Precision photometric redshift calibration for galaxy–galaxy weak lensing

Accurate photometric redshifts are among the key requirements for precision weak lensing measurements. Both the large size of the Sloan Digital Sky Survey (SDSS) and the existence of large spectroscopic redshift samples that are flux-limited beyond its depth have made it the optimal data source for developing methods to properly calibrate photometric redshifts for lensing. Here, we focus on galaxy–galaxy lensing in a survey with spectroscopic lens redshifts, as in the SDSS. We develop statistics that quantify the effect of source redshift errors on the lensing calibration and on the weighting scheme, and show how they can be used in the presence of redshift failure and sampling variance. We then demonstrate their use with 2838 source galaxies with spectroscopy from DEEP2 and zCOSMOS, evaluating several public photometric redshift algorithms, in two cases including a full p(z) for each object, and find lensing calibration biases as low as <1 per cent (due to fortuitous cancellation of two types of bias) or as high as 20 per cent for methods in active use (despite the small mean photoz bias of these algorithms). Our work demonstrates that lensing-specific statistics must be used to reliably calibrate the lensing signal, due to asymmetric effects of (frequently non-Gaussian) photoz errors. We also demonstrate that large-scale structure (LSS) can strongly impact the photoz calibration and its error estimation, due to a correlation between the LSS and the photoz errors, and argue that at least two independent degree-scale spectroscopic samples are needed to suppress its effects. Given the size of our spectroscopic sample, we can reduce the galaxy–galaxy lensing calibration error well below current SDSS statistical errors

The XMM-Newton Wide-Field Survey in the COSMOS field (XMM-COSMOS): demography and multiwavelength properties of obscured and unobscured luminous AGN

We report the final optical identifications of the medium-depth (~60 ksec), contiguous (2 deg^2) XMM-Newton survey of the COSMOS field. XMM-Newton has detected ~800 X-ray sources down to limiting fluxes of ~5x10^{-16}, ~3x10^{-15}, and ~7x10^{-15} erg/cm2/s in the 0.5-2 keV, 2-10 keV and 5-10 keV bands, respectively. The work is complemented by an extensive collection of multi-wavelength data from 24 micron to UV, available from the COSMOS survey, for each of the X-ray sources, including spectroscopic redshifts for ~50% of the sample, and high-quality photometric redshifts for the rest. The XMM and multiwavelength flux limits are well matched: 1760 (98%) of the X-ray sources have optical counterparts, 1711 (~95%) have IRAC counterparts, and 1394 (~78%) have MIPS 24micron detections. Thanks to the redshift completeness (almost 100%) we were able to constrain the high-luminosity tail of the X-ray luminosity function confirming that the peak of the number density of logL_X>44.5 AGN is at z~2. Spectroscopically-identified obscured and unobscured AGN, as well as normal and starforming galaxies, present well-defined optical and infrared properties. We devised a robust method to identify a sample of ~150 high redshift (z>1), obscured AGN candidates for which optical spectroscopy is not available. We were able to determine that the fraction of the obscured AGN population at the highest (L_X>10^{44} erg s^{-1}) X-ray luminosity is ~15-30% when selection effects are taken into account, providing an important observational constraint for X-ray background synthesis. We studied in detail the optical spectrum and the overall spectral energy distribution of a prototypical Type 2 QSO, caught in a stage transitioning from being starburst dominated to AGN dominated, which was possible to isolate only thanks to the combination of X-ray and infrared observations.Comment: ApJ, in press. 59 pages, 14 figures, 2 Tables. A few typos corrected and a reference added. Table 2 is also available at http://www.mpe.mpg.de/XMMCosmos/xmm53_release ; a version of the paper in ApJ format (27 pages) is available at http://www.mpe.mpg.de/XMMCosmos/xmm53_release/brusa_xmmcosmos_optid.pd

Usefulness of Routine Fractional Flow Reserve for Clinical Management of Coronary Artery Disease in Patients With Diabetes

Importance: Approximately one-third of patients considered for coronary revascularization have diabetes, which is a major determinant of clinical outcomes, often influencing the choice of the revascularization strategy. The usefulness of fractional flow reserve (FFR) to guide treatment in this population is understudied and has been questioned. Objective: To evaluate the usefulness and rate of major adverse cardiovascular events (MACE) of integrating FFR in management decisions for patients with diabetes who undergo coronary angiography. Design, setting, and participants: This cross-sectional study used data from the PRIME-FFR study derived from the merger of the POST-IT study (Portuguese Study on the Evaluation of FFR-Guided Treatment of Coronary Disease [March 2012-November 2013]) and R3F study (French Study of FFR Integrated Multicenter Registries Implementation of FFR in Routine Practice [October 2008-June 2010]), 2 prospective multicenter registries that shared a common design. A population of all-comers for whom angiography disclosed ambiguous lesions was analyzed for rates, patterns, and outcomes associated with management reclassification, including revascularization deferral, in patients with vs without diabetes. Data analysis was performed from June to August 2018. Main outcomes and measures: Death from any cause, myocardial infarction, or unplanned revascularization (MACE) at 1 year. Results: Among 1983 patients (1503 [77%] male; mean [SD] age, 65 [10] years), 701 had diabetes, and FFR was performed for 1.4 lesions per patient (58.2% of lesions in the left anterior descending artery; mean [SD] stenosis, 56% [11%]; mean [SD] FFR, 0.81 [0.01]). Reclassification by FFR was high and similar in patients with and without diabetes (41.2% vs 37.5%, P = .13), but reclassification from medical treatment to revascularization was more frequent in the former (142 of 342 [41.5%] vs 230 of 730 [31.5%], P = .001). There was no statistical difference between the 1-year rates of MACE in reclassified (9.7%) and nonreclassified patients (12.0%) (P = .37). Among patients with diabetes, FFR-based deferral identified patients with a lower risk of MACE at 12 months (25 of 296 [8.4%]) compared with those undergoing revascularization (47 of 257 [13.1%]) (P = .04), and the rate was of the same magnitude of the observed rate among deferred patients without diabetes (7.9%, P = .87). Status of insulin treatment had no association with outcomes. Patients (6.6% of the population) in whom FFR was disregarded had the highest MACE rates regardless of diabetes status. Conclusions and relevance: Routine integration of FFR for the management of coronary artery disease in patients with diabetes may be associated with a high rate of treatment reclassification. Management strategies guided by FFR, including revascularization deferral, may be useful for patients with diabetes.info:eu-repo/semantics/publishedVersio

Precision photometric redshift calibration for galaxy-galaxy weak lensing

Accurate photometric redshifts are among the key requirements for precision weak lensing measurements. Both the large size of the Sloan Digital Sky Survey (SDSS) and the existence of large spectroscopic redshift samples that are flux-limited beyond its depth have made it the optimal data source for developing methods to properly calibrate photometric redshifts for lensing. Here, we focus on galaxy-galaxy lensing in a survey with spectroscopic lens redshifts, as in the SDSS. We develop statistics that quantify the effect of source redshift errors on the lensing calibration and on the weighting scheme, and show how they can be used in the presence of redshift failure and sampling variance. We then demonstrate their use with 2838 source galaxies with spectroscopy from DEEP2 and zCOSMOS, evaluating several public photometric redshift algorithms, in two cases including a full p(z) for each object, and find lensing calibration biases as low as <1 per cent (due to fortuitous cancellation of two types of bias) or as high as 20 per cent for methods in active use (despite the small mean photoz bias of these algorithms). Our work demonstrates that lensing-specific statistics must be used to reliably calibrate the lensing signal, due to asymmetric effects of (frequently non-Gaussian) photoz errors. We also demonstrate that large-scale structure (LSS) can strongly impact the photoz calibration and its error estimation, due to a correlation between the LSS and the photoz errors, and argue that at least two independent degree-scale spectroscopic samples are needed to suppress its effects. Given the size of our spectroscopic sample, we can reduce the galaxy-galaxy lensing calibration error well below current SDSS statistical error

The close environment of 24 micron galaxies at 0.6<z<1.0 in the COSMOS field

We investigate the close environment of 203 Spitzer 24 micron-selected sources at 0.6<z<1.0 using zCOSMOS-bright redshifts and spectra of I<22.5 AB mag galaxies, over 1.5 sq. deg. of the COSMOS field. We quantify the degree of passivity of the LIRG and ULIRG environments by analysing the fraction of close neighbours with Dn(4000)>1.4. We find that LIRGs at 0.6<z<0.8 live in more passive environments than those of other optical galaxies that have the same stellar mass distribution. Instead, ULIRGs inhabit more active regions (e.g. LIRGs and ULIRGs at 0.6<z<0.8 have, respectively, (42.0 +/- 4.9)% and (24.5 +/- 5.9)% of neighbours with Dn (4000)>1.4 within 1 Mpc and +/- 500 km/s). The contrast between the activities of the close environments of LIRGs and ULIRGs appears especially enhanced in the COSMOS field density peak at z~0.67, because LIRGs on this peak have a larger fraction of passive neighbours, while ULIRGs have as active close environments as those outside the large-scale structure. The differential environmental activity is related to the differences in the distributions of stellar mass ratios between LIRGs/ULIRGs and their close neighbours, as well as in the general local density fields. At 0.8<z<1.0, instead, we find no differences in the environment densities of ULIRGs and other similarly massive galaxies, in spite of the differential activities. We discuss a possible scenario to explain these findings.Comment: ApJ, in press. 9 pages, including 5 figure

Overexpression of the Endoplasmic Reticulum Chaperone BiP3 Regulates XA21-Mediated Innate Immunity in Rice

Recognition of pathogen-associated molecular patterns by pattern recognition receptors (PRRs) activates the innate immune response. Although PRR-mediated signaling events are critical to the survival of plants and animals, secretion and localization of PRRs have not yet been clearly elucidated. Here we report the in vivo interaction of the endoplasmic reticulum (ER) chaperone BiP3 with the rice XA21 PRR, which confers resistance to the Gram negative bacterium, Xanthomonas oryzae pv. oryzae (Xoo). We show that XA21 is glycosylated and is primarily localized to the ER and also to the plasma membrane (PM). In BiP3-overexpressing rice plants, XA21-mediated immunity is compromised, XA21 stability is significantly decreased, and XA21 proteolytic cleavage is inhibited. BiP3 overexpression does not affect the general rice defense response, cell death or brassinolide-induced responses. These results indicate that BiP3 regulates XA21 protein stability and processing and that this regulation is critical for resistance to Xoo

Hypofractionated radiotherapy for prostate cancer

In the last few years, hypofractionated external beam radiotherapy has gained increasing popularity for prostate cancer treatment, since sufficient evidence exists that prostate cancer has a low alpha/beta ratio, lower than the one of the surrounding organs at risk and thus there is a potential therapeutic benefit of using larger fractionated single doses. Apart from the therapeutic rationale there are advantages such as saving treatment time and medical resources and thereby improving patient's convenience. While older trials showed unsatisfactory results in both standard and hypofractionated arm due to insufficient radiation doses and non-standard contouring of target volumes, contemporary randomized studies have reported on encouraging results of tumor control mostly without an increase of relevant side effects, especially late toxicity. Aim of this review is to give a detailed analysis of relevant, recently published clinical trials with special focus on rationale for hypofractionation and different therapy settings