116 research outputs found
Microscopic Realization of the Kerr/CFT Correspondence
Supersymmetric M/string compactifications to five dimensions contain BPS
black string solutions with magnetic graviphoton charge P and near-horizon
geometries which are quotients of AdS_3 x S^2. The holographic duals are
typically known 2D CFTs with central charges c_L=c_R=6P^3 for large P. These
same 5D compactifications also contain non-BPS but extreme Kerr-Newman black
hole solutions with SU(2)_L spin J_L and electric graviphoton charge Q obeying
Q^3 \leq J_L^2. It is shown that in the maximally charged limit Q^3 -> J_L^2,
the near-horizon geometry coincides precisely with the right-moving temperature
T_R=0 limit of the black string with magnetic charge P=J_L^{1/3}. The known
dual of the latter is identified as the c_L=c_R=6J_L CFT predicted by the
Kerr/CFT correspondence. Moreover, at linear order away from maximality, one
finds a T_R \neq 0 quotient of the AdS_3 factor of the black string solution
and the associated thermal CFT entropy reproduces the linearly sub-maximal
Kerr-Newman entropy. Beyond linear order, for general Q^3<J_L^2, one has a
finite-temperature quotient of a warped deformation of the magnetic string
geometry. The corresponding dual deformation of the magnetic string CFT
potentially supplies, for the general case, the c_L=c_R=6J_L CFT predicted by
Kerr/CFT.Comment: 18 pages, no figure
State-space Manifold and Rotating Black Holes
We study a class of fluctuating higher dimensional black hole configurations
obtained in string theory/ -theory compactifications. We explore the
intrinsic Riemannian geometric nature of Gaussian fluctuations arising from the
Hessian of the coarse graining entropy, defined over an ensemble of brane
microstates. It has been shown that the state-space geometry spanned by the set
of invariant parameters is non-degenerate, regular and has a negative scalar
curvature for the rotating Myers-Perry black holes, Kaluza-Klein black holes,
supersymmetric black holes, - configurations and the
associated BMPV black holes. Interestingly, these solutions demonstrate that
the principal components of the state-space metric tensor admit a positive
definite form, while the off diagonal components do not. Furthermore, the ratio
of diagonal components weakens relatively faster than the off diagonal
components, and thus they swiftly come into an equilibrium statistical
configuration. Novel aspects of the scaling property suggest that the
brane-brane statistical pair correlation functions divulge an asymmetric
nature, in comparison with the others. This approach indicates that all above
configurations are effectively attractive and stable, on an arbitrary
hyper-surface of the state-space manifolds. It is nevertheless noticed that
there exists an intriguing relationship between non-ideal inter-brane
statistical interactions and phase transitions. The ramifications thus
described are consistent with the existing picture of the microscopic CFTs. We
conclude with an extended discussion of the implications of this work for the
physics of black holes in string theory.Comment: 44 pages, Keywords: Rotating Black Holes; State-space Geometry;
Statistical Configurations, String Theory, M-Theory. PACS numbers: 04.70.-s
Physics of black holes; 04.70.Bw Classical black holes; 04.70.Dy Quantum
aspects of black holes, evaporation, thermodynamics; 04.50.Gh
Higher-dimensional black holes, black strings, and related objects. Edited
the bibliograph
What we talk about when we talk about "global mindset": managerial cognition in multinational corporations
Recent developments in the global economy and in multinational corporations have placed significant emphasis on the cognitive orientations of managers, giving rise to a number of concepts such as “global mindset” that are presumed to be associated with the effective management of multinational corporations (MNCs). This paper reviews the literature on global mindset and clarifies some of the conceptual confusion surrounding the construct. We identify common themes across writers, suggesting that the majority of studies fall into one of three research perspectives: cultural, strategic, and multidimensional. We also identify two constructs from the social sciences that underlie the perspectives found in the literature: cosmopolitanism and cognitive complexity and use these two constructs to develop an integrative theoretical framework of global mindset. We then provide a critical assessment of the field of global mindset and suggest directions for future theoretical and empirical research
Patient-defined desired outcome, success criteria, and expectation in outpatient physical therapy: a longitudinal assessment
Ischemia-Reperfusion Injury Leads to Distinct Temporal Cardiac Remodeling in Normal versus Diabetic Mice
Diabetes is associated with higher incidence of myocardial infarction (MI) and increased propensity for subsequent events post-MI. Here we conducted a temporal analysis of the influence of diabetes on cardiac dysfunction and remodeling after ischemia reperfusion (IR) injury in mice. Diabetes was induced using streptozotocin and IR performed by ligating the left anterior descending coronary artery for 30 min followed by reperfusion for up to 42 days. We first evaluated changes in cardiac function using echocardiography after 24 hours reperfusion and observed IR injury significantly decreased the systolic function, such as ejection fraction, fractional shortening and end systolic left ventricular volume (LVESV) in both control and diabetic mice. The longitudinal systolic and diastolic strain rate were altered after IR, but there were no significant differences between diabetic mice and controls. However, a reduced ability to metabolize glucose was observed in the diabetic animals as determined by PET-CT scanning using 2-deoxy-2-(18F)fluoro-D-glucose. Interestingly, after 24 hours reperfusion diabetic mice showed a reduced infarct size and less apoptosis indicated by TUNEL analysis in heart sections. This may be explained by increased levels of autophagy detected in diabetic mice hearts. Similar increases in IR-induced macrophage infiltration detected by CD68 staining indicated no change in inflammation between control and diabetic mice. Over time, control mice subjected to IR developed mild left ventricular dilation whereas diabetic mice exhibited a decrease in both end diastolic left ventricular volume and LVESV with a decreased intraventricular space and thicker left ventricular wall, indicating concentric hypertrophy. This was associated with marked increases in fibrosis, indicted by Masson trichrome staining, of heart sections in diabetic IR group. In summary, we demonstrate that diabetes principally influences distinct IR-induced chronic changes in cardiac function and remodeling, while a smaller infarct size and elevated levels of autophagy with similar cardiac function are observed in acute phase
Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing
Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a major obstacle to curing HIV infection. Pharmacological activation of HIV expression in latently infected cells is being explored as one of the strategies to deplete the latent HIV reservoir. In this study, we characterized the ability of romidepsin (RMD), a histone deacetylase inhibitor approved for the treatment of T-cell lymphomas, to activate the expression of latent HIV. In an in vitro T-cell model of HIV latency, RMD was the most potent inducer of HIV (EC50 = 4.5 nM) compared with vorinostat (VOR; EC50 = 3,950 nM) and other histone deacetylase (HDAC) inhibitors in clinical development including panobinostat (PNB; EC50 = 10 nM). The HIV induction potencies of RMD, VOR, and PNB paralleled their inhibitory activities against multiple human HDAC isoenzymes. In both resting and memory CD4 T cells isolated from HIV-infected patients on suppressive combination antiretroviral therapy (cART), a 4-hour exposure to 40 nM RMD induced a mean 6-fold increase in intracellular HIV RNA levels, whereas a 24-hour treatment with 1 μM VOR resulted in 2- to 3-fold increases. RMD-induced intracellular HIV RNA expression persisted for 48 hours and correlated with sustained inhibition of cell-associated HDAC activity. By comparison, the induction of HIV RNA by VOR and PNB was transient and diminished after 24 hours. RMD also increased levels of extracellular HIV RNA and virions from both memory and resting CD4 T-cell cultures. The activation of HIV expression was observed at RMD concentrations below the drug plasma levels achieved by doses used in patients treated for T-cell lymphomas. In conclusion, RMD induces HIV expression ex vivo at concentrations that can be achieved clinically, indicating that the drug may reactivate latent HIV in patients on suppressive cART
Route knowledge and configural knowledge in typical and atypical development: a comparison of sparse and rich environments
Background:
Individuals with Down syndrome (DS) and individuals with Williams syndrome (WS) have poor
navigation skills, which impact their potential to become independent. Two aspects of navigation were investigated
in these groups, using virtual environments (VE): route knowledge (the ability to learn the way from A to B by
following a fixed sequence of turns) and configural knowledge (knowledge of the spatial relationships between
places within an environment).
Methods:
Typically developing (TD) children aged 5 to 11 years (N = 93), individuals with DS (N = 29) and individuals
with WS (N = 20) were presented with a sparse and a rich VE grid maze. Within each maze, participants were asked to
learn a route from A to B and a route from A to C before being asked to find a novel shortcut from B to C.
Results:
Performance was broadly similar across sparse and rich mazes. The majority of participants were able to learn
novel routes, with poorest performance in the DS group, but the ability to find a shortcut, our measure of configural knowledge, was limited for all three groups. That is, 59 % TD participants successfully found a shortcut, compared to 10 % participants with DS and 35 % participants with WS. Differences in the underlying mechanisms associated with route knowledge and configural knowledge and in the developmental trajectories of performance across groups were observed. Only the TD participants walked a shorter distance in the last shortcut trial compared to the first, indicative of
increased configural knowledge across trials. The DS group often used an alternative strategy to get from B to C, summing the two taught routes together.
Conclusions:
Our findings demonstrate impaired configural knowledge in DS and in WS, with the strongest deficit in DS. This suggests that these groups rely on a rigid route knowledge based method for navigating and as a result are
likely to get lost easily. Route knowledge was also impaired in both DS and WS groups and was related to different underlying processes across all three groups. These are discussed with reference to limitations in attention and/or visuo-spatial processing in the atypical groups
Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies
Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons
Abortive Autophagy Induces Endoplasmic Reticulum Stress and Cell Death in Cancer Cells
Autophagic cell death or abortive autophagy has been proposed to eliminate damaged as well as cancer cells, but there remains a critical gap in our knowledge in how this process is regulated. The goal of this study was to identify modulators of the autophagic cell death pathway and elucidate their effects on cellular signaling and function. The result of our siRNA library screenings show that an intact coatomer complex I (COPI) is obligatory for productive autophagy. Depletion of COPI complex members decreased cell survival and impaired productive autophagy which preceded endoplasmic reticulum stress. Further, abortive autophagy provoked by COPI depletion significantly altered growth factor signaling in multiple cancer cell lines. Finally, we show that COPI complex members are overexpressed in an array of cancer cell lines and several types of cancer tissues as compared to normal cell lines or tissues. In cancer tissues, overexpression of COPI members is associated with poor prognosis. Our results demonstrate that the coatomer complex is essential for productive autophagy and cellular survival, and thus inhibition of COPI members may promote cell death of cancer cells when apoptosis is compromised
- …