Conversion Total Hip Arthroplasty: Perioperative and Postoperative Outcomes with the ABLE Approach

The ABLE™ Approach for Conversion Total Hip Arthroplasty decreases surgical duration and length of stayhttps://knowledgeconnection.mainehealth.org/lambrew-retreat-2023/1022/thumbnail.jp

Shortening the Postoperative Length of Stay following Total Knee Arthroplasty does not Negatively Impact Short-term Patient Outcomes; a Retrospective Review of the Response to the COVID-19 Pandemic

Safely Decreasing Postoperative Length of Stay for Total Knee Arthroplasty (TKA) Patients Following the COVID-19 Pandemichttps://knowledgeconnection.mainehealth.org/lambrew-retreat-2023/1024/thumbnail.jp

Risk assessment of the use of alternative animal and plant raw material resources in aquaculture feeds

A wide range of raw materials are now used routinely in aquaculture feeds throughout the world, primarily to supply protein and energy in the form of lipid from edible oils. Protein meals and oils used can generally be divided into those of plant or animal origin and many have considerable potential to supply the required dietary nutrients required by aquaculture species. However, the use of any raw material introduces a suite of risks that need to be considered to enable the production of safe, sustainable and functional feeds to underpin this sector. A lack of understanding of some of those risks can result in failure of dietary specifications being met and/or negative nutritional elements being introduced (e.g. antinutritional factors). Importantly, it is this feed that when fed to food‐producing animals is such an important element of food safety, and as such any undesirable aspects relating to feed production can also have a negative impact on the rest of the food chain. However, there is some disparity internationally among raw materials that are used and the perceptions surrounding the risk of their use. It is the scientific assessment of these risks that is the basis of this review

The Use of the iPACK Block with the Adductor Canal Block (ACB) Decreases 48-hour Narcotic Usage and Postoperative Pain following Total Knee Arthroplasty

Adductor Canal and iPACK Blocks reduce pain levels and narcotic consumption following Total Knee Arthroplastyhttps://knowledgeconnection.mainehealth.org/lambrew-retreat-2023/1023/thumbnail.jp

Comparison of the posture of school children carrying backpacks versus pulling them on trolleys

Objective: To investigate whether there is a difference in the posture of schoolchildren walking with a backpack versus pulling a trolley. Design: Comparative, controlled, pilot trial. Setting: “Grundschule Fallersleben” – primary school in Germany. Subjects: Thirty-four school children between 6 and 8 years of age. Methods: Initially, neutral posture was measured in a standing position. All children were then asked to walk a predetermined route without intervention for approximately seven minutes. This was followed by walking the same route with either a backpack (n = 19) or trolley (n = 15). Deviations from neutral of the thoracic and lumbar spine (flexion, extension, lateral flexion and rotation) from the final 30 seconds of the imaging sequences were taken and analysed. Results: Compared to unburdened walking, walking with a backpack led to a statistically significant (p ≤ 0.05) increase in thoracic extension (3.91°, 95% CI = 3.35 to 4.46) and right lumbar lateral flexion (2.29°, 95% CI = -3.41 to -1.18), and a statistically significant decrease of lumbar flexion (2.2°, 95% CI = 0.34 to 4.06). In contrast, walking with a trolley increased extension (1.4°, 95% CI = 0.72 to 2.08), right lateral flexion (1.24°, 95% CI = -1.91 to -0.57) and right rotation (3.09°, 95% CI = -3.85 to -2.32) of the thoracic spine, and a statistically significant increase in left rotation (3.57°, 95% CI = 2.58 to 4.55) of the lumbar spine. Comparing the backpack and trolley groups showed to a statistically significant (p ≤ 0.05) increase in thoracic extension and right lumbar lateral flexion in the backpack group. Posture during trolley pulling was characterized by a statistically significant (p ≤ 0.05) increase in right thoracic and left lumbar rotation. Conclusion: Participants adopted asymmetric postures during walking with a backpack and pulling a trolley. However, the trolley group was characterised by spinal rotation which possibly adds an extra source of stress. This suggests that school children should use backpacks rather than trolleys when the weight is within recommended limits

An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans

Open Access via the Springer Nature Agreement We thank the staff (Darrin Sheppard, Donna Wallace, Andrew Brown, Mark Herbert and Karen Heath) at the Medical Research Facility for their help and excellent advice in the completion of these studies. We also thank Giuseppe D’Agostino for his guidance and help throughout the study.Peer reviewe

Co-constructing Simulations with Learners: Roles, Responsibilities, and Impact

Co-constructed simulations were designed and piloted with senior occupational therapy master’s students in a neurorehabilitation practice module. The instructor served as the guide for the students through all phases of the case creation, simulation development, delivery, and debrief. The instructor facilitation promoted self-regulated learning (SRL) of knowledge and skill development through independent discovery and peer learning. This paper provides an evidence-informed co-construction simulation design with outlined stages, roles, and responsibilities for the instructor and learner. Thematic qualitative analysis of student feedback highlighted enhanced insight and SRL as a result of multiple role preparation, observation and interaction with peers, close interaction with the instructor, and the multi-stage debrief process. Recommended key features and critical interactions for a successful co-constructed design are also identified for the learner, instructor, and simulation. The co-construction simulation process and design elements are suitable for learners in any health-related field of study

The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet

Excess maternal fat intake and obesity increase offspring susceptibility to conditions such as chronic anxiety and substance abuse. We hypothesised that environmentally modulated DNA methylation changes (5mC/5hmC) in regulatory regions of the genome that modulate mood and consumptive behaviours could contribute to susceptibility to these conditions. We explored the effects of environmental factors on 5mC/5hmC levels within the GAL5.1 enhancer that controls anxiety-related behaviours and alcohol intake. We first observed that 5mC/5hmC levels within the GAL5.1 enhancer differed significantly in different parts of the brain. Moreover, we noted that early life stress had no significant effect of 5mC/5hmC levels within GAL5.1. In contrast, we identified that allowing access of pregnant mothers to high-fat diet (> 60% calories from fat) had a significant effect on 5mC/5hmC levels within GAL5.1 in hypothalamus and amygdala of resulting male offspring. Cell transfection-based studies using GAL5.1 reporter plasmids showed that 5mC has a significant repressive effect on GAL5.1 activity and its response to known stimuli, such as EGR1 transcription factor expression and PKC agonism. Intriguingly, CRISPR-driven disruption of GAL5.1 from the mouse genome, although having negligible effects on metabolism or general appetite, significantly decreased intake of high-fat diet suggesting that GAL5.1, in addition to being epigenetically modulated by high-fat diet, also actively contributes to the consumption of high-fat diet suggesting its involvement in an environmentally influenced regulatory loop. Furthermore, considering that GAL5.1 also controls alcohol preference and anxiety these studies may provide a first glimpse into an epigenetically controlled mechanism that links maternal high-fat diet with transgenerational susceptibility to alcohol abuse and anxiety

Immune cells fold and damage fungal hyphae

Acknowledgements We thank Ben Rutter and Alex Brand for providing Mycelia sterilia hyphae, and Gillian Griffiths for insightful advice. We are grateful to the Microscopy and Histology Core Facility at the University of Aberdeen for their help, advice and support. This work was funded by grants from the UK Medical Research Council [www.mrc.ac.uk], to AJPB, NARG, LPE, MN (MR/M026663/1, MR/M026663/2), and from the University of Aberdeen to AP, DL. The work was also supported by Wellcome [www.wellcome.ac.uk]: NARG, GDB, AJPB (097377); NARG (101873, 200208); and GDB (102705). Further support for this work was also provided by the Medical Research Council Centre for Medical Mycology (MR/N006364/1). MGN was supported by an ERC Advanced Grant (#833247) and a Spinoza grant of the Netherlands Organization for Scientific Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Co-constructing Simulations with Learners: Roles, Responsibilities, and Impact

Co-constructed simulations were designed and piloted with senior occupational therapy master’s students in a neurorehabilitation practice module. The instructor served as the guide for the students through all phases of the case creation, simulation development, delivery, and debrief. The instructor facilitation promoted self-regulated learning (SRL) of knowledge and skill development through independent discovery and peer learning. This paper provides an evidence-informed co-construction simulation design with outlined stages, roles, and responsibilities for the instructor and learner. Thematic qualitative analysis of student feedback highlighted enhanced insight and SRL as a result of multiple role preparation, observation and interaction with peers, close interaction with the instructor, and the multi-stage debrief process. Recommended key features and critical interactions for a successful co-constructed design are also identified for the learner, instructor, and simulation. The co-construction simulation process and design elements are suitable for learners in any health-related field of stud