426 research outputs found
Measurement of the CKM angles gamma and 2 beta+gamma at B-factories
On behalf of the Babar and Belle collaborations, we report on the measurement
of the angle gamma and on the sum of angles 2 beta+gamma of the Unitarity
Triangle.Comment: Flavor Physics and CP Violation Conference, Vancouver, 2006. 10 pages
13 figures - corrected one referenc
Authors' Reply to Coste et al.: "LevothyroxÂź New and Old Formulations: Are they Switchable for Millions of Patients?"
"Authors'Reply to Coste et al"International audienc
Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?
At the request of French Regulatory Authorities, a new formulation of LevothyroxÂź was licensed in France in 2017, with the objective of avoiding the stability deficiencies of an existing licensed formulation. Before launching the new formulation, an average bioequivalence (ABE) trial was conducted, having enrolled 204 subjects and selected for interpretation a narrow a priori bioequivalence range of 0.90â1.11. Bioequivalence was concluded. In a previous publication, we questioned the ability of an ABE trial to guarantee the switchability within patients of the new and old levothyroxine formulations. It was suggested that the two formulations should be compared using the conceptual framework of individual bioequivalence. The present paper is a response to those claiming that, despite the fact that ABE analysis does not formally address the switchability of the two formulations, future patients will nevertheless be fully protected. The basis for this claim is that the ABE study was established in a large trial and analyzed using a stringent a priori acceptance interval of equivalence. These claims are questionable, because the use of a very large number of subjects nullifies the implicit precautionary intention of the European guideline when, for a Narrow Therapeutic Index drug, it recommends shortening the a priori acceptance interval from 0.80â1.25 to 0.90â1.11
NectarCAM : a camera for the medium size telescopes of the Cherenkov Telescope Array
NectarCAM is a camera proposed for the medium-sized telescopes of the
Cherenkov Telescope Array (CTA) covering the central energy range of ~100 GeV
to ~30 TeV. It has a modular design and is based on the NECTAr chip, at the
heart of which is a GHz sampling Switched Capacitor Array and a 12-bit Analog
to Digital converter. The camera will be equipped with 265 7-photomultiplier
modules, covering a field of view of 8 degrees. Each module includes the
photomultiplier bases, high voltage supply, pre-amplifier, trigger, readout and
Ethernet transceiver. The recorded events last between a few nanoseconds and
tens of nanoseconds. The camera trigger will be flexible so as to minimize the
read-out dead-time of the NECTAr chips. NectarCAM is designed to sustain a data
rate of more than 4 kHz with less than 5\% dead time. The camera concept, the
design and tests of the various subcomponents and results of thermal and
electrical prototypes are presented. The design includes the mechanical
structure, cooling of the electronics, read-out, clock distribution, slow
control, data-acquisition, triggering, monitoring and services.Comment: In Proceedings of the 34th International Cosmic Ray Conference
(ICRC2015), The Hague, The Netherlands. All CTA contributions at
arXiv:1508.0589
Light meson spectroscopy from Dalitz plot analyses of ηc decays to η0 K+Kâ , η0 Ï + Ï â , and Î·Ï + Ï â produced in two-photon interactions
We study the processes γγâηcâηâČK+Kâ, ηâČÏ+Ïâ, and ηÏ+Ïâ using a data sample of 519ââfbâ1 recorded with the BABAR detector operating at the SLAC PEP-II asymmetric-energy e+eâ collider at center-of-mass energies at and near the ΄(nS) (n=2, 3, 4) resonances. This is the first observation of the decay ηcâηâČK+Kâ and we measure the branching fraction Î(ηcâηâČK+Kâ)/(Î(ηcâηâČÏ+Ïâ)=0.644±0.039stat±0.032sys. Significant interference is observed between γγâηcâηÏ+Ïâ and the nonresonant two-photon process γγâηÏ+Ïâ. A Dalitz plot analysis is performed of ηc decays to ηâČK+Kâ, ηâČÏ+Ïâ, and ηÏ+Ïâ. Combined with our previous analysis of ηcâKÂŻKÏ, we measure the Kâ0(1430) parameters and the ratio between its ηâČK and ÏK couplings. The decay ηcâηâČÏ+Ïâ is dominated by the f0(2100) resonance, also observed in J/Ï radiative decays. A new a0(1700)âÎ·Ï resonance is observed in the ηcâηÏ+Ïâ channel. We also compare ηc decays to η and ηâČ final states in association with scalar mesons as they relate to the identification of the scalar glueball.publishedVersio
Search for rare or forbidden decays of the D0 meson
We present a search for nine lepton-number-violating and three lepton-flavor-violating neutral charm decays of the type D0âh'âhââ'+â+ and D0âh'âh+â'±ââ, where h and hâČ represent a K or Ï meson and â and ââČ an electron or muon. The analysis is based on 468 fbâ1 of e+eâ annihilation data collected at or close to the ΄(4S) resonance with the BABAR detector at the SLAC National Accelerator Laboratory. No significant signal is observed for any of the twelve modes, and we establish 90% confidence level upper limits on the branching fractions in the range (1.0â30.6)Ă10â7. The limits are between 1 and 3 orders of magnitude more stringent than previous measurements.publishedVersio
Measurements of the absolute branching fractions of B± âk±Xc c
A study of the two-body decays B±âXcÂŻcK±, where XcÂŻc refers to one charmonium state, is reported by the BABAR Collaboration using a data sample of 424 fbâ1. The absolute determination of branching fractions for these decays are significantly improved compared to previous BABAR measurements. Evidence is found for the decay B+âX(3872)K+ at the 3Ï level. The absolute branching fraction B[B+âX(3872)K+]=[2.1±0.6(stat)±0.3(syst)]Ă10â4 is measured for the first time. It follows that B[X(3872)âJ/ÏÏ+Ïâ]=(4.1±1.3)%, supporting the hypothesis of a molecular component for this resonance.publishedVersio
Contribution française à l'upgrade de LHCb
La contribution française à l'upgrade de LHCb est d etaillée dans ce document et s'inscrit dans le prolongement du Framework TDR soumis au LHCC le 25 mai 2012. La France a contribué à la conception et à la réalisation de la mécanique et de l'électronique de lecture des calorimÚtres. Elle est l'acteur principal du systÚme de déclenchement de premier niveau et l'initiatrice du projet DIRAC, progiciel de traitement et d'analyse de données dans un environnement distribué. Les physiciens et ingénieurs français ont de nombreuses responsabilités de premier plan et sont trÚs fortement impliqués dans l'analyse des données. Les groupes français souhaitent poursuivre leur forte participation a l'expérience en contribuant a son upgrade, notamment l'électronique de lecture des calorimÚtres et du trajectographe en fibres scintillantes ainsi qu'au data processing
Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences
The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & NemĂ©sio 2007; Donegan 2008, 2009; NemĂ©sio 2009aâb; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported
by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on
18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based
researchers who signed it in the short time span from 20 September to 6 October 2016
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