DeLFI 2011 - Die 9. e-Learning Fachtagung Informatik: Poster | Workshops | Kurzbeiträge

Die 9. Tagung der Fachgruppe „E-Learning“ in der Gesellschaft für Informatik e.V. vom 5. - 8. September 2011 in Dresden setzt eine inzwischen gute Tradition wissenschaftlicher Diskussionen in diesem Fachgebiet fort. Erneut konnten interdisziplinäre Partner gewonnen werden, um unter dem Dach einer Veranstaltung mit dem Titel „Wissensgemeinschaften 2011“ unterschiedliche Facetten des Lernens mit elektronischen Medien gemeinsam zu diskutieren. Das betrifft Themenbereiche wie Wissensmanagement, Werkzeuge und Technologien für e-Learning, didaktische und technische Aspekte des Einsatzes elektronischer Hilfsmittel oder auch kooperatives Wirken in verschiedenen Arbeitsfeldern. Diese Teiltagungen - 16. Europäische Jahrestagung der Gesellschaft für Medien in der Wissenschaft „GMW 2011“, - 9. E-Learning Fachtagung Informatik der Gesellschaft für Informatik „DeLFI 2011“ und - 14. Tagung Gemeinschaften in Neuen Medien: Virtual Enterprises, Communities & Social Netorks „GeNeMe 2011“ haben mit jeweils eigenen Experten aus einer großen Zahl von Angeboten zu wissenschaftlichen Fachbeiträgen die wertvollsten ausgewählt und präsentieren diese in eigenen Tagungsbänden. Der vorliegende Band enthält darüber hinaus gehende Arbeiten, die der Teiltagung „DeLFI“ zuzuordnen sind. Dies sind vor allem Beiträge aus den Workshops: - Mobile Learning: Einsatz mobiler Endgeräte im Lernen, Wissenserwerb sowie der Lehr-/Lernorganisation - Lerninfrastruktur in Schulen: 1:1-Computing - Web 2.0 in der beruflichen Bildung aber auch die angenommenen Short Papers, Demonstrationen und Poster. Mit der Tagung „Wissensgemeinschaften 2011“ in Dresden wurde ein Ort gewählt, der in einer wachsenden Region ein Zentrum für Wissenschaft, Wirtschaft und Kultur bildet und dieser Tagung das nötige Ambiente verleiht, an dem die Zusammenarbeit zwischen Wissenschaft und Forschung auf einem hohen Niveau stattfindet und die Technische Universität eine Vorstufe zur Anerkennung auf Förderung im Rahmen der Exzellenzinitiative erreicht hat. Der besondere Dank gilt den Autoren für die eingereichten Beiträge sowie dem Programmausschuss für deren Begutachtung. Natürlich gilt dieser Dank auch den Sponsoren, Ausstellern und Gestaltern der Pre-Konferenz-Aktivitäten. Ferner möchten wir allen danken, die die Vorbereitung und Durchführung unterstützt haben, besonders den Studierenden der Fakultät Informatik der TU Dresden und Schülern der Europäische Wirtschafts- und Sprachenakademie (EWS) Dresden. Dresden, September 2011 Holger Rohland, Andrea Kienle, Steffen Friedric

Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway

Reduced cholesterol synthesis has been reported in patients with primary biliary cirrhosis but no data are available on changes in cholesterol catabolism induced by the disease. Serum levels of 7α-hydroxycholesterol and 27-hydroxycholesterol have been measured in 25 patients (either normocholesterolemic or hypercholesterolemic) with primary biliary cirrhosis and in control subjects. To evaluate cholesterol synthesis, serum levels of lathosterol were measured, and campesterol and sitosterol were considered to reflect intestinal absorption and biliary elimination of sterols. In normocholesterolemic patients with primary biliary cirrhosis, lathosterol was significantly lower than in normocholesterolemic controls (P < 0.05) whereas no difference was found between hypercholesterolemic patients and hypercholesterolemic controls. Serum concentrations of sitosterol were significantly higher in both normocholesterolemic and hypercholesterolemic patients with primary biliary cirrhosis as compared with the respective controls (P < 0.01). In patients with primary biliary cirrhosis, serum 7α-hydroxycholesterol was slightly higher than in controls. 27-Hydroxycholesterol was significantly higher in hypercholesterolemic compared to normocholesterolemic controls (P < 0.05) and a significant linear correlation (r = 0.771; P < 0.001) was found between 27-hydroxycholesterol and cholesterol. In contrast, in patients with primary biliary cirrhosis, high cholesterol concentrations were not associated with increased serum levels of 27-hydroxycholesterol. Our data confirm that in patients with primary biliary cirrhosis, cholesterol synthesis and biliary elimination of sterols are impaired and also suggest that both the feedback regulation of retained bile acids on cholesterol 7α-hydroxylase and the scavenger effect on elevated serum cholesterol by cholesterol 27-hydroxylase are deficient in these patients.—Del Puppo, M., M. Galli Kienle, M. L. Petroni, A. Crosignani, and M. Podda. Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway. J. Lipid Res. 1998. 39: 2477–2482

In-vivo multilaboratory investigation of the optical properties of the human head

The in-vivo optical properties of the human head are investigated in the 600–1100 nm range on different subjects using continuous wave and time domain diffuse optical spectroscopy. The work was performed in collaboration with different research groups and the different techniques were applied to the same subject. Data analysis was carried out using homogeneous and layered models and final results were also confirmed by Monte Carlo simulations. The depth sensitivity of each technique was investigated and related to the probed region of the cerebral tissue. This work, based on different validated instruments, is a contribution to fill the existing gap between the present knowledge and the actual in-vivo values of the head optical properties

Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink

A multi-center study has been set up to accurately characterize the optical properties of diffusive liquid phantoms based on Intralipid and India ink at near-infrared (NIR) wavelengths. Nine research laboratories from six countries adopting different measurement techniques, instrumental set-ups, and data analysis methods determined at their best the optical properties and relative uncertainties of diffusive dilutions prepared with common samples of the two compounds. By exploiting a suitable statistical model, comprehensive reference values at three NIR wavelengths for the intrinsic absorption coefficient of India ink and the intrinsic reduced scattering coefficient of Intralipid-20% were determined with an uncertainty of about 2% or better, depending on the wavelength considered, and 1%, respectively. Even if in this study we focused on particular batches of India ink and Intralipid, the reference values determined here represent a solid and useful starting point for preparing diffusive liquid phantoms with accurately defined optical properties. Furthermore, due to the ready availability, low cost, long-term stability and batch-to-batch reproducibility of these compounds, they provide a unique fundamental tool for the calibration and performance assessment of diffuse optical spectroscopy instrumentation intended to be used in laboratory or clinical environment. Finally, the collaborative work presented here demonstrates that the accuracy level attained in this work for optical properties of diffusive phantoms is reliable