A faint extended cluster in the outskirts of NGC 5128: evidence of a low mass accretion

We report the discovery of an extended globular cluster in a halo field in Centaurus A (NGC 5128), situated \sim 38\kpc from the centre of that galaxy, imaged with the Advanced Camera for Surveys on board the Hubble Space Telescope. At the distance of the galaxy, the half-light radius of the cluster is r_h ~ 17pc, placing it among the largest globular clusters known. The faint absolute magnitude of the star cluster, M_(V,o)=-5.2, and its large size render this object somewhat different from the population of extended globular clusters previously reported, making it the first firm detection in the outskirts of a giant galaxy of an analogue of the faint, diffuse globular clusters present in the outer halo of the Milky Way. The colour-magnitude diagram of the cluster, covering approximately the brightest four magnitudes of the red giant branch, is consistent with an ancient, i.e., older than ~8 Gyr, intermediate-metallicity, i.e., [M/H] ~-1.0 dex, stellar population. We also report the detection of a second, even fainter cluster candidate which would have r_h ~ 9pc, and M_(V,o)=-3.4 if it is at the distance of NGC 5128. The properties of the extended globular cluster and the diffuse stellar populations in its close vicinity suggest that they are part of a low mass accretion in the outer regions of NGC 5128.Comment: 9 pages, MNRAS, in pres

Measurements of PAN, alkyl nitrates, ozone, and hydrocarbons during spring in interior Alaska

Measurements of the atmospheric mixing ratios of ozone, peroxyacetylnitrate (PAN), hydrocarbons, and alkyl nitrates were made in a boreal forest ecosystem in the interior of Alaska from March 15 to May 14, 1993. During this period the mixing ratios of PAN, alkyl nitrates, and nonmethane hydrocarbons (NMHCs) generally decreased due to the influence of both meteorology and OH removal. Mean mixing ratios of ozone, PAN, C2 ‐ C6 alkyl nitrates, and total C2 ‐ C5 NMHC during southerly flow periods were 24.4 parts per billion (ppbv), 132.1 parts per trillion (pptv ), 34 pptv, and 8.2 ppbCv, respectively. During a short period of northerly flow, mixing ratios of PAN and total NMHC were approximately 2 times the southerly flow mixing ratios. PAN is correlated with ozone, and alkyl nitrates are correlated with alkanes. PAN and ozone mixing ratios exhibit similar diurnal variations on a number of days with an early morning minimum and afternoon maximum. This is likely due to a diurnal cycle in the boundary layer ‐ free troposphere exchange and loss processes in the boundary layer for both O3 and PAN. Higher molecular weight (mw) hydrocarbons and alkyl nitrates are observed to decrease more quickly than the lower mw hydrocarbons, consistent with removal by OH as the primary loss process

Investigations into the potential anticancer activity of Maximin H5

Here we report the first major example of anionic amphibian host defence peptides (HDPs) with anticancer activity. Maximin H5 is a C-terminally amidated, anionic host defence peptide (MH5N) from toads of the Bombina genus, which was shown to possess activity against the glioma cell line, T98G (EC50 = 125 μM). The peptide adopted high levels of α-helical structure (57.3%) in the presence of model cancer membranes (DMPC:DMPS in a molar ratio of 10:1). MH5N also showed a strong ability to penetrate these model membranes (Π = 10.5 mN m-1), which correlated with levels of DMPS (R2 > 0.98). Taken with the high ability of the peptide to lyse these membranes (65.7%), it is proposed that maximin H5 kills cancer cells via membranolytic mechanisms that are promoted by anionic lipid. It was also found that C-terminally deaminated maximin H5 (MH5C) exhibited lower levels of α-helical structure in the presence of cancer membrane mimics (44.8%) along with a reduced ability to penetrate these membranes (Π = 8.1 mN m-1) and induce their lysis (56.6%). These data suggested that the two terminal amide groups of native maximin H5 are required for its optimal membranolytic and anticancer activity

Observations of ozone and related species in the northeast Pacific during the PHOBEA campaigns 2. Airborne observations

During late March and April of 1999 the University of Wyoming's King Air research aircraft measured atmospheric concentrations of NO, O3, peroxyacetyl nitrate (PAN), CO, CH4, VOCs, aerosols, and J(NO2) off the west coast of the United States. During 14 flights, measurements were made between 39°-48° N latitude, 125°-129° W longitude, and at altitudes from 0-8 km. These flights were part of the Photochemical Ozone Budget of the Eastern North Pacific Atmosphere (PHOBEA) experiment, which included both ground-based and airborne measurements. Flights were scheduled when meteorological conditions minimized the impact of local pollution sources. The resulting measurements were segregated by air mass source region as indicated by back isentropic trajectory analysis. The chemical composition of marine air masses whose 5-day back isentropic trajectories originated north of 40° N latitude or west of 180° W longitude (WNW) differed significantly from marine air masses whose 5-day back isentropic trajectories originated south of 40° N latitude and east of 180° W longitude (SW). Trajectory and chemical analyses indicated that the majority of all encountered air masses, both WNW and SW, likely originated from the northwestern Pacific and have characteristics of emissions from the East Asian continental region. However, air masses with WNW back trajectories contained higher mixing ratios of NO, NOx, O3, PAN, CO, CH4, various VOC pollution tracers, and aerosol number concentration, compared to those air masses with SW back trajectories. Calculations of air mass age using two separate methods, photochemical and back trajectory, are consistent with transport from the northwestern Pacific in 8-10 days for air masses with WNW back trajectories and 16-20 days for air masses with SW back trajectories. Correlations, trajectory analysis, and comparisons with measurements made in the northwestern Pacific during NASA's Pacific Exploritory Mission-West Phase B (PEM-West B) experiment in 1994 are used to investigate the data. These analyses provide evidence that anthropogenically influenced air masses from the northwestern Pacific affect the overall chemical composition of the northeastern Pacific troposphere. Copyright 2001 by the American Geophysical Union

Investigation of hydrophobic moment and hydrophobicity properties for transmembrane α-helices

Integral membrane proteins are the primary targets of novel drugs but are largely without solved structures. As a consequence, hydrophobic moment plot methodology is often used to identify putative transmembrane α-helices of integral membrane proteins, based on their local maximum mean hydrophobic moment (<μH>) and the corresponding mean hydrophobicity (<H>). To calculate these properties, the methodology identifies an optimal eleven residue window (L = 11), assuming an amino acid angular frequency, θ, fixed at 100°. Using a data set of 403 transmembrane α-helix forming sequences, the relationship between <μH> and <H>, and the effect of varying of L and / or θ on this relationship, was investigated. Confidence intervals for correlations between <μH> and <H> are established. It is shown, using bootstrapping procedures that the strongest statistically significant correlations exist for small windows where 7 ≤ L ≤ 16. Monte Carlo analysis suggests that this correlation is dependent upon amino acid residue primary structure, implying biological function and indicating that smaller values of L give better characterisation of transmembrane sequences using <μH>. However, varying window size can also lead to different regions within a given sequence being identified as the optimal window for structure / function predictions. Furthermore, it is shown that optimal periodicity varies with window size; the optimum, based on <μH> over the range of window sizes, (7 ≤ L ≤ 16), was at θ = 102° for the transmembrane α-helix data set

The Globular Cluster System of NGC4374

We study the globular cluster system (GCS) of the giant elliptical NGC4374 (M84) in the Virgo cluster using B and R photometry. The colour distribution is bimodal with peaks at B-R=1.11 and B-R=1.36, fitting well to those found in other early-type galaxies. The radial profile of the cluster number density is flatter than the galaxy light. Using the luminosity function we derive a distance modulus of $\mu=31.61\pm0.2$, which within the uncertainty agrees with the distance from surface brightness fluctuations. Blue and red clusters show similar radial concentrations and azimuthal distributions. The total number of clusters is $N=1775\pm150$, which together with our distance modulus leads to a specific frequency of $S_{N}=1.6\pm0.3$. This value is surprisingly low for a giant elliptical, but resembles the case of merger remnants like NGC1316, where the low specific frequency is probably caused by the luminosity contribution of an intermediate-age population. A further common property is the high rate of type Ia supernovae which also may indicate the existence of a younger population. However, unlike in the case of NGC1316, one cannot find any further evidence that NGC4374 indeed hosts younger populations. The low specific frequency would also fit to a S0 galaxy seen face-on.Comment: Accepted for publication in Astronomy & Astrophysics. 11 page

The Star Formation History of the Large Magellanic Cloud

We present the first-ever global, spatially-resolved reconstruction of the star formation history (SFH) of the Large Magellanic Cloud (LMC), based on the application of our StarFISH analysis software to the multiband photometry of twenty million of its stars from the Magellanic Clouds Photometric Survey. The general outlines of our results are consistent with previously published results: following an initial burst of star formation, there was a quiescent epoch from approximately 12 to 5 Gyr ago. Star formation then resumed and has proceeded until the current time at an average rate of roughly 0.2 solar masses/yr, with temporal variations at the factor-of-two level. The re-ignition of star formation about 5 Gyr ago, in both the LMC and SMC, is suggestive of a dramatic event at that time in the Magellanic system. Among the global variations in the recent star formation rate are peaks at roughly 2 Gyr, 500 Myr, 100 Myr and 12 Myr. The peaks at 500 Myr and 2 Gyr are nearly coincident with similar peaks in the SFH of the Small Magellanic Cloud, suggesting a joint history for these galaxies extending back at least several Gyr. The chemical enrichment history recovered from our StarFISH analysis is in broad agreement with that inferred from the LMC's star cluster population, although our constraints on the ancient chemical enrichment history are weak. We conclude from the concordance between the star formation and chemical enrichment histories of the field and cluster populations that the field and cluster star formation modes are tightly coupled.Comment: 20 pages, with color figures. Accepted for publication in A

The Chemical Enrichment History of the Small Magellanic Cloud and Its Gradients

We present stellar metallicities derived from Ca II triplet spectroscopy in over 350 red giant branch stars in 13 fields distributed in different positions in the SMC, ranging from $\sim$1\arcdeg\@ to $\sim$4\arcdeg\@ from its center. In the innermost fields the average metallicity is [Fe/H] $\sim -1$. This value decreases when we move away towards outermost regions. This is the first detection of a metallicity gradient in this galaxy. We show that the metallicity gradient is related to an age gradient, in the sense that more metal-rich stars, which are also younger, are concentrated in the central regions of the galaxy.Comment: 30 pages, 13 figures, accepted for publication in Astronomical Journa

Establishing comprehensive oral assessments for children with safeguarding concerns.

The dental profession is well placed to contribute important information in child protection cases but no previous research has been reported that assesses the volume or impact of this information. Comprehensive oral assessment clinics were introduced and established as an integral part of comprehensive medical assessments for children with welfare concerns in Greater Glasgow and Clyde. An assessment protocol and standardised paperwork for comprehensive oral assessments were developed to enhance information sharing and patient access to appropriate care. Two cases are presented and discussed to demonstrate the value of dental input

Origin of the unusually low nitrogen abundances in young populations of the Large Magellanic Cloud

It is a longstanding problem that HII regions and very young stellar populations in the Large Magellanic Cloud (LMC) have the nitrogen abundances ([N/H]) by a factor of ~7 lower than the solar value. We here discuss a new scenario in which the observed unusually low nitrogen abundances can be closely associated with recent collision and subsequent accretion of HI high velocity clouds (HVCs) that surround the Galaxy and have low nitrogen abundances. We show that if the observed low [N/H] is limited to very young stars with ages less than ~10^7 yr, then the collision/accretion rate of the HVCs onto the LMC needs to be ~ 0.2 M_sun/yr (corresponding to the total HVC mass of 10^6-10^7 M_sun) to dilute the original interstellar medium (ISM) before star formation. The required accretion rate means that even if the typical mass of HVCs accreted onto the LMC is ~ 10^7 M_sun, the Galaxy needs to have ~2500 massive HVCs within the LMC's orbital radius with respect to the Galactic center. The required rather large number of massive HVCs drives us to suggest that the HVCs are not likely to efficiently dilute the ISM of the LMC and consequently lower the [N/H]. We thus suggest the transfer of gas with low [N/H] from the Small Magellanic Cloud (SMC) to the LMC as a promising scenario that can explain the observed low [N/H].Comment: 24pages, 6 figures, accepted in Ap