Pop-Culture Artifacts

In dealing with literary work such as Neil Gaiman\u27s, fiction that both inhabits and defies conventions of genre and medium and thus easy definition, it is clear that an examination of such work benefits from as eclectic a style as Gaiman\u27s own approach to story-telling. While this essay attempts no summary of the author\u27s entire literary corpus, an analysis of the underlying influences of the novel American Gods is necessary to map the details of its territory. A survey of the convergence of the various genres and allusions within this one text, and the ways in which Gaiman measures Old World belief systems with New World contemporary values offers an entrance into American Gods\u27 narrative cente

Core-shell Structured Composite Silica Micro- and Nanoparticles with Ability Release a De fined Quantity „on Demand“

The aim of this work was the preparation of biocompatible micro- and nanoparticles with a hollow in-terrior. The particles must be able to encapsulate and store a chemical payload for a certain time, followed by the release on demand of this payload. In our previous work [13] we have prepared silica microparticles with a hollow core and found that the diffusion across the mesoporous silica shell was strongly dependent on temperature. In this work, we used this dependence and attached iron oxide nanoparticles on the sur-face of the silica shell to create composite iron oxide/silica particles. The iron oxide nanoparticles were able to heat up in the presence of an alternating magnetic field. This property allowed us to use magnetic field as a tool for remote control of diffusion across the particle shell. To avoid spontaneous leakage of encapsu-lated payload in time, we have modified the surface of the composite micropaticles with a layer of palm oil. Palm oil is a phase change material which is solid under 37 °C. We showed that the resultant composite particles are able to store a payload for several months and release a defined quantity on demand by the application of a magnetic field. The particles were characterised in shape, size, heating ability and their mass transport properties. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3557

Internationalism, Technological Innovation, and New Associations: Bringing Change to Business Communication Research and Teaching

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68267/2/10.1177_108056999906200418.pd

The wall shear rate distribution for flow in random sphere packings

The wall shear rate distribution P(gamma) is investigated for pressure-driven Stokes flow through random arrangements of spheres at packing fractions 0.1 <= phi <= 0.64. For dense packings, P(gamma) is monotonic and approximately exponential. As phi --> 0.1, P(gamma) picks up additional structure which corresponds to the flow around isolated spheres, for which an exact result can be obtained. A simple expression for the mean wall shear rate is presented, based on a force-balance argument.Comment: 4 pages, 3 figures, 1 table, RevTeX 4; significantly revised with significantly extended scop

An assessment of the role of homogenization protocol in the performance of daily temperature series and trends: Application to northeastern Spain

[EN] This paper gives the complete details of the protocols applied for developing a spatially and temporarily high-resolution dataset of temperature for northeastern Spain. Our methodologies used data from a large number of observatories (1583) spanning some portions of the period between 1900 and 2006. The raw dataset was first tested for internal and external consistency to check data quality. To improve data completeness, a linear regression model was then utilized to infill gaps in the daily temperature series using the best correlated data from nearby sites. Discontinuities in the reconstructed series were determined by combining the results of three homogeneity-relative tests: the Standard Normal Homogeneity Test (SNHT), the Eastrerling and Peterson two-phased regression method and the Vincent test. To assess the possible impact of data homogenisation on trends and statistical properties of the final series, a set of tests (e.g. semivariance models and L-moment statistics) was applied to the series before and after correction. Semivariance models suggest a significant improvement in the spatial dependence of the corrected dataset on both seasonal and annual timescales. Also, L-moments gave no evidence of significant changes in the probability distribution of daily temperature series after correction. Taken together, the newly compiled dataset seems to be more robust and reveals more coherent spatial and temporal patterns of temperature compared with the original dataset. From the temporal and spatial perspectives, the new dataset comprises the most complete register of temperature in northeast Spain (1900-2006), with a reasonably spatial coverage. Accordingly, this database can provide a more reliable base for studying temperature changes and variability in the region. This dataset can also be of particular relevance to a number of meteorological, ecological, hydrological and agricultural applications on local, regional and continental scales. © 2011 Royal Meteorological Society.We are indebted to the anonymous reviewers for their constructive comments which were most helpful in improving this paper. We would like to thank the Agencia Estatal de Meteorologia for providing the temperature data used in this study. This work has been supported by the research projects CGL2006-11619/HID, CGL2008- 01189/BTE, CGL2011-27574-CO2-02, CGL2011-27753- CO2-01 and CGL2011-27536 financed by the Spanish Commission of Science and Technology; and also FEDER, EUROGEOSS (FP7-ENV-2008-1-226487) and ACQWA (FP7-ENV-2007-1- 212250) financed by the VII Framework Programme of the European Commission, La nieve en el Pirineo Aragones y su respuesta a ´ la variabilidad climatica, and Efecto de los escenarios ´ de cambio climatico sobre la hidrolog ´ ´ıa superficial y la gestion de embalses del Pirineo Aragon ´ es, financed by ´ Obra Social La Caixa and the Aragon Government and ´ Influencia del cambio climatico en el turismo de nieve, ´ CTTP01/10, financed by the Comision de Trabajo de los ´ Pirineos.Peer Reviewe

Using Higher Moments of Fluctuations and their Ratios in the Search for the QCD Critical Point

The QCD critical point can be found in heavy ion collision experiments via the non-monotonic behavior of many fluctuation observables as a function of the collision energy. The event-by-event fluctuations of various particle multiplicities are enhanced in those collisions that freeze out near the critical point. Higher, non-Gaussian, moments of the event-by-event distributions of such observables are particularly sensitive to critical fluctuations, since their magnitude depends on the critical correlation length to a high power. We present quantitative estimates of the contribution of critical fluctuations to the third and fourth moments of the pion, proton and net proton multiplicities, as well as estimates of various measures of pion-proton correlations, all as a function of the same five non-universal parameters, one of which is the correlation length that parametrizes proximity to the critical point. We show how to use nontrivial but parameter independent ratios among these more than a dozen fluctuation observables to discover the critical point. We also construct ratios that, if the critical point is found, can be used to overconstrain the values of the non-universal parameters.Comment: 16 pages, 5 figures. Version to appear in PRD. Footnote and reference adde

BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease.

Erdheim-Chester disease (ECD) is a rare histiocytosis with a high prevalence of BRAF V600E mutation (&gt;50% of patients). Patients with BRAF-mutant ECD can respond to BRAF inhibitors. Unfortunately, the lack of adequate archival tissue often precludes BRAF testing. We hypothesized that cell-free DNA (cfDNA) from plasma or urine can offer an alternative source of biologic material for testing. We tested for BRAF V600E mutation in cfDNA from the plasma and urine of 6 ECD patients. In patients with available archival tissue, the result of BRAF mutation analysis was concordant with plasma and urine cfDNA results in all 3 patients (100% agreement, kappa 1.00). In all 6 patients, BRAF mutation analysis of plasma and urine cfDNA was concordant in 5 of 6 patients (83% agreement, kappa 0.67). Testing for BRAF V600E mutation in plasma and urine cfDNA should be further investigated as an alternative to archival tissue mutation analysis

PIK3CA mutations in advanced cancers: characteristics and outcomes.

PIK3CA mutations are frequently diagnosed in diverse cancers and may predict response to PI3K/AKT/mTOR inhibitors. It remains unclear whether they are associated with other characteristics. We analyzed characteristics and outcome of 90 consecutive patients with diverse advanced tumors and PIK3CA mutations and 180 wild-type PIK3CA controls matched by tumor type, gender, and age referred to the Clinical Center for Targeted Therapy. PIK3CA and MAPK mutations (KRAS, NRAS, and BRAF) were analyzed using polymerase chain reaction-based DNA sequencing. The most frequent PIK3CA mutations were E545K (31/90, 34%), E542K (16/90, 18%) in exon 9, and H1047R (20/90, 22%) in exon 20. PIK3CA mutations compared to wild-type PIK3CA were associated with simultaneous KRAS (p=0.047) and MAPK mutations (p=0.03), but only MAPK mutations were confirmed as having an independent association in multivariate analysis. Rates of lung, bone, liver and brain metastases were similar in PIK3CA-mutant and wild-type patients. Patients with PIK3CA mutations treated on trials with PI3K/AKT/mTOR inhibitors had a higher partial/complete response (PR/CR) rate than wild-type PIK3CA patients treated with their best phase I therapy (10/56, 18% vs. 12/152, 8%; p=0.045), but not a prolonged progression-free survival. Patients with H1047R PIK3CA mutations had higher PR/CR rate with PI3K/AKT/mTOR inhibitors compared to wild-type PIK3CA patients treated with their best phase I therapy (6/16, 38% vs. 12/152, 8%; p=0.003). In conclusion, PIK3CA mutations in diverse cancers were not associated with clinical characteristics, but were correlated with MAPK mutations. PIK3CA mutations, especially, H1047R, were associated with attaining a PR/CR to PI3K/AKT/mTOR pathway inhibitors

Research Activities for the DORIS Contribution to the Next International Terrestrial Reference Frame

For the preparation of ITRF2008, the IDS processed data from 1993 to 2008, including data from TOPEX/Poseidon, the SPOT satellites and Envisat in the weekly solutions. Since the development of ITRF2008, the IDS has been engaged in a number of efforts to try and improve the reference frame solutions. These efforts include (i) assessing the contribution of the new DORIS satellites, Jason-2 and Cryosat2 (2008-2011), (ii) individually analyzing the DORIS satellite contributions to geocenter and scale, and (iii) improving orbit dynamics (atmospheric loading effects, satellite surface force modeling. . . ). We report on the preliminary results from these research activities, review the status of the IDS combination which is now routinely generated from the contributions of the IDS analysis centers, and discuss the prospects for continued improvement in the DORIS contribution to the next international reference frame

MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility

Preclinical experiments are carried out with ~20–30 μm wide, ~10 mm high parallel microbeams of hard, broad-‘‘white’’-spectrum x rays (~50–600 keV) to investigate microbeam radiation therapy (MRT) of brain tumors in infants for whom other kinds of radiotherapy are inadequate and/or unsafe. Novel physical microdosimetry (implemented with MOSFET chips in the ‘‘edge-on’’ mode) and Monte Carlo computer-simulated dosimetry are described here for selected points in the peak and valley regions of a microbeam-irradiated tissue-equivalent phantom. Such microbeam irradiation causes minimal damage to normal tissues, possible because of rapid repair of their microscopic lesions. Radiation damage from an array of parallel microbeams tends to correlate with the range of peak-valley dose ratios (PVDR). This paper summarizes comparisons of our dosimetric MOSFET measurements with Monte Carlo calculations. Peak doses at depths \u3c22 mm are 18% less than Monte Carlo values, whereas those depths \u3e22 mm and valley doses at all depths investigated (2 mm–62 mm) are within 2–13% of the Monte Carlo values. These results lend credence to the use of MOSFET detector systems in edge-on mode for microplanar irradiation dosimetry