Preparing pseudo-pure states with controlled-transfer gates

The preparation of pseudo-pure states plays a central role in the implementation of quantum information processing in high temperature ensemble systems, such as nuclear magnetic resonance. Here we describe a simple approach based on controlled-transfer gates which permits pseudo-pure states to be prepared efficiently using spatial averaging techniques.Comment: Significantly revised and extended: now 7 pages including 3 figures; Phys. Rev. A (in press

Plan of Alexander, No. 16

Blue print copy of properties of Plan of Alexander (previously Township No. 16). The map includes no scale. Handwritten caption reads: “The black dotted lines were run by B. R. Jones in 1807 & 8. The principal line were then run ten degrees to the left of the cardinal points. At present (1842) the same lines range eight degrees to the left of said points by the magnet. Dennysville, March 15, 1842 (signed) Benj. R. Jones. Copied by R. V. H. Sept. 16, 1843. B.E.G. May 31, 1901. From Gardner Family Papers, 1830-1939. John Gardner (1801-1888), was the principal surveyor in Calais, Maine. His son, Benjamin E. Gardner (1869-1939), a civil engineer and land surveyor took over for his father and worked most frequently with local attorneys doing land title research.https://digitalcommons.library.umaine.edu/mainebicentennial/1031/thumbnail.jp

RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1

Ribonucleases are critically important in many cellular and developmental processes and defects in their expression are associated with human disease. Pacman/XRN1 is a highly conserved cytoplasmic exoribonuclease which degrades RNAs in a 5' - 3' direction. In Drosophila, null mutations in pacman result in small imaginal discs, a delay in onset of pupariation and lethality during the early pupal stage. In this paper, we have used RNA-seq in a genome-wide search for mRNAs misregulated in pacman null wing imaginal discs. Only 4.2% of genes are misregulated ±>2-fold in pacman null mutants compared to controls, in line with previous work showing that Pacman has specificity for particular mRNAs. Further analysis of the most upregulated mRNAs showed that Pacman post-transcriptionally regulates the expression of the secreted insulin-like peptide Dilp8. Dilp8 is related to human IGF-1, and has been shown to co-ordinate tissue growth with developmental timing in Drosophila. The increased expression of Dilp8 is consistent with the developmental delay seen in pacman null mutants. Our analysis, together with our previous results, show that the normal role of this exoribonuclease in imaginal discs is to suppress the expression of transcripts that are crucial in apoptosis and growth control during normal development

Schemes for Parallel Quantum Computation Without Local Control of Qubits

Typical quantum computing schemes require transformations (gates) to be targeted at specific elements (qubits). In many physical systems, direct targeting is difficult to achieve; an alternative is to encode local gates into globally applied transformations. Here we demonstrate the minimum physical requirements for such an approach: a one-dimensional array composed of two alternating 'types' of two-state system. Each system need be sensitive only to the net state of its nearest neighbors, i.e. the number in state 1 minus the number in state 2. Additionally, we show that all such arrays can perform quite general parallel operations. A broad range of physical systems and interactions are suitable: we highlight two potential implementations.Comment: 12 pages + 3 figures. Several small corrections mad

Resource allocation for Lagrangian tracking

Author Posting. © American Meteorological Society, 2016. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Atmospheric and Oceanic Technology 33 (2016): 1225-1235, doi:10.1175/JTECH-D-15-0115.1.Accurate estimation of the transport probabilities among regions in the ocean provides valuable information for understanding plankton transport, the spread of pollutants, and the movement of water masses. Individual-based particle-tracking models simulate a large ensemble of Lagrangian particles and are a common method to estimate these transport probabilities. Simulating a large ensemble of Lagrangian particles is computationally expensive, and appropriately allocating resources can reduce the cost of this method. Two universal questions in the design of studies that use Lagrangian particle tracking are how many particles to release and how to distribute particle releases. A method is presented for tailoring the number and the release location of particles to most effectively achieve the objectives of a study. The method detailed here is a sequential analysis procedure that seeks to minimize the number of particles that are required to satisfy a predefined metric of result quality. The study assesses the result quality as the precision of the estimates for the elements of a transport matrix and also describes how the method may be extended for use with other metrics. Applying this methodology to both a theoretical system and a particle transport model of the Gulf of Maine results in more precise estimates of the transport probabilities with fewer particles than from uniformly or randomly distributing particle releases. The application of this method can help reduce the cost of and increase the robustness of results from studies that use Lagrangian particles.This research was supported by the Department of Defense (DoD) through the National Defense Science and Engineering Graduate Fellowship (NDSEG) program and the National Science Foundation through Grant OCE-1459133 and Grant OCE-1031256.2016-12-0

Engineering a Fluorescent Calmodulin for Use in Complex Models of Cardiac Physiology

Calmodulin (CaM) is a ubiquitously expressed calcium-binding protein that plays a critical role in cardiac physiology. CaM senses intracellular Ca2+ changes by binding the Ca2+ ion with one of its four calcium-binding loops, causing a conformational change in the CaM protein structure, and thereby affecting CaM’s affinity for its multiple intracellular protein targets. Since Ca2+ transients rise and fall in the heart on a beat-to-beat basis, an understanding of the kinetics of CaM-Ca2+ binding and dissociation events are essential for studying how cardiac systems are regulated. Isolated CaM kinetic experiments have described CaM behavior in controlled solutions, but aren’t directly applicable to the protein’s complex physiological environment. We employed site-directed mutagenesis to generate three CaM mutants with Threonine to Cysteine substitutions at residues 5, 34, and 44 (T5C, T34C, T44C). A fluorescent probe (IAANS) was covalently linked to the introduced Cysteine residue. These fluorescent Calmodulin proteins have a unique fluorescent behavior that differentiates them from any intrinsic (Tryptophan, Phenylalanine, Tyrosine) fluorescent signals. We demonstrate that two of these proteins (T5C, T34C) have fluorescent behavior that closely mimics that of WT CaM in the presence of representative peptide fragments of Myosin Light Chain Kinase (RS-20), Neural Nitric Oxide Synthase (nNOS), Calcineurin (CaN), and CaM-dependent Kinase II (CKII). Thus, T5C or T34C CaM labeled with IAANS has unique fluorescent properties without drastically affecting the behavior of the CaM protein. These fluorescent proteins give researchers the freedom to study CaM kinetic characteristics in the presence of enzymes regulated by CaM, allowing for more research with direct relevance to physiological pathways.No embarg

Rapport från arbetsgrupp för att utarbeta system för administration av landskapet Ålands stöd ur EU:s landsbygdsfond (EJFLU) för kommande programperiod

Jord- och skogsbruksministeriet tillsatte den 7.4.2006 en arbetsgrupp för att utarbeta ett system för administration av landskapet Ålands stöd ur EU:s landsbygdsfond (EJFLU) för programperioden 2007-2013. Arbetsgruppens uppgift har varit att utreda hur koordineringen av administrationen av rikets och Ålands landsbygdsutvecklingsprogram skall organiseras under nästa programperiod samt att utreda vissa särskilda implementeringsfrågor tillhörande miljö- och LFA-stödens tilläggsdelar. Arbetsgruppen har i sitt arbete konstaterat att en fortsättning och en utveckling av det administrationssystem och samarbete som utarbetades mellan jord- och skogsbruksministeriet och Ålands landskapsregering för programperioden 2000-2006 är den mest ändamålsenliga lösningen som grund för landskapsregeringens administrationssystem för perioden 2007-2013. Arbetsgruppens huvuduppgift har därför varit att utarbeta ett förslag till ny överenskommelseförordning och avtal mellan jord- och skogsbruksministeriet som reglerar detta administrationssystem. Arbetsgruppen utarbetade förslaget så att en ny överenskommelseförordningen har utfärdats av republikens president och trätt i kraft den 16.10.2006. (881/2006). Förordningen har bifogats i rapporten. Avtal mellan jord- och skogsbruksministeriet och Ålands landskapsregering om överförande av skötseln av vissa förvaltningsuppgifter till Ålands landskapsregering har undertecknats av parterna under hösten 2006. Avtalet har bifogats i rapporten. Arbetsgruppen föreslog att landskapet administrerar fr.o.m. 2007 under kvarvarande åren de avtal som jord- och skogsbruksministeriet ingått med åländska jordbrukare under åren 2004-2006 gällande miljö- och LFA-stödens nationella tilläggsdelar samt nya avtal om LFA-stödens nationella tilläggsdelar. Avtalen hör till landskapets behörighet som konsekvens av behörighetsarbetsgruppens arbete som redovisades i jord- och skogsbruksministeriets arbetsgruppspromemoria 2006:2. Arbetsgruppen föreslår vidare att parterna överenskommer om de praktiska frågorna kring implementeringsprocessen av tilläggsdelarna vid överflyttandet såsom redovisning till kommissionen, återkrav och tilläggsbetalningar i ett avtal. Arbetsgruppen föreslår att nuvarande stödövervakningssamarbete formaliseras i en lämplig form där vardera partens ansvar regleras gentemot den andra parten. Arbetsgruppens förslår att arbetet med att formalisera arbetet går vidare utanför arbetsgruppens ansvar på initiativ av Ålands landskapsregering. Gällande ett ytterligare utökat administrationssamarbete anser arbetsgruppen att arbetet förtjänar ett eget utredningsuppdrag på initiativ av Ålands landskapsregering och att man i utredningen bör involvera alla på Åland berörda parter. Dessutom föreslår arbetsgruppen att landskapsregeringen deltar i samarbetet och utbytet inom landsbygdsnätverket i den mån det är möjligt av språkliga skäl. Landskapsregeringen ersätter nätverket enbart för tjänster och uppdrag som nätverket utför specifikt för landskapsregeringens del. Arbetsgruppen anser ytterligare att landskapsregeringen skall vara representerad i den nationella koordinationsgruppen och att koordinationsgruppens eventuella rekommendationer är rådgivande inom landskapet på grund av behörighetsfördelningen. Dessutom gjordes förslag om ersättningen av kostnader som uppstår vid utförande av olika uppgifter