Speaker-normalized sound representations in the human auditory cortex

The acoustic dimensions that distinguish speech sounds (like the vowel differences in “boot” and “boat”) also differentiate speakers’ voices. Therefore, listeners must normalize across speakers without losing linguistic information. Past behavioral work suggests an important role for auditory contrast enhancement in normalization: preceding context affects listeners’ perception of subsequent speech sounds. Here, using intracranial electrocorticography in humans, we investigate whether and how such context effects arise in auditory cortex. Participants identified speech sounds that were preceded by phrases from two different speakers whose voices differed along the same acoustic dimension as target words (the lowest resonance of the vocal tract). In every participant, target vowels evoke a speaker-dependent neural response that is consistent with the listener’s perception, and which follows from a contrast enhancement model. Auditory cortex processing thus displays a critical feature of normalization, allowing listeners to extract meaningful content from the voices of diverse speakers

Combining remotely sensed and other measurements for hydrologic areal averages

A method is described for combining measurements of hydrologic variables of various sampling geometries and measurement accuracies to produce an estimated mean areal value over a watershed and a measure of the accuracy of the mean areal value. The method provides a means to integrate measurements from conventional hydrological networks and remote sensing. The resulting areal averages can be used to enhance a wide variety of hydrological applications including basin modeling. The correlation area method assigns weights to each available measurement (point, line, or areal) based on the area of the basin most accurately represented by the measurement. The statistical characteristics of the accuracy of the various measurement technologies and of the random fields of the hydrologic variables used in the study (water equivalent of the snow cover and soil moisture) required to implement the method are discussed

Electrostatic-field and surface-shape similarity for virtual screening and pose prediction.

We introduce a new method for rapid computation of 3D molecular similarity that combines electrostatic field comparison with comparison of molecular surface-shape and directional hydrogen-bonding preferences (called "eSim"). Rather than employing heuristic "colors" or user-defined molecular feature types to represent conformation-dependent molecular electrostatics, eSim calculates the similarity of the electrostatic fields of two molecules (in addition to shape and hydrogen-bonding). We present detailed virtual screening performance data on the standard 102 target DUD-E set. In its moderately fast screening mode, eSim running on a single computing core is capable of processing over 60 molecules per second. In this mode, eSim performed significantly better than all alternate methods for which full DUD-E data were available (mean ROC area of 0.74, p [Formula: see text], by paired t-test, compared with the best performing alternate method). In addition, for 92 targets of the DUD-E set where multiple ligand-bound crystal structures were available, screening performance was assessed using alternate ligands or sets thereof (in their bound poses) as similarity targets. Using the joint alignment of five ligands for each protein target, mean ROC area exceeded 0.82 for the 92 targets. Design-focused application of ligand similarity methods depends on accurate predictions of geometric molecular relationships. We comprehensively assessed pose prediction accuracy by curating nearly 400,000 bound ligand pose pairs across the DUD-E targets. Overall, beginning from agnostic initial poses, we observed an 80% success rate for RMSD [Formula: see text] Å  among the top 20 predicted eSim poses. These examples were split roughly 50/50 into cases with high direct atomic overlap (where a shared scaffold exists between a pair) and low direct atomic overlap (where where a ligand pair has dissimilar scaffolds but largely occupies the same space). Within the high direct atomic overlap subset, the pose prediction success rate was 93%. For the more challenging subset (where dissimilar scaffolds are to be aligned), the success rate was 70%. The eSim approach enables both large-scale screening and rational design of ligands and is rooted in physically meaningful, non-heuristic, molecular comparisons

Strategies for using remotely sensed data in hydrologic models

Present and planned remote sensing capabilities were evaluated. The usefulness of six remote sensing capabilities (soil moisture, land cover, impervious area, areal extent of snow cover, areal extent of frozen ground, and water equivalent of the snow cover) with seven hydrologic models (API, CREAMS, NWSRFS, STORM, STANFORD, SSARR, and NWSRFS Snowmelt) were reviewed. The results indicate remote sensing information has only limited value for use with the hydrologic models in their present form. With minor modifications to the models the usefulness would be enhanced. Specific recommendations are made for incorporating snow covered area measurements in the NWSRFS Snowmelt model. Recommendations are also made for incorporating soil moisture measurements in NWSRFS. Suggestions are made for incorporating snow covered area, soil moisture, and others in STORM and SSARR. General characteristics of a hydrologic model needed to make maximum use of remotely sensed data are discussed. Suggested goals for improvements in remote sensing for use in models are also established

Enthalpy and stagnation temperature determination of a high temperature laminar flow gas stream Patent

Measuring conductive heat flow and thermal conductivity of laminar gas stream in cylindrical plug to simulate atmospheric reentr

Molecular-Kinetic Simulations of Escape from the Ex-planet and Exoplanets: Criterion for Transonic Flow

The equations of gas dynamics are extensively used to describe atmospheric loss from solar system bodies and exoplanets even though the boundary conditions at infinity are not uniquely defined. Using molecular-kinetic simulations that correctly treat the transition from the continuum to the rarefied region, we confirm that the energy-limited escape approximation is valid when adiabatic expansion is the dominant cooling process. However, this does not imply that the outflow goes sonic. In fact in the sonic regime, the energy limited approximation can significantly under estimate the escape rate. Rather large escape rates and concomitant adiabatic cooling can produce atmospheres with subsonic flow that are highly extended. Since this affects the heating rate of the upper atmosphere and the interaction with external fields and plasmas, we give a criterion for estimating when the outflow goes transonic in the continuum region. This is applied to early terrestrial atmospheres, exoplanet atmospheres, and the atmosphere of the ex-planet, Pluto, all of which have large escape rates. The paper and its erratum, combined here, are published: ApJL 768, L4 (2013); ApJ, 779, L30 (2013).Comment: 11 pages, 3 figure

The History of the Mysterious Eclipses of KH 15D: Asiago Observatory, 1967-1982

We are gathering archival observations to determine the photometric history of the unique and unexplained eclipses of the pre-main-sequence star KH 15D. Here we present a light curve from 1967-1982, based on photographic plates from Asiago Observatory. During this time, the system alternated periodically between bright and faint states, as observed today. However, the bright state was 0.9 mag brighter than the modern value, and the fractional variation between bright and faint states (Delta I = 0.7 mag) was smaller than observed today (3.5 mag). A possible explanation for these findings is that the system contains a second star that was previously blended with the eclipsing star, but is now completely obscured.Comment: Accepted to AJ. 24 pages, 10 figures, 2 tables. v2: Phase error corrected in figures 8 and 1

The Symbolic Dynamics Of Multidimensional Tiling Systems

We prove a multidimensional version of the theorem that every shift of finite type has a power that can be realized as the same power of a tiling system. We also show that the set of entropies of tiling systems equals the set of entropies of shifts of finite type