Gray zones around diffuse large B cell lymphoma. Conclusions based on the workshop of the XIV meeting of the European Association for Hematopathology and the Society of Hematopathology in Bordeaux, France

The term “gray-zone” lymphoma has been used to denote a group of lymphomas with overlapping histological, biological, and clinical features between various types of lymphomas. It has been used in the context of Hodgkin lymphomas (HL) and non-Hodgkin lymphomas (NHL), including classical HL (CHL), and primary mediastinal large B cell lymphoma, cases with overlapping features between nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte-rich large B cell lymphoma, CHL, and Epstein–Barr-virus-positive lymphoproliferative disorders, and peripheral T cell lymphomas simulating CHL. A second group of gray-zone lymphomas includes B cell NHL with intermediate features between diffuse large B cell lymphoma and classical Burkitt lymphoma. In order to review controversial issues in gray-zone lymphomas, a joint Workshop of the European Association for Hematopathology and the Society for Hematopathology was held in Bordeaux, France, in September 2008. The panel members reviewed and discussed 145 submitted cases and reached consensus diagnoses. This Workshop summary is focused on the most controversial aspects of gray-zone lymphomas and describes the panel’s proposals regarding diagnostic criteria, terminology, and new prognostic and diagnostic parameters

2019 ESC/EAS Guidelines for themanagement of dyslipidaemias: lipid modification to reduce cardiovascular risk

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La figura de Sócrates como eslabón entre Sobre la libertad y El utilitarismo

This article attempts to be a different proposal from that of the utilitarianism norm to unify the human rights proposed in On Liberty and the utilitarian approach to the text called Utilitarianism by S. J. Mill. In this regard, we are invited to reflect from the ontological perspective of the human being that exists in Mill and which allows us to relate both proposals.Este articulo trata de ser una propuesta distinta a la que brinda el utilitarismo de regla para unificar los derechos humanos que se proponen en Sobre la Libertad y el planteamiento utilitarista que está en el texto denominado El utilitarismo de S.J. Mill. En este sentido, se invita a reflexionar desde cierta perspectiva ontológica del ser humano que existe en Mill y que permite relacionar ambas propuestas

The year 2018 in cardiology: aorta and peripheral circulation.

International audienc

Helicobacter pylori infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease

Anita Jukic,1,2 Dorotea Bozic,3,4 Dusko Kardum,5,6 Tina Becic,1,2 Bruno Luksic,7,8 Mislav Vrsalovic,9,10 Marko Ljubkovic,11 Damir Fabijanic1,2 1Department of Cardiology, University Hospital of Split, 2Department of Cardiology, University of Split School of Medicine, 3Department of Gastroenterology, University Hospital of Split, 4Department of Gastroenterology, University of Split School of Medicine, Split, 5Department of Gastroenterology, University Hospital Dubrava, Zagreb, 6Department of Gastroenterology, University of Osijek School of Medicine, Osijek, 7Department of Surgery, University Hospital of Split, 8Department of Surgery, University of Split School of Medicine, Split, 9Department of Vascular Medicine, Cardiovascular Center, Sestre Milosrdnice University Hospital, 10Department of Vascular Medicine, University of Zagreb School of Medicine, Zagreb, 11Department of Integrative Physiology, University of Split School of Medicine, Split, Croatia Aim: Controversy exists concerning the relation between Helicobacter pylori (HP) infection and coronary artery disease (CAD). We aimed to examine the relationship between HP infection and severity of coronary atherosclerosis in patients with chronic CAD.Patients and methods: A total of 150 patients (109 [73%] men; mean age 62.61±10.23 years) scheduled for coronary artery bypass grafting surgery were consecutively enrolled in the cross-sectional study. According to rapid urease test and/or gastric biopsy samples stained with hematoxylin and eosin and according to Giemsa, patients were classified as HP positive (n=87; 58%) or HP negative (n=63; 42%). Coronary angiograms were scored by quantitative assessment, using multiple angiographic scoring system: 1) vessel score (number of coronary arteries stenosed ≥50%), 2) Gensini score (assigning a severity score to each coronary stenosis according to the degree of luminal narrowing and its topographic importance) and 3) angiographic severity score (number of coronary artery segments stenosed ≥50%).Results: In comparison to HP-negative patients, HP-positive patients were more frequently hypertensive (P=0.014), had higher values of systolic (P=0.043) and diastolic (P=0.005) blood pressure and total cholesterol (P=0.013) and had lower values of high-density lipoprotein-cholesterol (HDL-C; P=0.010). There were no significant differences between the groups in the severity of coronary atherosclerosis: vessel score (P=0.152), Gensini score (P=0.870) and angiographic severity score (P=0.734).Conclusion: It is likely that HP infection is not a risk factor for the severity of coronary atherosclerosis in chronic CAD patients. Keywords: atherosclerosis, coronary artery disease, Helicobacter pylor