223 research outputs found
Advancing a Transnational, Transdisciplinary and Translingual Professional Development Framework for Teaching Assistants in Writing and Spanish Programs: An Update
In 2018, we published a translingual and transdisciplinary collaborative piece that sought to respond to the call for writing and language programs to develop professional development opportunities central to multilingual writers’ needs as language learners and writers and their sophisticated and diverse language and writing abilities (Guerra, 2008; Horner et al., 2011; Kells, 2007; Tardy, 2017). We described the design, implementation, and implications of a multilingual pedagogy professional development series for teaching assistants in a transnational and multilingual context (Cavazos, et al., 2018). In this chapter, we provide an update on what has transpired since the series ended. We arrange the chapter as follows: first, we give a brief description of the institutional context where the workshops took place. Then we briefly describe the professional development series for readers unfamiliar with our first piece. After that, we provide an update on what happened after the series ended that emphasizes the impact, affordances, and challenges of implementing this type of workshop and how the authors continue to enact the core components of the proposed workshop in their disciplinary contexts and teaching practices
Advancing a Transnational, Transdisciplinary and Translingual Framework: A Professional Development Series for Teaching Assistants in Writing and Spanish Programs
Considering the need for writing and language programs to develop translingual and transdisciplinary pedagogies for teacher development at the graduate level (Canagarajah, 2016; Williams & Rodrigue, 2016), the authors examine the design of a multilingual pedagogy professional development series for first-year Spanish and Writing teaching assistants (TAs). As designers of and participants in the series, the authors explore the benefits and challenges inherent in transdisciplinary and translingual conversations and discuss implications for teaching and research in language and writing instruction and teacher development. In order to advance transdisciplinary and translingual approaches as a new normal in composition studies (Tardy 2017; Horner, NeCamp, and Donahue 2011), the authors hope to provide a professional development framework that adapts to the linguistic realities of different institutional contexts and students’ lived language experiences
Optical absorption spectra and monomer interaction in polymers. Investigation of exciton coupling in DNA hairpins
We investigate the effect of exciton coupling on the optical absorption
spectrum of polymer molecules under conditions of strong inhomogeneous
broadening. We demonstrate that the dependence of the maximum in the rescaled
absorption spectrum on the number of monomers is determined by the average
monomer excitation energies and their resonant coupling and insensitive to the
inhomogeneous broadening. Thus the absorption spectrum can be used to determine
optical interactions between monomers. The results are applied to the
absorption spectra of poly-A poly-T DNA hairpins and used to interpret the
dependence of the absorption spectrum on the number of monomers. We also
discuss exciton localization in these hairpins.Comment: Submitted to Journal of Chemical Physic
Revision of the 15N(p,{\gamma})16O reaction rate and oxygen abundance in H-burning zones
The NO cycle takes place in the deepest layer of a H-burning core or shell,
when the temperature exceeds T {\simeq} 30 {\cdot} 106 K. The O depletion
observed in some globular cluster giant stars, always associated with a Na
enhancement, may be due to either a deep mixing during the RGB (red giant
branch) phase of the star or to the pollution of the primordial gas by an early
population of massive AGB (asymptotic giant branch) stars, whose chemical
composition was modified by the hot bottom burning. In both cases, the NO cycle
is responsible for the O depletion. The activation of this cycle depends on the
rate of the 15N(p,{\gamma})16O reaction. A precise evaluation of this reaction
rate at temperatures as low as experienced in H-burning zones in stellar
interiors is mandatory to understand the observed O abundances. We present a
new measurement of the 15N(p,{\gamma})16O reaction performed at LUNA covering
for the first time the center of mass energy range 70-370 keV, which
corresponds to stellar temperatures between 65 {\cdot} 106 K and 780 {\cdot}106
K. This range includes the 15N(p,{\gamma})16O Gamow-peak energy of explosive
H-burning taking place in the external layer of a nova and the one of the hot
bottom burning (HBB) nucleosynthesis occurring in massive AGB stars. With the
present data, we are also able to confirm the result of the previous R-matrix
extrapolation. In particular, in the temperature range of astrophysical
interest, the new rate is about a factor of 2 smaller than reported in the
widely adopted compilation of reaction rates (NACRE or CF88) and the
uncertainty is now reduced down to the 10% level.Comment: 6 pages, 5 figure
Astrophysical S-factor for the radiative capture reaction 13C(p,g)14N
The phase shift analysis, done on the basis of the known measurements of the
differential cross-sections of the p13C elastic scattering at the energy range
250-750 keV, shows that it is enough to take into account only 3S1 wave in the
considered energy region. The potential for the triplet 3S1 state in p13C
system at the resonance energy 0.55 MeV corresponding to quantum numbers JpT =
1-1 as well as the potential for the 3P1 bound state of 14N were constructed on
the basis of the obtained scattering phase shifts. The possibility to describe
the experimental data of the astrophysical S-factor of the p13C radiative
capture at the energies 0.03-0.8 MeV was considered within the potential
cluster model with the forbidden states. It was shown that we properly succeed
in explanation of the energy behavior of the astrophysical S-factor for the
p13C radiative capture at the resonance energy range 0.55 MeV (laboratory
system).Comment: 8 p., 2 fi
Hepatitis C Virus Induces the Cannabinoid Receptor 1
BACKGROUND: Activation of hepatic CB(1) receptors (CB(1)) is associated with steatosis and fibrosis in experimental forms of liver disease. However, CB(1) expression has not been assessed in patients with chronic hepatitis C (CHC), a disease associated with insulin resistance, steatosis and metabolic disturbance. We aimed to determine the importance and explore the associations of CB(1) expression in CHC. METHODS: CB(1) receptor mRNA was measured by real time quantitative PCR on extracted liver tissue from 88 patients with CHC (genotypes 1 and 3), 12 controls and 10 patients with chronic hepatitis B (CHB). The Huh7/JFH1 Hepatitis C virus (HCV) cell culture model was used to validate results. PRINCIPAL FINDINGS: CB(1) was expressed in all patients with CHC and levels were 6-fold higher than in controls (P<0.001). CB(1) expression increased with fibrosis stage, with cirrhotics having up to a 2 fold up-regulation compared to those with low fibrosis stage (p<0.05). Even in mild CHC with no steatosis (F0-1), CB(1) levels remained substantially greater than in controls (p<0.001) and in those with mild CHB (F0-1; p<0.001). Huh7 cells infected with JFH-1 HCV showed an 8-fold upregulation of CB(1), and CB(1) expression directly correlated with the percentage of cells infected over time, suggesting that CB(1) is an HCV inducible gene. While HCV structural proteins appear essential for CB(1) induction, there was no core genotype specific difference in CB(1) expression. CB(1) significantly increased with steatosis grade, primarily driven by patients with genotype 3 CHC. In genotype 3 patients, CB(1) correlated with SREBP-1c and its downstream target FASN (SREBP-1c; R=0.37, FASN; R=0.39, p<0.05 for both). CONCLUSIONS/SIGNIFICANCE: CB(1) is up-regulated in CHC and is associated with increased steatosis in genotype 3. It is induced by the hepatitis C virus
Sinusoidal Endothelial Dysfunction Precedes Inflammation and Fibrosis in a Model of NAFLD
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Most morbidity associated with the metabolic syndrome is related to vascular complications, in which endothelial dysfunction is a major pathogenic factor. However, whether NAFLD is associated with endothelial dysfunction within the hepatic vasculature is unknown. The aims of this study were to explore, in a model of diet-induced overweight that expresses most features of the metabolic syndrome, whether early NAFLD is associated with liver endothelial dysfunction. Wistar Kyoto rats were fed a cafeteria diet (CafD; 65% of fat, mostly saturated) or a control diet (CD) for 1 month. CafD rats developed features of the metabolic syndrome (overweight, arterial hypertension, hypertryglyceridemia, hyperglucemia and insulin resistance) and liver steatosis without inflammation or fibrosis. CafD rats had a significantly higher in vivo hepatic vascular resistance than CD. In liver perfusion livers from CafD rats had an increased portal perfusion pressure and decreased endothelium-dependent vasodilation. This was associated with a decreased Akt-dependent eNOS phosphorylation and NOS activity. In summary, we demonstrate in a rat model of the metabolic syndrome that shows features of NAFLD, that liver endothelial dysfunction occurs before the development of fibrosis or inflammation
Australian clinical practice guidelines for the diagnosis and management of Barrett's esophagus and early esophageal adenocarcinoma
Author version made available following 12 month embargo from date of publication according to publisher copyright policy.Barrett's esophagus (BE), a common condition, is the only known precursor to esophageal adenocarcinoma (EAC). There is uncertainty about the best way to manage BE as most people with BE never develop EAC and most patients diagnosed with EAC have no preceding diagnosis of BE. Moreover, there have been recent advances in knowledge and practice about the management of BE and early EAC. To aid clinical decision making in this rapidly moving field, Cancer Council Australia convened an expert working party to identify pertinent clinical questions. The questions covered a wide range of topics including endoscopic and histological definitions of BE and early EAC; prevalence, incidence, natural history, and risk factors for BE; and methods for managing BE and early EAC. The latter considered modification of lifestyle factors; screening and surveillance strategies; and medical, endoscopic, and surgical interventions. To answer each question, the working party systematically reviewed the literature and developed a set of recommendations through consensus. Evidence underpinning each recommendation was rated according to quality and applicability
The protective role of pregnancy in breast cancer
Epidemiological, clinical, and experimental data indicate that the risk of developing breast cancer is strongly dependent on the ovary and on endocrine conditions modulated by ovarian function, such as early menarche, late menopause, and parity. Women who gave birth to a child when they were younger than 24 years of age exhibit a decrease in their lifetime risk of developing breast cancer, and additional pregnancies increase the protection. The breast tissue of normally cycling women contains three identifiable types of lobules, the undifferentiated Lobules type 1 (Lob 1) and the more developed Lobules type 2 and Lobules type 3. The breast attains its maximum development during pregnancy and lactation (Lobules type 4). After menopause the breast regresses in both nulliparous and parous women containing only Lob 1. Despite the similarity in the lobular composition of the breast at menopause, the fact that nulliparous women are at higher risk of developing breast cancer than parous women indicates that Lob 1 in these two groups of women might be biologically different, or might exhibit different susceptibility to carcinogenesis. Based on these observations it was postulated that Lob 1 found in the breast of nulliparous women and of parous women with breast cancer never went through the process of differentiation, retaining a high concentration of epithelial cells that are targets for carcinogens and are therefore susceptible to undergo neoplastic transformation. These epithelial cells are called Stem cells 1, whereas Lob 1 structures found in the breast of early parous postmenopausal women free of mammary pathology, on the contrary, are composed of an epithelial cell population that is refractory to transformation, called Stem cells 2. It was further postulated that the degree of differentiation acquired through early pregnancy has changed the 'genomic signature' that differentiates Lob 1 of the early parous women from that of the nulliparous women by shifting the Stem cells 1 to Stem cells 2 that are refractory to carcinogenesis, making this the postulated mechanism of protection conferred by early full-term pregnancy. The identification of a putative breast stem cell (Stem cells 1) has, in the past decade, reached a significant impulse, and several markers also reported for other tissues have been found in the mammary epithelial cells of both rodents and humans. Although further work needs to be carried out in order to better understand the role of the Stem cells 2 and their interaction with the genes that confer them a specific signature, collectively the data presently available provide evidence that pregnancy, through the process of cell differentiation, shifts Stem cells 1 to Stem cells 2 – cells that exhibit a specific genomic signature that could be responsible for the refractoriness of the mammary gland to carcinogenesis
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