Current status of sentinel lymph node biopsy in solid malignancies

Lymphatic mapping and sentinel lymph node biopsy were first reported in 1977 by Cabanas for penile cancer. Since that time, the technique has become rapidly assimilated into clinical practice. The sentinel node concept has been validated in cutaneous melanoma and breast cancer. However, follow-up data of patients from randomised trials is needed to establish the clinical significance of sentinel lymph node biopsy before accepting the procedure as a standard of care. This technique has the potential to be utilised in all solid tumours like colon, gastric, oesophageal, lung, gynaecologic, and head and neck cancer. This paper reviews the current status of sentinel lymph node biopsy in solid tumours

"Hayatım bir serenattı"

Taha Toros Arşivi, Dosya No: 15-Fahrünnisa Zeidİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033

Fausto Zonaro:Court painter of Sultan Abdul Hamid II

Taha Toros Arşivi, Dosya No: 98-Fausto Zonaroİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033

Pathways to the Present: U.S. Development and Its Consequences in the Pacific

Ranging from the Hawaiian Archipelago to the Aleutian Islands, from Silicon Valley to Guam, Pathways to the Present is a thoroughly researched and concisely argued account of economic and environmental change in the postwar "American" Pacific. Following a brief survey of the history of the Pacific, the author takes the Hawaiian Islands as the center of American activities in the region and looks at interactions among native Hawaiian, developmental, military, and environmental issues in the archipelago after World War II. He then turns to land- and water-use problems that have intersected with more nebulous quality-of-life concerns to generate policy controversies in the Seattle region and the San Francisco Bay area, especially Silicon Valley. Economic expansion and environmentalism in Alaska are examined through the lens of changes occurring along the Aleutians. From there the study considers Hiroshima after its destruction by the atomic bomb in 1945, looking at residents’ desire to combine urban-planning concepts. The author investigates the effort to remake Hiroshima as a high-tech city in the 1990s, an attempt inspired by the perceived success of Silicon Valley, and postwar planning on Okinawa, where American influences were particularly strong. The final chapter takes into account issues raised on Guam regarding the growth of tourism and the use of the island for military purposes and links these to developments in the Philippines to the west and American Sâmoa to the south. An electronic version of this book is freely available thanks to the support of libraries working with Knowledge Unlatched, a collaborative initiative designed to make high-quality books open access for the public good. The open-access version of this book is licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), which means that the work may be freely downloaded and shared for non-commercial purposes, provided credit is given to the author. Derivative works and commercial uses require permission from the publisher.Knowledge Unlatche

Automatic differentiation of hessian matrices

Orientador: Margarida Pinheiro MelloDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matemática, Estatística e Computação CientíficaResumo: Dentro do contexto de programação não linear, vários algoritmos resumem-se à aplicação do método de Netwon aos sistemas constituídos pelas condições de primeira ordem de Lagrange. Nesta classe de métodos é necessário calcular a matriz hessiana. Nosso foco é o cálculo exato, dentro da precisão da máquina, de matrizes hessianas usando diferenciação automática. Para esse fim, exploramos o cálculo da matriz hessiana sob dois pontos de vista. O primeiro é um modelo de grafo que foca nas simetrias que ocorrem no processo do cálculo da hessiana. Este ângulo propicia a intuição de como deve ser calculada a hessiana e leva ao desenvolvimento de um novo método de modo reverso para o cálculo de matrizes hessianas denominado edge pushing. O segundo ponto de vista é uma representação puramente algébrica que reduz o cálculo da hessiana à avaliação de uma expressão. Esta expressão pode ser usada para demonstrar algoritmos já existentes e projetar novos. Para ilustrar, deduzimos dois novos algoritmos, edge pushing e um novo algoritmo de modo direto, e uma série de outros métodos conhecidos [1], [20, p.157] e [9]. Apresentamos estudos teóricos e empíricos sobre o algoritmo edge pushing. Analisamos sua complexidade temporal e de uso de memória. Implementamos o algoritmo como um driver do pacote ADOL-C [19] e efetuamos testes computacionais, comparando sua performance com à de dois outros drivers em dezesseis problemas da coleção CUTE [5]. Os resultados indicam que o novo algoritmo é muito promissor. Pequenas modificações em edge pushing produzem um novo algoritmo, edge pushing sp, para o cálculo da esparsidade de matrizes hessianas, um passo necessário de uma classe de métodos que calculam a matriz hessiana usando colorações de grafos, [14, 19, 30]. Estudos de complexidade e testes numéricos são realizados comparando o novo método contra um outro recentemente desenvolvido [30] e os testes favorecem o novo algoritmo edge pushing sp. No capítulo final, motivado pela disponibilidade crescente de computadores com multiprocesadores, investigamos o processamento em paralelo do cálculo de matrizes hessianas. Examinamos o cálculo em paralelo de matrizes hessianas de funções parcialmente separáveis. Apresentamos uma abordagem desenvolvida para o cômputo em paralelo que pode ser usando em conjunto com qualquer método de cálculo de hessiana e outra estratégia específica para métodos de modo reverso. Testes são executados em um computador com memória compartilhada usando a interface de programação de aplicativo OpenMPAbstract: In the context of nonlinear programming, many algorithms boil down to the application of Newton's method to the system constituted by the first order Lagrangian conditions. The calculation of Hessian matrices is necessary in this class of solvers. Our focus is on the exact calculation, within machine precision, of Hessian matrices through automatic differentiation. To this end, we detail the calculations of the Hessian matrix under two points of view. The first is an intuitive graph model that focuses on what symmetries occur throughout the Hessian calculation. This provides insight on how one should calculate the Hessian matrix, and we use this enlightened perspective to deduce a new reverse Hessian algorithm called edge pushing. The second viewpoint is a purely algebraic representation of the Hessian calculation via a closed formula. This formula can be used to demonstrate existing algorithms and design new ones. In order to illustrate, we deduce two new algorithms, edge pushing and a new forward algorithm, and a series of other known Hessian methods [1], [20, p.157] and [9]. We present theoretical and empirical studies of the edge pushing algorithm, establishing memory and temporal bounds, and comparing the performance of its computer implementation against that of two algorithms available as drivers of the software ADOL-C [14, 19, 30] on sixteen functions from the CUTE collection [5]. Test results indicate that the new algorithm is very promising. As a by-product of the edge pushing algorithm, we obtain an efficient algorithm, edge pushing sp, for automatically obtaining the sparsity pattern of Hessian matrices, a necessary step in a class of methods used for computing Hessian matrices via graph coloring, [14, 19, 30]. Complexity bounds are developed and numerical tests are carried out comparing the new sparsity detection algorithm against a recently developed method [30] and the results favor the new edge pushing sp algorithm. In the final chapter, motivated by the increasing commercial availability of multiprocessors, we investigate the implementation of parallel versions of the edge pushing algorithm. We address the concurrent calculation of Hessian matrices of partially separable functions. This includes a general approach to be used in conjunction with any Hessian software, and a strategy specific to reverse Hessian methods. Tests are carried out on a shared memory computer using the OpenMP paradigmMestradoAnalise NumericaMestre em Matemática Aplicad

"My life played me a serenade"

Taha Toros Arşivi, Dosya No: 15-Fahrünnisa Zeidİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033