189 research outputs found
ICE telemetry performance
Acquiring telemetry data from the International Cometary Explorer (ICE) at its encounter with the comet Giacobini-Zinner on September 11, 1985 proved to be among the more difficult challenges the DSN has met in recent years. The ICE spacecraft began its life as an Earth orbiting monitor of the Solar Wind. At the comet, ICE was nearly 50 times as distant as in its initial role, with its signal strength diminished nearly 2500 times. Collecting enough of that weak signal to provide meaningful scientific data about the comet required unique new telemetry capabilities and special handling by the DSN. This article describes the development and validation of the DSN telemetry capability for ICE from its early planning stages through the successful comet encounter
A growth path for deep space communications
Increased Deep Space Network (DPN) receiving capability far beyond that now available for Voyager is achievable through a mix of increased antenna aperture and increased frequency of operation. In this note a sequence of options are considered: adding midsized antennas for arraying with the existing network at X-band; converting to Ka-band and adding array elements; augmenting the DSN with an orbiting Ka-band station; and augmenting the DSN with an optical receiving capability, either on the ground or in space. Costs of these options are compared as means of achieving significantly increased receiving capability. The envelope of lowest costs projects a possible path for moving from X-band to Ka-band and thence to optical frequencies, and potentially for moving from ground-based to space-based apertures. The move to Ka-band is clearly of value now, with development of optical communications technology a good investment for the future
Communications link for SDS 900 series computers
High speed, self-clocking single channel control and data link apparatus interfaces between two computers. This combined system reduces data errors
The Evolution of Technology in the Deep Space Network: A History of the Advanced Systems Program
The Deep Space Network (DSN) of 1995 might be described as the evolutionary result of 45 years of deep space communication and navigation, together with the synergistic activities of radio science and radar and radio astronomy. But the evolution of the DSN did not just happen - it was carefully planned and created. The evolution of the DSN has been an ongoing engineering activity, and engineering is a process of problem solving under constraints, one of which is technology. In turn, technology is the knowledge base providing the capability and experience for practical application of various areas of science, when needed. The best engineering solutions result from optimization under the fewest constraints, and if technology needs are well anticipated (ready when needed), then the most effective engineering solution is possible. Throughout the history of the DSN it has been the goal and function of DSN advanced technology development (designated the DSN Advanced Systems Program from 1963 through 1994) to supply the technology needs of the DSN when needed, and thus to minimize this constraint on DSN engineering. Technology often takes considerable time to develop, and when that happens, it is important to have anticipated engineering needs; at times, this anticipation has been by as much as 15 years. Also, on a number of occasions, mission malfunctions or emergencies have resulted in unplanned needs for technology that has, in fact, been available from the reservoir of advanced technology provided by the DSN Advanced Systems Program. Sometimes, even DSN engineering personnel fail to realize that the organization of JPL permits an overlap of DSN advanced technology activities with subsequent engineering activities. This can result in the flow of advanced technology into DSN engineering in a natural and sometimes almost unnoticed way. In the following pages, we will explore some of the many contributions of the DSN Advanced Systems Program that were provided to DSN Engineering and Implementation. These contributions are, for the most part, unique capabilities that have met the requirements of flight projects for 45 years. These unique capabilities include not only the world's best deep-space communications system, but also outstanding competency in the fields of radio metric measurement, radar and radio astronomy, and radio science
Ka-band study: 1988
The Ka-band study team was chartered in late 1987 to bring together all the planning elements for establishing 32 GHz (Ka-band) as the primary downlink frequency for deep-space operation, and to provide a stable baseline from which to pursue that development. This article summarizes the results of that study at its conclusion in mid-1988, and corresponds to material presented to NASA's Office of Space Operations on July 14, 1988. For a variety of reasons, Ka-band is the right next major step in deep-space communications. It offers improved radio metric accuracy through reduced plasma sensitivity and increased bandwidth. Because of these improvements, it offers the opportunity to reduce costs in the flight radio system or in the DSN by allocating part of the overall benefits of Ka-band to this cost reduction. A mission scenario is being planned that can drive at least two and possibly all three of the DSN subnets to provide a Ka-band downlink capability by the turn of the century. The implementation scenario devised by the study team is believed to be feasible within reasonable resource expectations, and capable of providing the needed upgrade as a natural follow-on to the technology development which is already underway
Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses
Alum is used as a vaccine adjuvant and induces T<sub>h</sub>2 responses and T<sub>h</sub>2-driven antibody isotype production against co-injected antigens. Alum also promotes the appearance in the spleen of Gr1+IL-4+ innate cells that, via IL-4 production, induce MHC II-mediated signaling in B cells. To investigate whether these Gr1+ cells accumulate in the spleen in response to other T<sub>h</sub>2-inducing stimuli and to understand some of their functions, the effects of injection of alum and eggs from the helminth, Schistosoma mansoni, were compared. Like alum, schistosome eggs induced the appearance of Gr1+IL-4+ cells in spleen and promoted MHC II-mediated signaling in B cells. Unlike alum, however, schistosome eggs did not promote CD4 T cell responses against co-injected antigens, suggesting that the effects of alum or schistosome eggs on splenic B cells cannot by themselves explain the T cell adjuvant properties of alum. Accordingly, depletion of IL-4 or Gr1+ cells in alum-injected mice had no effect on the ability of alum to improve expansion of primary CD4 T cells. However, Gr1+ cells and IL-4 played some role in the effects of alum, since depletion of either resulted in antibody responses to antigen that included not only the normal T<sub>h</sub>2-driven isotypes, like IgG1, but also a T<sub>h</sub>1-driven isotype, IgG2c. These data suggest that alum affects the immune response in at least two ways: one, independent of Gr1+ cells and IL-4, that promotes CD4 T cell proliferation and another, via Gr1+IL-4+ cells, that participates in the polarization of the response
Inhomogeneous magnetism in single crystalline SrCuIrO: Implications to phase-separation concepts
The single crystalline form of an insulator, SrCuIrO, is
shown to exhibit unexpectedly more than one magnetic transition (at 5 and 19 K)
with spin-glass-like magnetic susceptibility behaviour. On the basis of this
finding, viz., inhomogeneous magnetism in a chemically homogeneous material, we
propose that the idea of "phase- separation" described for manganites [1] is
more widespread in different ways. The observed experimental features enable us
to make a comparison with the predictions of a recent toy model [2] on {\it
magnetic} phase separation in an insulating environment.Comment: 4 pages, 4 figure
Comparison of immune responses to Loa loa stage-specific antigen extracts in Loa loa-exposed BALB/c mice upon clearance of infection
Background:
Different immune mechanisms are capable of killing developmental stages of filarial nematodes and these mechanisms are also likely to vary between the primary and a challenge infection. However, the lack of a detailed analysis of cytokine, chemokine and immunoglobulin levels in human loiasis is still evident. Therefore, detailed analysis of immune responses induced by the different developmental stages of Loa loa in immune-competent BALB/c mice will aid in the characterization of distinct immune responses that are important for the immunity against loiasis.
Methods:
Different developmental stages of L. loa were obtained from human peripheral blood (microfilariae, MF), the transmitting vector, Chrysops (larval stage 3, L3) and infected immune-deficient BALB/cRAG2Ī³cā/ā mice (L4, L5, adult worms). Groups of wildtype BALB/c mice were then injected with the isolated stages and after 42 days postinfection
(pi), systemic cytokine, chemokine and immunoglobulin levels were determined. These were then compared to L. loa-specific responses from in vitro re-stimulated splenocytes from individual mice. All parameters were determined using Luminex technology.
Results:
In a pilot study, BALB/c mice cleared the different life stages of L. loa within 42 days pi and systemic cytokine, chemokine and munoglobulin levels were equal between infected and naive mice. Nevertheless, L. loa-specific re-stimulation of splenocytes from mice infected with L5, MF or adult worms led to induction of Th2, Th17 and chemokine secretion patterns.
Conclusions:
This study shows that although host immunity remains comparable to naive mice, clearance of L. loa life-cycle development stages can induce immune cell memory leading to cytokine, chemokine and mmunoglobulins secretion patterns which might contribute to immunity and protection against reinfection
- ā¦