349 research outputs found
Preosteoblast Cell Adhesion and Proliferation on Polycaprolactone (PCL) 3D Scaffolds with Hyaluronic Acid Nano Layer
Polycaprolactone (PCL) scaffolds have been widely used for bone tissue engineering. However, PCL is
not good due to the lack of cell recognition sites and hydrophobic surface. Hyaluronic acid (HA) is a glycosaminoglycan
that plays an important role in adhesion, migration and proliferation. The object of this
study is to fabricate the polymeric thin film in order to improving the preosteoblast cells adhesion and proliferation
on HA immobilized PCL scaffolds using amine plasma polymerization. HA immobilized PCL scaffold
showed no significant effect on preosteoblast cell attachment and proliferation.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3547
Searching for Ground Truth: a stepping stone in automating genre classification
This paper examines genre classification of documents and
its role in enabling the effective automated management of digital documents by digital libraries and other repositories. We have previously presented genre classification as a valuable step toward achieving automated extraction of descriptive metadata for digital material. Here, we present results from experiments using human labellers, conducted to assist in genre characterisation and the prediction of obstacles which need to be overcome by an automated system, and to contribute to the process of creating a solid testbed corpus for extending automated genre classification and testing metadata extraction tools across genres. We also describe the performance of two classifiers based on image and stylistic modeling features in labelling the data resulting from the agreement of three human labellers across fifteen genre classes.
Constraints on diffuse neutrino background from primordial black holes
We calculated the energy spectra and the fluxes of electron neutrino emitted
in the process of evaporation of primordial black holes (PBHs) in the early
universe. It was assumed that PBHs are formed by a blue power-law spectrum of
primordial density fluctuations. We obtained the bounds on the spectral index
of density fluctuations assuming validity of the standard picture of
gravitational collapse and using the available data of several experiments with
atmospheric and solar neutrinos. The comparison of our results with the
previous constraints (which had been obtained using diffuse photon background
data) shows that such bounds are quite sensitive to an assumed form of the
initial PBH mass function.Comment: 18 pages,(with 7 figures
Teacher support and guidelines for diverse student learners during COVID-19
Teachers serving students from low-income backgrounds, students with disabilities, and students from underrepresented racial and ethnic backgrounds are experiencing a myriad of challenges due to the pandemic that is exacerbating existing inequities and risks. The purpose of this study was to assess whether and to what extent teachers received access to professional development support that would enable them to more effectively respond to the education to the challenges experienced in managing through COVID-19 and evaluate the impact of this access on their perceptions on student engagement. Using the RAND 2020 American Teacher Panel (ATP) COVID-19 collected in October 2020, four clusters of support and resources were identified: Most Supported, Least Supported, Moderate Supported A (received support primarily with students with Disabilities) and Moderate Supported B (received support primarily with diverse backgrounds). Teachers classified as relatively less supported groups were more likely to be teaching in more urbanized settings with larger size schools than the other clusters and perceived their students as attending less often and being less ready for grade-level coursework. Recommendations for school psychologists and human service professionals organizing professional development to address teacher self-care and social emotional learning are described.First author draf
Viability of primordial black holes as short period gamma-ray bursts
It has been proposed that the short period gamma-ray bursts, which occur at a
rate of , may be evaporating primordial black holes
(PBHs). Calculations of the present PBH evaporation rate have traditionally
assumed that the PBH mass function varies as . This mass
function only arises if the density perturbations from which the PBHs form have
a scale invariant power spectrum. It is now known that for a scale invariant
power spectrum, normalised to COBE on large scales, the PBH density is
completely negligible, so that this mass function is cosmologically irrelevant.
For non-scale-invariant power spectra, if all PBHs which form at given epoch
have a fixed mass then the PBH mass function is sharply peaked around that
mass, whilst if the PBH mass depends on the size of the density perturbation
from which it forms, as is expected when critical phenomena are taken into
account, then the PBH mass function will be far broader than . In this paper we calculate the present day PBH evaporation rate,
using constraints from the diffuse gamma-ray background, for both of these mass
functions. If the PBH mass function has significant finite width, as recent
numerical simulations suggest, then it is not possible to produce a present day
PBH evaporation rate comparable with the observed short period gamma-ray burst
rate. This could also have implications for other attempts to detect
evaporating PBHs.Comment: 5 pages, 2 figures, version to appear in Phys. Rev. D with additional
reference
Bounds from Primordial Black Holes with a Near Critical Collapse Initial Mass Function
Recent numerical evidence suggests that a mass spectrum of primordial black
holes (PBHs) is produced as a consequence of near critical gravitational
collapse. Assuming that these holes formed from the initial density
perturbations seeded by inflation, we calculate model independent upper bounds
on the mass variance at the reheating temperature by requiring the mass density
not exceed the critical density and the photon emission not exceed current
diffuse gamma-ray measurements. We then translate these results into bounds on
the spectral index n by utilizing the COBE data to normalize the mass variance
at large scales, assuming a constant power law, then scaling this result to the
reheating temperature. We find that our bounds on n differ substantially
(\delta n > 0.05) from those calculated using initial mass functions derived
under the assumption that the black hole mass is proportional to the horizon
mass at the collapse epoch. We also find a change in the shape of the diffuse
gamma-ray spectrum which results from the Hawking radiation. Finally, we study
the impact of a nonzero cosmological constant and find that the bounds on n are
strengthened considerably if the universe is indeed vacuum-energy dominated
today.Comment: 24 pages, REVTeX, 5 figures; minor typos fixed, two refs added,
version to be published in PR
Tracking Performance of the Scintillating Fiber Detector in the K2K Experiment
The K2K long-baseline neutrino oscillation experiment uses a Scintillating
Fiber Detector (SciFi) to reconstruct charged particles produced in neutrino
interactions in the near detector. We describe the track reconstruction
algorithm and the performance of the SciFi after three years of operation.Comment: 24pages,18 figures, and 1 table. Preprint submitted to NI
Search for sterile neutrino oscillation using RENO and NEOS data
We present a reactor model independent search for sterile neutrino
oscillation using 2\,509\,days of RENO near detector data and 180 days of NEOS
data. The reactor related systematic uncertainties are significantly suppressed
as both detectors are located at the same reactor complex of Hanbit Nuclear
Power Plant. The search is performed by electron
antineutrino\,() disappearance between six reactors and two
detectors with baselines of 294\,m\,(RENO) and 24\,m\,(NEOS). A spectral
comparison of the NEOS prompt-energy spectrum with a no-oscillation prediction
from the RENO measurement can explore reactor oscillations
to sterile neutrino. Based on the comparison, we obtain a 95\% C.L. excluded
region of \,eV. We also obtain a 68\% C.L. allowed
region with the best fit of \,eV and
=0.080.03 with a p-value of 8.2\%. Comparisons of
obtained reactor antineutrino spectra at reactor sources are made among RENO,
NEOS, and Daya Bay to find a possible spectral variation.Comment: 6 pages, 5 figures: This manuscript has been significantly revised by
the joint reanalysis by RENO and NEOS Collaborations. (In the previous
edition, the RENO collaboration used publicly available NEOS data to evaluate
the expected neutrino spectrum at NEOS.
Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening
Cohesin stably holds together the sister chromatids from S phase until mitosis. To do so, cohesin must be protected against its cellular antagonist Wapl. Eco1 acetylates cohesin's Smc3 subunit, which locks together the sister DNAs. We used yeast genetics to dissect how Wapl drives cohesin from chromatin and identified mutants of cohesin that are impaired in ATPase activity but remarkably confer robust cohesion that bypasses the need for the cohesin protectors Eco1 in yeast and Sororin in human cells. We uncover a functional asymmetry within the heart of cohesin's highly conserved ABC-like ATPase machinery and find that both ATPase sites contribute to DNA loading, whereas DNA release is controlled specifically by one site. We propose that Smc3 acetylation locks cohesin rings around the sister chromatids by counteracting an activity associated with one of cohesin's two ATPase sites. Tight regulation of DNA entrapment and release by the cohesin complex is crucial for its multiple cellular functions. Elbatsh et al. find that cohesin's release from DNA requires an activity associated with one of its ATPase sites, whereas both sites control cohesin's loading onto DNA
Measurement of single pi0 production in neutral current neutrino interactions with water by a 1.3 GeV wide band muon neutrino beam
Neutral current single pi0 production induced by neutrinos with a mean energy
of 1.3 GeV is measured at a 1000 ton water Cherenkov detector as a near
detector of the K2K long baseline neutrino experiment. The cross section for
this process relative to the total charged current cross section is measured to
be 0.064 +- 0.001 (stat.) +- 0.007 (sys.). The momentum distribution of
produced pi0s is measured and is found to be in good agreement with an
expectation from the present knowledge of the neutrino cross sections.Comment: 6 pages, 4 figures, Submitted to Phys. Lett.
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