Cours d'instruction spéciale à l'usage des sous-officiers des régiments d'artillerie

par L. de CrépyHandschriftliches Exlibris: "F. Burnier" 002159223_0001 Exemplar der ETH-BI

Taking assessment and documentation of clinical relevance one step further: a suggestion to improve individual documentation and epidemiological usability

BACKGROUND: Full assessment of patients with (occupational) contact dermatitis should ideally include a standardized investigation of irritant exposures in addition to information pertaining to possible allergy guiding the selection of allergens (haptens) to be tested. Positive results of skin tests, performed according to current guidelines, are evaluated in terms of their clinical relevance. However, such diagnostic information is hitherto ill-represented in clinical documentation systems (patch test software) serving departmental documentation needs, and also in surveillance registries based upon these. OBJECTIVES: To develop, implement as a pilot study, and analyse concerning feasibility and contents a new concept of representing a full scope of diagnostic information utilized when diagnosing patients with (occupational) contact dermatitis. METHODS: Based on a European working group discussion on items to document and catalogue lists to use for this purpose, an online documentation system to collect data was set up, followed by a pilot use involving 9 dermatology departments across Europe. RESULTS: Data on 176 patients with suspected occupational hand dermatitis were included. Data were analysed with regard to occupations, product categories, substances (haptens), source of information the evaluation was based upon, and various combinations of these factors, to illustrate the usefulness of the proposed data representation. CONCLUSIONS: An improved method of data collection is presented which more accurately links allergen to exposure and to clinical disease and patient history, and thus better represents clinical relevance. This enables more precise analysis of causation of contact dermatitis, occupational or non-occupational, and thereby better targeting of prevention on an individual basis. In addition to the benefits for individual documentation, the surveillance of contact dermatitis is expected to be enhanced by the suggested concept, allowing a more in-depth investigation of profiles of patients at risk for certain allergies, while still serving other well-proven purposes, eg time trend analyses

The effect of side-chain length of cellulose fatty acid esters on their thermal, barrier and mechanical properties

Currently, long-chain cellulose esters are not produced commercially because of high price, and since their preparation typically requires a large quantity of chemicals. To reduce the chemical consumption, cellulose reactivity needs to be increased without losing its quality. One way to increase the reactivity of cellulose is to decrease its molar mass in a controlled manner. In this study, we have synthesized cellulose esters with different side-chain length (C6-C18) in a homogeneous system using ozone molar mass-controlled cellulose. The target was to keep the degree of substitution as low as possible while still ensuring the suitability of cellulose esters for solvent casting. Thermal, barrier and mechanical properties were studied depending on cellulose fatty acid ester side-chain length. All our molar mass-controlled cellulose esters form optically transparent, flexible and heat-sealable films with good water barrier properties and are processable without the addition of an external plasticizer. Furthermore, the films have mechanical properties comparable to some generally used plastics. These good properties suggest that our molar mass-controlled cellulose esters could be potential candidates for various applications such as films and composites

Occupational allergic contact dermatitis and major allergens in France: temporal trends for the period 2001-2010

International audienc

Occupational contact urticaria: lessons from the French National Network for Occupational Disease Vigilance and Prevention (RNV3P)

International audienceBackground - Occupational contact urticaria (OCU) is an occupational contact dermatitis that can cause serious health consequences and disability at work. Objectives - To describe OCU and its temporal trends by the main causal agents and activity sectors in a nationwide scheme in France. Methods - Using data from the French National Network for Occupational Disease Vigilance and Prevention (RNV3P), we described OCU reported during the period 2001-10 and analysed the temporal trends of OCU and OCU attributed to the most frequent agents over the study period. Trends analyses were supported by reporting odds ratios using a logistic regression model with reference to 2001, or with time as a continuous variable. Results - During the study period, 251 cases of OCU were reported in RNV3P, half of which were due to natural rubber latex, in particular in the health and social work activity sector (HSW). The number of these cases declined significantly over the study period (19% per year), and particularly after 2006. Conversely, the other causes of OCU did not decrease. Conclusions - Using surveillance data from a French national network, this study has found that there was a significant decline in OCU due to natural rubber latex, particularly in the HSW, when powdered latex gloves were banned from French hospitals. Our results show the effectiveness of this preventive measure, and suggest that this practice should be extended to other sectors