2,105 research outputs found
Midcourse maneuver operations program
Midcourse Maneuver Operations Program /MMOP/ computes the required velocity change to correct a spacecraft trajectory. The program establishes the existence of maneuvers which satisfy spacecraft constraints, explores alternate trajectories in the event that some out-of-tolerance condition forces a change in plans, and codes the maneuvers into commands
Recovery from disturbance requires resynchronization of ecosystem nutrient cycles
Nitrogen (N) and phosphorus (P) are tightly cycled in most terrestrial ecosystems, with plant uptake more than 10 times higher than the rate of supply from deposition and weathering. This near-total dependence on recycled nutrients and the stoichiometric constraints on resource use by plants and microbes mean that the two cycles have to be synchronized such that the ratio of N:P in plant uptake, litterfall, and net mineralization are nearly the same. Disturbance can disrupt this synchronization if there is a disproportionate loss of one nutrient relative to the other. We model the resynchronization of N and P cycles following harvest of a northern hardwood forest. In our simulations, nutrient loss in the harvest is small relative to postharvest losses. The low N:P ratio of harvest residue results in a preferential release of P and retention of N. The P release is in excess of plant requirements and P is lost from the active ecosystem cycle through secondary mineral formation and leaching early in succession. Because external P inputs are small, the resynchronization of the N and P cycles later in succession is achieved by a commensurate loss of N. Through succession, the ecosystem undergoes alternating periods of N limitation, then P limitation, and eventually co-limitation as the two cycles resynchronize. However, our simulations indicate that the overall rate and extent of recovery is limited by P unless a mechanism exists either to prevent the P loss early in succession (e.g., P sequestration not stoichiometrically constrained by N) or to increase the P supply to the ecosystem later in succession (e.g., biologically enhanced weathering). Our model provides a heuristic perspective from which to assess the resynchronization among tightly cycled nutrients and the effect of that resynchronization on recovery of ecosystems from disturbance
Finding Untriggered Gamma-Ray Transients in the Fermi GBM Data
No abstract availabl
Evaluation of an alternative ruxolitinib dosing regimen in patients with myelofibrosis: an open-label phase 2 study
Abstract
Background
Ruxolitinib improves splenomegaly and symptoms in patients with intermediate-2 or high-risk myelofibrosis; however, nearly half develop grade 3/4 anemia and/or thrombocytopenia, necessitating dose reductions and/or transfusions. We report findings from an open-label phase 2 study exploring a dose-escalation strategy aimed at preserving clinical benefit while reducing hematological adverse events early in ruxolitinib treatment.
Methods
Patients with myelofibrosis received ruxolitinib 10Â mg twice daily (BID), with incremental increases of 5Â mg BID at weeks 12 and 18 for lack of efficacy (maximum, 20Â mg BID). Symptom severity was measured using the Myelofibrosis Symptom Assessment Form Total Symptom Score (MFSAF TSS).
Results
Forty-five patients were enrolled, 68.9% of whom had a Dynamic International Prognostic Scoring System score of 1 to 2 (i.e., intermediate-1 disease risk). Median percentage change in spleen volume from baseline to week 24 was − 17.3% (≥ 10% reduction achieved by 26 patients [57.8%]), with a clear dose response. Median percentage change in MFSAF TSS from baseline at week 24 was − 45.6%, also with a dose response. The most frequent treatment-emergent adverse events were anemia (26.7%), fatigue (22.2%), and arthralgias (20.0%). Grade 3/4 anemia (20.0%) and dose decreases due to anemia (11.1%) or thrombocytopenia (6.7%) were infrequent.
Conclusions
A dose-escalation approach may mitigate worsening anemia during early ruxolitinib therapy in some patients with myelofibrosis.
Trial registration
ClinicalTrials.gov
identifier,
NCT01445769
. Registered September 23, 2011.https://deepblue.lib.umich.edu/bitstream/2027.42/145195/1/13045_2018_Article_642.pd
CacheZoom: How SGX Amplifies The Power of Cache Attacks
In modern computing environments, hardware resources are commonly shared, and
parallel computation is widely used. Parallel tasks can cause privacy and
security problems if proper isolation is not enforced. Intel proposed SGX to
create a trusted execution environment within the processor. SGX relies on the
hardware, and claims runtime protection even if the OS and other software
components are malicious. However, SGX disregards side-channel attacks. We
introduce a powerful cache side-channel attack that provides system adversaries
a high resolution channel. Our attack tool named CacheZoom is able to virtually
track all memory accesses of SGX enclaves with high spatial and temporal
precision. As proof of concept, we demonstrate AES key recovery attacks on
commonly used implementations including those that were believed to be
resistant in previous scenarios. Our results show that SGX cannot protect
critical data sensitive computations, and efficient AES key recovery is
possible in a practical environment. In contrast to previous works which
require hundreds of measurements, this is the first cache side-channel attack
on a real system that can recover AES keys with a minimal number of
measurements. We can successfully recover AES keys from T-Table based
implementations with as few as ten measurements.Comment: Accepted at Conference on Cryptographic Hardware and Embedded Systems
(CHES '17
Analysis of Sub-threshold Short Gamma-ray Bursts in Fermi GBM Data
The Fermi Gamma-ray Burst Monitor (GBM) is currently the most prolific
detector of Gamma-Ray Bursts (GRBs). Recently the detection rate of short GRBs
(SGRBs) has been dramatically increased through the use of ground-based
searches that analyze GBM continuous time tagged event (CTTE) data. Here we
examine the efficiency of a method developed to search CTTE data for
sub-threshold transient events in temporal coincidence with LIGO/Virgo compact
binary coalescence triggers. This targeted search operates by coherently
combining data from all 14 GBM detectors by taking into account the complex
spatial and energy dependent response of each detector. We use the method to
examine a sample of SGRBs that were independently detected by the Burst Alert
Telescope on board the Neil Gehrels Swift Observatory, but which were too
intrinsically weak or viewed with unfavorable instrument geometry to initiate
an on-board trigger of GBM. We find that the search can successfully recover a
majority of the BAT detected sample in the CTTE data. We show that the targeted
search of CTTE data will be crucial in increasing the GBM sensitivity, and
hence the gamma-ray horizon, to weak events such as GRB 170817A. We also
examine the properties of the GBM signal possibly associated with the LIGO
detection of GW150914 and show that it is consistent with the observed
properties of other sub-threshold SGRBs in our sample. We find that the
targeted search is capable of recovering true astrophysical signals as weak as
the signal associated with GW150914 in the untriggered data.Comment: 10 pages, 9 figures, 1 table, submitted to Ap
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