1,998 research outputs found
Applicability of different onboard routing and processing techniques to mobile satellite systems
The paper summarizes a study contract recently undertaken for ESA. The study compared the effectiveness of several processing architectures applied to multiple beam, geostationary global and European regional missions. The paper discusses architectures based on transparent SS-FDMA analog, transparent DSP and regenerative processing. Quantitative comparisons are presented and general conclusions are given with respect to suitability of the architectures to different mission requirements
Experimental and theoretical study of the F, Cl and Br reactions with formaldehyde and acetaldehyde
Population based study of genital Chlamydia trachomatis prevalence and associated factors in Norway: A cross sectional study
Unfreezing the discursive hegemonies underpinning current versions of āsocial sustainabilityā in ECE policies in AngloāCeltic, Nordic and Continental contexts
Social sustainability is linked to finding new ways of living together and strengthening social capital and participation, as well as to social justice and equity in societies, and it is becoming increasingly important for diverse multicultural societies. In this article, we trace understandings of social sustainability as established in Early Childhood Education (ECE) policy documents by following the chains of meaning connected to sense of belonging, local place and cultural diversity and through ECE collaboration with childrenās parents/caregivers. Critical discourse analysis has been applied to trace the chains of meaning attached to these concepts in ECE steering documents in Australia, Croatia, Denmark, Norway, Poland, Serbia, Slovenia, Sweden and the UK (England, Scot-land, Wales and Northern Ireland). Such analysis shows different ways in which the ECE polices indirectly work with social sustainability, as well as create critical distance from the sets of meanings established in each country (by proving a chain of meaning established in the policy documents of another country). In conclusion, we do not advocate in favour of any of the chains of meaning but argue for continual reflection and reflexivity, and we see research to be a particularly significant arena in which to unfreeze the taken for granted and sustainable notion
Long-term probability of detecting drug-resistant HIV in patients starting antiretroviral therapy within the first year of HIV infection
Regulation of denitrification at the cellular level: a clue to the understanding of N2O emissions from soils
Denitrifying prokaryotes use NOx as terminal electron acceptors in response to oxygen depletion. The process emits a mixture of NO, N2O and N2, depending on the relative activity of the enzymes catalysing the stepwise reduction of NO3ā to N2O and finally to N2. Cultured denitrifying prokaryotes show characteristic transient accumulation of NO2ā, NO and N2O during transition from oxic to anoxic respiration, when tested under standardized conditions, but this character appears unrelated to phylogeny. Thus, although the denitrifying community of soils may differ in their propensity to emit N2O, it may be difficult to predict such characteristics by analysis of the community composition. A common feature of strains tested in our laboratory is that the relative amounts of N2O produced (N2O/(N2+N2O) product ratio) is correlated with acidity, apparently owing to interference with the assembly of the enzyme N2O reductase. The same phenomenon was demonstrated for soils and microbial communities extracted from soils. Liming could be a way to reduce N2O emissions, but needs verification by field experiments. More sophisticated ways to reduce emissions may emerge in the future as we learn more about the regulation of denitrification at the cellular level
Biochemical properties of Paracoccus denitrificans FnrP:Reactions with molecular oxygen and nitric oxide
In Paracoccus denitrificans, three CRP/FNR family regulatory proteins, NarR, NnrR and FnrP, control the switch between aerobic and anaerobic (denitrification) respiration. FnrP is a [4Fe-4S] cluster containing homologue of the archetypal O2 sensor FNR from E. coli and accordingly regulates genes encoding aerobic and anaerobic respiratory enzymes in response to O2, and also NO, availability. Here we show that FnrP undergoes O2-driven [4Fe-4S] to [2Fe-2S] cluster conversion that involves up to 2 O2 per cluster, with significant oxidation of released cluster sulfide to sulfane observed at higher O2 concentrations. The rate of the cluster reaction was found to be ~6-fold lower than that of E. coli FNR, suggesting that FnrP can remain transcriptionally active under microaerobic conditions. This is consistent with a role for FnrP in activating expression of the high O2 affinity cytochrome c oxidase under microaerobic conditions. Cluster conversion resulted in dissociation of the transcriptionally active FnrP dimer into monomers. Therefore, along with E. coli FNR, FnrP belongs to the subset of FNR proteins in which cluster type is correlated with association state. Interestingly, two key charged residues, Arg140 and Asp154, that have been shown to play key roles in the monomer-dimer equilibrium in E. coli FNR are not conserved in FnrP, indicating that different protomer interactions are important for this equilibrium. Finally, the FnrP [4Fe-4S] cluster is shown to undergo reaction with multiple NO molecules, resulting in iron nitrosyl species and dissociation into monomers
The roles of migratory and resident birds in local avian influenza infection dynamics
Migratory birds are an increasing focus of interest when it comes to infection dynamics and the spread of avian influenza viruses (AIV ). However, we lack detailed understanding of migratory birdsā contribution to local AIV prevalence levels and their downstream socioāeconomic costs and threats.
To explain the potential differential roles of migratory and resident birds in local AIV infection dynamics, we used a susceptibleāinfectiousārecovered (SIR ) model. We investigated five (mutually nonā exclusive) mechanisms potentially driving observed prevalence patterns: (1) a pronounced birth pulse (e.g. the synchronised annual influx of immunologically naĆÆve individuals), (2) shortāterm immunity, (3) increase in susceptible migrants, (4) differential susceptibility to infection (i.e. transmission rate) for migrants and residents, and (5) replacement of migrants during peak migration.
SIR models describing all possible combinations of the five mechanisms were fitted to individual AIV infection data from a detailed longitudinal surveillance study in the partially migratory mallard duck (Anas platyrhynchos ). During autumn and winter, the local resident mallard community also held migratory mallards that exhibited distinct AIV infection dynamics.
Replacement of migratory birds during peak migration in autumn was found to be the most important mechanism driving the variation in local AIV infection patterns. This suggests that a constant influx of migratory birds, likely immunological naĆÆve to locally circulating AIV strains, is required to predict the observed temporal prevalence patterns and the distinct differences in prevalence between residents and migrants.
Synthesis and applications . Our analysis reveals a key mechanism that could explain the amplifying role of migratory birds in local avian influenza virus infection dynamics; the constant flow and replacement of migratory birds during peak migration. Apart from monitoring efforts, in order to achieve adequate disease management and control in wildlifeāwith knockāon effects for livestock and humans,āwe conclude that it is crucial, in future surveillance studies, to record host demographical parameters such as population density, timing of birth and turnover of migrants
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