170 research outputs found
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‘Like a part of a puzzle which is missing’: The impact on families of a relative missing in migration across the Mediterranean
The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter
Creatine transport has been assigned to creatine transporter 1 (CRT1), encoded by mental retardation associated SLC6A8. Here, we identified a second creatine transporter (CRT2) known as monocarboxylate transporter 12 (MCT12), encoded by the cataract and glucosuria associated gene SLC16A12. A non-synonymous alteration in MCT12 (p.G407S) found in a patient with age-related cataract (ARC) leads to a significant reduction of creatine transport. Furthermore, Slc16a12 knockout (KO) rats have elevated creatine levels in urine. Transport activity and expression characteristics of the two creatine transporters are distinct. CRT2 (MCT12)-mediated uptake of creatine was not sensitive to sodium and chloride ions or creatine biosynthesis precursors, breakdown product creatinine or creatine phosphate. Increasing pH correlated with increased creatine uptake. Michaelis-Menten kinetics yielded a Vmax of 838.8 pmol/h/oocyte and a Km of 567.4 µm. Relative expression in various human tissues supports the distinct mutation-associated phenotypes of the two transporters. SLC6A8 was predominantly found in brain, heart and muscle, while SLC16A12 was more abundant in kidney and retina. In the lens, the two transcripts were found at comparable levels. We discuss the distinct, but possibly synergistic functions of the two creatine transporters. Our findings infer potential preventive power of creatine supplementation against the most prominent age-related vision impaired conditio
Organised crime and social media; a system for detecting, corroborating and visualising weak signals of organised crime online
This paper describes an approach for detecting the presence or emergence of
Organised Crime (OC) signals on Social Media. It shows how words and phrases,
used by members of the public in Social Media posts, can be treated as weak
signals of OC, enabling information to be classi�ed according to a taxonomy.
Formal Concept Analysis (FCA) is used to group information sources, according
to Crime-type and Location, thus providing a means of corroboration and
creating OC Concepts that can be used to alert police analysts to the possible
presence of OC. The analyst is able to `drill down' into an OC Concept of
interest, discovering additional information that may be pertinent to the crime.
The paper describes the implementation of this approach into a fully-functional
prototype software system, incorporating a Social Media scanning system and a
map-based user interface. The approach and system are illustrated using Human
Tra�cking and Modern Slavery as an example. Real data is used to obtain results
that show that weak signals of OC have been detected and corroborated, thus
alerting to the possible presence of OC
Environmental changes and violent conflict
This letter reviews the scientific literature on whether and how environmental changes affect the risk of violent conflict. The available evidence from qualitative case studies indicates that environmental stress can contribute to violent conflict in some specific cases. Results from quantitative large-N studies, however, strongly suggest that we should be careful in drawing general conclusions. Those large-N studies that we regard as the most sophisticated ones obtain results that are not robust to alternative model specifications and, thus, have been debated. This suggests that environmental changes may, under specific circumstances, increase the risk of violent conflict, but not necessarily in a systematic way and unconditionally. Hence there is, to date, no scientific consensus on the impact of environmental changes on violent conflict. This letter also highlights the most important challenges for further research on the subject. One of the key issues is that the effects of environmental changes on violent conflict are likely to be contingent on a set of economic and political conditions that determine adaptation capacity. In the authors' view, the most important indirect effects are likely to lead from environmental changes via economic performance and migration to violent conflict. © 2012 IOP Publishing Ltd
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Missing Migrants in the Mediterranean : Addressing the Humanitarian Crisis Summary report
The Mediterranean Missing research project has sought to understand both the impact on families of having a relative missing in migration, and the law, policy and practice around the identification of bodies of dead migrants in Italy and Greece. Interviews with families of missing migrants from five countries confirmed the huge impact of not knowing the fate of loved ones, with families tortured by ambiguity and suffering a range of emotional and psychological consequences. In Lesbos, Greece, and Sicily, Italy, interviews with authorities, civil society and others confirm the presence of a policy vacuum around the issue of the missing, despite the duties on states imposed by human rights law. Investigation of deaths is inadequate, with effective post-mortem data collection and management challenged by the huge numbers of migrants , in some cases sufficiently to compromise future identification. In both Greece and Italy, response is characterised by a policy vacuum, with a large number of agencies with overlapping mandates lacking coordination. Whilst in Italy a dedicated Commission and its partners have demonstrated what can be done with appropriate resources, there is a need to ensure that all the dead benefit from such an approach. A constraint in both contexts remains the lack of outreach to families of the missing, who can provide ante-mortem data to enable identification, and who should anyway be at the centre of all efforts to address the issue and identify the dead
Portuguese emigration to Angola (2000-2015): Strengthening a specific postcolonial relationship in a new global framework?
Outflows to the Portuguese-speaking countries, although not dominant, played an important role in the growth of Portuguese emigration during the economic recession and austerity period, between 2010 and 2016. This chapter examines this migration process, considering that contemporary migration from Portugal to Angola is an example of reverse post-colonial migration within the framework of North-South movements.
It presents the historical and socio-demographic background of Angola and some theoretical insights on the issue of North-South migration. The analyses of the migration process and the emigrants’ profiles rely in statistics and academic literature but especially on data gathered in a direct survey. Attention is given to indicators of integration, relations with Portugal and the post-colonial nature of the process. The profile of Portuguese in Angola shows an overrepresentation of highly skilled males over 35 years old, which migrated for professional reasons and sustain relations with Portugal through diverse transnational practices. This supports explanations for the emergence of North-South migration by appeal to economic expansion associated to the increasing insertion of several developing countries into global networks. However, the analysis fails to back up the hypothesis that Portuguese emigration to Angola is a form of reverse post-colonial migration based in ancestral return.info:eu-repo/semantics/publishedVersio
Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target
Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective disease-modifying treatments. This study utilizes a comprehensive multiomic approach to investigate the early and sex-specific molecular mechanisms underlying ALS. By analyzing the prefrontal cortex of 51 patients with sporadic ALS and 50 control subjects, alongside four transgenic mouse models (C9orf72-, SOD1-, TDP-43-, and FUS-ALS), we have uncovered significant molecular alterations associated with the disease. Here, we show that males exhibit more pronounced changes in molecular pathways compared to females. Our integrated analysis of transcriptomes, (phospho)proteomes, and miRNAomes also identified distinct ALS subclusters in humans, characterized by variations in immune response, extracellular matrix composition, mitochondrial function, and RNA processing. The molecular signatures of human subclusters were reflected in specific mouse models. Our study highlighted the mitogen-activated protein kinase (MAPK) pathway as an early disease mechanism. We further demonstrate that trametinib, a MAPK inhibitor, has potential therapeutic benefits in vitro and in vivo, particularly in females, suggesting a direction for developing targeted ALS treatments
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