Prospectus, February 3, 1975

PC SPEECH, DEBATE RAP OPPONENTS; Forensics Squad Third In 27 Team Field; Debate Team Takes 1st In DuPage Tourney; Young Republicans To Try Again; Japanese Flower Arrangers Meeting; StuGo Ends Boycott Against Canteen; UFO Expert Speaks Today; Parkland-MTD Conference; WIU Offers BIO Scholarship; Get Your Own Inner Peace; Financial Aid; Quarter To Semester System Switch Coming; editorials; The Kaleidoscope; The Short Circuit; essay: Boycott Canteen?; True Happenings; letters; Classified Ads; Cobras Continue On Rampage; Lake Land Losses; Becky Beach Leads Women Cagers; Bouncing Bob\u27s Basketball Bonanza; Intramural Basketball; \u27Oswald Acted Alone\u27?; Parkland Events; Convocations To Show Marlon Brando Flicks; Deodato, Christopoulos To Play At ISU Wed.; Callboardhttps://spark.parkland.edu/prospectus_1975/1016/thumbnail.jp

Prospectus, May 5, 1975

MCCABE, MCMULLEN, REID….; StuGo Election May 7-8; PC News….In Brief: Art Exhibit To Be Held May 9th, Veterans Plan A Lake Of The Woods Cook-Out, Theta Epsilon Fair May 5, Recreation Society; Parkland Goes To Semester; StuGo Approves New Budget; Carnival A Tension Reliever ; editorials; \u27Next\u27; Vote! Vote!; letters; The Short Circuit; L.T.D.s Corner; Photography 35: Tips On Using An Exposure Meter, The Basic Elements Of Photography ; Candidate Platforms: McCabe, McMullen, Reid, Woodard, Eads, Hart, Weller, McQuinn, Weeks, Mandel, Miller; Skylines; Final Examination Schedule; Sports Views; Women\u27s Softball End With 5-1; Vets Scholarship Society; Cobras Eliminated From State Tourney; $44,000 Ripoff; Girl\u27s Volleyball Tournament May 5; sports; Wanted: Ace Reporters; Right To Life; Classified Ads; Parkland Events; Speeders....Beware!; New Communications 2yr. Program; Strike Freezes Construction; StuGo Minutes; The Parable, May 8 In C118; Band & Choir Scheduled Concerts; PC Hosts Teacher\u27s Aideshttps://spark.parkland.edu/prospectus_1975/1010/thumbnail.jp

Prospectus, December 6, 1974

OTHERS DISAGREE: STAERKEL: \u27DAY CARE JUST A CONVENIENCE\u27; Student Government Up For Grabs Again; P/C Model For Therapeutic Rec; Gunji Coordinator For Recognition Awards Selection; Our First Report On A Cape Kennedy Launch; Pre-Registration Helps Everyone; UPC: Consumer Aid Or Just A bother?; Fool Killer Does Wonder, The Pips Fool Mother Nature; Where Are We? A Few Facts On The New Signs; Prospectus Gets Bomb Threat, Caller \u27Disturbed\u27; Cyclowski Is First Fast Freddy Repeat; getting around day care; The Short Circuit; A Column By And For Women; getting the shaft; summary of report on possible child care services at parkland college; letters; High School Visitation Week; The Five Snow Queen Finalists; All Set For StuGo Election; Classified Ads; Cobras Notch Two Wins; Parkland-Rend Lake; Parkland-Wabash Valley; IM Basketball Starts Tomorrow; High Rollers Squeak Past BMF For IM Championship; Electronic Music Made Easy; 528 Earn Spot On Honors List; Author Richard Farina\u27s Latest \u27Interesting Despite The Flaws\u27; Parkland Events; Callboard; Europe Still Available At Low Cost; IM Basketball Schedulehttps://spark.parkland.edu/prospectus_1974/1001/thumbnail.jp

Dystonia Linked to EIF4A2 Haploinsufficiency: A Disorder of Protein Translation Dysfunction

Background: Protein synthesis is a tightly controlled process, involving a host of translation-initiation factors and microRNA-associated repressors. Variants in the translational regulator EIF2AK2 were first linked to neurodevelopmental-delay phenotypes, followed by their implication in dystonia. Recently, de novo variants in EIF4A2, encoding eukaryotic translation initiation factor 4A isoform 2 (eIF4A2), have been described in pediatric cases with developmental delay and intellectual disability. Objective: We sought to characterize the role of EIF4A2 variants in dystonic conditions. Methods: We undertook an unbiased search for likely deleterious variants in mutation-constrained genes among 1100 families studied with dystonia. Independent cohorts were screened for EIF4A2 variants. Western blotting and immunocytochemical studies were performed in patient-derived fibroblasts. Results: We report the discovery of a novel heterozygous EIF4A2 frameshift deletion (c.896_897del) in seven patients from two unrelated families. The disease was characterized by adolescence- to adulthood-onset dystonia with tremor. In patient-derived fibroblasts, eIF4A2 production amounted to only 50% of the normal quantity. Reduction of eIF4A2 was associated with abnormally increased levels of IMP1, a target of Ccr4-Not, the complex that interacts with eIF4A2 to mediate microRNA-dependent translational repression. By complementing the analyses with fibroblasts bearing EIF4A2 biallelic mutations, we established a correlation between IMP1 expression alterations and eIF4A2 functional dosage. Moreover, eIF4A2 and Ccr4-Not displayed significantly diminished colocalization in dystonia patient cells. Review of international databases identified EIF4A2 deletion variants (c.470_472del, c.1144_1145del) in another two dystonia-affected pedigrees. Conclusions: Our findings demonstrate that EIF4A2 haploinsufficiency underlies a previously unrecognized dominant dystonia-tremor syndrome. The data imply that translational deregulation is more broadly linked to both early neurodevelopmental phenotypes and later-onset dystonic conditions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

Energieeffizienz in Deutschland - eine Metastudie: Analyse und Empfehlungen

Das Stuttgarter Institut für Energieeffizienz in der Produktion hat die erste Metastudie "Energieeffizienz in Deutschland" erarbeitet. Sie liefert Zahlen, Daten und Fakten zum Entwicklungs- und Kenntnisstand der Energieeffizienz in Deutschland. Die Studie zeigt auf, welchen Beitrag einzelne Maßnahmen bisher geleistet haben und welche Potenziale zwar bekannt sind, aber bisher noch nicht gehoben wurden. Für diese Metastudie wurden mehr als 250 Veröffentlichungen von Forschungseinrichtungen, Ministerien, Fach- und Industrieverbänden mit Themenschwerpunkt Energieeffizienz identifiziert und ausgewertet. Sie bietet einen Überblick über den Stand der Entwicklung und ist ein wichtiges Nachschlagewerk für Industrie, Verbände und Politik

A Web-Based mHealth Intervention With Telephone Support to Increase Physical Activity Among Pregnant Patients With Overweight or Obesity: Feasibility Randomized Controlled Trial.

BackgroundPregnant patients with overweight or obesity are at high risk for perinatal complications. Excess gestational weight gain (GWG) further exacerbates this risk. Mobile health (mHealth) lifestyle interventions that leverage technology to facilitate self-monitoring and provide just-in-time feedback may motivate behavior change to reduce excess GWG, reduce intervention costs, and increase scalability by improving access.ObjectiveThis study aimed to test the acceptability and feasibility of a pilot mHealth lifestyle intervention for pregnant patients with overweight or obesity to promote moderate intensity physical activity (PA), encourage guideline-concordant GWG, and inform the design of a larger pragmatic cluster randomized controlled trial.MethodsWe conducted a mixed methods acceptability and feasibility randomized controlled trial among pregnant patients with a prepregnancy BMI of 25 to 40 kg/m2. Patients with singletons at 8 to 15 weeks of gestation who were aged ≥21 years and had Wi-Fi access were recruited via email from 2 clinics within Kaiser Permanente Northern California and randomized to receive usual prenatal care or an mHealth lifestyle intervention. Participants in the intervention arm received wireless scales, access to an intervention website, activity trackers to receive automated feedback on weight gain and activity goals, and monthly calls from a lifestyle coach. Surveys and focus groups with intervention participants assessed intervention satisfaction and ways to improve the intervention. PA outcomes were self-assessed using the Pregnancy Physical Activity Questionnaire, and GWG was assessed using electronic health record data for both arms.ResultsOverall, 33 patients were randomly assigned to the intervention arm, and 35 patients were randomly assigned to the usual care arm. All participants in the intervention arm weighed themselves at least once a week, compared with 20% (7/35) of the participants in the usual care arm. Participants in the intervention arm wore the activity tracker 6.4 days per week and weighed themselves 5.3 times per week, and 88% (29/33) of them rated the program "good to excellent." Focus groups found that participants desired more nutrition-related support to help them manage GWG and would have preferred an app instead of a website. Participants in the intervention arm had a 23.46 metabolic equivalent of task hours greater change in total PA per week and a 247.2-minute greater change in moderate intensity PA per week in unadjusted models, but these effects were attenuated in adjusted models (change in total PA: 15.55 metabolic equivalent of task hours per week; change in moderate intensity PA: 199.6 minutes per week). We found no difference in total GWG (mean difference 1.14 kg) compared with usual care.ConclusionsThe pilot mHealth lifestyle intervention was feasible, highly acceptable, and promoted self-monitoring. Refined interventions are needed to effectively affect PA and GWG among pregnant patients with overweight or obesity.Trial registrationClinicalTrials.gov NCT03936283; https://clinicaltrials.gov/ct2/show/NCT03936283

Mutational analysis of patients with X-linked adrenoleukodystrophy

International audienc

Practical guidance for telemedicine use in neuro-oncology.

While the COVID-19 pandemic has catalyzed the expansion of telemedicine into nearly every specialty of medicine, few articles have summarized current practices and recommendations for integrating virtual care in the practice of neuro-oncology. This article identifies current telemedicine practice, provides practical guidance for conducting telemedicine visits, and generates recommendations for integrating virtual care into neuro-oncology practice. Practical aspects of telemedicine are summarized including when to use and not use telemedicine, how to conduct a virtual visit, who to include in the virtual encounter, unique aspects of telehealth in neuro-oncology, and emerging innovations