A Face with a View

This thesis serves to examine my practice as a visual artist. In its contents I consider both the internal image and the external image and the constant negotiation that happens between these two sets of images. What comes to represent the internal is my own image, in particular, my face. What comes to represent the external are prevailing images of socially idealized beauty. Likewise, I argue that the face becomes especially important in this negotiation as it is the intersection between the internal and the external; the self and the social. Using artists such as Vito Acconci, Orlan, and Andy Warhol, as well as other thinkers such as Jean Baudrillard, Judith Butler, David Byrne, Amelia Jones, Carl Jung, Jacques Lacan, Susan Stewart, Kurt Vonnegut and Brian Wilson, I assert that what makes my artistic images powerful is simply my willingness to enact and display a kind of tangible struggle that is absent from these external images

Neural replay : a possible mechanism for differing rehersal strategies across parity

All mammalian females undergo behavioral and neurological changes during pregnancy and motherhood. Many of these changes lead to an enhanced ability to be an effective mother including: increased memory, foraging behaviors, and boldness. Here, we examined the differences in rehearsal strategies between mother and virgin rats. Stops made by rats when exploring their environment have been found to result in reverse replay activity in the hippocampus (Foster & Wilson, 2006). Reverse replay is sequential replay that occurs in the hippocampus immediately after a spatial experience; this replay/activation is in reversed order of the initial spatial episode (Foster & Wilson, 2006). Thus, rats are replaying the steps they have just taken. Here, animals were introduced into a linear track for 3 consecutive days. The number and duration of stops were recorded. We found that parous females made fewer stops compared to virgin females; however, they stopped for the same duration. Therefore, we propose that parous females may utilize reverse replay activation differently than virgin females

Editorial: From organisation to community?

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Effect of Reducing Mean Particle Sizeof Corn DDGS Using a Roller Mill or a Hammermillon Apparent Total Tract Digestibility of DM, GE, Nitrogen and NDF in Growing and Finishing Pigs

The aim of this studywas totest iffurther grinding of corn DDGS isadvantageous in terms of apparent total tract digestibility (ATTD) of DM, GE, nitrogen (N), and NDFingrowing and finishing pigs.It was also tested to determine if ATTD was different between hammermill and roller millgrinding methods.There were 3 diets. Each diet consisted of 51% corn ground at 500 microns with a roller mill, and 45% of corn DDGS ground at 450 microns using a hammermill, or 45% corn DDGS ground at 450 microns using a roller mill,or 45% of corn DDGS not further ground (unprocessed) at 650 microns.Results show thatparticle size reduction either with a roller mill or a hammermill (from 650 to 450 microns) increasedATTDof GE and DM of corn DDGS, tended to increase ATTD of N,but had no effect on ATTD of NDF. Finishing pigs had grater ATTD of GE and CP thangrowing pigs (tended to be greater for ATTD of DM). There were no effectsof growth stage in ATTD of NDF.There were no interactions betweenparticle size reduction and growth stage.In conclusion, reduction of particle size of corn DDGS (650 to 450 microns) either with a roller or with a hammermill has a beneficial effecton digestibilityof valuable dietary components in growing and finishing pigs

The Effectiveness of the School Nurse’s Role in Managing Chronic Illnesses

The purpose of this literature review was to understand the role and the importance of the school nurse within school systems. The role of the school nurse has gained attention due to the growing population of students with more severe illnesses. A foreground question was firstly created to support and lead this research project, “In school-aged children with chronic illnesses, what is the effect of having a school nurse to manage their conditions in comparison to not having a school nurse during their time at school?” The focus of the literature review was on the following chronic illness: Diabetes, Asthma, Sickle Cell Disease, Emergency Preparedness, and Bullying. In the literature findings revealed that student and nurse barriers impacted students’ overall health in school, both physiologically and psychosocially. Barriers found included: too large of a nurse to student ratio, no action care plans in place, reduced confidence and skill efficiency, failure to sufficiently advocate for self or students, missed opportunities for students due to chronic illness, little access to quality care, insufficient building of therapeutic relations, and little collaboration amongst other school professionals. Recommendations from the literature including making changes necessary to support the school nurse to ensure proper management of chronic illnesses, such as increased financial means for necessary resources and nurse benefits, further enhanced education and training to support best patient outcomes, and cohesiveness in care established through the creation of standardized care guidelines and a school nurse union. These subtle improvements would positively impact the quality of care, livelihood of children with chronic disease, and the school nurses providing care

Increasing access to CBT for psychosis patients: a feasibility, randomised controlled trial evaluating brief, targeted CBT for distressing voices delivered by assistant psychologists (GiVE2)

Background: The National Institute for Health and Care Excellence (NICE) recommends that Cognitive Behaviour Therapy for psychosis (CBTp) is offered to all patients with a psychosis diagnosis. However, only a minority of psychosis patients in England and Wales are offered CBTp. This is attributable, in part, to the resource-intensive nature of CBTp. One response to this problem has been the development of CBTp in brief formats that are targeted at a single symptom and the mechanisms that maintain distress. We have developed a brief form of CBTp for distressing voices and reported preliminary evidence for its effectiveness when delivered by highly trained therapists (clinical psychologists). This study will investigate the delivery of this intervention by a cost-effective workforce of assistant psychologists following a brief training and evaluate the acceptability and feasibility of conducting a future, definitive, randomised controlled trial (RCT). Methods: This is a feasibility study for a pragmatic, three-arm, parallel-group, superiority 1:1:1 RCT comparing a Guided self-help CBT intervention for voices and treatment as usual (GiVE) to Supportive Counselling and treatment as usual (SC) to treatment as usual alone (TAU), recruiting across two sites, with blinded post-treatment and follow-up assessments. A process evaluation will quantitatively and qualitatively explore stakeholder experience. Discussion: Expected outcomes will include an assessment of the feasibility of conducting a definitive RCT, and data to inform the calculation of its sample size. If evidence from a subsequent, fully powered RCT suggests that GiVE is clinically and cost-effective when delivered by briefly trained assistant psychologists, CBTp offered in these less resource-intensive forms has the potential to generate benefits for individual patients (reduced distress, enhanced recovery and enhanced quality of life), service-level patient benefit (increased access to evidence-based psychological therapies) and economic benefits to the NHS (in terms of the reduced use of mental health inpatient services). Trial registration: Current Controlled Trials, ISRCTN registration number: 16166070. Registered on 5 February 2019

The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis

Summary: Expression of the initiator methionine tRNA (tRNAi Met) is deregulated in cancer. Despite this fact, it is not currently known how tRNAi Met expression levels influence tumor progression. We have found that tRNAi Met expression is increased in carcinoma-associated fibroblasts, implicating deregulated expression of tRNAi Met in the tumor stroma as a possible contributor to tumor progression. To investigate how elevated stromal tRNAi Met contributes to tumor progression, we generated a mouse expressing additional copies of the tRNAi Met gene (2+tRNAi Met mouse). Growth and vascularization of subcutaneous tumor allografts was enhanced in 2+tRNAi Met mice compared with wild-type littermate controls. Extracellular matrix (ECM) deposited by fibroblasts from 2+tRNAi Met mice supported enhanced endothelial cell and fibroblast migration. SILAC mass spectrometry indicated that elevated expression of tRNAi Met significantly increased synthesis and secretion of certain types of collagen, in particular type II collagen. Suppression of type II collagen opposed the ability of tRNAi Metoverexpressing fibroblasts to deposit pro-migratory ECM. We used the prolyl hydroxylase inhibitor ethyl- 3,4-dihydroxybenzoate (DHB) to determine whether collagen synthesis contributes to the tRNAi Met-driven pro-tumorigenic stroma in vivo. DHB had no effect on the growth of syngeneic allografts in wild-type mice but opposed the ability of 2+tRNAi Met mice to support increased angiogenesis and tumor growth. Finally, collagen II expression predicts poor prognosis in high-grade serous ovarian carcinoma. Taken together, these data indicate that increased tRNAi Met levels contribute to tumor progression by enhancing the ability of stromal fibroblasts to synthesize and secrete a type II collagen-rich ECM that supports endothelial cell migration and angiogenesis

The Grizzly, November 21, 2002

Well-known Political Consultant Mark Moskowitz at Ursinus • Greek Organizations Come Together for GPC Activities Fair • Too Big for our Buildings • Eye on Your Future: Internships • \u27Tis the Season to Ignore the Needy? • Do You Care About Political Apathy? • Should a Minor Receive the Death Penalty? • Opinions: Feeling Uninvited in Your Own Home; Smoking or Non? You Decide; 17-Year-Old Could be Tried as Adult • Be a Film Society Member • Howard, Roesch Look to Lead Wrestling to C.C. Championship • On Your Mark...Indoor Track Ready to Go • Dougherty Rockets Off to National Meethttps://digitalcommons.ursinus.edu/grizzlynews/1526/thumbnail.jp

Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy.

TRACK-HD is a multicentre longitudinal observational study investigating the use of clinical assessments and 3-Tesla magnetic resonance imaging as potential biomarkers for future therapeutic trials in Huntington's disease (HD). The cross-sectional data from this large well-characterized dataset provide the opportunity to improve our knowledge of how the underlying neuropathology of HD may contribute to the clinical manifestations of the disease across the spectrum of premanifest (PreHD) and early HD. Two hundred and thirty nine gene-positive subjects (120 PreHD and 119 early HD) from the TRACK-HD study were included. Using voxel-based morphometry (VBM), grey and white matter volumes were correlated with performance in four domains: quantitative motor (tongue force, metronome tapping, and gait); oculomotor [anti-saccade error rate (ASE)]; cognition (negative emotion recognition, spot the change and the University of Pennsylvania smell identification test) and neuropsychiatric measures (apathy, affect and irritability). After adjusting for estimated disease severity, regionally specific associations between structural loss and task performance were found (familywise error corrected, P < 0.05); impairment in tongue force, metronome tapping and ASE were all associated with striatal loss. Additionally, tongue force deficits and ASE were associated with volume reduction in the occipital lobe. Impaired recognition of negative emotions was associated with volumetric reductions in the precuneus and cuneus. Our study reveals specific associations between atrophy and decline in a range of clinical modalities, demonstrating the utility of VBM correlation analysis for investigating these relationships in HD

Does the source migration pathway of HBCDs to household dust influence their bioaccessibility?

A study was conducted to assess the human bioaccessibility of dust contaminated with hexabromocyclododecane (HBCD) via two migration pathways a) volatilisation with subsequent partitioning to dust particles, and b) abrasion of treated textile fibres directly to the dust. This was achieved using previously developed experimental chamber designs to generate dust samples contaminated with HBCDs emit-ted from a HBCD treated textile curtain. The generated dust samples were exposed to an in vitro colon extended physiologically based extraction test (CE-PBET). The bioaccessibility of the HBCDs which were incorporated within dust as a result of volatilisation from the curtain material with subsequent partitioning to dust was higher than in dusts contaminated with HBCDs via abrasion of the curtain (35% and 15% respectively). We propose this occurs due to a stronger binding of HBCDs to treated fabric fibres than that experienced following volatilisation and sorption of HBCDs to dust particles