Super-paramagnetic clustering of yeast gene expression profiles

High-density DNA arrays, used to monitor gene expression at a genomic scale, have produced vast amounts of information which require the development of efficient computational methods to analyze them. The important first step is to extract the fundamental patterns of gene expression inherent in the data. This paper describes the application of a novel clustering algorithm, Super-Paramagnetic Clustering (SPC) to analysis of gene expression profiles that were generated recently during a study of the yeast cell cycle. SPC was used to organize genes into biologically relevant clusters that are suggestive for their co-regulation. Some of the advantages of SPC are its robustness against noise and initialization, a clear signature of cluster formation and splitting, and an unsupervised self-organized determination of the number of clusters at each resolution. Our analysis revealed interesting correlated behavior of several groups of genes which has not been previously identified

High resolution optical time-domain reflectometry based on correlation utilizing an all-fiber chaotic source

We propose a high-resolution optical time domain reflectometry (OTDR) based on an all-fiber supercontinuum source. The source simply consists of a laser with moderate power and a section of fiber which has a zero dispersion wavelength near the laser's central wavelength. Spectrum and time domain properties of the source are investigated, showing that the source has great capability in nonlinear optics, such as correlation OTDR. We analyze one of the key factors limiting the operational range of such an OTDR, i.e., sampling time. Finally, we experimentally demonstrate a correlation OTDR with 25km sensing range and 5.3cm spatial resolution, as a verification of theoretical analysis

Ultrafast extreme rejuvenation of metallic glasses by shock compression

Structural rejuvenation of glasses not only provides fundamental insights into their complicated dynamics but also extends their practical applications. However, it is formidably challenging to rejuvenate a glass on very short time scales. Here, we present the first experimental evidence that a specially designed shock compression technique can rapidly rejuvenate metallic glasses to extremely high-enthalpy states within a very short time scale of about 365 \ub1 8 ns. By controlling the shock stress amplitude, the shock-induced rejuvenation is successfully frozen at different degrees. The underlying structural disordering is quantitatively characterized by the anomalous boson heat capacity peak of glasses. A Deborah number, defined as a competition of time scales between the net structural disordering and the applied loading, is introduced to explain the observed ultrafast rejuvenation phenomena of metallic glasses

Long-range and high-resolution correlation optical time-domain reflectometry utilizing an all optical chaotic source

A high resolution optical time domain reflectometry (OTDR) based on an all-fiber chaotic source is demonstrated. We analyze the key factors limiting the operational range of such an OTDR, e.g., integral Rayleigh backscattering and the fiber loss, which degrade the optical signal to noise ratio at the receiver side, and then the guideline for counter-act such signal fading is discussed. The experimentally demonstrated correlation OTDR presents ability of 100km sensing range and 8.2cm spatial resolution (1.2 million resolved points), as a verification of the theoretical analysis. To the best of our knowledge, this is the first time that correlation OTDR measurement is performed over such a long distance with such high precision

Preparation, Properties, and Microstructure of Graphite Powder-Containing Conductive Concrete

Conductive concrete not only retains the advantages of ordinary concrete but also possesses high electrical conductivity. It can be applied to snow and ice control on the roads. In preparing the conductive concrete, sand as the conductive fine aggregate was replaced with graphite powder. Its properties and microstructure were also investigated. The conductive concrete strength is shown to decrease with a graphite powder ratio. The conductive concrete resistivity goes down with the powder fineness and content; the temperature grows after electrification, and the concrete exhibits a high heating effect. Graphite powder exerts little influence on the hydration products of the concrete. With an increase in the content and fineness of graphite powder, its filling efficiency becomes rather helpful to form the conductive path.Проводящий бетон не только сохраняет преимущества обычного бетона, но и имеет высокую электропроводность; может использоваться для удаления снега и плавления льда на дорогах. Для получения такого бетона применялся вместо песка в качестве проводящего мелкого заполнителя графитовый порошок. Исследуются свойства и микроструктура бетона. Установлено, что прочность бетона уменьшается с увеличением содержания графитового порошка. Электрическое удельное сопротивление бетона уменьшается с увеличением мелкости и содержания графитового порошка; температура повышается после электризации, и бетон проявляет высокий нагревательный эффект. Графитовый порошок оказывает незначительное влияние на продукты гидратации проводящего бетона. С увеличением содержания и мелкости графитового порошка увеличивается положительный эффект заполнения графитовым порошком для формирования проводящей дорожки.Електропровідний бетон не тільки зберігає переваги звичайного бетону, але і має високу електропровідність; може використовуватися для видалення снігу та плавлення льоду на дорогах. Для отримання такого бетону застосовувався замість піску в якості провідного дрібний заповнювач графітовий порошок. Досліджуються властивості і мікроструктура бетону. Встановлено, що міцність бетону зменшується зі збільшенням вмісту графітового порошку. Електричний питомий опір бетону зменшується зі збільшенням дрібноту і змісту графітового порошку; температура підвищується після електризації, і бетон проявляє високий нагрівальний ефект. Графітовий порошок має незначний вплив на продукти гідратації проводить бетону. Зі збільшенням вмісту і дрібноту графітового порошку збільшується позитивний ефект заповнення графітовим порошком для формування провідної доріжк

Visible-light optical coherence tomography platform for the characterization of the skin barrier

We demonstrate a free-space, trolley-mountable Fourier domain visible-light optical coherence tomography (OCT) system for studying the stratum corneum in non-palmar human skin. An axial resolution of 1 µm in tissue and at least −75 dB sensitivity have been achieved. High-quality B-scans, containing 1600 A-scans, are acquired at a rate of 39 Hz. Images from the dorsal hand, ventral wrist and ventral forearm areas are obtained, with a clearly resolved stratum corneum layer (typically 5–15 µm thick) presenting as a hypoechogenic dark layer below the bright entrance signal, similar to that found in palmar skin with traditional OCT systems. We find that the appearance of the stratum corneum layer strongly depends on its water content, becoming brighter after occlusive hydration

K0-Sigma+ Photoproduction with SAPHIR

Preliminary results of the analysis of the reaction p(gamma,K0)Sigma+ are presented. We show the first measurement of the differential cross section and much improved data for the total cross section than previous data. The data are compared with model predictions from different isobar and quark models that give a good description of p(gamma,K+)Lambda and p(gamma,K+)Sigma0 data in the same energy range. Results of ChPT describe the data adequately at threshold while isobar models that include hadronic form factors reproduce the data at intermediate energies.Comment: 4 pages, Latex2e, 4 postscript figures. Talk given at the International Conference on Hypernuclear and Strange Particle Physics (HYP97), Brookhaven National Laboratory, USA, October 13-18, 1997. To be published in Nucl. Phys. A. Revised version due to changes in experimental dat

Photoproduction of mesons in nuclei at GeV energies

In a transport model that combines initial state interactions of the photon with final state interactions of the produced particles we present a calculation of inclusive photoproduction of mesons in nuclei in the energy range from 1 to 7 GeV. We give predictions for the photoproduction cross sections of pions, etas, kaons, antikaons, and $\pi^+\pi^-$ invariant mass spectra in ^{12}C and ^{208}Pb. The effects of nuclear shadowing and final state interaction of the produced particles are discussed in detail.Comment: Text added in summary in general reliability of the method, references updated. Phys. Rev. C (2000) in pres

Rare Decays of \Lambda_b->\Lambda + \gamma and \Lambda_b ->\Lambda + l^{+} l^{-} in the Light-cone Sum Rules

Within the Standard Model, we investigate the weak decays of $\Lambda_b \to \Lambda + \gamma$ and $\Lambda_b \to \Lambda + l^{+} l^{-}$ with the light-cone sum rules approach. The higher twist distribution amplitudes of $\Lambda$ baryon to the leading conformal spin are included in the sum rules for transition form factors. Our results indicate that the higher twist distribution amplitudes almost have no influences on the transition form factors retaining the heavy quark spin symmetry, while such corrections can result in significant impacts on the form factors breaking the heavy quark spin symmetry. Two phenomenological models (COZ and FZOZ) for the wave function of $\Lambda$ baryon are also employed in the sum rules for a comparison, which can give rise to the form factors approximately 5 times larger than that in terms of conformal expansion. Utilizing the form factors calculated in LCSR, we then perform a careful study on the decay rate, polarization asymmetry and forward-backward asymmetry, with respect to the decays of $\Lambda_b \to \Lambda \gamma$, $\Lambda l^{+}l^{-}$.Comment: 38 pages, 15 figures, some typos are corrected and more references are adde

Vector meson production and nucleon resonance analysis in a coupled-channel approach for energies m_N < sqrt(s) < 2 GeV II: photon-induced results

We present a nucleon resonance analysis by simultaneously considering all pion- and photon-induced experimental data on the final states gamma N, pi N, 2 pi N, eta N, K Lambda, K Sigma, and omega N for energies from the nucleon mass up to sqrt(s) = 2 GeV. In this analysis we find strong evidence for the resonances P_{31}(1750), P_{13}(1900), P_{33}(1920), and D_{13}(1950). The omega N production mechanism is dominated by large P_{11}(1710) and P_{13}(1900) contributions. In this second part we present the results on the photoproduction reactions and the electromagnetic properties of the resonances. The inclusion of all important final states up to sqrt(s) = 2 GeV allows for estimates on the importance of the individual states for the GDH sum rule.Comment: 41 pages, 26 figures, discussion extended, typos corrected, references updated, to appear in Phys. Rev.