267 research outputs found
Renal cell carcinoma with concomitant solid pseudopapillary tumor of the pancreas: A case report
AbstractINTRODUCTIONSolid pseudopapillary tumor (SPT) of pancreas is an unusual low-grade malignant epithelial tumor that usually occurs in young women and can be treated with surgical resection. Renal cell carcinoma (RCC) is the most common solid lesion of the kidney and primarily a disease of the elderly patient.PRESENTATION OF CASEIn this article we present a case of RCC with concomitant SPT of the pancreas who was treated successfully with a radical nephrectomy and distal pancreatectomy.DISCUSSIONRCC with concomitant SPT may associated in β-catenin gene mutation. But no prior reports have described RCC with concomitant SPT of the pancreas in the same patient.CONCLUSIONTo the best of our knowledge, this is the first report of RCC with concomitant SPT of the pancreas in the same patient
Dosimetric uncertainties related to the elasticity of bladder and rectal walls: Adenocarcinoma of the prostate
Purpose. - Radiotherapy is an important treatment for prostate cancer.During
treatment sessions, bladder and rectal repletion is difficult to quantify and
cannot be measured with a single and initial CT scan acquisition. Some methods,
such as image-guided radiation therapy and dose-guided radiation therapy, aimto
compensate thismissing information through periodic CT acquisitions. The aimis
to adapt patient's position, beam configuration or prescribed dose for a
dosimetric compliance. Methods. -We evaluated organmotion (and repletion) for
54 patients after having computed the original ballistic on a new CT scan
acquisition. A new delineation was done on the prostate, bladder and rectum to
determine the newdisplacements and define organ dosesmistakes (equivalent
uniformdose, average dose and dose-volume histograms). Results. - The new CT
acquisitions confirmed that bladder and rectal volumes were not constant during
sessions. Some cases showed that previously validated treatment plan became
unsuitable. A proposed solution is to correct dosimetries when bladder volume
modifications are significant. The result is an improvement for the stability
of bladder doses, D50 error is reduced by 25.3%, mean dose error by 5.1% and
equivalent uniform dose error by 2.6%. For the rectum this method decreases
errors by only 1%. This process can reduce the risk of mismatch between the
initial scan and following treatment sessions. Conclusion. - For the
proposedmethod, the cone-beamCT is necessary to properly position the isocenter
and to quantify bladder and rectal volume variation and deposited doses. The
dosimetries are performed in the event that bladder (or rectum) volume
modification limits are exceeded. To identify these limits, we have calculated
that a tolerance of 10% for the equivalent uniformdose (compared to the initial
value of the first dosimetry), this represents 11% of obsolete dosimetries for
the bladder, and 4% for the rectum
The changing material around (2060) Chiron from an occultation on 2022 December 15
We could accurately predict the shadow path and successfully observe an
occultation of a bright star by Chiron on 2022 December 15. The Kottamia
Astronomical Observatory in Egypt did not detect the occultation by the solid
body, but we detected three extinction features in the light curve that had
symmetrical counterparts with respect to the central time of the occultation.
One of the features is broad and shallow, whereas the other two features are
sharper with a maximum extinction of 25 at the achieved spatial
resolution of 19 km per data point. From the Wise observatory in Israel, we
detected the occultation caused by the main body and several extinction
features surrounding the body. When all the secondary features are plotted in
the sky plane we find that they can be caused by a broad 580 km disk with
concentrations at radii of 325 \pm 16 km and 423 \pm 11 km surrounding Chiron.
At least one of these structures appears to be outside the Roche limit. The
ecliptic coordinates of the pole of the disk are = 151
8 and = 18 11, in agreement with previous
results. We also show our long-term photometry indicating that Chiron had
suffered a brightness outburst of at least 0.6 mag between March and September
2021 and that Chiron was still somewhat brighter at the occultation date than
at its nominal pre-outburst phase. The outermost extinction features might be
consistent with a bound or temporarily bound structure associated with the
brightness increase. However, the nature of the brightness outburst is unclear,
and it is also unclear whether the dust or ice released in the outburst could
be feeding a putative ring structure or if it emanated from it.Comment: 6 pages, 4, figure
Mucopolysaccharidosis VI
Mucopolysaccharidosis VI (MPS VI) is a lysosomal storage disease with progressive multisystem involvement, associated with a deficiency of arylsulfatase B leading to the accumulation of dermatan sulfate. Birth prevalence is between 1 in 43,261 and 1 in 1,505,160 live births. The disorder shows a wide spectrum of symptoms from slowly to rapidly progressing forms. The characteristic skeletal dysplasia includes short stature, dysostosis multiplex and degenerative joint disease. Rapidly progressing forms may have onset from birth, elevated urinary glycosaminoglycans (generally >100 μg/mg creatinine), severe dysostosis multiplex, short stature, and death before the 2nd or 3rd decades. A more slowly progressing form has been described as having later onset, mildly elevated glycosaminoglycans (generally <100 μg/mg creatinine), mild dysostosis multiplex, with death in the 4th or 5th decades. Other clinical findings may include cardiac valve disease, reduced pulmonary function, hepatosplenomegaly, sinusitis, otitis media, hearing loss, sleep apnea, corneal clouding, carpal tunnel disease, and inguinal or umbilical hernia. Although intellectual deficit is generally absent in MPS VI, central nervous system findings may include cervical cord compression caused by cervical spinal instability, meningeal thickening and/or bony stenosis, communicating hydrocephalus, optic nerve atrophy and blindness. The disorder is transmitted in an autosomal recessive manner and is caused by mutations in the ARSB gene, located in chromosome 5 (5q13-5q14). Over 130 ARSB mutations have been reported, causing absent or reduced arylsulfatase B (N-acetylgalactosamine 4-sulfatase) activity and interrupted dermatan sulfate and chondroitin sulfate degradation. Diagnosis generally requires evidence of clinical phenotype, arylsulfatase B enzyme activity <10% of the lower limit of normal in cultured fibroblasts or isolated leukocytes, and demonstration of a normal activity of a different sulfatase enzyme (to exclude multiple sulfatase deficiency). The finding of elevated urinary dermatan sulfate with the absence of heparan sulfate is supportive. In addition to multiple sulfatase deficiency, the differential diagnosis should also include other forms of MPS (MPS I, II IVA, VII), sialidosis and mucolipidosis. Before enzyme replacement therapy (ERT) with galsulfase (Naglazyme®), clinical management was limited to supportive care and hematopoietic stem cell transplantation. Galsulfase is now widely available and is a specific therapy providing improved endurance with an acceptable safety profile. Prognosis is variable depending on the age of onset, rate of disease progression, age at initiation of ERT and on the quality of the medical care provided
Belle II Executive Summary
Belle II is a Super Factory experiment, expected to record 50 ab
of collisions at the SuperKEKB accelerator over the next decade. The
large samples of mesons, charm hadrons, and tau leptons produced in the
clean experimental environment of collisions will provide the basis of
a broad and unique flavor-physics program. Belle II will pursue physics beyond
the Standard Model in many ways, for example: improving the precision of weak
interaction parameters, particularly Cabibbo-Kobayashi-Maskawa (CKM) matrix
elements and phases, and thus more rigorously test the CKM paradigm, measuring
lepton-flavor-violating parameters, and performing unique searches for
missing-mass dark matter events. Many key measurements will be made with
world-leading precision.Comment: 7 pages, to be submitted to the "Rare and Precision Measurements
Frontier" of the APS DPF Community Planning Exercise Snowmass 202
D13.2 Techniques and performance analysis on energy- and bandwidth-efficient communications and networking
Deliverable D13.2 del projecte europeu NEWCOM#The report presents the status of the research work of the
various Joint Research Activities (JRA) in WP1.3 and the results
that were developed up to the second year of the project. For
each activity there is a description, an illustration of the
adherence to and relevance with the identified fundamental
open issues, a short presentation of the main results, and a
roadmap for the future joint research. In the Annex, for each
JRA, the main technical details on specific scientific activities
are described in detail.Peer ReviewedPostprint (published version
An exploratory study of the determinants of the quality of strategic decision implementation in Turkish industrial firms
This paper investigates the determinants of quality of decision implementation. By drawing on a sample of 116 firms located in Turkey, the authors test whether the features of important team processes (i.e. trust and participation), of the organisation (i.e. past performance) and of implementation (i.e. its speed and uncertainty) exert an influence on the quality with which decisions are implemented. Exploratory and confirmatory factor analyses were used to test the validity of the measures, while path analysis was used in hypotheses testing. The results suggest that quality of decision implementation is positively related to trust, participation and past performance, and negatively to implementation speed and uncertainty. The implications of these findings for theory, practice and general management are discussed
Alternative HER/PTEN/Akt Pathway Activation in HPV Positive and Negative Penile Carcinomas
Copyright: 2011 Stankiewicz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background: The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood, though risk factors include human papillomavirus (HPV). Disruption of HER/PTEN/Akt pathway is present in many cancers; however there is little information on its function in PSCC. We investigated HER family receptors and phosphatase and tension homolog (PTEN) in HPV-positive and negative PSCC and its impact on Akt activation using immunohistochemistry and fluorescent in situ hybridisation (FISH). Methodology/Principal Findings: 148 PSCCs were microarrayed and immunostained for phosphorylated EGFR (pEGFR), HER2, HER3, HER4, phosphorylated Akt (pAkt), Akt1 and PTEN proteins. EGFR and PTEN gene status were also evaluated using FISH. HPV presence was assessed by PCR. pEGFR expression was detected significantly less frequently in HPV-positive than HPV-negative tumours (p = 0.0143). Conversely, HER3 expression was significantly more common in HPV-positive cases (p = 0.0128). HER4, pAkt, Akt and PTEN protein expression were not related to HPV. HER3 (p = 0.0054) and HER4 (p = 0.0002) receptors significantly correlated with cytoplasmic Akt1 immunostaining. All three proteins positively correlated with tumour grade (HER3, p = 0.0029; HER4, p = 0.0118; Akt1, p = 0.0001). pEGFR expression correlated with pAkt but not with tumour grade or stage. There was no EGFR gene amplification. HER2 was not detected. PTEN protein expression was reduced or absent in 62% of tumours but PTEN gene copy loss was present only in 4% of PSCCs. Conclusions/Significance: EGFR, HER3 and HER4 but not HER2 are associated with penile carcinogenesis. HPV-negative tumours tend to express significantly more pEGFR than HPV-positive cancers and this expression correlates with pAkt protein, indicating EGFR as an upstream regulator of Akt signalling in PSCC. Conversely, HER3 expression is significantly more common in HPV-positive cases and positively correlates with cytoplasmic Akt1 expression. HER4 and PTEN protein expression are not related to HPV infection. Our results suggest that PSCC patients could benefit from therapies developed to target HER receptors.Peer reviewedFinal Published versio
High Resolution Genome-Wide Analysis of Chromosomal Alterations in Burkitt's Lymphoma
Additional chromosomal abnormalities are currently detected in Burkitt's lymphoma. They play major roles in the progression of BL and in prognosis. The genes involved remain elusive. A whole-genome oligonucleotide array CGH analysis correlated with karyotype and FISH was performed in a set of 27 Burkitt's lymphoma-derived cell lines and primary tumors. More than half of the 145 CNAs<2 Mb were mapped to Mendelian CNVs, including GSTT1, glutathione s-transferase and BIRC6, an anti-apoptotic protein, possibly predisposing to some cancers. Somatic cell line-specific CNVs localized to the IG locus were consistently observed with the 244 K aCGH platform. Among 136 CNAs >2 Mb, gains were found in 1q (12/27), 13q (7/27), 7q (6/27), 8q(4/27), 2p (3/27), 11q (2/27) and 15q (2/27). Losses were found in 3p (5/27), 4p (4/27), 4q (4/27), 9p (4/27), 13q (4/27), 6p (3/27), 17p (3/27), 6q (2/27),11pterp13 (2/27) and 14q12q21.3 (2/27). Twenty one minimal critical regions (MCR), (range 0.04–71.36 Mb), were delineated in tumors and cell lines. Three MCRs were localized to 1q. The proximal one was mapped to 1q21.1q25.2 with a 6.3 Mb amplicon (1q21.1q21.3) harboring BCA2 and PIAS3. In the other 2 MCRs, 1q32.1 and 1q44, MDM4 and AKT3 appeared as possible drivers of these gains respectively. The 13q31.3q32.1 <89.58–96.81> MCR contained an amplicon and ABCC4 might be the driver of this amplicon. The 40 Kb 2p16.1 <60.96–61> MCR was the smallest gained MCR and specifically encompassed the REL oncogene which is already implicated in B cell lymphomas. The most frequently deleted MCR was 3p14.1 <60.43–60.53> that removed the fifth exon of FHIT. Further investigations which combined gene expression and functional studies are essential to understand the lymphomagenesis mechanism and for the development of more effective, targeted therapeutic strategies
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