Mixture-like behavior near a liquid-liquid phase transition in simulations of supercooled water

In simulations of a water-like model (ST2) that exhibits a liquid-liquid phase transition, we test for the occurrence of a thermodynamic region in which the liquid can be modelled as a two-component mixture. We assign each molecule to one of two species based on the distance to its fifth-nearest neighbor, and evaluate the concentration of each species over a wide range of temperature and density. Our concentration data compare well with mixture-model predictions in a region between the liquid-liquid critical temperature and the temperature of maximum density. Fits of the model to the data in this region yield accurate estimates for the location of the critical point. We also show that the liquid outside the region of density anomalies is poorly modelled as a simple mixture.Comment: 5 pages, 4 figures; Phys. Rev. Lett., in press (2011

Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity

BackgroundAgeing and type 2 diabetes mellitus (T2DM) are risk factors for skeletal muscle loss. We investigated whether anabolic resistance to feeding might underlie accelerated muscle loss in older people with T2DM and whether dysregulated mTOR signalling was implicated.Subjects8 obese men with T2DM, and 12 age-matched controls were studied (age 68±3 vs. 68±6y; BMI: 30±2 vs. 27±5 kg·m-2).MethodsBody composition was measured by dual-X-ray absorptiometry. Insulin and glucose were clamped at post-absorptive concentrations (13±2 vs. 9±3 mU·l-1; 7.4±1.9 vs. 4.6±0.4 mmol·l-1; T2DM vs. controls). Fractional synthetic rates (FSR) of myofibrillar and sarcoplasmic proteins were measured as the rate of incorporation of [13C] leucine during a primed, constant infusion of [1-13C] α-ketoisocaproic acid, 3 h after 10 or 20g of essential amino acids (EAA) were orally administered. Protein expression of total and phosphorylated mTOR signalling proteins was determined by Western blot analysis.ResultsDespite a significantly lower appendicular lean mass index and a greater fat mass index in T2DM vs. controls, basal myofibrillar and sarcoplasmic and post-prandial myofibrillar FSR were similar. After 20g EAA, stimulation of sarcoplasmic FSR was slightly blunted in T2DM patients. Furthermore, feeding 20g EAA increased phosphorylation of mTOR, p70S6k and 4E-BP1 by 60-100% in controls with no response observed in T2DM.ConclusionsThere was clear dissociation between changes in mTOR signalling versus changes in protein synthesis rates. However, the intact anabolic response of myofibrillar FSR to feeding in both groups suggests anabolic resistance may not explain accelerated muscle loss in T2DM

An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study.

INTRODUCTION: The socio-economic impact of critical illnesses on patients and their families in Europe has yet to be determined. The aim of this exploratory study was to estimate changes in family circumstances, social and economic stability, care requirements and access to health services for patients during their first 12 months after ICU discharge. METHODS: Multi-center questionnaire-based study of survivors of critical illness at 6 and 12 months after ICU discharge. RESULTS: Data for 293 consenting patients who spent greater than 48 hours in one of 22 UK ICUs were obtained at 6 and 12 months post-ICU discharge. There was little evidence of a change in accommodation or relationship status between pre-admission and 12 months following discharge from an ICU. A negative impact on family income was reported by 33% of all patients at 6 months and 28% at 12 months. There was nearly a 50% reduction in the number of patients who reported employment as their sole source of income at 12 months (19% to 11%) compared with pre-admission. One quarter of patients reported themselves in need of care assistance at 6 months and 22% at 12 months. The majority of care was provided by family members (80% and 78%, respectively), for half of whom there was a negative impact on employment. Amongst all patients receiving care, 26% reported requiring greater than 50 hours a week. Following discharge, 79% of patients reported attending their primary care physician and 44% had seen a community nurse. Mobility problems nearly doubled between pre-admission and 6 months (32% to 64%). Furthermore, 73% reported moderate or severe pain at 12 months and 44% remained significantly anxious or depressed. CONCLUSIONS: Survivors of critical illness in the UK face a negative impact on employment and commonly have a care requirement after discharge from hospital. This has a corresponding negative impact on family income. The majority of the care required is provided by family members. This effect was apparent by 6 months and had not materially improved by 12 months. This exploratory study has identified the potential for a significant socio-economic burden following critical illness

Atomic oxygen beam source for erosion simulation

A device for the production of low energy (3 to 10 eV) neutral atomic beams for surface modification studies is described that reproduces the flux of atomic oxygen in low Earth orbit. The beam is produced by the acceleration of plasma ions onto a negatively biased plate of high-Z metal; the ions are neutralized and reflected by the surface, retaining some fraction of their incident kinetic energy, forming a beam of atoms. The plasma is generated by a coaxial RF exciter which produces a magnetically-confined (4 kG) plasma column. At the end of the column, ions fall through the sheath to the plate, whose bias relative to the plasma can be varied to adjust the beam energy. The source provides a neutral flux approximately equal to 5 x 10(exp 16)/sq cm at a distance of 9 cm and a fluence approximately equal to 10(exp 20)/sq cm in five hours. The composition and energy of inert gas beams was diagnosed using a mass spectometer/energy analyzer. The energy spectra of the beams demonstrate energies in the range 5 to 15 eV, and qualitatively show expected dependences upon incident and reflecting atom species and potential drop. Samples of carbon film, carbon-based paint, Kapton, mylar, and teflon exposed to atomic O beams show erosion quite similar to that observed in orbit on the space shuttle

Gravity currents in rotating, wedge-shaped, adverse channels

Results are presented from a series of parametric experimental and analytical studies of the behaviour of dense gravity currents along rotating, up-sloping, wedge-shaped channels. High resolution density profile measurements at fixed cross-and along-channel locations reveal the outflowing bottom gravity currents to adjust to quasi-steady, geostrophically-balanced conditions along the channels, with the outflow layer thickness and cross-channel interface slope shown to scale with the inlet Burger number for all experimental conditions tested. A general analytical solution to the classic rotating hydraulics problem has been developed under the assumption of inviscid, zero-potential-vorticity conditions to model dense water flow through a triangular constriction and thus simulate the vee-channel configurations under consideration. Predictions from this zero-PV model are shown to provide good overall quantitative agreement with experimental measurements obtained both under hydraulically-controlled conditions at the channel exit and for subcritical conditions generated along the channel length. Quantitative discrepancies between measurements and analytical predictions are attributed primarily to assumptions and limitations associated with the zero-PV modelling approach adopted, as well as the to the rapid adjustment in outflow characteristics as the channel exit is approached, as characterised by the along-channel variation in densimetric Froude number for the outflows.</p

The Subjective Dimension of a Bipolar Family Education/Support Group: A Sociology of Emotions Approach

This article reports on the predominant emotions experienced by members of an education/support group for the relatives and partners of individuals with bipolar manic-depression. Identified are the specific types of emotions experienced as well as the situational, definitional, and behavioral frameworks in which particular emotions or combinations of emotions were generated, experienced, interpreted, expressed, and managed. Special attention is focused on emotional uncertainty, mixed and fluctuating emotions, the erosion of positive by negative emotions, and emotional stalemates. In addition, the personal and social consequences of members\u27 adopting particular emotion management roles are examined. Finally, the article outlines the education/ support group contexts and processes through which members were able to normalize, alter, or reduce a number of particularly distressful emotions and create or reinforce specific positive emotions

Monitoring and characterisation of sand-mud sedimentation processes

Estuaries and tidal inlets are often characterised by the presence of both cohesive and non-cohesive sediments. Knowledge of the sedimentation behaviour of sand-mud mixtures is therefore crucial to the understanding and prediction of the time-dependent structure (i.e. mixed or segregated), composition and erodibility of sediment bed deposits developing within these environments. In the current study, a series of settling column tests are conducted to investigate the hindered settling and initial bed consolidation phases of a range of sand-clay mixtures to determine the parametric conditions under which bed segregation occurs. A new, non-invasive, electrical resistivity measurement technique is employed to capture both temporal and spatial changes in the density, porosity and composition of the evolving sand-clay bed deposits, complimented by time-lapse images of the sedimentation process within the column. The results show that the formation of segregated (sand-clay) bed layers with bed deposits is largely controlled by the initial fractional composition (i.e. relative sand and clay concentrations). Specifically, mixtures with low clay contents are shown to form well-defined (sand-clay) layer segregation within the resulting deposits, while higher clay contents result in more transitional segregation patterns or no layer segregation (for very high clay concentrations). The physical mechanisms under which these different segregation types can be generated are illustrated through predictions from an existing polydisperse hindered settling model. This model indicates that the degree of bed segregation, and time scale over which this occurs, correlates well with the difference in predicted hindered settling characteristics and upward displacements associated with the sand and clay fractions, respectively. In this regard, the new experimental dataset provides validation for the polydisperse model (for the first time), with the combined data and model predictions providing new insight into mixed (sand-clay) sedimentation processes

Clinical components and associated behavioural aspects of a complex healthcare intervention : Multi-methods study of selective decontamination of the digestive tract in critical care

Copyright © 2013 Australian College of Critical Care Nurses Ltd. Published by Elsevier Ltd. All rights reserved.Peer reviewedPostprin

Model studies for flocculation of sand-clay mixtures

Results are presented from a combined experimental and numerical study aimed at comparing the flocculation behaviour of purely-cohesive (clay) and mixed (sand-clay) sediment suspensions under equivalent controlled hydrodynamic conditions. The experiments were conducted in a grid-stirred settling column and focussed on measuring the parametric influences of grid-generated shear rate and local suspended sediment concentrations on the time-evolution of the micro- and macrofloc size distributions generated in the column, as well as representative maximal and root-mean-square floc sizes. The results indicate that for kaolin clay suspensions under low-medium shear rates, initial aggregation rates and the peak or quasi-equilibrium floc sizes attained increase with the clay input concentration; this latter effect due to the larger proportion of macroflocs generated within these runs. By contrast, under high shear rates, representative floc sizes for kaolin clay suspensions remain largely unchanged over the experimental duration, with little influence from clay input or in-situ concentrations, and no macroflocs present in the resulting floc size distributions. The addition of the fine sand fraction to the kaolin clay suspensions is shown to reduce both initial aggregation rates and the representative floc sizes attained in the column for runs under low-medium shear rates, whilst having negligible effect on the flocculation behaviour for the sand-clay mixtures under high shear rates. These results suggest that the sand fraction inhibits flocculation at lower shear rates due to an additional floc break-up mechanism resulting from direct sand-clay interactions (e.g. particle-floc collisions). The importance of these inter-fractional (sand-clay) interactions diminishes, in comparison to shear-induced floc break-up, under higher shear conditions. A one dimensional vertical (1DV) model incorporating a population balance equation (PBE) that includes new representation of these multi-fractional (sand-clay) collisions is applied to simulate the kaolin clay and sand-clay settling column tests. In general, the 1DV PBE model predictions provide good agreement with the measured in-situ concentrations and quasi-equilibrium floc sizes attained, but under-predict floc sizes during the initial aggregation phase due to uncertainty with the upper boundary condition in the 1DV model domain. Furthermore, the reliance of the 1DV PBE model predictions on empirical floc break-up rates associated with shear-induced floc fragmentation and multi-fractional (sand-clay) collisions warrants further attention to better define the microscale dynamics of these processes for their improved representation in the PBE model. It is anticipated that this multi-fractional approach represents an improved basis for modelling flocculation processes within natural sedimentary environments, such as estuaries and tidal inlets, where bed sediments often consist of interacting cohesive (i.e. muds) and non-cohesive (i.e. silts, sands) fractions