Reference to index of Frederick Mackie's journal 1852 - 1855

Frederick William Mackie (1812-1893), Quaker, son of William Aram and Sarah Mackie, accompanied Robert Lindsey (1801-1863) on a "mission of concern" for the Society of Friends (Quakers) to the Australasian colonies. They left England in July 1852 in the barque "Wellington", arrived in Hobart, Van Diemen's Land in November 1852 and later travelled to New Zealand in 1853, New South Wales (1853), V.D.L. again (1853-4), Victoria (1854), South Australia(1854), N.S.W. and Victoria again (1854), a brief third visit to V.D.L., the Victorian goldfields (1854-5) and West Australia (1855), finishing their journey in South Africa. Mackie kept a diary of his travels, illustated by little pen or pencil sketches, in small notebooks still held by the May family, descendants of the family of Mackie's wife. After the mission journey was completed in 1855 Mackie did not return toEngland but went to South Australia to marry, in May 1856, Rachel Ann May, daughter of Joseph and Hannah May of Mount Barker, South Australia. For a few years they ran a Quaker school in Hobart, but returned to South Australia in 1861

The clerical population of the Province of York : an edition of the clerical poll tax enrolments 1377-1381.

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN025873 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Uniqueness Typing for Resource Management in Message-Passing Concurrency

We view channels as the main form of resources in a message-passing programming paradigm. These channels need to be carefully managed in settings where resources are scarce. To study this problem, we extend the pi-calculus with primitives for channel allocation and deallocation and allow channels to be reused to communicate values of different types. Inevitably, the added expressiveness increases the possibilities for runtime errors. We define a substructural type system which combines uniqueness typing and affine typing to reject these ill-behaved programs

Measurement and analysis of broadband UVB solar radiation in Spain

Measurements of broadband UVB irradiance (290-315 nm) at 14 locations in Spain for the period 2000-2009 have been used to generate instantaneous, hourly and daily values of irradiance (W m−2) and radiant exposure (kJ m−2). These measurements, and its statistical indices, have been analyzed. For the UVB irradiance, the values corresponding to July (maximum) and December (minimum) have been analyzed as representative of the year during the whole period for all locations. For the UVB radiant exposure, the temporal evolution of daily values has been evaluated for all locations to estimate an average yearly behavior. The accumulated radiant exposure for an average year has also been studied for each location. Finally, to determine possible trends in the evolution of the UVB levels, the linear regressions for the mean daily values for all locations have been determined

Cholesterol Pathways Affected by Small Molecules That Decrease Sterol Levels in Niemann-Pick Type C Mutant Cells

Niemann-Pick type C (NPC) disease is a genetically inherited multi-lipid storage disorder with impaired efflux of cholesterol from lysosomal storage organelles.The effect of screen-selected cholesterol lowering compounds on the major sterol pathways was studied in CT60 mutant CHO cells lacking NPC1 protein. Each of the selected chemicals decreases cholesterol in the lysosomal storage organelles of NPC1 mutant cells through one or more of the following mechanisms: increased cholesterol efflux from the cell, decreased uptake of low-density lipoproteins, and/or increased levels of cholesteryl esters. Several chemicals promote efflux of cholesterol to extracellular acceptors in both non-NPC and NPC1 mutant cells. The uptake of low-density lipoprotein-derived cholesterol is inhibited by some of the studied compounds.Results herein provide the information for prioritized further studies in identifying molecular targets of the chemicals. This approach proved successful in the identification of seven chemicals as novel inhibitors of lysosomal acid lipase (Rosenbaum et al, Biochim. Biophys. Acta. 2009, 1791:1155-1165)

A New Fluorescence-Based Method Identifies Protein Phosphatases Regulating Lipid Droplet Metabolism

In virtually every cell, neutral lipids are stored in cytoplasmic structures called lipid droplets (LDs) and also referred to as lipid bodies or lipid particles. We developed a rapid high-throughput assay based on the recovery of quenched BODIPY-fluorescence that allows to quantify lipid droplets. The method was validated by monitoring lipid droplet turnover during growth of a yeast culture and by screening a group of strains deleted in genes known to be involved in lipid metabolism. In both tests, the fluorimetric assay showed high sensitivity and good agreement with previously reported data using microscopy. We used this method for high-throughput identification of protein phosphatases involved in lipid droplet metabolism. From 65 yeast knockout strains encoding protein phosphatases and its regulatory subunits, 13 strains revealed to have abnormal levels of lipid droplets, 10 of them having high lipid droplet content. Strains deleted for type I protein phosphatases and related regulators (ppz2, gac1, bni4), type 2A phosphatase and its related regulator (pph21 and sap185), type 2C protein phosphatases (ptc1, ptc4, ptc7) and dual phosphatases (pps1, msg5) were catalogued as high-lipid droplet content strains. Only reg1, a targeting subunit of the type 1 phosphatase Glc7p, and members of the nutrient-sensitive TOR pathway (sit4 and the regulatory subunit sap190) were catalogued as low-lipid droplet content strains, which were studied further. We show that Snf1, the homologue of the mammalian AMP-activated kinase, is constitutively phosphorylated (hyperactive) in sit4 and sap190 strains leading to a reduction of acetyl-CoA carboxylase activity. In conclusion, our fast and highly sensitive method permitted us to catalogue protein phosphatases involved in the regulation of LD metabolism and present evidence indicating that the TOR pathway and the SNF1/AMPK pathway are connected through the Sit4p-Sap190p pair in the control of lipid droplet biogenesis

Photograph of Frederick Mackie, Tasmania

Photograph of Frederick Mackie husband of Rachel Anne, Tasmania, originally from South Australia. The photographer was Charles Alfred Woolley who had studios at 42 Macquarie Street, Hobart from 1860-1870

Nuclear physics and dense matter

Crucial to understanding the properties of dense matter in supernova explosions and neutron stars is determining the role of the nuclei present in such matter. Because many of the properties of the matter do not depend strongly on the fine details of nuclear structure, the liquid drop model of the nucleus provides a convenient starting point. The influence of the matter outside the nuclei on the properties of the nuclei must, however, be taken into account. In this thesis we study several aspects of the liquid drop model and its applications. In particular we first study the theory of surface tension as used in the liquid drop model. We then develop a refined version of the compressible liquid drop model, which enables us to redetermine semi-empirically the properties of bulk nuclear matter. Finally, we apply the resultant nuclear mass formula to the equation of state of hot, dense matter. In part A we examine the concept of surface tension and study the consequences of relaxing the assumption that the surface tension of all nuclei is isotropic. First we present a macroscopic theory of anisotropic surface tension. Then, with a particular choice for the functional form of the surface tension tensor, we apply this theory in the case of a uniformly charged liquid drop. We show that a small anisotropy in the surface tension can significantly distort a highly charged drop and lower its fission barrier without greatly affecting the total energy. The theory developed in part A shows how the concept of surface tension enters the liquid drop model. This knowledge is applied in part B where we develop a refined version of the compressible liquid drop model introduced by Baym, Bethe and Pethick. By fitting this model to the binding and Coulomb energies of heavy nuclei, we redetermine phenomenologically the bulk and surface properties of symmetric nuclear matter. The principal refinement made is in the description of the surface tension, the semi-phenomenological expression used here being constructed to agree with microscopic surface energy calculations. The resulting six parameter mass formula reproduces known nuclear masses with an rms deviation of 2 2.6 MeV/c (attributable primarily to shell effects). Because the compressible liquid drop model contains the physics needed to describe both ordinary and neutron star nuclei, we expect this mass formula to be a reliable indicator of highly neutron-rich nuclei. The compressible liquid drop mass formula is used in part C where we present a simple calculation of the equation of state of hot, dense matter for application to hydrodynamic calculations of the collapse of massive, highly evolved stars. The temperatures and densities we consider range from 5 x 10^9 to 5 x lO^ll K and 109 to 1014 g/cm3, with the low temperature, high density region excluded. Heavy nuclei are represented by a single, characteristic species whose neutron and proton numbers are determined thermodynamically. The binding energies of these nuclei are determined from the mass formula described in part B. We treat all particles present in the. matter as perfect gases but include ion-ion Coulomb correlation effects with a simple Wigner-Seitz correction.U of I OnlyThesi

Devil Hill, Cape Town [picture] /

Title from inscription below image.; In: Sketches taken in the Australian colonies, Van Diemen's Land, New Zealand and South Africa.; Also available online at: http://nla.gov.au/nla.pic-an4769616