Increased CK5/CK8-Positive Intermediate Cells with Stromal Smooth Muscle Cell Atrophy in the Mice Lacking Prostate Epithelial Androgen Receptor

Results from tissue recombination experiments documented well that stromal androgen receptor (AR) plays essential roles in prostate development, but epithelial AR has little roles in prostate development. Using cell specific knockout AR strategy, we generated pes-ARKO mouse with knock out of AR only in the prostate epithelial cells and demonstrated that epithelial AR might also play important roles in the development of prostate gland. We found mice lacking the prostate epithelial AR have increased apoptosis in epithelial CK8-positive luminal cells and increased proliferation in epithelial CK5-positive basal cells. The consequences of these two contrasting results could then lead to the expansion of CK5/CK8-positive intermediate cells, accompanied by stromal atrophy and impaired ductal morphogenesis. Molecular mechanism dissection found AR target gene, TGF-β1, might play important roles in this epithelial AR-to-stromal morphogenesis modulation. Collectively, these results provided novel information relevant to epithelial AR functions in epithelial-stromal interactions during the development of normal prostate, and suggested AR could also function as suppressor in selective cells within prostate

Training in childhood obesity management in the United States: a survey of pediatric, internal medicine-pediatrics and family medicine residency program directors

<p>Abstract</p> <p>Background</p> <p>Information about the availability and effectiveness of childhood obesity training during residency is limited.</p> <p>Methods</p> <p>We surveyed residency program directors from pediatric, internal medicine-pediatrics (IM-Peds), and family medicine residency programs between September 2007 and January 2008 about childhood obesity training offered in their programs.</p> <p>Results</p> <p>The response rate was 42.2% (299/709) and ranged by specialty from 40.1% to 45.4%. Overall, 52.5% of respondents felt that childhood obesity training in residency was extremely important, and the majority of programs offered training in aspects of childhood obesity management including prevention (N = 240, 80.3%), diagnosis (N = 282, 94.3%), diagnosis of complications (N = 249, 83.3%), and treatment (N = 242, 80.9%). However, only 18.1% (N = 54) of programs had a formal childhood obesity curriculum with variability across specialties. Specifically, 35.5% of IM-Peds programs had a formal curriculum compared to only 22.6% of pediatric and 13.9% of family medicine programs (p < 0.01). Didactic instruction was the most commonly used training method but was rated as only somewhat effective by 67.9% of respondents using this method. The most frequently cited significant barrier to implementing childhood obesity training was competing curricular demands (58.5%).</p> <p>Conclusions</p> <p>While most residents receive training in aspects of childhood obesity management, deficits may exist in training quality with a minority of programs offering a formal childhood obesity curriculum. Given the high prevalence of childhood obesity, a greater emphasis should be placed on development and use of effective training strategies suitable for all specialties training physicians to care for children.</p

The establishment of the Standard Cosmological Model through observations

Over the last decades, observations with increasing quality have revolutionized our understanding of the general properties of the Universe. Questions posed for millenia by mankind about the origin, evolution and structure of the cosmos have found an answer. This has been possible mainly thanks to observations of the Cosmic Microwave Background, of the large-scale distribution of matter structure in the local Universe, and of type Ia supernovae that have revealed the accelerated expansion of the Universe. All these observations have successfully converged into the so-called "concordance model". In spite of all these observational successes, there are still some important open problems, the most obvious of which are what generated the initial matter inhomogeneities that led to the structure observable in today's Universe, and what is the nature of dark matter, and of the dark energy that drives the accelerated expansion. In this chapter I will expand on the previous aspects. I will present a general description of the Standard Cosmological Model of the Universe, with special emphasis on the most recent observations that have us allowed to consolidate this model. I will also discuss the shortfalls of this model, its most pressing open questions, and will briefly describe the observational programmes that are being planned to tackle these issues.Comment: Accepted for publication in the book "Reviews in Frontiers of Modern Astrophysics: From Space Debris to Cosmology" (eds Kabath, Jones and Skarka; publisher Springer Nature) funded by the European Union Erasmus+ Strategic Partnership grant "Per Aspera Ad Astra Simul" 2017-1-CZ01-KA203-03556

Women’s responses to changes in U.S. preventive task force’s mammography screening guidelines: results of focus groups with ethnically diverse women

Background: The 2009 U.S. Preventive Services Task Force (USPSTF) changed mammography guidelines to recommend routine biennial screening starting at age 50. This study describes women’s awareness of, attitudes toward, and intention to comply with these new guidelines. Methods: Women ages 40–50 years old were recruited from the Boston area to participate in focus groups (k = 8; n = 77). Groups were segmented by race/ethnicity (Caucasian = 39%; African American = 35%; Latina = 26%), audio-taped, and transcribed. Thematic content analysis was used. Results: Participants were largely unaware of the revised guidelines and suspicious that it was a cost-savings measure by insurers and/or providers. Most did not intend to comply with the change, viewing screening as obligatory. Few felt prepared to participate in shared decision-making or advocate for their preferences with respect to screening. Conclusions: Communication about the rationale for mammography guideline changes has left many women unconvinced about potential disadvantages or limitations of screening. Since further guideline changes are likely to occur with advances in technology and science, it is important to help women become informed consumers of health information and active participants in shared decision-making with providers. Additional research is needed to determine the impact of the USPSTF change on women’s screening behaviors and on breast cancer outcomes

ANALISIS REPRESENTASI TRADISI KEMATIAN PADA NOVEL PUYA KE PUYA KARYA FAISAL ODDANG

Death tradition is a ceremonial process that is done from generation to generation as the delivery of died people before actually going to another world (immortality).One of death traditions in Indonesia that is still done and well-known to foreign countries is Rambu Solo’ in Toraja. Rambu Solo’ is done as the process of perfecting died people. Death tradition is depicted in Puya Ke Puya novel by Faisal Oddang. Based on that thing, the problem formulation in this research, are (1) how is the representation of death ceremony stages in Puya Ke Puya novel by Faisal Oddang, (2) how are the meanings of death ceremony stages in Puya Ke Puya novel by Faisal Oddang. The method used in this research is descriptive method of analysis using literary anthropology approach. The source of data in this study is Puya Ke Puya novel by Faisal Oddang by concerning data quotations, sentences, as well as units of stories in the novel. Data found in this researh is processed through several stages, such as (1) collecting data, (2) classifying data, (3) data assessment, (4) drawing conclusion. The result of the analysis and discussion shows that in Puya Ke Puya novel by Faisal Oddang, it is found two processes of ceremonial stages and the meaning of process stages as representation of death tradition in Rambu Solo '. Death ceremony stages are (1) before death ceremony process and (2) during death ceremony process. Before the ceremony, there are several things that are need to be done and prepared by the family including holding big family meeting to determine when the Rambu Solo’ ceremony will be held, determining the level of death ceremony, preparing or buying buffaloes and pigs, preparing the necessary equipments. The next stage is the process of death ceremony. In this stage which includes Mappassulu ', Mangriu' Batu, Mapopengkaloa, Ma'pasonglo, Tau-tau, Lantang, Mappasilaga Tedong, Mantunu Tedong and ipalao. The meaning of Rambu Solo’ ceremony stage is a process of completion of died people so that they can get to puya. If it is not celebrated, thw aoul of died people will be stuck between heaven and earth in uncertain fate or become ghosts. It is also believed that it brings misfortune for families of died people. This is the belief of Toraja people

New solutions with accelerated expansion in string theory

We present concrete solutions with accelerated expansion in string theory, requiring a small, tractable list of stress energy sources. We explain how this construction (and others in progress) evades previous no go theorems for simple accelerating solutions. Our solutions respect an approximate scaling symmetry and realize discrete sequences of values for the equation of state, including one with an accumulation point at w=-1 and another accumulating near w=-1/3 from below. In another class of models, a density of defects generates scaling solutions with accelerated expansion. We briefly discuss potential applications to dark energy phenomenology, and to holography for cosmology.Comment: 37 pages, 1 figure. v2: comments and references adde

CMB lensing tomography with the DES science verification galaxies

We measure the cross-correlation between the galaxy density in the Dark Energy Survey (DES) Science Verification data and the lensing of the cosmic microwave background (CMB) as reconstructed with the Planck satellite and the South Pole Telescope (SPT). When using the DES main galaxy sample over the full redshift range 0.2 2σ) detections in all bins. Comparing to the fiducial Planck cosmology, we find the redshift evolution of the signal matches expectations, although the amplitude is consistently lower than predicted across redshift bins. We test for possible systematics that could affect our result and find no evidence for significant contamination. Finally, we demonstrate how these measurements can be used to constrain the growth of structure across cosmic time. We find the data are fit by a model in which the amplitude of structure in the z < 1.2 universe is 0.73 ± 0.16 times as large as predicted in the Λ cold dark matter Planck cosmology, a 1.7σ deviation

Cosmological lensing ratios with DES Y1, SPT and Planck

International audienceCorrelations between tracers of the matter density field and gravitational lensing are sensitive to the evolution of the matter power spectrum and the expansion rate across cosmic time. Appropriately defined ratios of such correlation functions, on the other hand, depend only on the angular diameter distances to the tracer objects and to the gravitational lensing source planes. Because of their simple cosmological dependence, such ratios can exploit available signal-to-noise ratio down to small angular scales, even where directly modelling the correlation functions is difficult. We present a measurement of lensing ratios using galaxy position and lensing data from the Dark Energy Survey, and CMB lensing data from the South Pole Telescope and Planck, obtaining the highest precision lensing ratio measurements to date. Relative to the concordance ΛCDM model, we find a best-fitting lensing ratio amplitude of A = 1.1 ± 0.1. We use the ratio measurements to generate cosmological constraints, focusing on the curvature parameter. We demonstrate that photometrically selected galaxies can be used to measure lensing ratios, and argue that future lensing ratio measurements with data from a combination of LSST and Stage-4 CMB experiments can be used to place interesting cosmological constraints, even after considering the systematic uncertainties associated with photometric redshift and galaxy shear estimation

Dark Energy Survey Year 1 Results:tomographic cross-correlations between DES galaxies and CMB lensing from SPT+Planck

International audienceWe measure the cross-correlation between redMaGiC galaxies selected from the Dark Energy Survey (DES) year 1 data and gravitational lensing of the cosmic microwave background (CMB) reconstructed from South Pole Telescope (SPT) and Planck data over 1289  deg2. When combining measurements across multiple galaxy redshift bins spanning the redshift range of 0.15<z<0.90, we reject the hypothesis of no correlation at 19.9σ significance. When removing small-scale data points where thermal Sunyaev-Zel’dovich signal and nonlinear galaxy bias could potentially bias our results, the detection significance is reduced to 9.9σ. We perform a joint analysis of galaxy-CMB lensing cross-correlations and galaxy clustering to constrain cosmology, finding Ωm=0.276-0.030+0.029 and S8=σ8Ωm/0.3=0.800-0.094+0.090. We also perform two alternate analyses aimed at constraining only the growth rate of cosmic structure as a function of redshift, finding consistency with predictions from the concordance ΛCDM model. The measurements presented here are part of a joint cosmological analysis that combines galaxy clustering, galaxy lensing and CMB lensing using data from DES, SPT and Planck