De long in een vijandige wereld

Afscheidscollege, Erasmus Univesiteit Rotterdam, op 11 oktober 1978. Geen organisme kan als biologische eenheid optimaal functioneren, tenzij alle verrichtingen, die nodig zijn voor zijn groei en voor zijn onderhoud, in de vereiste kwaliteit en kwantiteit kurmen plaatsvinden in een volkomen harmonieuze wisselwerking. Of deze verrichtingen nu plaatsvinden in het micromilieu van de eencellige' organismen, dan wel in het macromilieu van hoger gedifferentieerd'e' levensvormen, waarbij in toenemende mate bepaalde functies aan bepaalde organen of orgaansystemen in een vaak vergaande differentiatie worden gedelegeerd, in alle gevallen is een optimaal functioneren van het organisme als geheel alleen mogelijk, als een harmonieuae wisselwerking gewaarborgd is

Performance Effects of the Corporatisation of Port of Rotterdam Authority

Port of Rotterdam Authority is a publicly owned but corporatized port development company. In 2004, this organisation was transformed from a municipal department to an independently operating company. The corporatisation intended to improve the overall performance of the port of Rotterdam. Relevant performance indicators to evaluate the effect of this corporatisation include market share, turnover, operating costs, profits, and investments. These indicators are evaluated for two periods, one prior to the corporatisation (1997-2003) and the other afterwards (2005-2011). The comparison of these two periods shows that corporatisation has led to significant performance improvements. This finding is relevant for the ongoing discussion on port governance models

Hypoxia and muscle maintenance regulation: implications for chronic respiratory disease

PURPOSE OF REVIEW: Muscle wasting and impaired muscle oxidative metabolism are common extrapulmonary features of chronic respiratory failure (CRF) that significantly increase disease burden. This review aims to address the question whether hypoxia, an obvious consequence of this disease, actually plays a causal role in these muscle impairments. RECENT FINDINGS: In experimental models, a causal role for hypoxia in muscle atrophy and metabolic impairments has clearly been shown. Although the hypoxia-inducible factors and nuclear factor kappa B are putative mediators of these hypoxia-induced alterations, their true involvement remains to be proven. Molecular signatures of disrupted regulation of muscle mass and oxidative metabolism observed in these experimental models also have been shown in muscles of patients suffering from CRF, suggestive of but not conclusive for a causal role of hypoxia. Therapies, including but not restricted to those aimed at alleviating hypoxia, have been shown to partially but not completely restore muscle mass and oxidative capacity in CRF patients, which may imply an additive effect of nutritional modulation of substrate metabolism. SUMMARY: Although hypoxia clearly affects skeletal muscle maintenance, it remains to be confirmed whether and by which underlying molecular mechanisms hypoxia is causally involved in CRF-related muscle atrophy and impaired oxidative capacity

Repeatability of quantitative18F-FLT uptake measurements in solid tumors: an individual patient data multi-center meta-analysis

INTRODUCTION: 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) positron emission tomography (PET) provides a non-invasive method to assess cellular proliferation and response to antitumor therapy. Quantitative18F-FLT uptake metrics are being used for evaluation of proliferative response in investigational setting, however multi-center repeatability needs to be established. The aim of this study was to determine the repeatability of18F-FLT tumor uptake metrics by re-analyzing individual patient data from previously published reports using the same tumor segmentation method and repeatability metrics across cohorts. METHODS: A systematic search in PubMed, EMBASE.com and the Cochrane Library from inception-October 2016 yielded five18F-FLT repeatability cohorts in solid tumors.18F-FLT avid lesions were delineated using a 50% isocontour adapted for local background on test and retest scans. SUVmax, SUVmean, SUVpeak, proliferative volume and total lesion uptake (TLU) were calculated. Repeatability was assessed using the repeatability coefficient (RC = 1.96 × SD of test-retest differences), linear regression analysis, and the intra-class correlation coefficient (ICC). The impact of different lesion selection criteria was also evaluated. RESULTS: Images from four cohorts containing 30 patients with 52 lesions were obtained and analyzed (ten in breast cancer, nine in head and neck squamous cell carcinoma, and 33 in non-small cell lung cancer patients). A good correlation was found between test-retest data for all18F-FLT uptake metrics (R2 ≥ 0.93; ICC ≥ 0.96). Best repeatability was found for SUVpeak(RC: 23.1%), without significant differences in RC between different SUV metrics. Repeatability of proliferative volume (RC: 36.0%) and TLU (RC: 36.4%) was worse than SUV. Lesion selection methods based on SUVmax ≥ 4.0 improved the repeatability of volumetric metrics (RC: 26-28%), but did not affect the repeatability of SUV metrics. CONCLUSIONS: In multi-center studies, differences ≥ 25% in18F-FLT SUV metrics likely represent a true change in tumor uptake. Larger differences are required for FLT metrics comprising volume estimates when no lesion selection criteria are applied

From planning the port/city to planning the port-city : exploring the economic interface in European port cities

In last three decades, planning agencies of most ports have institutionally evolved into a (semi-) independent port authority. The rationale behind this process is that port authorities are able to react more quickly to changing logistical and spatial preferences of maritime firms, hence increasing the competitiveness of ports. Although these dedicated port authorities have proven to be largely successful, new economic, social, and environmental challenges are quickly catching up on these port governance models, and particularly leads to (spatial) policy ‘conflicts’ between port and city. This chapter starts by assessing this conflict and argue that the conflict is partly a result of dominant—often also academic—spatial representations of the port city as two separate entities. To escape this divisive conception of contemporary port cities, this chapter presents a relational visualisation method that is able to analyse the economic interface between port and city. Based on our results, we reflect back on our proposition and argue that the core challenge today for researchers and policy makers is acknowledging the bias of port/city, being arguably a self-fulfilling prophecy. Hence, we turn the idea of (planning the) port/city conflicts into planning the port-city’s strengths and weaknesses

Shot noise of series quantum point contacts intercalating chaotic cavities

Shot noise of series quantum point contacts forming a sequence of cavities in a two dimensional electron gas are studied theoretically and experimentally. Noise in such a structure originates from local scattering at the point contacts as well as from chaotic motion of the electrons in the cavities. We found that the measured shot noise is in reasonable agreement with our theoretical prediction taking the cavity noise into account.Comment: 4 pages, 5 figure

Adapting to the sea:Human habitation in the coastal area of the northern Netherlands before medieval dike building

Before medieval dike building, the coastal area of the northern Netherlands was a wide, regularly inundated salt-marsh area. Despite the dynamic natural conditions, the area was inhabited already in the Iron Age. The inhabitants adapted to this marine environment by living on artificial dwelling mounds, so-called terps. Terp habitation was a highly successful way of life for over 1500 years, and may be re-introduced as a useful strategy for present and future communities in low-lying coastal regions that are facing accelerated sea-level rise. This already has been recommended in several reports, but detailed knowledge of the technology of terp habitation is usually lacking. The aim of this paper is to present nearly two decades of archaeological research in the coastal region of the northern Netherlands, in order to inform the current debate on the possibilities of adapting to the effects of climate change in low-lying coastal areas. It presents the multi-disciplinary methods of this research and its results, supplying details of terp construction and other strategies such as the construction of low summer dikes that are still useful today. The results and discussion of the presented research also make it possible to describe the conditions that must be met to make terp habitation possible. Terp habitation could have continued, were it not for the considerable subsidence of inland areas due to peat reclamation. That made the entire coastal area increasingly vulnerable to the sea. In response to this threat, dike building began in the 11th or 12th century, but these increasingly higher dikes decreased the water storage capacity and caused impoundment of seawater during storm surges. Moreover, accretion through sedimentation was halted from then on. Unlike terp habitation, the construction of high dikes therefore cannot be considered a sustainable solution for living in low-lying coastal areas in the long term

Port connectivity indices: an application to European RoRo shipping

In recent years, there has been significant interest in the development of connectivity indicators for ports. For short sea shipping, especially in Europe, Roll-on Roll-off (RoRo) shipping is almost equally important as container shipping. In contrast with container shipping, RoRo shipments are primarily direct, thus the measurement of its connectivity requires a different methodology. In this paper, we present a methodology for measuring the RoRo connectivity of ports and illustrate its use through an application to European RoRo shipping. We apply the methodology on data collected from 23 different RoRo shipping service providers concerning 620 unique routes connecting 148 ports. We characterize the connectivity of the ports in our sample and analyze the results. We show that in terms of RoRo connectivity, neither the number of links nor the link quality (frequency, number of competing providers, minimum number of indirect stops) strictly dominate the results of our proposed indicator. The highest ranking ports combine link quality and number. Finally, we highlight promising areas for future research based on the insights obtained.</p

Effect of incoherent scattering on shot noise correlations in the quantum Hall regime

We investigate the effect of incoherent scattering in a Hanbury Brown and Twiss situation with electrons in edge states of a three-terminal conductor submitted to a strong perpendicular magnetic field. The modelization of incoherent scattering is performed by introducing an additional voltage probe through which the current is kept equal to zero which causes voltage fluctuations at this probe. It is shown that inelastic scattering can lead in this framework to positive correlations, whereas correlations remain always negative for quasi-elastic scattering.Comment: 5 pages latex, 5 eps figure