Designing capacity-building in e-learning expertise: Challenges and strategies

This research study looks at how organizations in developing countries perceive the challenge of building capacity in e-learning expertise. Data was collected on six such organizations, and a range of perceived rationales and constraints were identified. The paper hypothesizes a four-part framework to define the e-learning capacity gaps that these circumstances appear to represent: the 'instructional design capacity gap', the 'production capacity gap', the 'tutorial capacity gap' and the 'community building gap'. The framework is used to re-examine the data to explore the ways in which the organizations' e-learning activities might constitute strategic responses to the hypothesized capacity gaps

Multi-stakeholder consensus on a target product profile for an HIV cure

Developing a cure for HIV is a global priority. Target product profiles are a tool commonly used throughout the drug development process to align interested parties around a clear set of goals or requirements for a potential product. Three distinct therapeutic modalities (combination therapies, ex-vivo gene therapy, and in-vivo gene therapy) for a target product profile for an HIV cure were identified. Using a process of expert face-to-face consultation and an online Delphi consultation, we found a high degree of agreement regarding the criteria for the optimum target product profile. Although the minimum attributes for a cure were debated, the broad consensus was that an acceptable cure need not be as safe and effective as optimally delivered antiretroviral therapy. An intervention that successfully cured a reasonable fraction of adults would be sufficient to advance to the clinic. These target product profiles will require further discussion and ongoing revisions as the field matures

Supernova Observation Via Neutrino-Nucleus Elastic Scattering in the CLEAN Detector

Development of large mass detectors for low-energy neutrinos and dark matter may allow supernova detection via neutrino-nucleus elastic scattering. An elastic-scattering detector could observe a few, or more, events per ton for a galactic supernova at 10 kpc ($3.1 \times 10^{20}$ m). This large yield, a factor of at least 20 greater than that for existing light-water detectors, arises because of the very large coherent cross section and the sensitivity to all flavors of neutrinos and antineutrinos. An elastic scattering detector can provide important information on the flux and spectrum of $\nu_\mu$ and $\nu_\tau$ from supernovae. We consider many detectors and a range of target materials from $^4$He to $^{208}$Pb. Monte Carlo simulations of low-energy backgrounds are presented for the liquid-neon-based Cryogenic Low Energy Astrophysics with Noble gases (CLEAN) detector. The simulated background is much smaller than the expected signal from a galactic supernova.Comment: 10 pages, 5 figures, submitted to Phys. Rev.

Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART

The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well characterized. In resting CD4 T cell subpopulations from 24 HIV-infected ART-suppressed and 6 HIV-uninfected individuals, we directly measured cellular turnover by heavy water labeling, HIV reservoir size by integrated HIV-DNA (intDNA) and cell-associated HIV-RNA (caRNA), and HIV reservoir clonality by proviral integration site sequencing. Compared to HIV-negatives, ART-suppressed individuals had similar fractional replacement rates in all subpopulations, but lower absolute proliferation rates of all subpopulations other than effector memory (TEM) cells, and lower plasma IL-7 levels (p = 0.0004). Median CD4 T cell half-lives decreased with cell differentiation from naïve to TEM cells (3 years to 3 months, p<0.001). TEM had the fastest replacement rates, were most highly enriched for intDNA and caRNA, and contained the most clonal proviral expansion. Clonal proviruses detected in less mature subpopulations were more expanded in TEM, suggesting that they were maintained through cell differentiation. Earlier ART initiation was associated with lower levels of intDNA, caRNA and fractional replacement rates. In conclusion, circulating integrated HIV proviruses appear to be maintained both by slow turnover of immature CD4 subpopulations, and by clonal expansion as well as cell differentiation into effector cells with faster replacement rates

Svestka's Research: Then and Now

Zdenek Svestka's research work influenced many fields of solar physics, especially in the area of flare research. In this article I take five of the areas that particularly interested him and assess them in a "then and now" style. His insights in each case were quite sound, although of course in the modern era we have learned things that he could not readily have envisioned. His own views about his research life have been published recently in this journal, to which he contributed so much, and his memoir contains much additional scientific and personal information (Svestka, 2010).Comment: Invited review for "Solar and Stellar Flares," a conference in honour of Prof. Zden\v{e}k \v{S}vestka, Prague, June 23-27, 2014. This is a contribution to a Topical Issue in Solar Physics, based on the presentations at this meeting (Editors Lyndsay Fletcher and Petr Heinzel

Morphological identification of animal hairs: Myths and misconceptions, possibilities and pitfalls

The examination of hair collected from crime scenes is an important and highly informative discipline relevant to many forensic investigations. However, the forensic identification of animal (non-human) hairs requires different skill sets and competencies to those required for human hair comparisons. The aim of this is paper is not only to highlight the intrinsic differences between forensic human hair comparison and forensic animal hair identification, but also discuss the utility and reliability of the two in the context of possibilities and pitfalls. It also addresses and dispels some of the more popular myths and misconceptions surrounding the microscopical examination of animal hairs. Furthermore, future directions of this discipline are explored through the proposal of recommendations for minimum standards for the morphological identification of animal hairs and the significance of the newly developed guidelines by SWGWILD is discussed

Track A Basic Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138319/1/jia218438.pd

TOI 564 b and TOI 905 b: Grazing and Fully Transiting Hot Jupiters Discovered by TESS

We report the discovery and confirmation of two new hot Jupiters discovered by the Transiting Exoplanet Survey Satellite (TESS): TOI 564 b and TOI 905 b. The transits of these two planets were initially observed by TESS with orbital periods of 1.651 and 3.739 days, respectively. We conducted follow-up observations of each system from the ground, including photometry in multiple filters, speckle interferometry, and radial velocity measurements. For TOI 564 b, our global fitting revealed a classical hot Jupiter with a mass of MJ and a radius of RJ. Also a classical hot Jupiter, TOI 905 b has a mass of MJ and radius of RJ. Both planets orbit Sun-like, moderately bright, mid-G dwarf stars with V ∼ 11. While TOI 905 b fully transits its star, we found that TOI 564 b has a very high transit impact parameter of, making it one of only ∼20 known systems to exhibit a grazing transit and one of the brightest host stars among them. Therefore, TOI 564 b is one of the most attractive systems to search for additional nontransiting, smaller planets by exploiting the sensitivity of grazing transits to small changes in inclination and transit duration over a timescale of several years