10 research outputs found
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particles’
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.status: publishe
Usability and effectiveness of auditory sensory substitution models for the visually impaired
This paper focuses on auditory sensory substitution for providing visually impaired users with suitable information in both static scene recognition and dynamic obstacle avoidance. We introduce three different sonification models together with three temporal presentation schemes, i.e. ways of temporally organizing the sonic events in order to provide suitable information. Following an overview of the motivation and challenges behind each of the solutions, we describe their implementation and an evaluation of their relative strengths and weaknesses based on a set of experiments conducted in a virtual environment
Sound of vision : spatial audio output and sonification approaches
The paper summarizes a number of audio-related studies conducted by the Sound of Vision consortium, which focuses on the construction of a new prototype electronic travel aid for the blind. Different solutions for spatial audio were compared by testing sound localization accuracy in a number of setups, comparing plain stereo panning with generic and individual HRTFs, as well as testing different types of stereo headphones vs custom designed quadrophonic proximaural headphones. A number of proposed sonification approaches were tested by sighted and blind volunteers for accuracy and efficiency in representing simple virtual environments
InFutURe Wood Report 1: Design for deconstruction and reuse of timber structures – state of the art review
This report represents the first publication of the InFutURe Wood project - Innovative Design for the Future – Use and Reuse of Wood (Building) Components.InFutUReWood is supported under the umbrella of ERA-NET and financed by funding agencies from each of the participating countries. The industry partners participate mostly with in-kind.The research and academia project partners are RISE (Sweden), Edinburgh Napier University (UK), National University of Ireland Galway (Ireland), University College Dublin (Ireland), Polytechnic University of Madrid (Spain), University of Ljubljana (Slovenia), Aalto University Helsinki (Finland), and Technical University Munich (Germany).The industry partners are Kiruna Municipality Technical Service, Swedish Wood, Derome, Isotimber, Offsite Solutions Scotland, Hegarty Demolition, SIP Energy, Connaught Timber, The Federation of the Finnish Woodworking Industries, Jelovica, The Swedish Federation of Wood and Furniture Industry, Balcas Timber, Stora Enso, Klimark + Nova domus Hábitat, and Brenner Planungsgesellschaft
Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo
Background: Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagonlike peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated. Methods: ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallelgroup, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population at high CV risk. The primary efficacy end point is a composite of time to CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Data are systematically collected for safety outcomes, including hypoglycemia, pancreatitis, and malignancy. Results: Enrollment began in July 2010 and ended in August 2013; 6,068 patients from 49 countries were randomized. Of these, 69% are men and 75% are white; at baseline, the mean ± SD age was 60.3 ± 9.7 years, body mass index was 30.2 ± 5.7 kg/m2, and duration of T2DM was 9.3±8.2 years. The qualifying ACS wasamyocardial infarctionin83% and unstableangina in 17%. The study will continue until the positive adjudication of the protocol-specified number of primary CV events. Conclusion: ELIXA will be the first trial to report the safety and efficacy of a glucagon-like peptide 1 receptor agonist in people with T2DM and high CV event risk. © 2015 Elsevier Inc. All rights reserved
Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo
BACKGROUND:
Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagon-like peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated.
METHODS:
ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallel-group, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population at high CV risk. The primary efficacy end point is a composite of time to CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Data are systematically collected for safety outcomes, including hypoglycemia, pancreatitis, and malignancy.
RESULTS:
Enrollment began in July 2010 and ended in August 2013; 6,068 patients from 49 countries were randomized. Of these, 69% are men and 75% are white; at baseline, the mean ± SD age was 60.3 ± 9.7 years, body mass index was 30.2 ± 5.7 kg/m(2), and duration of T2DM was 9.3 ± 8.2 years. The qualifying ACS was a myocardial infarction in 83% and unstable angina in 17%. The study will continue until the positive adjudication of the protocol-specified number of primary CV events.
CONCLUSION:
ELIXA will be the first trial to report the safety and efficacy of a glucagon-like peptide 1 receptor agonist in people with T2DM and high CV event risk