1,498 research outputs found
Determining 3-D Motion and Structure of a Rigid Body Using the Spherical Projection
Coordinated Science Laboratory was formerly known as Control Systems LaboratoryNational Science Foundation / NSF ECS 81-1208
Aggregate-strength interaction test suite prioritization
Combinatorial interaction testing is a widely used approach. In testing, it is often assumed that all combinatorial test cases have equal fault detection capability, however it has been shown that the execution order of an interaction test suite's test cases may be critical, especially when the testing resources are limited. To improve testing cost-effectiveness, test cases in the interaction test suite can be prioritized, and one of the best-known categories of prioritization approaches is based on “fixed-strength prioritization”, which prioritizes an interaction test suite by choosing new test cases which have the highest uncovered interaction coverage at a fixed strength (level of interaction among parameters). A drawback of these approaches, however, is that, when selecting each test case, they only consider a fixed strength, not multiple strengths. To overcome this, we propose a new “aggregate-strength prioritization”, to combine interaction coverage at different strengths. Experimental results show that in most cases our method performs better than the test-case-generation, reverse test-case-generation, and random prioritization techniques. The method also usually outperforms “fixed-strength prioritization”, while maintaining a similar time cost
Uniqueness and Estimation of Three-Dimensional Motion Parameters of Rigid Objects with Curved Surfaces
Coordinated Science Laboratory was formerly known as Control Systems LaboratoryOffice of Naval Research / N00014-79-C-042
An Algorithm for Matching Perspective Views of 3-D Object by Using Composite Circuits
National Science Foundation / MCS 82-06926Ope
Extensive Renyi Statistics from Non-Extensive Entropy
We show that starting with either the non-extensive Tsallis entropy in Wang's
formalism or the extensive Renyi entropy, it is possible to construct the
equilibrium statistical mechanics with non-Gibbs canonical distribution
functions. The transformation formulas between Tsallis statistics and Renyi
statistics are presented. The one-particle distribution function in Renyi
statistics with extensive entropy for the classical ideal gas at finite
particle number develops a power-law tail for high momenta.Comment: 14 pages, 2 figures, LaTe
Modified Hagedorn formula including temperature fluctuation - Estimation of temperatures at RHIC experiments -
We have systematically estimated the possible temperatures obtained from an
analysis of recent data on distributions observed at RHIC experiments.
Using the fact that observed distributions cannot be described by the
original Hagedorn formula in the whole range of transverse momenta (in
particular above 6 GeV/c), we propose a modified Hagedorn formula including
temperature fluctuation. We show that by using it we can fit
distributions in the whole range and can estimate consistently the relevant
temperatures, including their fluctuations.Comment: Some misprints corrected, references updated. To be published in Eur.
Phys. J. C (2006
Development of a unilateral ureteral obstruction model in cynomolgus monkeys
Background
Chronic kidney disease (CKD) has a high global prevalence and large unmet need. Central to developing new CKD therapies are in vivo models in CKD. However, next-generation antibody, protein, and gene therapies are highly specific, meaning some do not cross-react with rodent targets. This complicates preclinical development, as established in vivo rodent models cannot be utilized unless tool therapeutics are also developed. Tool compounds can be difficult to develop and, if available, typically have different epitopes, sequences, and/or altered affinity, making it unclear how efficacious the lead therapeutic may be, or what dosing regimen to investigate. To address this, we aimed to develop a nonhuman primate model of CKD.
Methods
In vivo rodent unilateral ureteral obstruction (UUO) models kidney fibrosis and is commonly used due to its rapidity, consistency, and ease. We describe translation of this model to the cynomolgus monkey, specifically optimizing the model duration to allow adequate time for assessment of novel therapeutics prior to the fibrotic plateau.
Results
We demonstrated that disease developed more slowly in cynomolgus monkeys than in rodents post-UUO, with advanced fibrosis developing by 6 weeks. The tubulointerstitial fibrosis in cynomolgus monkeys was more consistent with human obstructive disease than in rodents, having a more aggressive tubular basement expansion and a higher fibroblast infiltration. The fibrosis was also associated with increased transglutaminase activity, consistent with that seen in patients with CKD.
Conclusion
This cynomolgus monkey UUO model can be used to test potential human-specific therapeutics in kidney fibrosis
Equilibrium statistical mechanics for incomplete nonextensive statistics
The incomplete nonextensive statistics in the canonical and microcanonical
ensembles is explored in the general case and in a particular case for the
ideal gas. By exact analytical results for the ideal gas it is shown that
taking the thermodynamic limit, with being an extensive variable of
state, the incomplete nonextensive statistics satisfies the requirements of
equilibrium thermodynamics. The thermodynamical potential of the statistical
ensemble is a homogeneous function of the first degree of the extensive
variables of state. In this case, the incomplete nonextensive statistics is
equivalent to the usual Tsallis statistics. If is an intensive variable of
state, i.e. the entropic index is a universal constant, the requirements of
the equilibrium thermodynamics are violated.Comment: 7 page
DCC dynamics with the SU(3) linear sigma model
The SU(3) extension of the linear sigma model is employed to elucidate the
effect of including strangeness on the formation of disoriented chiral
condensates. By means of a Hartree factorization, approximate dispersion
relations for the 18 scalar and pseudoscalar meson species are derived and
their self-consistent solution makes it possible to trace out the thermal path
of the two order parameters as well as delineate the region of instability
within which spontaneous pair creation becomes possible. The results depend
significantly on the employed sigma mass, with the highest values yielding the
largest regions of instability. An approximate solution of the equations of
motion for the order parameter in scenarios emulating uniform scaling
expansions show that even with a rapid quench only the pionic modes grow
unstable. Nevertheless, the rapid and oscillatory relaxation of the order
parameters leads to enhanced production of both pions and (to a lesser degree)
kaons.Comment: 29 pages, RevTeX, 11 postscript figures, discussion about anomaly
term adde
Issues on Generating Primordial Anisotropies at the End of Inflation
We revisit the idea of generating primordial anisotropies at the end of
inflation in models of inflation with gauge fields. To be specific we consider
the charged hybrid inflation model where the waterfall field is charged under a
U(1) gauge field so the surface of end of inflation is controlled both by
inflaton and the gauge fields. Using delta N formalism properly we find that
the anisotropies generated at the end of inflation from the gauge field
fluctuations are exponentially suppressed on cosmological scales. This is
because the gauge field evolves exponentially during inflation while in order
to generate appreciable anisotropies at the end of inflation the spectator
gauge field has to be frozen and scale invariant. We argue that this is a
generic feature, that is, one can not generate observable anisotropies at the
end of inflation within an FRW background.Comment: V3: new references added, JCAP published versio
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