4,559 research outputs found
Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2.
In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs) and synaptonemal complexes. Here, we show that levels of ESCO2, acSMC3, and the pro-cohesion factor sororin increase on meiotic chromosomes as homologs synapse. These proteins are less abundant on the largely unsynapsed sex chromosomes, whose sister chromatid cohesion appears weaker throughout the meiotic prophase. Using three distinct conditional Esco2 knockout mouse strains, we demonstrate that ESCO2 is essential for male gametogenesis. Partial depletion of ESCO2 in prophase I spermatocytes delays chromosome synapsis and further weakens cohesion along sex chromosomes, which show extensive separation of AEs into single chromatids. Unsynapsed regions of autosomes are associated with the sex chromatin and also display split AEs. This study provides the first evidence for a specific role of ESCO2 in mammalian meiosis, identifies a particular ESCO2 dependence of sex chromosome cohesion and suggests support of autosomal synapsis by acSMC3-stabilized cohesion
Strange matter in core-collapse supernovae
We discuss the possible impact of strange quark matter on the evolution of
core-collapse supernovae with emphasis on low critical densities for the
quark-hadron phase transition. For such cases the hot proto-neutron star can
collapse to a more compact hybrid star configuration hundreds of milliseconds
after core-bounce. The collapse triggers the formation of a second shock wave.
The latter leads to a successful supernova explosion and leaves an imprint on
the neutrino signal. These dynamical features are discussed with respect to
their compatibility with recent neutron star mass measurements which indicate a
stiff high density nuclear matter equation of state.Comment: 8 pages, 3 figures, Invited talk at the "Strangeness in Quark Matter"
conference, 18-24 September 2011, Polish Academy of Arts and Sciences,
Cracow, Polan
Experimental quantum verification in the presence of temporally correlated noise
Growth in the complexity and capabilities of quantum information hardware
mandates access to practical techniques for performance verification that
function under realistic laboratory conditions. Here we experimentally
characterise the impact of common temporally correlated noise processes on both
randomised benchmarking (RB) and gate-set tomography (GST). We study these
using an analytic toolkit based on a formalism mapping noise to errors for
arbitrary sequences of unitary operations. This analysis highlights the role of
sequence structure in enhancing or suppressing the sensitivity of quantum
verification protocols to either slowly or rapidly varying noise, which we
treat in the limiting cases of quasi-DC miscalibration and white noise power
spectra. We perform experiments with a single trapped Yb ion as a
qubit and inject engineered noise () to probe protocol
performance. Experiments on RB validate predictions that the distribution of
measured fidelities over sequences is described by a gamma distribution varying
between approximately Gaussian for rapidly varying noise, and a broad, highly
skewed distribution for the slowly varying case. Similarly we find a strong
gate set dependence of GST in the presence of correlated errors, leading to
significant deviations between estimated and calculated diamond distances in
the presence of correlated errors. Numerical simulations demonstrate
that expansion of the gate set to include negative rotations can suppress these
discrepancies and increase reported diamond distances by orders of magnitude
for the same error processes. Similar effects do not occur for correlated
or errors or rapidly varying noise processes,
highlighting the critical interplay of selected gate set and the gauge
optimisation process on the meaning of the reported diamond norm in correlated
noise environments.Comment: Expanded and updated analysis of GST, including detailed examination
of the role of gauge optimization in GST. Full GST data sets and
supplementary information available on request from the authors. Related
results available from
http://www.physics.usyd.edu.au/~mbiercuk/Publications.htm
EROs found behind lensing clusters: II.Empirical properties, classification, and SED modelling based on multi-wavelength observations
We study the properties and nature of extremely red galaxies (ERO, R-K>5.6)
found behind two lensing clusters and compare them with other known galaxy
populations. New HST/ACS observations, Spitzer IRAC and MIPS, and Chandra/ACIS
observations of the two lensing clusters Abell 1835 and AC114 contemplate our
earlier optical and near-IR observations and have been used to study extremely
red objects (EROs) in these deep fields. We have found 6 and 9 EROs in Abell
1835 and AC114. Several (7) of these objects are undetected up to the I and/or
z band, and are hence ``optical'' drop-out sources. The photometric redshifts
of most of our sources (80%) are z~0.7-1.5. According to simple colour-colour
diagrams the majority of our objects would be classified as hosting old stellar
populations. However, there are clear signs of dusty starbursts for several
among them. These objects correspond to the most extreme ones in R-K colour. We
estimate a surface density of (0.97+-0.31) arcmin-2 for EROs with (R-K>5.6) at
K<20.5. Among our 15 EROs 6 (40 %) also classify as distant red galaxies
(DRGs). 11 of 13 EROs with available IRAC photometry also fulfil the selection
criteria for IRAC selected EROs (IEROs) of Yan et al. (2004). SED modelling
shows that ~ 36 % of the IEROs in our sample are luminous or ultra-luminous
infrared galaxies ((U)LIRG). Some very red DRGs are found to be very dusty
starbursts, even (U)LIRGs, as also supported by their mid-IR photometry. No
indication for AGNs is found, although faint activity cannot be excluded for
all objects. From mid-IR and X-ray data 5 objects are clearly classified as
starbursts. The derived properties are quite similar to those of DRGs and
IEROs, except for 5 extreme objects in terms of colours, for which a very high
extinction (Av>3) is found.Comment: 20 pages, 10 figures, accepted for publication in A&
Pushing 1D CCSNe to explosions: model and SN 1987A
We report on a method, PUSH, for triggering core-collapse supernova
explosions of massive stars in spherical symmetry. We explore basic explosion
properties and calibrate PUSH such that the observables of SN1987A are
reproduced. Our simulations are based on the general relativistic hydrodynamics
code AGILE combined with the detailed neutrino transport scheme IDSA for
electron neutrinos and ALS for the muon and tau neutrinos. To trigger
explosions in the otherwise non-exploding simulations, we rely on the
neutrino-driven mechanism. The PUSH method locally increases the energy
deposition in the gain region through energy deposition by the heavy neutrino
flavors. Our setup allows us to model the explosion for several seconds after
core bounce. We explore the progenitor range 18-21M. Our studies
reveal a distinction between high compactness (HC) and low compactness (LC)
progenitor models, where LC models tend to explore earlier, with a lower
explosion energy, and with a lower remnant mass. HC models are needed to obtain
explosion energies around 1 Bethe, as observed for SN1987A. However, all the
models with sufficiently high explosion energy overproduce Ni. We
conclude that fallback is needed to reproduce the observed nucleosynthesis
yields. The nucleosynthesis yields of Ni depend sensitively on the
electron fraction and on the location of the mass cut with respect to the
initial shell structure of the progenitor star. We identify a progenitor and a
suitable set of PUSH parameters that fit the explosion properties of SN1987A
when assuming 0.1M of fallback. We predict a neutron star with a
gravitational mass of 1.50M. We find correlations between explosion
properties and the compactness of the progenitor model in the explored
progenitors. However, a more complete analysis will require the exploration of
a larger set of progenitors with PUSH.Comment: revised version as accepted by ApJ (results unchanged, text modified
for clarification, a few references added); 26 pages, 20 figure
Manifolds associated with -colored regular graphs
In this article we describe a canonical way to expand a certain kind of
-colored regular graphs into closed -manifolds by
adding cells determined by the edge-colorings inductively. We show that every
closed combinatorial -manifold can be obtained in this way. When ,
we give simple equivalent conditions for a colored graph to admit an expansion.
In addition, we show that if a -colored regular graph
admits an -skeletal expansion, then it is realizable as the moment graph of
an -dimensional closed -manifold.Comment: 20 pages with 9 figures, in AMS-LaTex, v4 added a new section on
reconstructing a space with a -action for which its moment graph is
a given colored grap
Quantum simulation of the Klein paradox with trapped ions
We report on quantum simulations of relativistic scattering dynamics using
trapped ions. The simulated state of a scattering particle is encoded in both
the electronic and vibrational state of an ion, representing the discrete and
continuous components of relativistic wave functions. Multiple laser fields and
an auxiliary ion simulate the dynamics generated by the Dirac equation in the
presence of a scattering potential. Measurement and reconstruction of the
particle wave packet enables a frame-by-frame visualization of the scattering
processes. By precisely engineering a range of external potentials we are able
to simulate text book relativistic scattering experiments and study Klein
tunneling in an analogue quantum simulator. We describe extensions to solve
problems that are beyond current classical computing capabilities.Comment: 3 figures, accepted for publication in PR
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