Addressing Xenophobia in the Equality Courts of South Africa

South African society bears a legacy of inequality and struggle against oppression. In the Constitutional era, our courts have held that the right to equality is a core fundamental value against which all law and state practice must be tested. South Africa’s Equality Courts have been heralded as a transformative mechanism for the redressing of systemic inequality and the promotion of the right to equality. Following the aftermath of the 2008 xenophobic attacks in South Africa, the University of Cape Town Refugee Law Clinic, on behalf of some of the victims of these attacks, launched equality claims against the South African Police Services in order to address the unfair discrimination and xenophobia of police officials in protecting these victims. This paper reviews the two matters launched by the Clinic in the Equality Courts, examining the challenges that effectively reduce the accessibility of the Equality Courts and the difficulty inherent in proving discrimination in equality claims, and commenting on the benefits of using these courts to address xenophobia.La société sud-africaine porte un héritage d’inégalité et de lutte contre l’oppression. Dans la période constitutionnelle, nos tribunaux ont statué que le droit à l’égalité était une valeur fondamentale, à la mesure de la quelle toute loi et pratique d’État doit être testée. Les Tribunaux de l’Égalité d’Afrique du Sud ont été salués en tant que mécanisme de transformation et de redressement des inégalités systémiques, et de la promotion du droit à l’ égalité. Suite aux conséquences des attaques xénophobes de 2008 en Afrique du Sud, la Clinique du Droit des Réfugiés de la University of Cape Town a lancé, au nom de certaines victimes de ces attaques, des revendications d’égalité à l’endroit des services de police sud-africains, dans le but de soulever le problème de l’attitude discriminatoire et xénophobe des officiers de police lors de la protection des victimes. Cet article examine les deux causes présentées par la Clinique aux Tribunaux de l’Égalité, les facteurs réduisant l’accès aux Tribunaux de l’Égalité, les difficultés de prouver la discrimination dans les revendications d’égalité, et évalue l’utilité de faire appel à ces tribunaux en matière de xénophobie

Answering Developmental Questions Using Secondary Data

Secondary data analysis of large longitudinal and national data sets is a standard method used in many social sciences to answer complex questions regarding behavior. In this article, we detail the advantages of using these data sets to study developmental questions across the life span. First, we provide an overview of how using secondary data can increase studies' scientific integrity. Then, we detail where and how data sets can be obtained that answer specific questions. Finally, we discuss methodological issues related to using longitudinal, population data sets. These data sets can enhance science and test theories by increasing the rigor and generalizability of research to the general population, making secondary data analysis an important method to consider.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115923/1/cdep12151.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/115923/2/cdep12151_am.pd

The Impact of Social Status on Levels of Psychological Well-Being: A Dynamic, Developmental Approach.

Our understanding regarding how social statuses interact with one another to impact psychological well-being is limited, and most available research typically ignores issues of development while focusing on the cross-section. In the aim of increasing our understanding on this matter, a developmental model was formulated – The Social Status/Vulnerable Period (SS/VP) model – that takes into account (1) when over the lifespan each social status typically impacts growth of well-being, (2) what proximal developmental changes underlie the timing of that impact, and (3) how distal factors moderate the impact of those proximal developmental changes. By exploring how race and sex status interact to impact psychological well-being across adolescence and early adulthood, the validity of the SS/VP model was examined. Using data from the Maryland Adolescent Growth in Context (MADICS) study (PI’s: J. Eccles & A. Sameroff) - a five-wave longitudinal study consisting of around 1,600 participants - a series of growth models and structural equation models were tested. During early adulthood, relative to European Americans, levels of depressive affect appear to be increasing among African Americans, and the differential growth across race was largely attributed to the differential impact of non-college attendance across the two races. Moreover, distal factors such as adolescent levels of social support, family income, and perceived discrimination all served to dampen this effect. In addition, the SS/VP model posits that two at-risk social statuses will compound (i.e. individuals with both at-risk statuses show especially low levels of psychological well-being) only if the two at-risk social statuses impact well-being during the same period of development. Consistent with the SS/VP model, findings suggest that the impact of European American and female status, which are both associated with deficits in psychological well-being during early adolescence, compound such that those individuals with both at-risk statuses show especially low levels of psychological well-being, and, this effect appears to manifest during early adolescence. Highlighting the need for a lifespan approach, it appears that the particular racial group at-risk for psychological well-being depends on the developmental period of focus. The implications of these findings for the SS/VP model and future directions for research are discussed.Ph.D.PsychologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/57680/2/jagerj_1.pd

Social Network Typologies of Black and White Married Couples in Midlife

Although research shows that conjoint social networks are associated with well‐being among newlyweds, little is known about how these network types are linked to marital quality and psychological well‐being for long‐term married couples and about potential race differences in their configurations and associations. Using a pattern‐centered approach to examine the social networks of 91 White and 62 Black couples in their 16th year of marriage, this study revealed four couple network types (friend‐focused, wife family‐focused, bilateral family‐focused, and diverse). Results suggested that spouses in the wife family‐focused network type (characterized by above‐average contact with the wife’s family and below average contact with the husband’s family and with nonkin) reported the lowest positive marital quality and highest negative marital quality. The association of network type with negative marital quality was also moderated by gender and race. The findings highlight the importance of considering the meaningful complexity within couples’ shared networks.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136463/1/jomf12330.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136463/2/jomf12330_am.pd

Defining a research agenda for layperson prehospital hemorrhage control: A consensus statement

Importance: Trauma is the leading cause of death for US individuals younger than 45 years, and uncontrolled hemorrhage is a major cause of trauma mortality. The US military\u27s medical advancements in the field of prehospital hemorrhage control have reduced battlefield mortality by 44%. However, despite support from many national health care organizations, no integrated approach to research has been made regarding implementation, epidemiology, education, and logistics of prehospital hemorrhage control by layperson immediate responders in the civilian sector.Objective: To create a national research agenda to help guide future work for prehospital hemorrhage control by laypersons.Evidence review: The 2-day, in-person, National Stop the Bleed (STB) Research Consensus Conference was conducted on February 27 to 28, 2019, to identify and achieve consensus on research gaps. Participants included (1) subject matter experts, (2) professional society-designated leaders, (3) representatives from the federal government, and (4) representatives from private foundations. Before the conference, participants were provided a scoping review on layperson prehospital hemorrhage control. A 3-round modified Delphi consensus process was conducted to determine high-priority research questions. The top items, with median rating of 8 or more on a Likert scale of 1 to 9 points, were identified and became part of the national STB research agenda.Findings: Forty-five participants attended the conference. In round 1, participants submitted 487 research questions. After deduplication and sorting, 162 questions remained across 5 a priori-defined themes. Two subsequent rounds of rating generated consensus on 113 high-priority, 27 uncertain-priority, and 22 low-priority questions. The final prioritized research agenda included the top 24 questions, including 8 for epidemiology and effectiveness, 4 for materials, 9 for education, 2 for global health, and 1 for health policy.Conclusions and relevance: The National STB Research Consensus Conference identified and prioritized a national research agenda to support laypersons in reducing preventable deaths due to life-threatening hemorrhage. Investigators and funding agencies can use this agenda to guide their future work and funding priorities

Diffuse X-Ray Emission from the Quiescent Superbubble M17, the Omega Nebula

The emission nebula M17 contains a young ~1 Myr-old open cluster; the winds from the OB stars of this cluster have blown a superbubble around the cluster. ROSAT observations of M17 detected diffuse X-ray emission peaking at the cluster and filling the superbubble interior. The young age of the cluster suggests that no supernovae have yet occurred in M17; therefore, it provides a rare opportunity to study hot gas energized solely by shocked stellar winds in a quiescent superbubble. We have analyzed the diffuse X-ray emission from M17, and compared the observed X-ray luminosity of ~2.5*10^33 ergs/s and the hot gas temperature of ~8.5*10^6 K and mass of ~1 M_Sun to model predictions. We find that bubble models with heat conduction overpredict the X-ray luminosity by two orders of magnitude; the strong magnetic fields in M17, as measured from HI Zeeman observations, have most likely inhibited heat conduction and associated mass evaporation. Bubble models without heat conduction can explain the X-ray properties of M17, but only if cold nebular gas can be dynamically mixed into the hot bubble interior and the stellar winds are clumpy with mass-loss rates reduced by a factor of >=3. Future models of the M17 superbubble must take into account the large-scale density gradient, small-scale clumpiness, and strong magnetic field in the ambient interstellar medium.Comment: 21 pages, 4 figures, to be published in the Astrophysical Journal, June 200

MS AHI1 genetic risk promotes IFNγ+ CD4+ T cells

Objective: To study the influence of the Abelson helper integration site 1 (AHI1) locus associated with MS susceptibility on CD4+ T cell function. Methods: We characterized the chromatin state of T cells in the MS-associated AHI1 linkage disequilibrium (LD) block. The expression and the role of the AHI1 variant were examined in T cells from genotyped healthy subjects who were recruited from the PhenoGenetic Project, and the function of AHI1 was explored using T cells from Ahi1 knockout mice. Results: Chromatin state analysis reveals that the LD block containing rs4896153, which is robustly associated with MS susceptibility (odds ratio 1.15, p = 1.65 × 10−13), overlaps with strong enhancer regions that are present in human naive and memory CD4+ T cells. Relative to the rs4896153A protective allele, the rs4896153T susceptibility allele is associated with decreased AHI1 mRNA expression, specifically in naive CD4+ T cells (p = 1.73 × 10−74, n = 213), and we replicate this effect in an independent set of subjects (p = 2.5 × 10−9, n = 32). Functional studies then showed that the rs4896153T risk variant and the subsequent decreased AHI1 expression were associated with reduced CD4+ T cell proliferation and a specific differentiation into interferon gamma (IFNγ)–positive T cells when compared with the protective rs4896153A allele. This T cell phenotype was also observed in murine CD4+ T cells with genetic deletion of Ahi1. Conclusions: Our findings suggest that the effect of the AHI1 genetic risk for MS is mediated, in part, by enhancing the development of proinflammatory IFNγ+ T cells that have previously been implicated in MS and its mouse models

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis

A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis

We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927 SNPs in 1618 MS cases and 3413 controls of European ancestry, we identified seven SNPs that were independently associated with MS conditional on the others (each ). All associations were significant in an independent replication cohort of 2212 cases and 2251 controls () and were highly significant in the combined dataset (). The associated SNPs included proxies for HLA-DRB1*15:01 and HLA-DRB1*03:01, and SNPs in moderate linkage disequilibrium (LD) with HLA-A*02:01, HLA-DRB1*04:01 and HLA-DRB1*13:03. We also found a strong association with rs9277535 in the class II gene HLA-DPB1 (discovery set , replication set , combined ). HLA-DPB1 is located centromeric of the more commonly typed class II genes HLA-DRB1, -DQA1 and -DQB1. It is separated from these genes by a recombination hotspot, and the association is not affected by conditioning on genotypes at DRB1, DQA1 and DQB1. Hence rs9277535 represents an independent MS-susceptibility locus of genome-wide significance. It is correlated with the HLA-DPB1*03:01 allele, which has been implicated previously in MS in smaller studies. Further genotyping in large datasets is required to confirm and resolve this association

International Society of Sports Nutrition Position Stand: Probiotics.

Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of probiotic supplementation to optimize the health, performance, and recovery of athletes. Based on the current available literature, the conclusions of the ISSN are as follows: 1)Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host (FAO/WHO).2)Probiotic administration has been linked to a multitude of health benefits, with gut and immune health being the most researched applications.3)Despite the existence of shared, core mechanisms for probiotic function, health benefits of probiotics are strain- and dose-dependent.4)Athletes have varying gut microbiota compositions that appear to reflect the activity level of the host in comparison to sedentary people, with the differences linked primarily to the volume of exercise and amount of protein consumption. Whether differences in gut microbiota composition affect probiotic efficacy is unknown.5)The main function of the gut is to digest food and absorb nutrients. In athletic populations, certain probiotics strains can increase absorption of key nutrients such as amino acids from protein, and affect the pharmacology and physiological properties of multiple food components.6)Immune depression in athletes worsens with excessive training load, psychological stress, disturbed sleep, and environmental extremes, all of which can contribute to an increased risk of respiratory tract infections. In certain situations, including exposure to crowds, foreign travel and poor hygiene at home, and training or competition venues, athletes' exposure to pathogens may be elevated leading to increased rates of infections. Approximately 70% of the immune system is located in the gut and probiotic supplementation has been shown to promote a healthy immune response. In an athletic population, specific probiotic strains can reduce the number of episodes, severity and duration of upper respiratory tract infections.7)Intense, prolonged exercise, especially in the heat, has been shown to increase gut permeability which potentially can result in systemic toxemia. Specific probiotic strains can improve the integrity of the gut-barrier function in athletes.8)Administration of selected anti-inflammatory probiotic strains have been linked to improved recovery from muscle-damaging exercise.9)The minimal effective dose and method of administration (potency per serving, single vs. split dose, delivery form) of a specific probiotic strain depends on validation studies for this particular strain. Products that contain probiotics must include the genus, species, and strain of each live microorganism on its label as well as the total estimated quantity of each probiotic strain at the end of the product's shelf life, as measured by colony forming units (CFU) or live cells.10)Preclinical and early human research has shown potential probiotic benefits relevant to an athletic population that include improved body composition and lean body mass, normalizing age-related declines in testosterone levels, reductions in cortisol levels indicating improved responses to a physical or mental stressor, reduction of exercise-induced lactate, and increased neurotransmitter synthesis, cognition and mood. However, these potential benefits require validation in more rigorous human studies and in an athletic population