Collaborative platforms for streamlining workflows in Open Science

Despite the internet’s dynamic and collaborative nature, scientists continue to produce grant proposals, lab notebooks, data files, conclusions etc. that stay in static formats or are not published online and therefore not always easily accessible to the interested public. Because of limited adoption of tools that seamlessly integrate all aspects of a research project (conception, data generation, data evaluation, peer-reviewing and publishing of conclusions), much effort is later spent on reproducing or reformatting individual entities before they can be repurposed independently or as parts of articles.

We propose that workflows - performed both individually and collaboratively - could potentially become more efficient if all steps of the research cycle were coherently represented online and the underlying data were formatted, annotated and licensed for reuse. Such a system would accelerate the process of taking projects from conception to publication stages and allow for continuous updating of the data sets and their interpretation as well as their integration into other independent projects.

A major advantage of such workflows is the increased transparency, both with respect to the scientific process as to the contribution of each participant. The latter point is important from a perspective of motivation, as it enables the allocation of reputation, which creates incentives for scientists to contribute to projects. Such workflow platforms offering possibilities to fine-tune the accessibility of their content could gradually pave the path from the current static mode of research presentation into
a more coherent practice of open science

Die mögliche Rolle der antennalen Cuticularporen beim Sexualverhalten von Cyaneolytta sp. (Coleoptera: Meloidae)

Cantharidin, which is mainly found in blister beetles (Coleoptera: Meloidae), is one of the most intensively studied natural products of insect (Dettner, 1997; McCormick & Carrel, 1987). The involvement of cantharidin in courtship behaviour has been already confirmed for certain canthariphilous insects (Eisner & al. 1996a,b; Frenzel & Dettner 1994; Frenzel & al. 1992; Schütz & Dettner, 1992; Hemp & al. 1999). The function and intrinsinc role of cantharidin in the courtship behaviour of Meloids has been never fully established. McCormick & Carrel (1987) only suggested that cantharidin might be used by female meloids when selecting a mate at close range. Pinto (1974, 1975) was, in fact, the first to consider male cuticular pores as being involved in the courtship behaviour of species from the genus Linsleya and Tegrodera (Meloidae). Based on morphology and chemical analyses of Cyaneolytta sp. (Coleoptera: Meloidae), we have hereby provided some further evidences that cantharidin may act as an infochemical in courtship behaviour of meloid beetles.Ölkäfer (Col: Meloidae) gehören zu den Insekten mit medizinischer Bedeutung. Cantharidin, das im gesamten Körper (v.a. in den Sexualorganen beider Geschlechter) der Käfer zu finden ist, verursacht Blasen auf der Haut. Die mögliche Rolle des Cantharidins im Sexualverhalten der Ölkäfer ist von besonderem wissenschaftlichem Interesse. Cyaneolytta sp. wurde in Karen, Kenia, gesammelt. Nach der Sektion wurden die Insektenkompartimente hydrolysiert und mittels quantitativer GC-MS chemisch analysiert. Um Poren der Kutikula und andere äußere Merkmale zu untersuchen, wurde ein Rasterelektronenmikroskop verwendet. Für Dünnschnitte der inneren Gewebe wurden Mikrotomschnitte angefertigt. Statistische Analysen wurden mit dem Softwarepaket Statistica durchgeführt. In den Antennen von Cyaneolytta sp. Péringuey, 1909 finden sich extrem hohe Cantharidinmengen. Die Daten zeigen eine deutliche Korrelation zwischen der Dichte der Kutikularporen und dem Cantharidingehalt der Antennenglieder Scapus und Pedicellus der Cyaneolytta-Männchen. Es existieren zahlreiche kanalartige Strukturen, die sich von der Hämolymphe der Antennen zur Oberfläche erstrecken, wo sich die Kutikularporen befinden. Betrachtet man den Cantharidingehalt der Antennensegmente, so enthalten die Glieder der Männchen viel größere Mengen als die der Weibchen. Auch besitzen die Kutikularporen der Weibchen eine deutlich geringere Dichte auf den Antennensegmenten. Die kanalartigen Strukturen auf den ersten beiden Antennensegmenten der Weibchen könnten uni- oder multizelluläre Tubuli sein, die das in der Hämolymphe zirkulierende Cantharidin an die Oberfläche bringen, aber die Poren auf den Antennen der Weibchen müssen eine andere Funktion haben. Während des Balzverhaltens berühren sich beide Geschlechter mit den Antennen, wobei die cantharidinhaltigen Poren in direkten Kontakt mit den weiblichen Antennen gelangen. Es wird vermutet, dass Cantharidin an die Oberfläche der Antennen der Männchen abgegeben wird. Demnach könnte der porenhaltige Bereich der männlichen Antennen eine Struktur sein, die Cantharidin abgibt, während der porenhaltige Bereich der weiblichen Antennen ein Rezeptorfeld darstellen könnte, dessen Chemorezeptoren einen bevorzugten Geschlechtspartner erkennen. Damit wurden weitere Hinweise für die Hypothese gesammelt, dass Cantharidin eine Rolle bei der sexuellen Selektion im Nahbereich spielt

Compilation of canthariphilous insects.

Die durch Cantharidin angezogenen Insekten werden aufgelistet. Die meisten Cantharidin-abhängigen Insekten sind in der Käferfamilie Anthicidae mit 185 Arten in den drei Unterfamilien Anthicinae (179), Lemodiinae (1) und Tomoderinae (5) gefunden worden. Weitere Cantharidin-abhängige Arten sind bekannt aus den Käferfamilien Endomychidae (5), Cleridae (4), Chrysomelidae (3), und Staphylinidae (1). In der Familie Pyrochroidae sind 23 Arten aus der Unterfamilie Pedilinae und 6 Arten aus den Pyrochroinae Cantharidin beeinflußt. Bei den Dipteren sind dies in den Familien Anthomyiidae (3), Cecidomyidae (2), Ceratopogonidae (22) Chloropidae (1), Platystomatidae (1) und Sciaridae (5). Manche Arten der Heteropterenfamilie Miridae (29) sind bekannt wegen des Einflusses von Cantharidin ebenso jeweils eine Art aus den Familien Lygaeidae und Tingidae. Parasiten der Hymenopterenfamilie Braconidae (6) zeigen eine positive Reaktion auf Cantharidin, ebenso wie Arten der Unterfamilie Diapriinae der Familie Diapriidae. Chemische Analysen von Arten der Fulgoridae und Cicadidae zeigen, dass auch Arten der Homoptera Cantharidin-abhängig scheinen.Stichwörtercantharidin, canthariphilous insects, Coleoptera, Diptera, Heteroptera, Homoptera.A list of insects attracted to cantharidin is given. Most canthariphilous insects are found within the heteromeran beetle family Anthicidae with 185 species in the three subfamilies Anthicinae (179), Lemodiinae (1) and Tomoderinae (5). Further cantharidin baited species are known from the beetle families Endomychidae (5), Cleridae (4), Chrysomelidae (3), and Staphylinidae (1). In the beetle family Pyrochroidae 23 species from the subfamily Pedilinae and 6 species of the Pyrochroinae are canthariphilous. The insect order Diptera is represented by the families Anthomyiidae (3), Cecidomyidae (2), Ceratopogonidae (22) Chloropidae (1), Platystomatidae (1) and Sciaridae (5). Many species from the heteropteran family Miridae (29) are known to be attracted by cantharidin, also one species from the families Lygaeidae and Tingidae respectively. Parasites of the hymenopteran family Braconidae (6) show a positive reaction to cantharidin as well as species from the subfamily Diapriinae of the family Diapriidae. Chemical analyses of a fulgorid and a cicadid species revealed that also species of Homoptera may contain cantharidin.Keywordscantharidin, canthariphilous insects, Coleoptera, Diptera, Heteroptera, Homoptera

Schreiben Englisch

Das DESI-Modul semikreatives Schreiben dient der Erfassung der Fähigkeit des task-orientierten Schreibens in der Fremdsprache (vgl. Harsch/Lehmann/Neuma/Schröder 2007). Dabei sollen den Schülerinnen und Schülern bei gleichzeitiger Lenkung möglichst große kommunikative Freiräume geboten werden. Das Testkonstrukt Schreiben Englisch ist in Analogie zum Konstrukt der Textproduktion Deutsch dreifach verortet in der linguistischen Text- und Schreibprozessforschung sowie in der didaktischen Forschung zur Schreibentwicklung, in der Analyse der relevanten Curricula aller Schularten und Bundesländer und in der empirischen Forschung zur Aufsatzbewertung. (DIPF/Orig.

Wikis in scholarly publishing

Scientific research is a process concerned with the creation, collective accumulation, contextualization, updating and maintenance of knowledge. Wikis provide an environment that allows to collectively accumulate, contextualize, update and maintain knowledge in a coherent and transparent fashion. Here, we examine the potential of wikis as platforms for scholarly publishing. In the hope to stimulate further discussion, the article itself was drafted on "Species-ID":http://species-id.net/w/index.php?title=Wikis_in_scholarly_publishing&oldid=3815 - a wiki that hosts a prototype for wiki-based scholarly publishing - where it can be updated, expanded or otherwise improved

Frequent Pet Contact as Risk Factor for Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis

Aspergillus fumigatus (Af) frequently colonizes the respiratory tract of patients with cystic fibrosis (CF). Af is associated with loss of pulmonary function and allergic bronchopulmonary aspergillosis (ABPA), a hypersensitivity fungal lung disease. Environmental factors have impact on CF patients' lung function variation. The aim of this nationwide questionnaire survey was to investigate the amount of CF patients with frequent pet contact including pet species and to examine the potential impact of frequent pet contact on the occurrence of Af colonization and ABPA diagnosis in these patients. The survey was carried out in 31 German CF centers in 2018. A total of 1232 who completed the surveys were included, and statistical analysis was performed by chi-squared test. Within the study cohort 49.8% of subjects (n = 614; CF patients < 18years: 49.4%, n = 234; ≥ 18years: 50.1%, n = 380) reported frequent contact to pets, of which 60.7% reported frequent contact to dogs, 42.3% to cats and other animals. Of those with frequent pet contact, 71.8% (n = 441) had contact to one pet or more pets from the same family. Af colonization was not significantly associated with frequent pet contact. ABPA diagnosis was documented in 16.7% (n = 206) of all included CF patients and was significantly associated with frequent pet contact (18.9%, n = 116, p = 0.042), confirming previous single center examinations. Particularly, patients with frequent contact to dogs showed an increased ABPA prevalence of 21.3%. Frequent pet contact might be a risk factor for ABPA. CF patients who are sensitized to Af should be informed about the increased risk to develop an ABPA by frequent pet contact. Patients with recurrent onset of ABPA should be evaluated in terms of frequent pet contact

Urban Life as Risk Factor for Aspergillosis

Aspergillus fumigatus (Af) frequently colonizes the airways of patients with cystic fibrosis (CF) and can cause severe diseases, such as allergic bronchopulmonary aspergillosis, Af bronchitis or even Af pneumonia. However, risk factors, including environmental factors, for acquiring Af in the respiratory tract of patients with CF are rarely studied and described. The aim of this study was to investigate whether urban or rural life could affect colonization with Af in the respiratory tract of patients with CF. Due to privacy policy, registry data are usually not linked to patients ' home addresses. It is therefore very difficult to analyze the influence of the patient ' s residential environment. This prospective questionnaire survey was carried out in 31 German CF centers in 2018. Only completed surveys, including a clearly assigned type of residential area were included. Statistical analysis was performed by chi-squared test and logistic regression models. A total of 1016 questionnaires were analyzed (Patients` age: 23 ± 13; 0-88 years; female gender: n=492; 48%). The majority of patients with CF live in large cities (n =314; 30.9%) or urban districts (n=461; 45.4%). Prevalence of 30.2% was found for Af, within the 12 months of investigation period. Af colonization was significantly associated with urban life (p=0.004). Urban live should be considered as possible new risk factor for colonization with Af in the respiratory tract of patients with CF. These new results may raise the awareness of the influence of environmental factors on patient outcomes and should be included in patient guidance and preventive measures

Synthesis and Neurotrophic Activity Studies of Illicium Sesquiterpene Natural Product Analogues

Neurotrophic natural products hold potential as privileged structures for the development of therapeutic agents against neurodegeneration. However, only a few studies have been conducted to investigate a common pharmacophoric motif and structure–activity relationships (SARs). Here, an investigation of structurally more simple analogues of neurotrophic sesquiterpenes of the illicium family is presented. A concise synthetic route enables preparation of the carbon framework of (±)-Merrilactone A and (±)-Anislactone A/B on a gram scale. This has allowed access to a series of structural analogues by modification of the core structure, including variation of oxidation levels and alteration of functional groups. In total, 15 derivatives of the natural products have been synthesized and tested for their neurite outgrowth activities. Our studies indicate that the promising biological activity can be retained by structurally simpler natural product analogues, which are accessible by a straightforward synthetic route

Atomic scale structure and bond stretching force constants in stoichiometric and off-stoichiometric kesterites

The deviation from stoichiometry and the understanding of its consequences are key factors for the application of kesterites as solar cell absorbers. Therefore, this study investigates the local atomic structure of off-stoichiometric Cu2ZnSnS4 (CZTS), Cu2ZnSnSe4 (CZTSe) and Cu2ZnGeSe4 (CZGSe) by means of Extended X-ray Absorption Fine Structure Spectroscopy. Temperature dependent measurements yield the bond stretching force constants of all cation-anion bonds in stoichiometric CZTS and CZTSe and nearly stoichiometric CZGSe. Low temperature measurements allow high precision analysis of the influence of off-stoichiometry on the element specific average bond lengths and their variances. The overall comparison between the materials is in excellent agreement with measures like ionic/atomic radii and bond ionicities. Furthermore, the small uncertainties allow the identification of systematic trends in the Cu–Se and Zn–Se bond lengths of CZTSe and CZGSe. These trends are discussed in context of the types and concentrations of certain point defects, which gives insight into the possible local configurations and their influence on the average structural parameters. The findings complement the understanding of the effect of off-stoichiometry on the local structure of kesterites, which affects their electronic properties and thus their application for solar cells

New Insights into the Distribution, Physiology and Life Histories of South American Galaxiid Fishes, and Potential Threats to this Unique Fauna

South American galaxiids occupy both Patagonia and the ichthyogeographic Chilean Province, encompassing glacial Andean deep lakes, shallow plateau lakes, reservoirs, short Pacific rivers and long Atlantic rivers. The total fish fauna includes 29 species, comprising Neotropical fishes (siluriforms and characids), galaxiids, percichthyids, atherinopsids and mugilids, two lamprey species, and several exotic fishes (salmonids, Gambusia spp. and common carp). The family Galaxiidae shares a common ancestry with the Gondwanan temperate fish fauna, played a major role in the post-glacial colonization of Andean lakes and streams, and contributes key species to the food webs. Galaxiid species occupy an enormous latitudinal gradient, show a wide variety of life history patterns and are the southernmost native freshwater fishes of the world. Knowledge of South American galaxiids has improved notably, but new challenges arise due to climate change, biological invasions, damming, aquaculture and contamination. In this changing environment, the future of South American galaxiids should be carefully considered as a legacy of the old Gondwana and a unique attribute of the freshwaters of southern South America.Fil: Cussac, Victor Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; ArgentinaFil: Barrantes, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Boy, Claudia Clementina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Górski, Konrad. Universidad Austral de Chile; ChileFil: Habit, Evelyn. Universidad de Concepción; ChileFil: Lattuca, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Rojo, Javier Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentin