Qualite de vie des Patients ayant une Gonarthrose a Brazzavile, Congo

Objective: To evaluate the quality of life in patients with knee osteoarthritis. Patients and Methods: Cross-sectional, descriptive and analytical study, conducted in two steps in the Department of Rheumatology at the University Hospital of Brazzaville. The first step made it possible to collect data of patients diagnosed as having knee osteoarthritis according to the ACR criteria of 1986 and followed up from January 1st, 2013 to December 31st, 2017. After informed consent was obtained, the second step consisted in measuring the quality of life of patients using a specific quality-of-life questionnaire for knee and hip osteoarthritis OAKHQOL (OsteoArthritis of Knee Hip Quality Of Life). It took place from May 2nd to November 2nd, 2018 (6 months). Results: We included in this study 103 women and 16 men (sex ratio F / H of 6/1). The average age was 56.1 ± 9 years (range 27 to 77 years). The mean evolution time was 5.1 ± 3.6 years. The knee osteoarthritis moderately impaired the overall quality of life of patients. The most affected dimensions were physical activity and pain, with respectively 51.3% and 42.9% of patients between 25 and 50. Mean scores for additional items were 35.3 +/- 24.4, respectively, (n = 84) for employment, 36.2 +/- 20.8 (n = 61) for relationship with the partner and 39.4 +/- 27.2 (n = 61) for sexuality. Conclusion: Knee osteoarthritis affects the overall quality of life of patients, especially in the physical activity and pain dimensions.Objectif : Evaluer la qualité de vie des patients ayant une gonarthrose. Patients et Méthodes: Etude transversale, descriptive, menée dans le Service de Rhumatologie du CHU de Brazzaville, en deux étapes. La première a permis de colliger les dossiers des patients diagnostiqués selon les critères de l’ACR de 1986 et suivis pour une gonarthrose du 1 er janvier 2013 au 31 décembre 2017.La seconde consistait, après consentement éclairé, en la mesure de la qualité de vie à l’aide du questionnaire Arthrose des Membres Inférieurs et Qualité de vie (AMIQUAL) des patients identifiés. Elle s’est déroulée du 02 mai au 02 novembre 2018 (6 mois). Résultats : Nous avons inclus 103 femmes et 16 hommes (sexe ratio H/F de 1/6). L’âge moyen était de 56,1 +/- 9 ans (extrêmes 27 à 77 ans). La durée moyenne d’évolution était de 5,1 +/- 3,6 ans. La gonarthrose altérait de façon modérée la qualité de vie globale des patients. Les dimensions les plus touchées étaient les activités physiques et la douleur, avec respectivement 51,3% et 42,9% des patients compris entre 25 et 50. Les scores moyens des items indépendants étaient respectivement de 35,3 +/- 24,4 (n=84) pour la dimension activité professionnelle, 36,2 +/- 20,8 (n=61) pour la relation de couple et 39,4+/-27,2 (n=61) pour la sexualité. Conclusion : la gonarthrose affecte la qualité de vie globale des patients notamment dans les dimensions activités physiques et douleur

PHARMACOLOGICAL EVALUATIONS FOR THE RELAXANT EFFECT OF THE HYDROALCOHOLIC EXTRACT OF TAPINANTHUS DODONEIFOLIUS ON RAT TRACHEA

The present study was designed to investigate the blocking of calcium by the hydroalcoholic extract of Tapinanthus dodoneifolius (Tapidod), "in vitro", on rat trachea. To evaluate this effect, the contractile activity of tracheal chains from Wistar Kyoto rats was isometrically recorded. On the isolated tracheal rings the extract produced the following effects: (a) a reduction of the contraction obtained by BaCl2, (b) a bronchorelaxing action, on strips precontracted by KCl, which was not influenced by TEA (3x10-3 M), (c) a concentration-dependent decrease of the spasm evoked by calcium chloride (CaCl2) in K+-rich Ca2+-free physiological salt solution, before and after intracellular calcium depletion (d), an inhibitory effect on contraction induced by acetylcholine in Ca2+-free Krebs-Heinseleit solution supplemented with EDTA (5x10-4M). It is concluded that: 1. The activation of the potassium channels does not play a significant role in the relaxant effect of Tapidod. 2. The antispasmodic property of Tapidod seems to be mediated by the blockade of intracellular Ca2+ release. 3. Most likely an inhibition of the intracellular Ca2+-regulating proteins is involved

Pharmacological Evaluations for the Relaxant Effect of the Hydroalcoholic Extract of Tapinanthus dodoneifolius on Rat Trachea

The present study was designed to investigate the blocking of calcium by the hydroalcoholic extract of Tapinanthus dodoneifolius (Tapidod), \"in vitro\", on rat trachea. To evaluate this effect, the contractile activity of tracheal chains from Wistar Kyoto rats was isometrically recorded. On the isolated tracheal rings the extract produced the following effects: (a) a reduction of the contraction obtained by BaCl2, (b) a bronchorelaxing action, on strips precontracted by KCl, which was not influenced by TEA (3x10-3 M), (c) a concentrationdependent decrease of the spasm evoked by calcium chloride (CaCl2) in K+ -rich Ca2+ -free physiological salt solution, before and after intracellular calcium depletion (d), an inhibitory effect on contraction induced by acetylcholine in Ca2+ -free Krebs-Heinseleit solution supplemented with EDTA (5x10-4M). It is concluded that: 1. The activation of the potassium channels does not play a significant role in the relaxant effect of Tapidod. 2. The antispasmodic property of Tapidod seems to be mediated by the blockade of intracellular Ca2+ release. 3. Most likely an inhibition of the intracellular Ca2+-regulating proteins is involved. Key Words: Extract of Tapinanthus dodoneifolius (Tapidod); Trachea; Calcium. Afr. J. Trad. CAM (2005) 2 (2): 166-17

Research Paper - PHARMACOLOGICAL EVALUATIONS FOR THE RELAXANT EFFECT OF THE HYDROALCOHOLIC EXTRACT OF TAPINANTHUS DODONEIFOLIUS ON RAT TRACHEA

The present study was designed to investigate the blocking of calcium by the hydroalcoholic extract of Tapinanthus dodoneifolius (Tapidod), "in vitro" on rat trachea. To evaluate this effect, the contractile activity of tracheal chains from Wistar Kyoto rats was isometrically recorded. On the isolated tracheal rings the extract produced the following effects: (a) a reduction of the contraction obtained by BaCl2, (b) a bronchorelaxing action, on strips precontracted by KCl, which was not influenced by TEA (3x10-3 M), (c) a concentration-dependent decrease of the spasm evoked by calcium chloride (CaCl2) in K+-rich Ca2+-free physiological salt solution, before and after intracellular calcium depletion (d), an inhibitory effect on contraction induced by acetylcholine in Ca2+-free Krebs-Heinseleit solution supplemented with EDTA (5x10-4M). It is concluded that: 1. The activation of the potassium channels does not play a significant role in the relaxant effect of Tapidod. 2. The antispasmodic property of Tapidod seems to be mediated by the blockade of intracellular Ca2+ release. 3. Most likely an inhibition of the intracellular Ca2+-regulating proteins is involved