysis around the pedicle screws affects the quality of life of patients who underwent posterolateral arthrodesis of the lumbosacral spine. Methods: A retrospective study of patients undergoing lumbar posterolateral or lumbosacral arthrodesis due to spinal degenerative disease. CT scans of the operated segments were performed at intervals of 45, 90, 180, and 360 postoperatively. In these tests, the presence of a peri-implant radiolucent halo was investigated, which was considered present when greater than 1mm in the coronal section. Concurrently with the completion of CT scans, the participants completed the questionnaire Oswestry Disability Index (ODI) to assess the degree of disability of the patients. Results: A total of 38 patients were evaluated, and 14 (36.84%) of them showed some degree of osteolysis around at least one pedicle screw at the end of follow-up. Of the 242 analyzed screws, 27 (11.15%) had osteolysis in the CT coronal section, with the majority of these occurrences located at the most distal level segment of the arthrodesis. There was no correlation between the presence of the osteolysis to the quality of life of patients. The quality of life has significantly improved when comparing the preoperative results with the postoperative results at different times of application of ODI. This improvement in ODI maintains linearity over time. Conclusion: There is no correlation between the presence of peri-implant osteolysis to the quality of life of patients undergoing lumbar or posterolateral lumbosacral arthrodesis in the follow-up period up to 360 days. The quality of life in postoperative has significantly improvement when compared to the preoperative period.15429029
Estudio de la Interacción Fluido-Estructura en Tableros de Puentes
El estudio de problemas acoplados, tales como la interacción entre fluido y estructura se ha convertido en los últimos años en un tópico de creciente importancia en la ingeniería. Particularmente, en la ingeniería civil, el flujo de viento atmosférico puede provocar inestabilidades aeroelásticas en puentes de grandes luces, rascacielos y estructuras livianas y esbeltas, donde el amortiguamiento estructural es bajo. En este trabajo se estudia mediante el modelado numérico la interacción entre el viento atmosférico y un tablero de puente, considerando al flujo laminar. El acople entre los sistemas fluido – estructura se realiza de forma débil, utilizando las capacidades del software comercial FLUENT, mediante funciones que deben ser específicamente definidas y mallas dinámicas. Los resultados mostraron concordancia con los obtenidos mediante simulaciones numéricas publicadas en otros trabajos y evidenciaron que el movimiento de flutter en estructuras de baja frecuencia natural es el resultado de las vibraciones inducidas por el desprendimiento de vórtices.Fil: Castro, Hugo Guillermo. Universidad Tecnológica Nacional. Facultad Regional Resistencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Adotti, Marcelo Italo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste. Facultad de Ingeniería; ArgentinaFil: Paz, Rodrigo Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; ArgentinaFil: de Bortoli, Mario Eduardo. Universidad Tecnológica Nacional. Facultad Regional Resistencia; Argentin
Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux
Accumulation of protein aggregates is a histopathological hallmark of several neurodegenerative diseases, but in most cases the aggregation occurs without defined mutations or clinical histories, suggesting that certain endogenous metabolites can promote aggregation of specific proteins. One example that supports this hypothesis is dopamine and its metabolites. Dopamine metabolism generates several oxidative metabolites that induce aggregation of alpha-synuclein, and represents the main etiology of Parkinson's diseases. Because dopamine and its metabolites are unstable and can be highly reactive, we investigated whether these molecules can also affect other proteins that are prone to aggregate, such as cellular prion protein (PrPC). in this study, we showed that dopamine treatment of neuronal cells reduced the number of viable cells and increased the production of reactive oxygen species (ROS) as demonstrated in previous studies. Overall PrPC expression level was not altered by dopamine treatment, but its unglycosylated form was consistently reduced at 100 mu M of dopamine. At the same concentration, the level of phosphorylated mTOR and 4EBP1 was also reduced. Moreover, dopamine treatment decreased the solubility of PrPC, and increased its accumulation in autophagosomal compartments with concomitant induction of LC3-II and p62/SQSTM1 levels. in vitro oxidation of dopamine promoted formation of high-order oligomers of recombinant prion protein. These results suggest that dopamine metabolites alter the conformation of PrPC, which in turn is sorted to degradation pathway, causing autophagosome overload and attenuation of protein synthesis. Accumulation of PrPC aggregates is an important feature of prion diseases. Thus, this study brings new insight into the dopamine metabolism as a source of endogenous metabolites capable of altering PrPC solubility and its subcellular localization.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)EMU (programa de equipamentos multiusuarios)Universidade Federal de São Paulo, Dept Biochem Mol & Cell Biol, BR-04039032 São Paulo, BrazilUniv Metodista São Paulo, São Paulo, BrazilAC Camargo Canc Ctr, Int Res Ctr, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biophys, BR-04039032 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biochem Mol & Cell Biol, BR-04039032 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biophys, BR-04039032 São Paulo, BrazilFAPESP: 2008/06152-9FAPESP: 2009/14027-2FAPESP: 2013/22413-5FAPESP: 2012/18093-2Web of Scienc
A importância da segurança do paciente e o cumprimento da antibioticoprofilaxia nas cirurgias dentro de uma hora
The aim was to understand the factors behind non-use of the checklist and the relevance of using antibiotic prophylaxis for patient safety. This is an integrative review study of secondary sources, carried out through the Virtual Health Library and ANVISA documents. In eight countries, a reduction from 11% to 7% in the occurrence of complications in surgical patients and a reduction in mortality from 1.5% to 0.8% was found with the use of the checklist. It is concluded that not using the checklist can pose risks to patient safety, increasing the percentage of errors, causing losses to institutions, in addition to the imminent death of patients. It was evident that the use of antibiotic prophylaxis must be carried out up to 60 minutes before the surgical incision, with it being carried out before 60 minutes or after the recommended time due to low efficacy.Objetivou-se compreender os fatores da não utilização do checklist e a relevância do uso do antibioticoprofilaxia para segurança do paciente. Trata-se de um estudo revisão integrativa de fontes secundarias, realizado por meio da Biblioteca Virtual de Saúde e documentos da ANVISA. Em oito países encontrou-se uma redução de 11% para 7% da ocorrência de complicações em pacientes cirúrgicos e uma diminuição de mortalidade de 1,5% para 0,8% com o uso da lista de verificação. Conclui-se que a não utilização do checklist pode trazer riscos à segurança do paciente, aumentando o percentual de erros, favorecendo prejuízos para as instituições, além da eminência de óbitos dos pacientes. Evidenciou-se que o uso do antibioticoprofilaxia deve ser realizado até 60 minutos que antecedem a incisão cirúrgica, sendo irrelevante a realização anterior aos 60 minutos ou posterior ao tempo preconizado devido à baixa eficácia
Natural ventilation in hangars with permeable enclosure
La ventilación industrial permite controlar factores como presencia de compuestos tóxicos, temperatura o humedad excesiva, presencia de polvo o impurezas, existencia de agentes explosivos o inflamables, entre otros, manteniendo el confort térmico y la prevención de fuego o explosiones, siendo la ventilación natural la alternativa que optimiza la economía en equipos y consumo de energía. Se analizó el proceso de ventilación natural de un hangar de grandes dimensiones, mediante estudio experimental en túnel de viento y modelado numérico de un modelo reducido, escala 1:50, de baja permeabilidad y aislación térmica. Se examinaron movimientos de masas de aire por convección natural, para distintos niveles de permeabilidad, sin intervención del viento atmosférico exterior; y posteriormente sometido a viento de capa límite atmosférico en túnel de viento. El modelado numérico se realizó con flujo laminar y estacionario, utilizando software de código libre y abierto OpenFOAM aplicando el procedimiento del método de volúmenes finitos, evaluándose distintas geometrías de mallas para representar adecuadamente las configuraciones de las permeabilidades adoptadas. La utilización de coeficientes de presión según normas para determinar caudales evidenció importantes limitaciones; la disposición con ambas filas de aberturas abiertas exteriorizó líneas de corriente con mínima recirculación y caudales superiores. Los resultados numéricos fueron consistentes con los experimentales.Industrial ventilation allows control factors such as presence of toxic compounds, excessive temperature or moisture, dust or impurities or even explosive or flammable agents, thus maintaining thermal comfort or preventing fire or explosion, being natural ventilation the very first choice for its evident resource economy and least energy consumption when implementing it. The ventilation process of a large size hangar was analyzed by means an experimental numerical research in a reduced prototype having a 1:50 scale and low permeability on their walls and a very low thermal insulation. Air mass motion by natural convection was researched for different permeability levels with no external atmospheric wind involvement at first and later subjected to external wind simulated into boundary wind tunnel. Numerical test made on hypothesis of laminar steady flow with open free code OpenFoam by means finite volume method, assessing different mesh settings in order to depict different openings adopted. By Using pressure coefficients according standard at determining flow showed strong limitations; opening arrangements having both rows opened threw more intense ventilation but ordered. Numerical results were consistent with the tested ones.Fil: Canela, Eduardo. Universidad Nacional del Nordeste. Facultad de Ingeniería; ArgentinaFil: Udrizar Lezcano, Maria Sandra. Universidad Nacional del Nordeste. Facultad de Ingeniería; ArgentinaFil: Adotti, Marcelo Italo. Universidad Nacional del Nordeste. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Modelado e Innovación Tecnológica. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Modelado e Innovación Tecnológica; ArgentinaFil: Marighetti, Jorge Omar. Universidad Nacional del Nordeste. Facultad de Ingeniería; ArgentinaFil: de Bortoli, Mario Eduardo. Universidad Nacional del Nordeste. Facultad de Ingeniería; Argentin
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