42 research outputs found
Allostatic load in an environmental riskscape: The role of stressors and gender
Stressors are theorized to be associated with higher allostatic load (AL), a concept of physiological wear measured as a composite of physical biomarkers. Risk of high AL may vary by gender and may be intensified in places with significant environmental risks, otherwise known as âenvironmental riskscapesâ. Yet, no study has examined the relationship between stressors, gender, and allostatic load in an environmental riskscape. Using primary data collected in a sample (N=1072) exposed to various environmental and social stressors, we find that long-term residence in Texas City (more than 30 years), residential proximity to petrochemical plants, perceived poor neighborhood conditions, and daily hassles are associated with higher allostatic load components. Variation in AL differs by gender and the types of biomarkers examined. Gender moderates the effect of length of residence in Texas City on cardiovascular health risk. We discuss our findings in light of current research on stressors, gender, allostatic load, and double jeopardy within environmental riskscapes
Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age
Recent studies have shown that Cytomegalovirus (CMV) may be an emerging marker of immunosenescence. CMV can affect the immune system by directly infecting leukocytes and hematopoietic cells or by eliciting an expansion of oligoclonal CD8+ T cells/contraction of the naĂŻve T cell compartment that may reduce the hostâs ability to fight other pathogens. To investigate further CMV-associated changes in immunity, a study was conducted with 1,454 adults (ages 25â91) to determine the association between CMV and reactivation of another latent herpesvirus, Herpes simplex virus type 1 (HSV-1), as indexed by antibody titers. Elevated antibody titers to latent HSV-1 were significantly associated with both CMV seropositivity and high CMV antibody levels. Evaluation by specific age groups (<45, 45â64, and 65+ years old) revealed that this association was detectable early in life (<45 years of age). Increases in HSV-1 antibodies by age occurred in CMV seropositive individuals but not CMV seronegative subjects. Within CMV seropositive subjects, increases in HSV-1 antibodies by age were only found in individuals with low CMV antibody levels as those with high CMV antibodies already exhibited elevated HSV-1 antibodies. These associations remained significant after accounting for body mass index, gender, and socioeconomic status. These results suggest that CMV can influence the immune response to another pathogen and support the concept that CMV may accelerate immunosenescence
Understanding the circumgalactic medium is critical for understanding galaxy evolution
Galaxies evolve under the influence of gas flows between their interstellar
medium and their surrounding gaseous halos known as the circumgalactic medium
(CGM). The CGM is a major reservoir of galactic baryons and metals, and plays a
key role in the long cycles of accretion, feedback, and recycling of gas that
drive star formation. In order to fully understand the physical processes at
work within galaxies, it is therefore essential to have a firm understanding of
the composition, structure, kinematics, thermodynamics, and evolution of the
CGM. In this white paper we outline connections between the CGM and galactic
star formation histories, internal kinematics, chemical evolution, quenching,
satellite evolution, dark matter halo occupation, and the reionization of the
larger-scale intergalactic medium in light of the advances that will be made on
these topics in the 2020s. We argue that, in the next decade, fundamental
progress on all of these major issues depends critically on improved empirical
characterization and theoretical understanding of the CGM. In particular, we
discuss how future advances in spatially-resolved CGM observations at high
spectral resolution, broader characterization of the CGM across galaxy mass and
redshift, and expected breakthroughs in cosmological hydrodynamic simulations
will help resolve these major problems in galaxy evolution.Comment: Astro2020 Decadal Science White Pape
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
The Science Performance of JWST as Characterized in Commissioning
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60â109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
âTypicalâ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (â€â18 years: 69, 48, 23; 85%), older adults (â„â70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each Pâ<â0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
Age differences in the effects of network composition on psychological distress
The main goal of this research is to better understand age differences in the effects of social networks on mental health. Using a social network approach to revise the convoy of social support model (Kahn and Antonucci, 1980), we examine specifically how two aspects of social support networks (kin composition and convoy dimensions) influence psychological distress for older and younger samples (18-59 and 60+). We hypothesize that kin composition will influence distress in general but especially for the younger sample, while two competing hypotheses for the convoy of social support model are tested. Using data from a three-wave panel health study, structural equation models (LISREL 8.20) indicate that a greater proportion of kin in the perceived support network and the presence of family members in the inner circle of the convoy significantly reduce distress, primarily for the younger sample. Implications for the convoy model are discussed.Social Networks Psychological Distress Age Differences
The Effect of Acculturation on Frailty Among Older Mexican Americans
El presente trabajo constituye una primera aproximaciĂłn al anĂĄlisis de la situaciĂłn de mujeres de origen venezolano y colombiano que han migrado en los Ășltimos años a la Argentina, particularmente a la ciudad de La Plata, capital de la provincia de Buenos Aires. En este sentido, hemos recurrido a fuentes bibliogrĂĄficas y a la realizaciĂłn de entrevistas para conocer las causas y los motivos de la emigraciĂłn, las condiciones de vida en el paĂs receptor, y las significaciones que cobran estas experiencias de vida.Centro Interdisciplinario de Investigaciones en GĂ©ner
Marital Status, the Economic Benefits of Marriage, and Days of Inactivity due to Poor Health
Purpose. This study explored whether the economic benefits of marriage mediate the association between marriage and health and if that relationship is conditional on the level of shared economic resources. Methods. Pooled, cross-sectional data from NHANES 2001â2006 were analyzed using multivariate zero-inflated negative binomial regression for the number of days of inactivity due to poor physical or mental health. Results. Persons that were divorced/separated reported the highest average number of days of inactivity (meanâ=â2.5) within a 30 day period, and married persons reported the lowest number of days of inactivity (meanâ=â1.4). Multivariate results indicated that widowed persons did not report significantly more days of inactivity than married persons. Income to poverty ratio reduced the size and eliminated statistical significance of the difference between divorced/separated and never married marital statuses compared to married persons. The interaction effect for marital status and income to poverty ratio was statistically significant suggesting that the relationship between marital status and inactivity is conditional on shared income. Conclusion. Marriage confers health protective benefits in part through pooled income relative to other marital statuses