Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress

It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumours. It has an innate ability to irradiate tumours with greater doses and spatial selectivity compared with electron and photon therapy and hence is a tissue sparing procedure. For more than twenty years powerful lasers have generated high energy beams of protons and heavy ions and hence it has been frequently speculated that lasers could be used as an alternative to RF accelerators to produce the particle beams necessary for cancer therapy. The present paper reviews the progress made towards laser driven hadron cancer therapy and what has still to be accomplished to realise its inherent enormous potential.Comment: 40 pages, 24 figure

How cold is cold dark matter? Small scales constraints from the flux power spectrum of the high-redshift Lyman-alpha forest

We present constraints on the mass of warm dark matter (WDM) particles derived from the Lyman-alpha flux power spectrum of 55 high- resolution HIRES spectra at 2.0 < z < 6.4. From the HIRES spectra, we obtain a lower limit of mwdm > 1.2 keV 2 sigma if the WDM consists of early decoupled thermal relics and mwdm > 5.6 keV (2 sigma) for sterile neutrinos. Adding the Sloan Digital Sky Survey Lyman-alpha flux power spectrum, we get mwdm > 4 keV and mwdm > 28 keV (2 sigma) for thermal relics and sterile neutrinos. These results improve previous constraints by a factor two.Comment: Some issues clarified (especially resolution related). Conclusions unchanged. Accepted version by PR

Phase Transitions in Quantum Dots

We perform Hartree-Fock calculations to show that quantum dots (i.e. two dimensional systems of up to twenty interacting electrons in an external parabolic potential) undergo a gradual transition to a spin-polarized Wigner crystal with increasing magnetic field strength. The phase diagram and ground state energies have been determined. We tried to improve the ground state of the Wigner crystal by introducing a Jastrow ansatz for the wavefunction and performing a variational Monte Carlo calculation. The existence of so called magic numbers was also investigated. Finally, we also calculated the heat capacity associated with the rotational degree of freedom of deformed many-body states.Comment: 14 pages, 7 postscript figure

Closing in on the picture : analyzing interactions in video recordings

This paper provides a detailed account of the processing and analysing of data, obtained through video recording during reflective practitioner research. It sets out five stages in the analysis of video recordings of classroom interactions during a series of educational drama lessons: from decisions relating to the selection of data for close analysis, to the seeking of themes, and finally to the presentation of conclusions. The researcher adapted and synthesised several processes derived from discourse analysis (Wells, 2001; Spiers, 2004; Gee, 2005) to produce a range of instruments for use in transcription and analysis of verbal and non-verbal discourse. These include: a simple transcription key; classifications for verbal and non-verbal discourse; and a template for a transcription and analysis matrix

How neutral is the intergalactic medium surrounding the redshift z=7.085 quasar ULAS J1120+0641?

The quasar ULAS J1120+0641 at redshift z=7.085 has a highly ionised near zone which is smaller than those around quasars of similar luminosity at z~6. The spectrum also exhibits evidence for a damping wing extending redward of the systemic Lya redshift. We use radiative transfer simulations in a cosmological context to investigate the implications for the ionisation state of the inhomogeneous IGM surrounding this quasar. Our simulations show that the transmission profile is consistent with an IGM in the vicinity of the quasar with a volume averaged HI fraction of f_HI>0.1 and that ULAS J1120+0641 has been bright for 10^6--10^7 yr. The observed spectrum is also consistent with smaller IGM neutral fractions, f_HI ~ 10^-3--10-4, if a damped Lya system in an otherwise highly ionised IGM lies within 5 proper Mpc of the quasar. This is, however, predicted to occur in only ~5 per cent of our simulated sight-lines for a bright phase of 10^6--10^7 yr. Unless ULAS J1120+0641 grows during a previous optically obscured phase, the low age inferred for the quasar adds to the theoretical challenge of forming a 2x10^9 M_sol black hole at this high redshift.Comment: 5 pages, 4 figures, accepted to MNRAS letter

Multilevel blocking approach to the fermion sign problem in path-integral Monte Carlo simulations

A general algorithm toward the solution of the fermion sign problem in finite-temperature quantum Monte Carlo simulations has been formulated for discretized fermion path integrals with nearest-neighbor interactions in the Trotter direction. This multilevel approach systematically implements a simple blocking strategy in a recursive manner to synthesize the sign cancellations among different fermionic paths throughout the whole configuration space. The practical usefulness of the method is demonstrated for interacting electrons in a quantum dot.Comment: 4 pages RevTeX, incl. two figure

The impact of relative position and returns on sacrifice and reciprocity: an experimental study using individual decisions

We present a comprehensive experimental design that makes it possible to characterize other-regarding preferences and their relationship to the decision maker’s relative position. Participants are faced with a large number of decisions involving variations in the trade-offs between own and other’s payoffs, as well as in other potentially important factors like the decision maker’s relative position. We find that: (1) choices are responsive to the cost of helping and hurting others; (2) The weight a decision maker places on others’ monetary payoffs depends on whether the decision maker is in an advantageous or disadvantageous relative position; and (3) We find no evidence of reciprocity of the type linked to menu-dependence. The results of a mixture-model estimation show considerable heterogeneity in subjects’ motivations and confirm the absence of reciprocal motives. Pure selfish behavior is the most frequently observed behavior. Among the subjects exhibiting social preferences, social-welfare maximization is the most frequent, followed by inequality-aversion and by competitiveness

Survival of low-birth-weight infants at Baragwanath Hospital - 1950 - 1996

Objectives. To examine changes in survival rates among lowbirth- weight (LBW) infants between the years 1950 and 1996:Methods. Survival figures were analysed for LBW infants managed at Baragwanath Hospital, a tertiary care centre in Soweto, Johannesburg, over four periods spanning five decades.Results. The overall mortality rates of LBW infants decreased markedly between the early 1950s and the period 1995/96. By the mid-1990s approximately four times the number of infants with birth weight less than 1 500 g were surviving compared with the early 1950s. The reduction in mortality rates occurred in all LBW groups during the first three decades. However, since 1981 infants who weighed less than 1 500 g at birth were the major contributors to the overall reduction in mortality. Between the years 1981/82 and 1995/96, survival increased significantly from 64% to 79% for infants with birth weight 1 000 - 1 499 g, and from 14% to 32% for those with birth weight less than 1 000 g. Since infants in the latter group were seldom offered mechanical ventilation or artificial surfactant, a large part of these increases in survival can be attributed. to improvement in the general level of care.Conclusion. There have been dramatic improvements in the survival of LBW infants over this time period at Baragwanath Hospital. Although newer interventions such as mechanical ventilation and artificial surfactant have played a significant role, improvement in care at primary and secondary levels has been of major importance