Influence of a Bi surfactant on Sb incorporation in InAsSb alloys

The influence of using a Bi surfactant during the growth of InAsSb on the composition was examined, and it was found that increasing Bi flux on the surface during growth inhibits the incorporation of Sb. Analysis of the data via a kinetic model of anion incorporation shows that surface Bi acts as a catalyst for InAs formation, thus inhibiting Sb incorporation

Washington DC Model North Atlantic Treaty Organization

Model North Atlantic Treaty Organization (NATO) consists of several committees, each of whom draft policy relevant to their respective topics of discussion. The Committees debate for the course of the conference, drafting NATO policy to solve a multitude of issues. During this time, a simulated crisis also occurs, and each committee must respond to the updates from the crisis as well as focus on their original goals. After the final committee sessions of the conference, the final resolutions passed by each committee are sent to the North Atlantic Council (NAC), who works to approve all of them unanimously. The end result is a final communique, consisting of the unanimously approved policy from the body of the entire conference. This final communique is sent to NATO Headquarters, where it is used by actual NATO officials to guide potential policy directives in the future. POSTER PRESENTATION EAGLE PRIZE AWAR

Turbulent kinetic energy over large offshore wind farms observed and simulated by the mesoscale model WRF (3.8.1)

Wind farms affect local weather and microclimates; hence, parameterizations of their effects have been developed for numerical weather prediction models. While most wind farm parameterizations (WFPs) include drag effects of wind farms, models differ on whether or not an additional turbulent kinetic energy (TKE) source should be included in these parameterizations to simulate the impact of wind farms on the boundary layer. Therefore, we use aircraft measurements above large offshore wind farms in stable conditions to evaluate WFP choices. Of the three case studies we examine, we find the simulated ambient background flow to agree with observations of temperature stratification and winds. This agreement allows us to explore the sensitivity of simulated wind farm effects with respect to modeling choices such as whether or not to include a TKE source, horizontal resolution, vertical resolution and advection of TKE. For a stably stratified marine atmospheric boundary layer (MABL), a TKE source and a horizontal resolution on the order of 5 km or finer are necessary to represent the impact of offshore wind farms on the MABL. Additionally, TKE advection results in excessively reduced TKE over the wind farms, which in turn causes an underestimation of the wind speed deficit above the wind farm. Furthermore, using fine vertical resolution increases the agreement of the simulated wind speed with satellite observations of surface wind speed

Micrometeorological impacts of offshore wind farms as seen in observations and simulations

In Europe, offshore wind farms have a capacity of 16 GW, with 71% installed at the North Sea. These wind farms represent an additional source of turbulence and may influence the stratification of the marine boundary layer. We present aircraft measurements and simulations showing an impact on temperature and humidity at hub height in the order of 0.5 K 0.5 g kg$^{-1}$ even 60 km downwind of a wind farm cluster.We extend these simulations to explore a realistic future scenario, suggesting wakes in potential temperature and water vapor propagating more than 100 km downwind. Such impacts of wind farms are only observed in case of a strong stable stratification at rotor height, allowing wind farms to mix warmer air downward

Turbulent kinetic energy over large offshore wind farms observed and simulated by the mesoscale model WRF (3.8.1)

Wind farms affect local weather and microclimates; hence, parameterizations of their effects have been developed for numerical weather prediction models. While most wind farm parameterizations (WFPs) include drag effects of wind farms, models differ on whether or not an additional turbulent kinetic energy (TKE) source should be included in these parameterizations to simulate the impact of wind farms on the boundary layer. Therefore, we use aircraft measurements above large offshore wind farms in stable conditions to evaluate WFP choices. Of the three case studies we examine, we find the simulated ambient background flow to agree with observations of temperature stratification and winds. This agreement allows us to explore the sensitivity of simulated wind farm effects with respect to modeling choices such as whether or not to include a TKE source, horizontal resolution, vertical resolution and advection of TKE. For a stably stratified marine atmospheric boundary layer (MABL), a TKE source and a horizontal resolution on the order of 5&thinsp;km or finer are necessary to represent the impact of offshore wind farms on the MABL. Additionally, TKE advection results in excessively reduced TKE over the wind farms, which in turn causes an underestimation of the wind speed deficit above the wind farm. Furthermore, using fine vertical resolution increases the agreement of the simulated wind speed with satellite observations of surface wind speed. </div

Identification of a Putative Crf Splice Variant and Generation of Recombinant Antibodies for the Specific Detection of Aspergillus fumigatus

BACKGROUND: Aspergillus fumigatus is a common airborne fungal pathogen for humans. It frequently causes an invasive aspergillosis (IA) in immunocompromised patients with poor prognosis. Potent antifungal drugs are very expensive and cause serious adverse effects. Their correct application requires an early and specific diagnosis of IA, which is still not properly achievable. This work aims to a specific detection of A. fumigatus by immunofluorescence and the generation of recombinant antibodies for the detection of A. fumigatus by ELISA. RESULTS: The A. fumigatus antigen Crf2 was isolated from a human patient with proven IA. It is a novel variant of a group of surface proteins (Crf1, Asp f9, Asp f16) which belong to the glycosylhydrolase family. Single chain fragment variables (scFvs) were obtained by phage display from a human naive antibody gene library and an immune antibody gene library generated from a macaque immunized with recombinant Crf2. Two different selection strategies were performed and shown to influence the selection of scFvs recognizing the Crf2 antigen in its native conformation. Using these antibodies, Crf2 was localized in growing hyphae of A. fumigatus but not in spores. In addition, the antibodies allowed differentiation between A. fumigatus and related Aspergillus species or Candida albicans by immunofluorescence microscopy. The scFv antibody clones were further characterized for their affinity, the nature of their epitope, their serum stability and their detection limit of Crf2 in human serum. CONCLUSION: Crf2 and the corresponding recombinant antibodies offer a novel approach for the early diagnostics of IA caused by A. fumigatus

Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice.

The role of the newly discovered estrogen receptor GPR30 in islet physiology and pathophysiology is unclear. We examined GPR30 expression in relation to hormone secretion and possible anti-apoptotic effects in isolated mouse islets using the synthetic GPR30 ligand G-1. The mRNA and protein expression of GPR30 was analyzed by qPCR, Western blot and confocal microscopy. Hormone secretion and cAMP content were determined with RIA and apoptosis in islet cells with the Annexin-V method. GPR30 mRNA and protein expression was markedly higher in islets from females compared to male. This gender difference was not found for the genomic estrogen receptors ERalpha and ERbeta, the ERalpha expression being 10-fold higher than ERbeta in both genders. Confocal microscopy revealed abounden GPR30 expression in insulin, glucagon and somatostatin cells. Dose-response studies of G-1 vs 17beta-estradiol in isolated islets at 1 or 12mM glucose showed an almost identical pattern in that both compounds increased insulin and inhibited glucagon and somatostatin secretion. ICI-182,780 and EM-652, potent antagonists of the 17beta-estradiol receptors (ERalpha and ERbeta) did not influence the amplifying effect of G-1 or 17beta-estradiol on cAMP content or insulin secretion from isolated islets. Cytokine-induced (IL-1beta+TNFalpha+INFgamma) apoptosis in islets, cultured for 24h at 5mM glucose, was almost abolished by G-1 or 17beta-estradiol treatment. Addition of ICI-182,780 or EM-652 did not affect this beneficial effect of G-1 or 17beta-estradiol. Taken together, our findings show that GPR30 is expressed in most islet endocrine cells. The synthetic GPR30 ligand G-1 mimics the non-genomic effects of 17beta-estradiol on islet hormone secretion, cAMP content in islets and its anti-apoptotic effects. G-1 or analogs thereof might be new potential candidates in the therapeutic strategy for type 2 diabetes in women

Professional caregivers' perceptions on how persons with mild dementia might experience the usage of a digital photo diary

Cognitive impairments influence the possibility of persons with dementia to remember daily events and maintain a sense of self. In order to address these problems a digital photo diary was developed to capture information about events in daily life. The device consisted of a wearable digital camera, smart phone with Global Positioning System (GPS) and a home memory station with computer for uploading the photographs and touch screen. The aim of this study was to describe professional caregiver's perceptions on how persons with mild dementia might experience the usage of this digital photo diary from both a situation when wearing the camera and a situation when viewing the uploaded photos, through a questionnaire with 408 respondents. In order to catch the professional caregivers' perceptions a questionnaire with the semantic differential technique was used and the main question was "How do you think Hilda (the fictive person in the questionnaire) feels when she is using the digital photo diary?". The factor analysis revealed three factors; Sense of autonomy, Sense of self-esteem and Sense of trust. An interesting conclusion that can be drawn is that professional caregivers had an overall positive view of the usage of digital photo diary as supporting autonomy for persons with mild dementia. The meaningfulness of each situation when wearing the camera and viewing the uploaded pictures to be used in two different situations and a part of an integrated assistive device has to be considered separately. Individual needs and desires of the person who is living with dementia and the context of each individual has to be reflected on and taken into account before implementing assistive digital devices as a tool in care