620 research outputs found
Constraints on chiral operators in N=2 SCFTs
Open Access, © The Authors. Article funded by SCOAP3.
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The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases.
The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality. The molecular pathways involved in their pathogenesis are complex and despite intensive investigations have not been fully elucidated. Whereas chronic inflammatory cell infiltration is universally present in fibrotic lesions, the central role of monocytes and macrophages as regulators of inflammation and fibrosis has only recently become apparent. However, the precise mechanisms involved in the contribution of monocytes/macrophages to the initiation, establishment, or progression of the fibrotic process remain largely unknown. Several monocyte and macrophage subpopulations have been identified, with certain phenotypes promoting inflammation whereas others display profibrotic effects. Given the unmet need for effective treatments for fibroproliferative diseases and the crucial regulatory role of monocyte/macrophage subpopulations in fibrogenesis, the development of therapeutic strategies that target specific monocyte/macrophage subpopulations has become increasingly attractive. We will provide here an overview of the current understanding of the role of monocyte/macrophage phenotype subpopulations in animal models of tissue fibrosis and in various systemic and organ-specific human fibrotic diseases. Furthermore, we will discuss recent approaches to the design of effective anti-fibrotic therapeutic interventions by targeting the phenotypic differences identified between the various monocyte and macrophage subpopulations
Electroweak Symmetry Breaking in the DSSM
We study the theoretical and phenomenological consequences of modifying the
Kahler potential of the MSSM two Higgs doublet sector. Such modifications
naturally arise when the Higgs sector mixes with a quasi-hidden conformal
sector, as in some F-theory GUT models. In the Delta-deformed Supersymmetric
Standard Model (DSSM), the Higgs fields are operators with non-trivial scaling
dimension 1 < Delta < 2. The Kahler metric is singular at the origin of field
space due to the presence of quasi-hidden sector states which get their mass
from the Higgs vevs. The presence of these extra states leads to the fact that
even as Delta approaches 1, the DSSM does not reduce to the MSSM. In
particular, the Higgs can naturally be heavier than the W- and Z-bosons.
Perturbative gauge coupling unification, a large top quark Yukawa, and
consistency with precision electroweak can all be maintained for Delta close to
unity. Moreover, such values of Delta can naturally be obtained in
string-motivated constructions. The quasi-hidden sector generically contains
states charged under SU(5)_GUT as well as gauge singlets, leading to a rich,
albeit model-dependent, collider phenomenology.Comment: v3: 40 pages, 3 figures, references added, typos correcte
Health promoting settings in primary health care - "hälsotorg": an implementation analysis
Background
Sweden, like many other western countries, faces increasing rates of lifestyle
related diseases and corresponding rise in costs for health care. To meet these
challenges, a number of efforts have been introduced at different societal
levels. One such effort is "Hälsotorg" (HS). HS is a new health promotion
setting that emerged in collaboration between the Swedish County Councils and
Apoteket AB, a state-owned pharmacy company. HS's overall aim was to improve
population health and facilitate inhabitants' responsibility for self-care. A
new National Public Health Policy, introduced in 2008, emphasizes more focus on
individual's needs and responsibility as well as strong need for county
councils to provide supportive environment for individual-centred health
services and increased health literacy among the population. In light of this
policy, there is a need to examine existing settings that can provide
supportive environment for individuals at community level. The aim of this
study was to explore HS's policy implementation at local level and analyse HS's
activities, in order to provide a deeper understanding of HS's potential as a
health promoting setting.
Methods
Materials included a survey and key documents related to the development and
nature of HS on local and national levels. A policy analysis inspired by Walt
and Gilson was used in data analysis. In addition, an analysis using the
principles of health promotion in relation to HS policy process and activities
was also carried out.
Results
The analysis illuminated strengths and weaknesses in the policy process, its
actors, contextual factors and activities. The health communication approach in
the analysed documents contained health promoting intentions but the health
promoting approach corresponding to a health promoting setting was neither
apparent nor shared among the stakeholders. This influenced the interpretation
and implementation of HS negatively.
Conclusions
The analysis indicates that HS has potential to be a valuable health promotion
setting for both population and individuals, given the strong intentions for a
health and empowerment building approach that is expressed in the documents.
However, for a more sustainable implementation of HS, there is need for an in-
depth understanding of the health promotion approach among HS stakeholders
Genetic architecture of common bunt resistance in winter wheat using genome-wide association study
Background: Common bunt (caused by Tilletia caries and T. foetida) has been considered as a major disease in wheat (Triticum aestivum) following rust (Puccinia spp.) in the Near East and is economically important in the Great Plains, USA. Despite the fact that it can be easily controlled using seed treatment with fungicides, fungicides often cannot or may not be used in organic and low-input fields. Planting common bunt resistant genotypes is an alternative.
Results: To identify resistance genes for Nebraska common bunt race, the global set of differential lines were inoculated. Nine differential lines carrying nine different genes had 0% infected heads and seemed to be resistant to Nebraska race. To understand the genetic basis of the resistance in Nebraska winter wheat, a set of 330 genotypes were inoculated and evaluated under field conditions in two locations. Out of the 330 genotypes, 62 genotypes had different degrees of resistance. Moreover, plant height, chlorophyll content and days to heading were scored in both locations. Using genome-wide association study, 123 SNPs located on fourteen chromosomes were identified to be associated with the resistance. Different degrees of linkage disequilibrium was found among the significant SNPs and they explained 1.00 to 9.00% of the phenotypic variance, indicating the presence of many minor QTLs controlling the resistance.
Conclusion: Based on the chromosomal location of some of the known genes, some SNPs may be associated with Bt1, Bt6, Bt11 and Bt12 resistance loci. The remaining significant SNPs may be novel alleles that were not reported previously. Common bunt resistance seems to be an independent trait as no correlation was found between a number of infected heads and chlorophyll content, days to heading or plant height
Minimal distances between SCFTs
My work is supported by DOE grant DE-FG02-96ER40959
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